Home | Community | Message Board


This site includes paid links. Please support our sponsors.


Welcome to the Shroomery Message Board! You are experiencing a small sample of what the site has to offer. Please login or register to post messages and view our exclusive members-only content. You'll gain access to additional forums, file attachments, board customizations, encrypted private messages, and much more!

Kraken Kratom Shop: Kratom Capsules for Sale, Red Vein Kratom

Jump to first unread post Pages: 1
Some of these posts are very old and might contain outdated information. You may wish to search for newer posts instead.
InvisibleFantod
Stranger

Registered: 06/09/03
Posts: 10
Loc: Island of Lost Toys
Science Behind Grapefruit Juice Potentiation
    #5433445 - 03/23/06 09:17 AM (17 years, 10 months ago)

I just read this article on grapefruit juice in the Times. The information isn't new, but the description of how it works is pretty good.

If GF juice has this effect on the metabolization of SSRI's, it probably helps to explain the lime juice & black currant juice experiments...

New York Times Article


Experts Reveal the Secret Powers of Grapefruit Juice

* Sign In to E-Mail This
* Printer-Friendly
* Reprints
* Save Article

Article Tools Sponsored By
By NICHOLAS BAKALAR
Published: March 21, 2006

In 1989, a group of Canadian researchers studying a blood pressure drug were astonished to discover that drinking a glass of grapefruit juice dangerously increased the drug's potency.
Skip to next paragraph Multimedia
Graphic Refreshing but Risky
Refreshing but Risky

They were testing the effects of drinking alcohol on a medicine called Plendil. The scientists needed something that would hide the taste of alcohol so that subjects would know only that they were taking the drug and not know whether they were drinking alcohol with it.

"One Saturday night, my wife and I tested everything in the refrigerator," said David G. Bailey, a research scientist at the London Health Sciences Center in London, Ontario, and the lead author on the study. "The only thing that covered the taste was grapefruit juice."

So they used it in their experiment, expecting the grapefruit juice to be irrelevant to their results. But blood levels of the drug went up significantly in the control group that drank just grapefruit juice, without alcohol.

"People didn't believe us," Dr. Bailey said. "They thought it was a joke. We had trouble getting it published in a major medical journal."

Eventually the paper was accepted and published by Lancet, in February 1991.

Finding why juice had that effect was the next question.

The answer, it turned out, lay in a family of enzymes called the cytochrome P-450 system, in particular one known as CYP 3A4. This enzyme metabolizes many drugs, and toxins as well, into substances that are less potent or more easily excreted or both.

Grapefruit juice interferes with the ability of CYP 3A4 to do that, increasing the potency of a drug by letting more of it enter the bloodstream, in effect producing an excessive dose.

Grapefruit interacts with this enzyme only in the intestines, not in the liver or other places where it is found. As a result, the effect is seen only with medicines taken orally, not with injected drugs.

Numerous studies now show the interaction of grapefruit juice with many widely used medicines. Most interactions have no serious consequences, but a few do. For example, drugs used to lower cholesterol, like Lipitor, Mevacor and Zocor, have increased potency when taken with grapefruit juice. Excessive levels of those drugs can lead to a serious and sometimes fatal muscle disorder called rhabdomyolysis.

Does this mean a person could reduce the amount of medicine required simply by drinking grapefruit juice? No, according to Dr. Bailey.

"The problem is the unpredictability of the effect," he said. "You can't just lower your dose of Lipitor and increase your consumption of grapefruit juice. There's no uniformity from one individual to another or from one bottle of grapefruit juice to the next.

"There's huge variation in the amount of enzyme people have in their guts. Fooling around with grapefruit juice is not a good idea."

Grapefruit juice can also interfere with the metabolism of selective serotonin reuptake inhibitors, or S.S.R.I.'s, like Prozac, which are used to treat depression.

Dr. Marshall Forstein, an associate professor of psychiatry at Harvard, said he told patients to switch from grapefruit juice to something else because most oranges and other citrus fruits do not have the same effect.

"If they insist," Dr. Forstein said, "I try to prescribe the S.S.R.I. or other medication to be taken at a time when the grapefruit juice would have mostly been metabolized."

Among fruit juices, grapefruit has the strongest effect, but lime juice and orange juice made from Seville oranges similarly inhibit the CYP 3A4 enzyme. With some drugs, apple juice may interact in the same way.

While Dr. Bailey suggests avoiding grapefruit juice entirely when taking medicine, some experts say the effect of the juice should not be exaggerated.

"The circumstances under which an interaction will occur are relatively unusual," said Dr. David J. Greenblatt, a professor of pharmacology at Tufts. First, he said, the drug has to be metabolized significantly by intestinal CYP 3A4, and relatively few are. "When you look at the actual data for each drug, the scientific conclusions are that the interactions are unusual, sometimes quite small and not of clinical importance. But there are some cases in which it's significant."

Dr. Greenblatt and his co-investigators at Tufts have conducted research sponsored by the National Institutes of Health in this field for years, and he has been a paid consultant to the Florida Citrus Commission.

Dr. Richard B. Kim, a professor of medicine and pharmacology at Vanderbilt University, agreed that the interaction was a serious health concern in some patients.

"Grapefruit consumption is a clinically relevant issue, especially for the elderly, who are most likely to be taking the drugs affected by it," Dr. Kim said. "If you're taking multiple medications, or have recently switched to a different type of medication, you should be particularly careful. The easiest thing to do under those circumstances is to take the medicine with water and avoid the juice completely."


Edited by Wiccan_Seeker (03/23/06 06:59 PM)


Extras: Filter Print Post Top
OfflinePlatformStrange
Most Ancient
I'm a teapot User Gallery

Registered: 01/18/06
Posts: 275
Loc: The most ancient county o... Flag
Last seen: 3 years, 2 months
Re: Science Behind Grapefruit Juice Potentiation [Re: Fantod]
    #5433725 - 03/23/06 10:11 AM (17 years, 10 months ago)
Log in to view attachment

ahaaa!!! knew from experience.... there we have it !!
Cheers..


--------------------
==================================================
"Confusion is when neither of your feet are left and your trousers have infinite sides each of which has infinite surfaces."
"Do i need trousers where I'm going?"
"NO, GOOD LUCK SOLDIER"


Extras: Filter Print Post Top
Offlineshneck
Stranger
 User Gallery

Registered: 09/16/05
Posts: 222
Last seen: 1 year, 5 months
Re: Science Behind Grapefruit Juice Potentiation [Re: PlatformStrange]
    #5435199 - 03/23/06 05:04 PM (17 years, 10 months ago)

Just a few words to add: freshly pressed juice is quite more effective than bottled one, and fresh juice of yellow grapefruits is more effective than that of the red ones.
Also, works great if incorporated into lemon/lime method (tested on humans successfully :headbang: )


Extras: Filter Print Post Top
Offlinethe_psychonaut
psychonaut
 User Gallery
Registered: 01/09/05
Posts: 394
Last seen: 8 years, 5 months
Re: Science Behind Grapefruit Juice Potentiation [Re: shneck]
    #5435432 - 03/23/06 06:20 PM (17 years, 10 months ago)

finally some kind of "proof" although i still think of that phrase "dont believer everything you read". i have done this with dxm and was proven more potent though, i think ill try that next instead of lemon


--------------------
never be afraid to let your mind explore, just know what you are getting into b4 you jump in the deep end, and do your research on this site and erowid.com


Extras: Filter Print Post Top
Jump to top Pages: 1

Kraken Kratom Shop: Kratom Capsules for Sale, Red Vein Kratom


Similar ThreadsPosterViewsRepliesLast post
* Grapefruit juice and potentiation cubeladd 1,589 3 01/24/06 11:59 AM
by Koala Koolio
* Grapefruit juice and shrooms???
( 1 2 all )
Psilocybeingzz 21,761 26 09/23/09 01:10 AM
by starfirex
* Grapefruit Juice Catalysis 1,402 8 05/17/06 04:31 PM
by A0999
* Gummihuasca experiment - Black Currant Juice to increase mushroom effects - Please contribute
( 1 2 3 4 ... 14 15 )
infinitedot 155,215 294 06/25/17 12:03 PM
by AtomHeart
* Grapefruit potentiation and a recent study Zen Peddler 3,258 10 07/01/06 02:08 AM
by Iamthewalrus
* The Lemon Experience... [now a community experiment - please contribute]
( 1 2 3 4 ... 73 74 )
Underhillmaster 483,531 1,462 09/28/21 09:45 AM
by RonsonD
* Just dosed 4 grams and lemon juice TrancedShroom 1,489 11 10/26/06 12:11 AM
by Eternitys_Child
* What's This I Hear About Orange Juice Hampering a Trip?
( 1 2 all )
fireworks_godS 5,252 20 11/16/15 03:41 PM
by Caesare

Extra information
You cannot start new topics / You cannot reply to topics
HTML is disabled / BBCode is enabled
Moderator: psilocybinjunkie, Rose, mushboy, LogicaL Chaos, Northerner, bodhisatta
3,363 topic views. 3 members, 45 guests and 11 web crawlers are browsing this forum.
[ Show Images Only | Sort by Score | Print Topic ]
Search this thread:

Copyright 1997-2024 Mind Media. Some rights reserved.

Generated in 0.025 seconds spending 0.009 seconds on 14 queries.