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InvisibleZen Peddler
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Registered: 06/18/01
Posts: 6,379
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Grapefruit potentiation and a recent study
    #5802186 - 06/29/06 04:51 AM (17 years, 8 months ago)

Researchers Discover Why Grapefruit Juice Interacts With Drugs
05.09.06, 12:00 AM ET

TUESDAY, May 9 (HealthDay News) -- Researchers say they've identified the substances in grapefruit juice that can produce unwanted side effects when the juice is taken with certain drugs.

The discovery may make it possible to offer grapefruit juice that is free of these substances, called furanocoumarins, or add them to drugs to boost their effect, the researchers say.

People are routinely told by their doctors to avoid drinking grapefruit juice while taking a variety of medications because of potentially dangerous side effects. For instance, the beverage should be avoided when taking certain blood-pressure or cholesterol-lowering drugs, as well as HIV medications, organ-transplant drugs and sedatives.

The reason: Grapefruit juice can cause these drugs to enter the blood stream more efficiently, thereby increasing the dose and effect -- and the potential for undesirable and even dangerous side effects.


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OfflineIamthewalrus
every evening Idied and everynight I wasreborn
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Re: Grapefruit potentiation and a recent study [Re: Zen Peddler]
    #5802189 - 06/29/06 04:54 AM (17 years, 8 months ago)

I have it all over my ssri meds(effexor) tho I'll admit I still eat grapefruit :laugh:

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Invisibleohmatic
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Re: Grapefruit potentiation and a recent study [Re: Iamthewalrus]
    #5802222 - 06/29/06 05:28 AM (17 years, 8 months ago)

i think i can feel it amplify the thc a bit,
is this just imagination or is there something to it ?

i think people combine grapefruit juice with dxm right ?


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:penis: MONOTUB tek :sun: HEATBOMB tek :penis:

RIP #cultivation! ....can't associate? well FUCK U !

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OfflineIamthewalrus
every evening Idied and everynight I wasreborn
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Re: Grapefruit potentiation and a recent study [Re: ohmatic]
    #5802223 - 06/29/06 05:31 AM (17 years, 8 months ago)

I swear it made my shrooms a lot stronger once...I think it was 3gs dry with some acid but still they hit pretty fuckin hard and I usually need 10+ gs dry

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OfflineIamthewalrus
every evening Idied and everynight I wasreborn
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Registered: 03/24/04
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Re: Grapefruit potentiation and a recent study [Re: Iamthewalrus]
    #5802224 - 06/29/06 05:32 AM (17 years, 8 months ago)

I can't help but wonder what lemon juice + grapefruit juice would provide

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OfflineIamthewalrus
every evening Idied and everynight I wasreborn
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Re: Grapefruit potentiation and a recent study [Re: Iamthewalrus]
    #5802255 - 06/29/06 06:08 AM (17 years, 8 months ago)

it most definitely works for opiates as well...actually I don't really like using it with oxy cause I get way to noddy...I prefer the mental stimulation oxy can provide without the nods(the only other time I got the nods REAL bad was when I had a pinched nerve in my back) don't know what the corrolation is but there was definitely a noticable increase on the nods...I couldn't even play gamecube...I was playing zelda and I kept noddin and thinking I was playing the game but I was noddin...it was VERY frustrating..I kept coming too realizin that link was standin still...my sister said I was mumbling jibberish as well lol...stupid stupid shit but kinda funny as well...but I"m off topic back to gf

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InvisibleZen Peddler
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Re: Grapefruit potentiation and a recent study [Re: Iamthewalrus]
    #5806186 - 06/30/06 07:31 AM (17 years, 8 months ago)

it definately works with our mushroom friends - fucking mind breaker - in a good way of course - or is there a bad way?


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OfflineIamthewalrus
every evening Idied and everynight I wasreborn
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Re: Grapefruit potentiation and a recent study [Re: Zen Peddler]
    #5806228 - 06/30/06 08:01 AM (17 years, 8 months ago)

ya I thought so

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OfflineJalruza
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Re: Grapefruit potentiation and a recent study [Re: ohmatic]
    #5806385 - 06/30/06 09:34 AM (17 years, 8 months ago)

Quote:

ohmatic said:
i think i can feel it amplify the thc a bit,
is this just imagination or is there something to it ?

i think people combine grapefruit juice with dxm right ?




This is pscichedelic chemistry 101, it works with Ecstasy, drink a pint an hour before roll


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Time keeps ticking and running away
And It's taking us fast to a brand new free dimension
Too cool to mention well that's the intention
But some of us too dame blind to see
Jesus is the King Volume I
Jesus is the King Volume II
Shroomery MSN club
I'm talking to aliens!
Volcano Vap and Brain Chakras
Hilary Duff!!
:gethigh:

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Invisiblebadchad
Mad Scientist

Registered: 03/02/05
Posts: 13,377
Re: Grapefruit potentiation and a recent study [Re: Jalruza]
    #5806495 - 06/30/06 10:42 AM (17 years, 8 months ago)

Grapefruit juice works by inhibiting the cytochrome P450 systems of the liver. The "CYP's" are involved in the metabolism of many things (not just drugs, but also environmental toxins, etc.).

However, there are specific subtypes of CYP's which break down specific drugs. For instance, MDMA is usually broken down by CYP2D6, while grapefruit juice inhibits CYP3A4.

There is probably a pretty large overlap, but you would expect much more "potentiation" by grapefruit jucie of a drug broken down by CYP3A4 then say MDMA (CYP2D6).


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...the whole experience is (and is as) a profound piece of knowledge.  It is an indellible experience; it is forever known.  I have known myself in a way I doubt I would have ever occurred except as it did.

Smith, P.  Bull. Menninger Clinic (1959) 23:20-27; p. 27.

...most subjects find the experience valuable, some find it frightening, and many say that is it uniquely lovely.

Osmond, H.  Annals, NY Acad Science (1957) 66:418-434; p.436

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OfflineIamthewalrus
every evening Idied and everynight I wasreborn
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Re: Grapefruit potentiation and a recent study [Re: badchad]
    #5808746 - 07/01/06 02:08 AM (17 years, 8 months ago)

so what breaks down psilocybin and oxycodone?

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