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Unfolding Nature Shop: Unfolding Nature: Being in the Implicate Order

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Get Out. Schizophrenics endogenously produce LSD? * 1
    #16250711 -

I just completely randomly stumbled onto this article that said this:

"But get this. Forty-five percent of schizophrenics tested positive in one study for both T. gondii and D-lysergic acid diethylamide, better known as LSD. To quote a recent paper: "These results support the hypothesis that T. gondii may cause schizophrenia and may do so by producing or triggering the production of an hallucinogenic chemical" ("Genes, Germs, and Schizophrenia," Ledgerwood et al, Perspectives in Biology and Medicine, 2003). Mindful that rodents are often an intermediate host for the parasite, the authors go on to say, "Production of such a compound may have been favored by natural selection because an infected, hallucinating rodent would be more easily captured by a cat." In other words, schizophrenia in humans may be a side effect of T. gondii's attempt to set cats up with a steady supply of tripping mice, the better to ensure its own reproductive success. Told you this was bizarre."


http://www.straightdope.com/columns/read/2637/if-cat-poop-is-so-toxic-to-pregnant-women-why-arent-there-more-birth-defects

What are the chances that of that?

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Re: Get Out. Schizophrenics endogenously produce LSD? [Re: Epigallo] * 1
    #16250728 -

What???? Hmmmmmm research time


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:penis: AMU Q&A Thread :penis:Come Chat About Stand up Comedians


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Re: Get Out. Schizophrenics endogenously produce LSD? [Re: Epigallo] * 1
    #16250749 -

What are the chances that of that?

100%


--------------------
"Don't believe everything you think". -Anom.

" All that lives was born to die"-Anom.

With much wisdom comes much sorrow,
The more knowledge, the more grief.
Ecclesiastes circa 350 BC

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Re: Get Out. Schizophrenics endogenously produce LSD? [Re: Icelander] * 1
    #16250774 -

I thought everyone knew about eating infected rats to trip ballz.


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Edited by OrgoneConclusion (05/18/12 04:50 PM)

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Re: Get Out. Schizophrenics endogenously produce LSD? [Re: OrgoneConclusion] * 1
    #16250799 -

And bufotenine, apparently.
Quote:
Urine bufotenine levels were significantly higher in ASD subjects (3.30 +/- 0.49 microg/L, p<0.05) and patients with schizophrenia (4.39 +/- 0.43 microg/L, p<0.001) compared with controls (1.53 +/- 0.30 microg/L). Among patients with ASD, there was a significant positive correlation between urine bufotenine and hyperactivity scores on the Vineland Adaptive Behavior Scale (r=0.479, p<0.05). No other associations were detected.


http://www.ncbi.nlm.nih.gov/pubmed/20150873


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Re: Get Out. Schizophrenics endogenously produce LSD? [Re: OrgoneConclusion] * 1
    #16250805 -

I ate one in my survival training and I'm still out in the desert out of my skull sitting at my computer posting at the shroomery what never existed on my home planet of Zardoz. :braindamage:


--------------------
"Don't believe everything you think". -Anom.

" All that lives was born to die"-Anom.

With much wisdom comes much sorrow,
The more knowledge, the more grief.
Ecclesiastes circa 350 BC

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Re: Get Out. Schizophrenics endogenously produce LSD? [Re: OrgoneConclusion] * 1
    #16250827 -

Ok so this seems a little out there, never seen lsd being produced in nature.
However the first anti psychotics where developed specifically blocking the action of LSD.
I fond it interesting that these drugs have a broad range of physical side effects whereas pure LSD has practically zero.

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Re: Get Out. Schizophrenics endogenously produce LSD? [Re: Icelander] * 1
    #16250852 -

Icelander said:
I ate one in my survival training and I'm still out in the desert out of my skull sitting at my computer posting at the shroomery what never existed on my home planet of Zardoz. :braindamage:




Seems a bit gay...


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Re: Get Out. Schizophrenics endogenously produce LSD? [Re: OrgoneConclusion] * 1
    #16250934 -

but stoned nonetheless  :feelingfab:


--------------------
"Don't believe everything you think". -Anom.

" All that lives was born to die"-Anom.

With much wisdom comes much sorrow,
The more knowledge, the more grief.
Ecclesiastes circa 350 BC

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Re: Get Out. Schizophrenics endogenously produce LSD? [Re: Icelander] * 1
    #16250993 -

Holy shit, this got me thinking.

What if governments conspire to produce some new type of drug that works long term which prevents the effects of psychedelics. Then the government unleashes it to the pubic for some crazy reason that all 'normal' folks believe.

It's my fictional tragedy scenario.

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Re: Get Out. Schizophrenics endogenously produce LSD? [Re: Dest] * 1
    #16251417 -

Dest said:
Ok so this seems a little out there, never seen lsd being produced in nature.
However the first anti psychotics where developed specifically blocking the action of LSD.
I fond it interesting that these drugs have a broad range of physical side effects whereas pure LSD has practically zero.


it's genetics

the witches of salem passed it down

lysergic bloodline brah

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Re: Get Out. Schizophrenics endogenously produce LSD? [Re: swimmingfast] * 1
    #16251439 -

swimmingfast said:
Holy shit, this got me thinking.

What if governments conspire to produce some new type of drug that works long term which prevents the effects of psychedelics. Then the government unleashes it to the pubic for some crazy reason that all 'normal' folks believe.

It's my fictional tragedy scenario.



In the future, let us do the thinking please. :whacker:


--------------------
"Don't believe everything you think". -Anom.

" All that lives was born to die"-Anom.

With much wisdom comes much sorrow,
The more knowledge, the more grief.
Ecclesiastes circa 350 BC

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Re: Get Out. Schizophrenics endogenously produce LSD? [Re: Icelander] * 1
    #16251873 -

Very interesting :o similarly.. I have heard some that they also produce higher levels of natural DMT than most human beings.. And for w/e reason some is released while awake, rather than only to create dreams :o

I don't really know much about it at all.. So don't quote me :p but I've read a few stories about this :o anyone else hear of this?

*side note* I feel kinda sorry for these people.. Must be very frustrating to meet a new person you really like and get along with only to find they don't exist :s (as only one example)
I know a family of schizophrenics.. And it's rather interesting/sad.. But you just chime in on their conversions and don't act surprised and you can learn a lot.. Kinda a good experience IMO :o


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-Sykes :3

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Re: Get Out. Schizophrenics endogenously produce LSD? [Re: Sykes] * 1
    #16253056 -

Quoting - ---The Straight Dope (which is not a credible scientific journal)
Quote:
But get this. Forty-five percent of schizophrenics tested positive in one study for both T. gondii and D-lysergic acid diethylamide, better known as LSD. To quote a recent paper: "These results support the hypothesis that T. gondii may cause schizophrenia and may do so by producing or triggering the production of an hallucinogenic chemical" ("Genes, Germs, and Schizophrenia," Ledgerwood et al, Perspectives in Biology and Medicine, 2003).


are we to believe that "Genes, Germs, and Schizophrenia," Ledgerwood et al, Perspectives in Biology and Medicine, 2003, was a scientific experimental report finding those numbers, or was it possibly the opinion in some review article wherein there were actually no lab results at all (most likely).

Also there is no endogenous DMT in schizophrenics or non-schizophrenics

------------------------HOWEVER MORE INTERESTINGLY----------------------------------

Quoting - ---US National Library of Medicine National Institutes of Health http://www.ncbi.nlm.nih.gov/pubmed/20150873
Quote:
Urine bufotenine levels were significantly higher in ASD subjects (3.30 +/- 0.49 microg/L, p<0.05) and patients with schizophrenia (4.39 +/- 0.43 microg/L, p<0.001) compared with controls (1.53 +/- 0.30 microg/L). Among patients with ASD, there was a significant positive correlation between urine bufotenine and hyperactivity scores on the Vineland Adaptive Behavior Scale (r=0.479, p<0.05). No other associations were detected.


Apparently all of us DO have some bufotenine in our urine, and it measures higher in nutbars.

more about that would be very interesting to read, also why the variance between normal and nutty is so slight (indicative that we are all slightly - well you know - goofy)


----------------------------------------


Quoting - ---Wikepedia  http://en.wikipedia.org/wiki/Bufotenin
Quote:
Association with schizophrenia and other mental disorders
A study conducted in the late 1960s reported the detection of bufotenin in the urine of schizophrenic subjects;[26] however, subsequent research has failed to confirm these findings.[27][28][29][30]
Studies have detected endogenous bufotenin in urine specimens from individuals with other psychiatric disorders,[31] such as infant autistic patients.[32] Another study indicated that paranoid violent offenders or those who committed violent behaviour towards family members have higher bufotenin levels in their urine than other violent offenders.[33]
A 2010 study utilized a mass spectrometry approach to detect levels of bufotenin in the urine of individuals with severe autism spectrum disorder (ASD), schizophrenia, and asymptomatic subjects. Their results indicate significantly higher levels of bufotenin in the urine of the ASD and schizophrenic groups when compared to asymptomatic individuals.[34]


I read somewhere that it is a metabolite of serotonin...


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:brainfart: _ :finger:

Edited by redgreenvines (05/19/12 05:03 AM)

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Re: Get Out. Schizophrenics endogenously produce LSD? [Re: redgreenvines] * 1
    #16253198 -

No, it isn't a scientific journal, but I do not immediately suspect it is entirely fabricated. If the report is that 45% of schizos tested positive for T. Gondii and LSD, what would it refer to if not lab results? Besides, Icelander says the chance of it is 100%.

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Re: Get Out. Schizophrenics endogenously produce LSD? [Re: Epigallo] * 1
    #16253685 -

well if icelander says so, I rest my case.

note: the format of a claim is often much more specific when it is scientific. i.e. (4.39 +/- 0.43 microg/L, p<0.001) compared with controls (1.53 +/- 0.30 microg/L); and even scientific journals will report bunk if the style of the report is consistent with the genre... future experiments will need to follow to uptake the idea into scientific theory and practice.


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:brainfart: _ :finger:

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Re: Get Out. Schizophrenics endogenously produce LSD? [Re: redgreenvines] * 1
    #16253710 -

What would Harpo say?


--------------------
"Don't believe everything you think". -Anom.

" All that lives was born to die"-Anom.

With much wisdom comes much sorrow,
The more knowledge, the more grief.
Ecclesiastes circa 350 BC

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Re: Get Out. Schizophrenics endogenously produce LSD? [Re: Icelander] * 1
    #16254142 -

beep beep


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:brainfart: _ :finger:

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Re: Get Out. Schizophrenics endogenously produce LSD? [Re: redgreenvines] * 1
    #16255146 -

How do you separate the bunk from the non-bunk within a scientific journal then?

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Re: Get Out. Schizophrenics endogenously produce LSD? [Re: Epigallo] * 1
    #16255830 -

this is not a trivial process,
once you have a deep and well rounded appreciation
you can tell when a series of experiments are chasing things that are not going to fit together.
some theories require much more space time or matter than exists to work.
these are usually wrong but they still may be fund-able for a while.


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:brainfart: _ :finger:

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Unfolding Nature Shop: Unfolding Nature: Being in the Implicate Order

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