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 Ini
daughter of theyew- tree
Registered: 12/10/01
Posts: 102
Loc: Switzerland
Last seen: 18 years, 10 months
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 Scientists! What does psilocibin to the serotonine 
#786100 - 07/30/02 09:54 AM (22 years, 4 months ago) |
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I suffer from so called "endogenous depressions" caused by a lack of serotonine. My grandfather, my mother and my brother had the same problem and commited suicide. So the docs say that it is a kind of hereditary disease. They say, it can only be allayed with meds like "Prozac" or "Zoloft". I hate them, the docs and the meds!!!
During the last years, I found out that when I trip on psilocybin mushrooms frequently, at least once in a month, I feel much better. I use the shrooms since 1986, but there where times when I took none for more than a year.
The beneficial effects of the shrooms last for allmost two weeks after the trip. In this time, I feel much more serene and energetic. Also the physical symtoms which accompany a depression, like tiredness and digestion problems, nearly dissapear.
So I realy wonder what psilocybin does exactly to the serotonine system.
Thanks
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Remain in Light
Greez Ini
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 Asante
all is one - you are that
 
Registered: 02/06/02
Posts: 89,180
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 Re: Scientists! What does psilocibin to the serotonine [Re: Ini]
#787406 - 07/30/02 11:39 PM (22 years, 4 months ago) |
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Hi INI!
Right off the bat: I'm a science hobbyist, no scientist. The major difference is that allthough both tend to be nerdy, I don't have a college degree.
I've read somewhere Psilocybin blocks Serotonin thus enhancing Dopamine. Perhaps the elevated Dopamine makes your depressions diminish in intensity, but it may also have a very strong beneficial psychological effect on you, provided it's a good trip.
Perhaps the antidepressant "Zyban" (Bupropion, also used to quit smoking) works better for you by Dopamine enhancement.
In the natural world there's a thing called St. John's Wort. It's a psychotropic drug that works against light to moderate Depressions as well as against Anxiety and Insomnia. There are good pills and bad ones of this herb. I've heard the "Kira" brand is quite good, albeit expensive. It takes 2-3 weeks to kick in fully, but may never be combined with SSRIs like Prozac or Zoloft.
It enhances Serotonin, Noradrenalin AND Dopamine as well as having more functions. In times of depression I've benefitted from it greatly and euphorically so without any side-fx.  But: I think it's somewhat weaker than chemical ones.
I took 2 pills of 900 micrograms HYPERICINE (the polyphenol that in part does SJWs trick) a day and noticed no side-fx, a lift within 2 hours or so and synergism (enhancement) of the Shroom experience.
If only more people took SJW: it ain't addictive and unless you're severely depressed it brightens almost anyones mood convincingly.
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Omnicyclion.org
higher knowledge starts here
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Ini
daughter of theyew- tree
Registered: 12/10/01
Posts: 102
Loc: Switzerland
Last seen: 18 years, 10 months
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 Re: Scientists! What does psilocibin to the serotonine [Re: Asante]
#788344 - 07/31/02 11:15 AM (22 years, 4 months ago) |
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Hi Wiccan
Thanks a lot for your detailed answer. Maybe a hobby scientist sometimes has a less narrowed view...
Yes, it might be the enhanced dopamine that makes me feel better. I' ve allready tried some Ritalin I bought on the street. Ritalin also enhances the dopamine.This affected me much similar to cocaine. I (ab)used cocain for a long time and quiting it gave me the worst time of my whole life. Ritalin makes me feel quite fine but I' m afraid to get addict when using it frequently. It is hard to get on prescription because it is under drug law and every prescription has to be authorized. And to buy it on the street is very expensive.
I' ve tried St. John' s Worth a few years ago for half a year or so. Unfortunately, it gave me more unpleasant side effects than beneficial effects. It made me sweat a lot, sometimes I thought I was in the climacteric period. I think, I will try a daylight lamp soon.
In a book I saw that the psilocybine molecule is very similar to the serotonine. Maybe it takes the place of it in my brain (and body). To me, this is a nice idea. A substitute for serotonin that I can grow in my bedroom, hehe!
From my (shamanic) point of view I see it like this: The shrooms came to me because I need them.
 Greetings to Holland! I' ve been there so many times. To me, it is the country with the friendliest people I' ve ever met. But I could never live there, I' ve lost my heart to the mountains...
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Remain in Light
Greez Ini
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perplexed
member
Registered: 05/24/02
Posts: 149
Last seen: 22 years, 13 days
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Re: Scientists! What does psilocibin to the serotonine [Re: Ini]
#788684 - 07/31/02 02:49 PM (22 years, 4 months ago) |
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In reply to:
In a book I saw that the psilocybine molecule is very similar to the serotonine. Maybe it takes the place of it in my brain (and body).
Thats exacly what it does. It simply takes the place of serotonine and lets you see things from a whole new perspective.
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sharkdiver
PE fool
Registered: 05/14/13
Posts: 64
Last seen: 8 months, 7 days
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 Re: Scientists! What does psilocibin to the serotonine [Re: Ini]
#25271273 - 06/16/18 12:26 AM (6 years, 5 months ago) |
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FYI. Anyone prone to migraines.. Don't take St Johns Wort. I just started Zoloft about 4mo ago and it seems if I try to quit..I get super sad. I hate script meds that mess with my receptor sites, and brain chemistry in general. Who knows what my brain will do without the Phamacutical SSRI.when I want to ween off?? For me only. They are lifesaving treatment for many.
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feevers
Registered: 12/28/10
Posts: 9,584
Loc: 
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Re: Scientists! What does psilocibin to the serotonine [Re: sharkdiver]
#25271682 - 06/16/18 08:02 AM (6 years, 5 months ago) |
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Edit: wow, just realized this got bumped from 16 years ago! 
I'll leave my post up though just in case anyone can benefit
Serotonin is far from fully understood. SSRI's barely work better than placebo in many cases.
About the whole "lack of serotonin" thing, did you receive a PET scan or any more invasive brain procedure? It's nearly or maybe even fully impossible to measure serotonin levels in a living human brain. You're not born with a certain amount anyway, they're synthesized from food.
If it really is a lack of serotonin and not some sort of synaptic underutilization, a precursor like 5htp might be more effective than an SSRI (but never take both together).
The neuroscience can be summed up by saying we know the timeline and what receptors psilocin is an agonist/partial agonist of, but there's not enough known yet to get much out of that information.
Do some reading on depression and the Default Mode Network, basically a set of structures in the brain that forms the sense of self (ego). It's been found to be overactive in depressed and anxious people.
Brains scans have shown that mushrooms take the DMN mostly offline during the trip (ego death). They also increase activity and connectivity in other areas of the brain. The hypothesis is that they let the brain form new pathways of thought circumventing the 'I' and 'Me' based thinking, which is prevalent in negative/depressed lexicon.
If it works for you, I'd keep it up. Maybe experiment with microdosing as well.
Edited by feevers (06/16/18 08:04 AM)
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