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The Uncertainty Principle says that solid matter could pass through solid matter, but that it's not all that likely. But if you wanted to predict the Universe entirely then you'd have to get right down to sub-atomic particles (or strings) and it would all fall apart as some kind of infinite variety of probability futures.
New theories however could always come up with a reasonable explanation for the Uncertainty Principle and dispute it (for example, string theory could be complete without any variables). We won't know until we get there