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InvisibleHeavyToilet
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Serotonin levels?
    #2698194 - 05/18/04 08:42 PM (12 years, 6 months ago)

I checked on Erowid and couldn't really find anything on about this, so I was wondering if anyone here knew the answer.

So I was wondering, does Psilocybin increase, decrease, or do nothing to the levels of Serotonin in the brain?
If it does do something to the levels, is there any indication of the levels returning to normal? If so, how long does it take?

The reason I ask, is that someone said it 'changes' the levels. I haven't seen anything about this before, so I thought I should ask here.

Please list sources, thanks.


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OfflineRequiem
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Re: Serotonin levels? [Re: HeavyToilet]
    #2698200 - 05/18/04 08:44 PM (12 years, 6 months ago)

I don't know much, but I believe it increases serotonin levels.


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OfflineNoviseer
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Re: Serotonin levels? [Re: HeavyToilet]
    #2698819 - 05/18/04 11:57 PM (12 years, 6 months ago)

its the only drug that makes me feel better for the three or four days after having taken it, I don't know if thats biological or psychological, however.


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Offline0xYg3n
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Re: Serotonin levels? [Re: HeavyToilet]
    #2699011 - 05/19/04 12:29 AM (12 years, 6 months ago)

I'm not sure either..... i'd like to know that as well.

I know that your body is interconnected--that if you create an imbalance at one thing it will effect others.

What i'm wondering is that what do high serotonin levels effect?


Edited by 0xYg3n (05/19/04 12:30 AM)


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Offline0xYg3n
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Re: Serotonin levels? [Re: 0xYg3n]
    #2699043 - 05/19/04 12:35 AM (12 years, 6 months ago)

interesting.........

Quote:

What is Serotonin?

"Serotonin [a neurotransmitter] is believed to play an important part of the biochemistry of depression, bipolar disorder and anxiety. It is also believed to be influential on sexuality."

Wikipedia: Serotonin



"This neurotransmitter regulates

? the onset of sleep,

? sensory perception,

? mood and depression,

? body temperature,

? hyperacusis (noise sensitivity)?

? photophobia (sensitivity to light)

Low levels may contribute to muscle weakness and stiffness experienced by Fibromyalgia sufferers."

Chronic Fatigue Syndrome / M.E. / Fibromyalgia Information, Treatment & Support






I didn't know high serotonin levels would also help play a role with psilocybin and psilocin. It's almost like they act in synergy together.


Edited by 0xYg3n (05/19/04 12:37 AM)


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Offline0xYg3n
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Re: Serotonin levels? [Re: HeavyToilet]
    #2699054 - 05/19/04 12:36 AM (12 years, 6 months ago)

Quote:

Serotonin Levels

Normal Serotonin Levels

"Regulates sleep, reduces pain and appetite, and generally calms you down and improves your mood. (Page 46)"

Book: Somer, Elizabeth, M.A., R.D. Food & Mood. Henry Holt and Company, LLC, 1999.



Low Seratonin Levels

"Low levels of serotonin are associated with

? increased carbohydrate cravings

? depression

? heightened sensitivity to pain, and

? troubled sleep patterns (Page 144)"

Book: Somer, Elizabeth, M.A., R.D. Food & Mood. Henry Holt and Company, LLC, 1999.



High Serotonin Levels

"When serotonin levels are high,

? carbohydrate cravings subside,

? mood is elevated,

? pain tolerance improves, and

? sleep is more restful. (Page 144)"

Book: Somer, Elizabeth, M.A., R.D. Food & Mood. Henry Holt and Company, LLC, 1999.



Overproduction of Serotonin

Positive Ions

? Indoor Air Pollution: Ions: Effects: Effects on the Brain: Serotonin



Serotonin Irritation Syndrome

? The Brain: Serotonin Irritation Syndrome (SIS)



Electromagnetic Waves

? Indoor Air Pollution: Electromagnetic Waves: Effects






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InvisibleLocus
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Re: Serotonin levels? [Re: 0xYg3n]
    #2699221 - 05/19/04 01:04 AM (12 years, 6 months ago)

Serotonin is a very vital neurotransmitter.. something you definitely want to have a good amount of. :smile: But you want to have good levels and balance of all the neurotransmitters, so whatever.

But yes, shrooms do increase seratonin levels, at least while on them. I don't if it has any long term benefit though.


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InvisibleHeavyToilet
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Re: Serotonin levels? [Re: Locus]
    #2699244 - 05/19/04 01:12 AM (12 years, 6 months ago)

Where did you see that from? Do you have any sources on it...?


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Offline0xYg3n
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Re: Serotonin levels? [Re: HeavyToilet]
    #2699276 - 05/19/04 01:23 AM (12 years, 6 months ago)

http://pages.prodigy.net/unohu/topics_sero.htm

i think i jsut search serotonin on google and found it


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InvisibleLocus
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Re: Serotonin levels? [Re: HeavyToilet]
    #2699375 - 05/19/04 01:46 AM (12 years, 6 months ago)

Alright, well I've been trying to look for more info on this subject. I don't have a source on the increase in serotonin levels but I've read it sometime in the past, sorry about that.

I tried looking for articles that may include that but haven't found much. Found one article though in which it says that scientists have found that there are two major groups of serotonin receptors. The mushrooms act on both classes by blocking one and stimulating the other. (http://www.pbs.org/wgbh/pages/frontline/shows/drugs/buyers/pharmacology/shrooms.html)

It's still not understood very well so a lot of what's out there is inconclusive ya know. I'll keep looking.


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Offline0xYg3n
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Re: Serotonin levels? [Re: Locus]
    #2699473 - 05/19/04 02:12 AM (12 years, 6 months ago)

yeah kinda sux on how much stuff is known about it.


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Invisiblejux
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Re: Serotonin levels? [Re: HeavyToilet]
    #2699511 - 05/19/04 02:19 AM (12 years, 6 months ago)

Well, thanx to the fucking gov't, little research will be done in the near to distant future on the boomers. I know for certain that mushrooms act on the receptors, but I haven't the foggiest of clues if it actually alters the level of serotonins.

On the bright side, I don't know of any ill effects of shrooming (other than bad gas or nausea, lol ) and most people feel the exact same as they did in a short amount of time. But for those few days after the trip, you deffinitely feel a renewed sense of well being, accomplishment, and satisfaction with your life. Might be attributed to increased serotonin, or perhaps lingering psychoactives. Only speculation on my half though, nothing to back it up with.


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InvisibleHeavyToilet
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Re: Serotonin levels? [Re: Locus]
    #2699522 - 05/19/04 02:22 AM (12 years, 6 months ago)

Thanks for searching guys.

Locus, that site seems to be saying that "many of them [mushrooms] contain psychoactive compounds that can be extremely dangerous or lethal to the user. Some species contain toxins that produce fatal damage to the liver and kidneys." If they are implying that most psilocybin mushrooms cause damage to the liver and kidneys, that is simply untrue. Perhaps it's just meaningless propaganda.

Oh well, thanks anyways guys.


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InvisiblePhencyclidine
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Re: Serotonin levels? [Re: HeavyToilet]
    #2699569 - 05/19/04 02:36 AM (12 years, 6 months ago)

I'm curious what the long term effects of these substances would be also. If they upregulate serotonin in the short run, do they have a long term effect? How do they increase serotonin levels? reuptake inhibition? increasing the production from substrate level? inhibition of enzyme breaking down serotonin?


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Invisiblepsyphon
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Re: Serotonin levels? [Re: HeavyToilet]
    #2699713 - 05/19/04 03:43 AM (12 years, 6 months ago)

Another question is how do serotonin levels affect the trip / effects of the mushrooms? For example is potency increased or decreased with high or low serotonin levels?

I would think it would always be best to have high serotonin levels in a set and setting context but it would be extremely interesting to see some studies on the state of neutotransmitters immediately prior to the trip and the changes that take place during.


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OfflineRequiem
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Re: Serotonin levels? [Re: psyphon]
    #2700383 - 05/19/04 10:58 AM (12 years, 6 months ago)

A little off topic, but close.
http://www.shroomery.org/index/par/25115


--------------------

"I want your Soul.
I will eat your soul."
-Aphex Twin

:dancing: :blah: :dancing: :blah: :dancing: :blah: :dancing: :blah: :dancing: :blah: :dancing:


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OfflineImmortalAngel
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Re: Serotonin levels? [Re: Requiem]
    #2700430 - 05/19/04 11:12 AM (12 years, 6 months ago)

So if im reading the post right, psilocybin actually acts as a artificial serotonin giving you the same affects that naturally occurs as opposed to XTC which just depletes your levels of serotonin, and makes you drained and fucked up.

is this assumption right or am i way off base


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Invisibleshamantra
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Re: Serotonin levels? [Re: ImmortalAngel]
    #2700465 - 05/19/04 11:23 AM (12 years, 6 months ago)

you arent way off.
see this two links;

serotonin vs psilocin
http://www.erowid.org/cgi-bin/chem_compa...ocin_3d_mid.jpg

and serotonin vs psilocybin
http://www.erowid.org/cgi-bin/chem_compa...ilocybin_2d.jpg

if you study these closley you will see that these are very similar but also very diffrent at the same time.


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note: english is my 3rd languange, please ignore misspelling and poor english, im doing my best :smile:

http://youtube.com/watch?v=ug98TKkWKy0


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InvisibleXlea321
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Re: Serotonin levels? [Re: HeavyToilet]
    #2700522 - 05/19/04 11:48 AM (12 years, 6 months ago)

The short answer is no-one really knows. The research hasn't been done because they've been class A drugs for the last 35 years.


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InvisibleLocus
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Re: Serotonin levels? [Re: psyphon]
    #2701411 - 05/19/04 03:03 PM (12 years, 6 months ago)

Yeah, I've actually been tested for my serotonin levels and they came back very, very low. I've never tripped before, but I plan on doing so.


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