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Zen Peddler
Registered: 06/18/01
Posts: 6,379
Loc: orbit
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Grapefruit potentiation and a recent study
#5802186 - 06/29/06 04:51 AM (17 years, 8 months ago) |
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Researchers Discover Why Grapefruit Juice Interacts With Drugs 05.09.06, 12:00 AM ET
TUESDAY, May 9 (HealthDay News) -- Researchers say they've identified the substances in grapefruit juice that can produce unwanted side effects when the juice is taken with certain drugs.
The discovery may make it possible to offer grapefruit juice that is free of these substances, called furanocoumarins, or add them to drugs to boost their effect, the researchers say.
People are routinely told by their doctors to avoid drinking grapefruit juice while taking a variety of medications because of potentially dangerous side effects. For instance, the beverage should be avoided when taking certain blood-pressure or cholesterol-lowering drugs, as well as HIV medications, organ-transplant drugs and sedatives.
The reason: Grapefruit juice can cause these drugs to enter the blood stream more efficiently, thereby increasing the dose and effect -- and the potential for undesirable and even dangerous side effects.
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Iamthewalrus
every evening Idied and everynight I wasreborn
Registered: 03/24/04
Posts: 3,744
Loc: Ontario
Last seen: 15 years, 5 months
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Re: Grapefruit potentiation and a recent study [Re: Zen Peddler]
#5802189 - 06/29/06 04:54 AM (17 years, 8 months ago) |
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I have it all over my ssri meds(effexor) tho I'll admit I still eat grapefruit
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ohmatic
searcher
Registered: 02/28/04
Posts: 6,742
Loc: europe
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Re: Grapefruit potentiation and a recent study [Re: Iamthewalrus]
#5802222 - 06/29/06 05:28 AM (17 years, 8 months ago) |
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i think i can feel it amplify the thc a bit, is this just imagination or is there something to it ?
i think people combine grapefruit juice with dxm right ?
-------------------- MONOTUB tek HEATBOMB tek RIP #cultivation! ....can't associate? well FUCK U !
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Iamthewalrus
every evening Idied and everynight I wasreborn
Registered: 03/24/04
Posts: 3,744
Loc: Ontario
Last seen: 15 years, 5 months
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Re: Grapefruit potentiation and a recent study [Re: ohmatic]
#5802223 - 06/29/06 05:31 AM (17 years, 8 months ago) |
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I swear it made my shrooms a lot stronger once...I think it was 3gs dry with some acid but still they hit pretty fuckin hard and I usually need 10+ gs dry
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Iamthewalrus
every evening Idied and everynight I wasreborn
Registered: 03/24/04
Posts: 3,744
Loc: Ontario
Last seen: 15 years, 5 months
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Re: Grapefruit potentiation and a recent study [Re: Iamthewalrus]
#5802224 - 06/29/06 05:32 AM (17 years, 8 months ago) |
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I can't help but wonder what lemon juice + grapefruit juice would provide
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Iamthewalrus
every evening Idied and everynight I wasreborn
Registered: 03/24/04
Posts: 3,744
Loc: Ontario
Last seen: 15 years, 5 months
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Re: Grapefruit potentiation and a recent study [Re: Iamthewalrus]
#5802255 - 06/29/06 06:08 AM (17 years, 8 months ago) |
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it most definitely works for opiates as well...actually I don't really like using it with oxy cause I get way to noddy...I prefer the mental stimulation oxy can provide without the nods(the only other time I got the nods REAL bad was when I had a pinched nerve in my back) don't know what the corrolation is but there was definitely a noticable increase on the nods...I couldn't even play gamecube...I was playing zelda and I kept noddin and thinking I was playing the game but I was noddin...it was VERY frustrating..I kept coming too realizin that link was standin still...my sister said I was mumbling jibberish as well lol...stupid stupid shit but kinda funny as well...but I"m off topic back to gf
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Zen Peddler
Registered: 06/18/01
Posts: 6,379
Loc: orbit
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Re: Grapefruit potentiation and a recent study [Re: Iamthewalrus]
#5806186 - 06/30/06 07:31 AM (17 years, 8 months ago) |
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it definately works with our mushroom friends - fucking mind breaker - in a good way of course - or is there a bad way?
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Iamthewalrus
every evening Idied and everynight I wasreborn
Registered: 03/24/04
Posts: 3,744
Loc: Ontario
Last seen: 15 years, 5 months
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Re: Grapefruit potentiation and a recent study [Re: Zen Peddler]
#5806228 - 06/30/06 08:01 AM (17 years, 8 months ago) |
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ya I thought so
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Jalruza
Boot Lover
Registered: 10/09/04
Posts: 1,985
Last seen: 15 years, 9 months
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Re: Grapefruit potentiation and a recent study [Re: ohmatic]
#5806385 - 06/30/06 09:34 AM (17 years, 8 months ago) |
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Quote:
ohmatic said: i think i can feel it amplify the thc a bit, is this just imagination or is there something to it ?
i think people combine grapefruit juice with dxm right ?
This is pscichedelic chemistry 101, it works with Ecstasy, drink a pint an hour before roll
-------------------- Time keeps ticking and running away And It's taking us fast to a brand new free dimension Too cool to mention well that's the intention But some of us too dame blind to see Jesus is the King Volume I Jesus is the King Volume II Shroomery MSN club I'm talking to aliens! Volcano Vap and Brain Chakras Hilary Duff!!
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badchad
Mad Scientist
Registered: 03/02/05
Posts: 13,377
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Re: Grapefruit potentiation and a recent study [Re: Jalruza]
#5806495 - 06/30/06 10:42 AM (17 years, 8 months ago) |
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Grapefruit juice works by inhibiting the cytochrome P450 systems of the liver. The "CYP's" are involved in the metabolism of many things (not just drugs, but also environmental toxins, etc.).
However, there are specific subtypes of CYP's which break down specific drugs. For instance, MDMA is usually broken down by CYP2D6, while grapefruit juice inhibits CYP3A4.
There is probably a pretty large overlap, but you would expect much more "potentiation" by grapefruit jucie of a drug broken down by CYP3A4 then say MDMA (CYP2D6).
-------------------- ...the whole experience is (and is as) a profound piece of knowledge. It is an indellible experience; it is forever known. I have known myself in a way I doubt I would have ever occurred except as it did. Smith, P. Bull. Menninger Clinic (1959) 23:20-27; p. 27. ...most subjects find the experience valuable, some find it frightening, and many say that is it uniquely lovely. Osmond, H. Annals, NY Acad Science (1957) 66:418-434; p.436
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Iamthewalrus
every evening Idied and everynight I wasreborn
Registered: 03/24/04
Posts: 3,744
Loc: Ontario
Last seen: 15 years, 5 months
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Re: Grapefruit potentiation and a recent study [Re: badchad]
#5808746 - 07/01/06 02:08 AM (17 years, 8 months ago) |
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so what breaks down psilocybin and oxycodone?
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