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Offlinesunshine
Sin18DwireWuTang

Registered: 04/03/04
Posts: 43,592
Loc: higher plane of sex
Last seen: 2 years, 10 months
Will Seratonin get you high?
    #5097512 - 12/23/05 01:07 PM (15 years, 11 months ago)

I mean, exactly like si already in your brain?


--------------------
One Love True Indeed.  Have Good Trips.  Mike/sunshine's mom.


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Offlinedubbyah
Stranger
Registered: 09/07/05
Posts: 198
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Re: Will Seratonin get you high? [Re: sunshine]
    #5097530 - 12/23/05 01:13 PM (15 years, 11 months ago)

Serotonin taken orally does not pass into the serotonergic pathways of the central nervous system (CNS). This is due to the blood-brain barrier's preventing serotonin in the blood stream from affecting serotonin levels in the brain. So, no.


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Invisibledblaney
Human Being

Registered: 10/03/04
Posts: 7,894
Loc: Here & Now
Re: Will Seratonin get you high? [Re: sunshine]
    #5097536 - 12/23/05 01:15 PM (15 years, 11 months ago)

Nope, sorry man.


--------------------
"What is in us that turns a deaf ear to the cries of human suffering?"

"Belief is a beautiful armor
But makes for the heaviest sword"
- John Mayer

Making the noise "penicillin" is no substitute for actually taking penicillin.

"This country, with its institutions, belongs to the people who inhabit it. Whenever they shall grow weary of the existing government, they can exercise their constitutional right of amending it, or their revolutionary right to dismember or overthrow it." -Abraham Lincoln


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Offlinesunshine
Sin18DwireWuTang

Registered: 04/03/04
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Re: Will Seratonin get you high? [Re: dblaney]
    #5097538 - 12/23/05 01:16 PM (15 years, 11 months ago)

WHat if it somehow got into the brain?


--------------------
One Love True Indeed.  Have Good Trips.  Mike/sunshine's mom.


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Offlinesafe
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Registered: 12/10/05
Posts: 95
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Re: Will Seratonin get you high? [Re: sunshine]
    #5097553 - 12/23/05 01:21 PM (15 years, 11 months ago)

then it would make you high, as long as it can perform the same functin taht seratonin normally does when released by mdma


Edited by safe (12/23/05 01:22 PM)


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Offlinesunshine
Sin18DwireWuTang

Registered: 04/03/04
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Re: Will Seratonin get you high? [Re: safe]
    #5097565 - 12/23/05 01:25 PM (15 years, 11 months ago)

But i thought that's not how drugs acted?


--------------------
One Love True Indeed.  Have Good Trips.  Mike/sunshine's mom.


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Offlinesafe
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Re: Will Seratonin get you high? [Re: sunshine]
    #5097572 - 12/23/05 01:29 PM (15 years, 11 months ago)

what do you mean?

im just saying if seratonin an get in yuor brain from an outside source and do exactley what seratonin does normally when realsead due to mdma why wouldn't it get you high


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Offlinesunshine
Sin18DwireWuTang

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Re: Will Seratonin get you high? [Re: safe]
    #5097573 - 12/23/05 01:31 PM (15 years, 11 months ago)

Mj shroomer posted an old study that stated drugs plug into your seratonin receptors.


--------------------
One Love True Indeed.  Have Good Trips.  Mike/sunshine's mom.


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Invisibledblaney
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Posts: 7,894
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Re: Will Seratonin get you high? [Re: safe]
    #5097578 - 12/23/05 01:33 PM (15 years, 11 months ago)

It wouldn't though. The body has enzymes and other safeguards to ensure that levels of bio and neurochemicals don't go too low or too high. You would need a drug that releases the serotonin quickly, maybe even going up through the way serotonin goes out, and temporarily preventing the reabsorption of it, like MDMA.


--------------------
"What is in us that turns a deaf ear to the cries of human suffering?"

"Belief is a beautiful armor
But makes for the heaviest sword"
- John Mayer

Making the noise "penicillin" is no substitute for actually taking penicillin.

"This country, with its institutions, belongs to the people who inhabit it. Whenever they shall grow weary of the existing government, they can exercise their constitutional right of amending it, or their revolutionary right to dismember or overthrow it." -Abraham Lincoln


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Invisiblebadchad
Mad Scientist

Registered: 03/02/05
Posts: 13,200
Re: Will Seratonin get you high? [Re: sunshine]
    #5097585 - 12/23/05 01:35 PM (15 years, 11 months ago)

Yes, most hallucinogens bind to receptors. However, the effects that occur AFTER the drug binds are what's important (second messenger effects). Also, MDMA does more than simply release serotonin it's mechanism of action s relatively complex.


--------------------
...the whole experience is (and is as) a profound piece of knowledge.  It is an indellible experience; it is forever known.  I have known myself in a way I doubt I would have ever occurred except as it did.

Smith, P.  Bull. Menninger Clinic (1959) 23:20-27; p. 27.

...most subjects find the experience valuable, some find it frightening, and many say that is it uniquely lovely.

Osmond, H.  Annals, NY Acad Science (1957) 66:418-434; p.436


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Offlinesafe
Stranger
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Re: Will Seratonin get you high? [Re: badchad]
    #5097605 - 12/23/05 01:42 PM (15 years, 11 months ago)

ah rite, sorry then


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OfflineKonnrade
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Re: Will Seratonin get you high? [Re: sunshine]
    #5097610 - 12/23/05 01:44 PM (15 years, 11 months ago)

Quote:

sunshine said:
Mj shroomer posted an old study that stated drugs plug into your seratonin receptors.




and yet it's allready been proven that it'd be a sticky wicket trying to actually get seratonin to these receptors.

So unless you become a neurosurgeon between now and whenever you want to use seratonin, I advise you to call this impossible


--------------------

I find your lack of faith disturbing


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Offlinecubeladd
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Re: Will Seratonin get you high? [Re: Konnrade]
    #5098253 - 12/23/05 04:56 PM (15 years, 11 months ago)

Large amounts of extra Serotonin alone will probably just put you in a very happy but drowsy state, as it is also the chemical that regulates sleep and anxiety/calmness. Serotonin release may be the principal chemical involved in the the MDMA experience, but dopamine and norephinephrine (is that spelt right?) are also involved.

Secondly there would still be a risk of Serotonin syndrome and the receptors would still shrink with heavy/frequent from being bombarded with Serotonin cells, even though there probably wouldn't be any toxicity due to the fact that once the extra Serotonin had been used up, your brain would return to it's normal Serotonin activity level. As no Serotonin would have been depleted, there would not be an issue with Dopamine entering Serotonin receptors therefore no Dopamine to breakdown into the toxic Hydrogen Peroxide (H202) which happens once dopamine enters Serotonin cells after MDMA use I believe.

I don't beleive that pure Serotonin has ever been made. I may be wrong but I think that it is a chemical that can only be manufactured in the body. We can take 5-HTP to increase our Serotonin levels but our bodies will probably break down any excess so I very much doubt that you could get high from just taking excess amounts of 5-HTP.


--------------------
"The only thing I'm high on is Love for my Son and Daughters. Yes, a little LSD is all I need."
-Marge Simpson


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OfflineChuangTzu
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Re: Will Seratonin get you high? [Re: cubeladd]
    #5100667 - 12/24/05 05:11 AM (15 years, 11 months ago)

As other people have said, taking serotonin will not get you high, it won't pass into your brain, it won't make you happy, it won't make you drowsy, and it won't cause serotonin syndrome. Serotonin is 5-HO-tryptamine. It's easy as cake to synthesize.


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Offlinesunshine
Sin18DwireWuTang

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Re: Will Seratonin get you high? [Re: ChuangTzu]
    #5101399 - 12/24/05 01:04 PM (15 years, 11 months ago)

Thanks everybody for answering my thingy. Now I know I will probably never get high from Seratonin.


--------------------
One Love True Indeed.  Have Good Trips.  Mike/sunshine's mom.


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Offlinesome1whoisntme
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Re: Will Seratonin get you high? [Re: sunshine]
    #5101878 - 12/24/05 02:52 PM (15 years, 11 months ago)

Would it make it to your brain if you injested it with an MAOI? I'm thinking of an ayahuasca type cocktail, but serotonin instead of DMT. On second thought, this sounds like Serotonin-Syndrome-In-A-Glass...


--------------------
"Ignore the distortion you're forced to percieve and believe that what supercedes is love, but who agrees?"


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Offlinecubeladd
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Re: Will Seratonin get you high? [Re: some1whoisntme]
    #5101918 - 12/24/05 03:02 PM (15 years, 11 months ago)

Quote:

some1whoisntme said:
...On second thought, this sounds like Serotonin-Syndrome-In-A-Glass...




Perhaps you could market the idea.  :rolleyes: :grin:


--------------------
"The only thing I'm high on is Love for my Son and Daughters. Yes, a little LSD is all I need."
-Marge Simpson


Edited by cubeladd (12/24/05 03:02 PM)


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OfflineShroomArtist84
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Re: Will Seratonin get you high? [Re: cubeladd]
    #5103054 - 12/24/05 10:24 PM (15 years, 11 months ago)

very useful knowledge i have read here tonight.


--------------------
No matter what I say and no matter what I write here.

I'm sick of always looking at this page with a blank stare.


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OfflineTodcasil
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Re: Will Seratonin get you high? [Re: ShroomArtist84]
    #5103080 - 12/24/05 10:33 PM (15 years, 11 months ago)

useful like a wet dog in a room where youre not allowed to shake your dog.


--------------------
Men look at themselves and they see flawed humans, we look at women and we see perfect
GODDESSES
Women look at themselves and they seem utterly human, when looking at men they see proud
GODS.


~Casil



:cactus:


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OfflineThePredator
Your a eunich ifyou don't useunix!

Registered: 08/23/05
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Re: Will Seratonin get you high? [Re: Todcasil]
    #5103247 - 12/24/05 11:46 PM (15 years, 11 months ago)

Not onl that but most drugs are 5-hydroxytryptamine site specific meaning they effect all sites differently, just 5-hydroxytryptamine would affect all sites equally and you would end up with serotonin syndrome.


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