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Registered: 05/22/02
Posts: 2,511
MAOI's and pot?
    #3958173 - 03/23/05 09:39 AM (12 years, 7 months ago)

I have a feeling this topic has been covered a million times, however my search returned a lot of extraneous crap. I was simply wondering if taking an MAOI will increase your high at all when smoking pot. Thanks.


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The Heaviest OfThem All

Registered: 08/06/03
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Loc: British Columbia
Re: MAOI's and pot? [Re: blacksabbathrulz]
    #3958406 - 03/23/05 11:00 AM (12 years, 7 months ago)

MAOIs are for drugs that have a similar struture to serotonin, I believe.

So no, I don't think it'll work.

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Active Ingredient
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Registered: 10/29/04
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Re: MAOI's and pot? [Re: HeavyToilet]
    #3958570 - 03/23/05 11:51 AM (12 years, 7 months ago)

erowid: basic maoi information

MAO metabolizes serotonin, norepinephrine and dopamine. By inhibiting this, MAOIs increase levels of those neurotransmitters. Phenelzine (Nardil) and tranycypromine (Parnate) are the two popular MAOIs. moclobemide (Aurorex -- called something else in canada) is a recently introduced MAOI which is slightly different and apparently not as effictatious, although it eliminates the hazards associated with the earlier MAOIs.

Cannabis does not work on the seratonin or dopamine systems; Cannabinoids connect to cannabinoid receptors and that is not at all related to seratonin or dopamine.

In effect, no effect.


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work in progress

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Re: MAOI's and pot? [Re: delta9]
    #3958612 - 03/23/05 12:02 PM (12 years, 7 months ago)

in another post I read the high of those two combined is interesting, that is rue (extract) and cannabis. Although they may not potentiate each other there can be an additive effect when using both substances.

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Mushrooms, Mycology and Psychedelics >> The Psychedelic Experience

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