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Invisibleifoundwaldo


Registered: 09/28/10
Posts: 8,389
Loc: Denver, CO Flag
Re: EASY WAYS TO POTENTIATE/LENGTHEN A TRIP BY PRELOADING ON OTHER SUBSTANCES [Re: mattritt]
    #13935429 - 02/09/11 06:28 PM (13 years, 9 days ago)

Quote:

mattritt said:
I STRONGLY, VERY STRONGLY feel that you need to include a warning ANY time you mention MAOI usage in a non ayahuasca forum.  Wizard would you PLEASE consider adding one to your original post for safety purposes.  This is an information site aswell as a harm reduction site, as such we must reduce the chances that someone could take an MOAI with medication or a substance that will cause an adverse reaction, which include headaches and even death.

Im not positive but I believe that it is adverse to take 5-HTP with MAOI's as it can lead to serotonin syndrome.  I'm not positive on this but the fact that you mention both in your post, I feel you should look into that and if it is such should include the warning for your safety aswell as the safety of your readers. 

Thanks :grin:




I don't know the exact chemistry, but plant-based MAOIs don't have the dietary restrictions that prescription MAOIs do.
(EDIT: Something about inhibiting MAO-A versus MAO-B.)
I'm not sure if they interact with prescriptions (e.g. SSRIs) the same way though.

5-HTP with many psychedelics (e.g. MDMA) can cause serotonin syndrome.
This thread, in general, has some questionable information.


--------------------


Edited by ifoundwaldo (02/09/11 06:29 PM)


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Offlinemattritt
Mind Chemist
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Posts: 2,292
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Re: EASY WAYS TO POTENTIATE/LENGTHEN A TRIP BY PRELOADING ON OTHER SUBSTANCES [Re: ifoundwaldo]
    #13935803 - 02/09/11 07:41 PM (13 years, 9 days ago)

Quote:

ifoundwaldo said:
Quote:

mattritt said:
I STRONGLY, VERY STRONGLY feel that you need to include a warning ANY time you mention MAOI usage in a non ayahuasca forum.  Wizard would you PLEASE consider adding one to your original post for safety purposes.  This is an information site aswell as a harm reduction site, as such we must reduce the chances that someone could take an MOAI with medication or a substance that will cause an adverse reaction, which include headaches and even death.

Im not positive but I believe that it is adverse to take 5-HTP with MAOI's as it can lead to serotonin syndrome.  I'm not positive on this but the fact that you mention both in your post, I feel you should look into that and if it is such should include the warning for your safety aswell as the safety of your readers. 

Thanks :grin:




I don't know the exact chemistry, but plant-based MAOIs don't have the dietary restrictions that prescription MAOIs do.
(EDIT: Something about inhibiting MAO-A versus MAO-B.)
I'm not sure if they interact with prescriptions (e.g. SSRIs) the same way though.

5-HTP with many psychedelics (e.g. MDMA) can cause serotonin syndrome.
This thread, in general, has some questionable information.




MAO-A is what the harmalas inhibit and you cant take ANY perscription medications with them or ANY stimulants and NO alcohol.  MAO-B is totally different and ive heard anicdotal evidence of it actually being safe with phenethylamines.  BUT no one will be taking MAO-B's so dissregard that. 

MAOI's CAN NOT be be taken with any drugs other than basic tryptamines safely.  I would recommend also only using them with natural tryptamine (ie mushrooms and DMT) as solvents and impurities can could cause complications.  You are correct that the dietary restrictions (this means the food you are eating) are more "lax" but they are still to definitely be taken into consideration as they can cause great disscomfort and unpleasantness if too much is ingested.

The reason you cant take MAOI's with things like MDMA for example is that MAO is an enzyme that breaks down chemicals in the body.  MAOI's inhibit this enzyme from metabolizing the compounds, this is why it extends trips as the compound stays in the body to be absorbed instead of rapidly being broken down by MAO.  When taking MDMA serotonin floods the brain but without MAO the serotonin is not broken down and you basically have pools of serotonin in your brain and this causes SERIOUS health risks, ie extreme headaches and death.

Also I believe the 5-HTP is ok with MDMA but not MAOI's.  5-HTP is generally used to combat the MDMA hangover and Ive taken it before, after, and I believe during (but dont take that as fact, do your own research).  And taking too much 5-HTP can also put you at risk of serotonin syndrome.

BE CAREFUL with MAOI's people!!


--------------------
**Metaphysical Crystal, Stones, Gems, and Minerals**
Every individual reacts differently to every chemical.
Know your Body - Know your Mind - Know your Substance - Know your Source.
:bongload:  :gethigh:  "You need more THC to your brain, faster." - Drr  :gethigh:  :bongload:


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