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Mushrooms, Mycology and Psychedelics > The Psychedelic Experience
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Re: Types of LSD ~ Difference between LSD-25, needlepoint, white fluff [Re: CaptainTrips420] * 2
    #29405813 -

Even if an RC is a prodrug of LSD, the change in metabolism can affect the experience.

Consider the dose response curve of lemon tek vs psilocybin.  A pro drug is going to take longer to reach peak blood plasma and the curve is going to look more like a hill than a steep mountain.

There's a recent patent for a modified LSD.  It's not even a prodrug, but a mirrored molecule.  This changes the metabolism substantially.

Anyway, my point is RCs aren't LSD.  Even if the body metabolizes them into LSD, there will be differences in how they're metabolized, and the end result will look different.


--------------------
And if I only could
I'd make a deal with God
And I'd get him to swap our places
I'd be running up that road
Be running up that hill
With no problems

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Re: Types of LSD ~ Difference between LSD-25, needlepoint, white fluff [Re: CaptainTrips420]
    #29405859 -

CaptainTrips420 said:
I mostly noticed a difference in 1V-LSD and ETH-LAD they feel way different than LSD.



Indeed:

s240779 said:
I'm confident that there are substantial differences in different batches of LSD because I've felt it. My last comparison can't be placebo. I mail ordered 1V-LSD, expecting it to simply metabolize into LSD, like everyone said. I was dumbfounded when I felt a unique body high and the slowest onset I'd every felt. The body high felt like cannabis—1V is fat soluble! The whole experience was slowed down. As I stick to low dose territory, I was extremely intrigued: that "muffled" experience was what I was looking for. I ordered more as soon as I could, expecting the same unique experience.

This new batch was not the same at all. It did not feel smooth and mellow like cannabis. It was rusty feeling—TV static is another comparison. The first time, I had every reason to suspect that I was getting what was basically the same thing as LSD and I was surprised by a unique experience. For the second batch, I had every reason to believe I was going to get the same experience as the previous ones, and I was shocked when I didn't. No placebo effect, just different qualities.

I brought this up with someone who mentioned he had tried at least 4 LSD prodrugs and said, "all almost identical to each other and to LSD." I challenged him, "You didn't find 1V to have a slow release effect and a unique body high?" He replied, "
Yes it took 3 hours to start". Followup: "But was the effect itself slowed down? And did you find that its body high was unique?" "Yeah it had its quirks, but LSD". Source: https://old.reddit.com/r/LSA/comments/18twzgq/comment/kfh05nx/


#29403723


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AI Thread

Northerner said:
I agree psilocybin is smokable though.

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Re: Types of LSD ~ Difference between LSD-25, needlepoint, white fluff [Re: s240779] * 3
    #29405952 -

Like I said, an RC that is a pro drug of LSD is going to have different effects than regular LSD.

I don't think a pharmacologist would argue differently.

We see the same thing in psilocin vs psilocybin.  Lemon tek changes the dose response curve substantially.  Which has significant down stream effects on acute tolerance and subjective intensity of the experience.

I guess what I'm saying is that this is a different conversation than needlepoint vs white fluff, etc.


--------------------
And if I only could
I'd make a deal with God
And I'd get him to swap our places
I'd be running up that road
Be running up that hill
With no problems

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Re: Types of LSD ~ Difference between LSD-25, needlepoint, white fluff [Re: CaptainTrips420] * 2
    #29406186 -

CaptainTrips420 said:
Its mostly the purity that causes nauseous feeling but even the purest LSD has some body load but I don't mind.


How do you know it's impurities causing nausea? Nausea is a known effect of LSD, even Hoffman's first deliberate dose caused nausea and bodyload.

Do you think you might be searching for a reason for the nausea and deciding it's because of impurities, but didn't realise that's a known effect of LSD?


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The nearest we come to knowing truth is when we are witness to paradox.

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Re: Types of LSD ~ Difference between LSD-25, needlepoint, white fluff [Re: Northerner] * 1
    #29406246 -

Northerner said:
CaptainTrips420 said:
Its mostly the purity that causes nauseous feeling but even the purest LSD has some body load but I don't mind.


How do you know it's impurities causing nausea? Nausea is a known effect of LSD, even Hoffman's first deliberate dose caused nausea and bodyload.

Do you think you might be searching for a reason for the nausea and deciding it's because of impurities, but didn't realise that's a known effect of LSD?


Im not certain honestly I hardly ever feel nauseous from white fluff or needle point just a tense feeling like when im stressed out. But with the impure stuff I vomited sometimes.

I been told I got fluff told I got needle point from someone else but its hard to tell. The best was the needle point it was almost zero nausea just felt kinda wired amped up stressed feeling. It would come in waves like I would think about the future and feel nervous about the unknown.

I can't really say there was a difference between fluff and needlepoint I enjoyed both and they felt the same. Also I really can't tell a difference between 1P-LSD and LSD 1cP-LSD was a little bit weaker and 1A-LSD felt a little more like AL-LAD.

I just noticed that the visuals were stronger on 1V-LSD 300 ug had me tripping as hard as 400 ug of LSD at about 5 hours into it. It may have been 45 minutes slower onset but I thought it was great stuff. I avoid it though I was using a bunch of RC chemicals and was doing stuff like misplacing my things forgetting to shower and brush my teeth.It was like I had alzheimer's luckily it got better I was just kinda burnt out from using every week.


--------------------
I am the master of my fate,
      I am the captain of my soul.

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Re: Types of LSD ~ Difference between LSD-25, needlepoint, white fluff [Re: CaptainTrips420] * 1
    #29406272 -

I had 'bad acid' once.

I use quotes because I didn't test it, I don't know what it was.

And it could have been diet related you know, maybe I was deprived of electrolytes.

The worst cramping I've ever felt.  The little muscles that moved my eyes even cramped up.

And I also knew a raver kid that would cramp up every time he would drop, and other people would take the same stuff and be fine.  I don't know why he kept doing it, but he did.

Anyway, biological stress and excitement of a drug combined with poor young adult diet.  Not to mention placebo, bias, priming, thinking I'm taking 'good' or 'bad' acid; side effects can vary.


--------------------
And if I only could
I'd make a deal with God
And I'd get him to swap our places
I'd be running up that road
Be running up that hill
With no problems

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Re: Types of LSD ~ Difference between LSD-25, needlepoint, white fluff [Re: tree frog] * 1
    #29406298 -

Captaintrips, remember when you were throwing up recently from smoking DMT? You were also drinking pretty heavily at the time if you don’t mind me saying… alcohol wrecks your stomach, and when you ingest psychedelics when your stomach is in a bad way you will get much worse nausea, and potentially even throw up.

I know this is true for myself. The worst nausea on LSD I’ve ever had is when I took a big dose after days and weeks of binging on alcohol.

When my stomach is in good health I only ever get very mild nausea at the most.

Try having a trip after a couple of weeks of the alcohol, eat good healthy foods in the meantime and let your stomach repair itself. See what the acid or DMT does then.


--------------------
"God is an intelligible sphere, whose center is everywhere and whose circumference is nowhere."

Llamando la Mareacion

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Re: Types of LSD ~ Difference between LSD-25, needlepoint, white fluff [Re: Bardy]
    #29406825 -

I have had annoying stomache nausea on the later tails of some trips as well as muscle cramps here and there, while other trips with the same dose were pure bliss.

All from the same sheet/batch.

-


--------------------
.. harmala extraction TEK.. / .. mescaline extraction TEK.. / .. cactus tar pellets TEK..
.. long distance trip / are you shpongled? / ELDER / TUBER / Jordso / IAH / Sleeping Pandora ... / Thurnin / OPETH ...
.. essential psychedelic guide, by D.M.Turner
.. Tihkal .. / .. Pihkal .. / .. Psilohuasca ..

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Re: Types of LSD ~ Difference between LSD-25, needlepoint, white fluff [Re: CaptainTrips420]
    #29408992 -

CaptainTrips420 said:
As for the impurities its like that for all types I got sick from a batch of 1cP-LSD I read was around 95% pure. Then they got 99% pure 1cP-LSD I tried it and had very little nausea it was much better.

Its mostly the purity that causes nauseous feeling but even the purest LSD has some body load but I don't mind.


But did you test the two different batches of 1cp-lsd? I admit i got some 1cp microdots that were fire and then blotters that seemed weak, but it wasn't impure, just underdosed.

I don't think if you don't know which you taking that you will get stomach problems. You should try this if you still have samples of both get someone else to administer them and see if you can pick out the "impure" one.

In my experience stomach issues are never batch related. You can give yourself any side effect by thinking about it though.

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Re: Types of LSD ~ Difference between LSD-25, needlepoint, white fluff [Re: Northerner]
    #29409012 -

Bardy said:
Once you drank a red bull you noticed LSD nausea… wasn’t the red bull? Haha


serotonergic nausea is different from sugar caffeine red bull stomach ache

sero is more uneasy pre exam anxiety, caffeine/sugar is more just sick/achy

Northerner said:
Ah, it was the wings. He got wings. :awesome:


yea i try to add some wings to the lsd, it usually works. but it can also add nausea, not just red bull nausea (caffeine + sugar), actually the serotonergic LSD nausea increases . hard to explain to someone without a sensitive stomach

caffeine can increase some of the fx a little, innit?

Edited by epilectric (11/22/25 06:09 AM)

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Re: Types of LSD ~ Difference between LSD-25, needlepoint, white fluff [Re: epilectric] * 1
    #29409943 -

Ok guys, reading an article of Nichols, with a pic of him laughing, i finally had an epiphany why he claims all LSD is the same - he was simply unable to explain the obvious differences between crystals, and even more so unable to reproduce some of them, so he just decided to usurp the whole discourse, radically oversimplifying things, ruling out iso as the only possible contributing factor and calling it science.

Just thoughts...


--------------------
i :heartpump: shroomery

https://soundcloud.com/cyberhops

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Re: Types of LSD ~ Difference between LSD-25, needlepoint, white fluff [Re: epilectric] * 1
    #29409967 -

So you're saying that Nichols is a liar?


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The nearest we come to knowing truth is when we are witness to paradox.

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Re: Types of LSD ~ Difference between LSD-25, needlepoint, white fluff [Re: Northerner]
    #29409973 -

no not a liar, but not all knowing either.

he surely investigated and answered us many important questions, thanks David, but drew a too hasty conclusion regarding purity matters. just my own opinion


--------------------
i :heartpump: shroomery

https://soundcloud.com/cyberhops

Edited by epilectric (11/23/25 08:34 AM)

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Re: Types of LSD ~ Difference between LSD-25, needlepoint, white fluff [Re: Northerner] * 1
    #29409981 -

That makes no sense.

https://www.semanticscholar.org/paper/LSD-and-Its-Lysergamide-Cousins-Nichols-Nichols/221224cf372a23e81a5f949730bf5d5075bfe221

https://shaunlacob.com/wp-content/uploads/2020/12/DC-LSD.pdf

There's many more. Exacting, thorough and scientific describes the man. Usurping discourse does not.

There's other scientists that also explain the quantities found of different compounds in different stages of LSD synthesis, and refer to the psychoactivity of these compounds.

https://patents.google.com/patent/EP4178956A2/en

https://patents.google.com/patent/WO2023250298A1/en

Research about LSD and it's byproducts aren't exclusive to Nichols, there are many. It's just that he is the most respected, his knowledge as a preeminent researcher with hundreds of published papers being exceptional.


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The nearest we come to knowing truth is when we are witness to paradox.

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Re: Types of LSD ~ Difference between LSD-25, needlepoint, white fluff [Re: Northerner] * 3
    #29410012 -

You must've missed the bit where Nichols was laughing in the photo...

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Re: Types of LSD ~ Difference between LSD-25, needlepoint, white fluff [Re: Lithop]
    #29410023 -

a laugh tells more than 1000 studies. old american indian proverb


--------------------
i :heartpump: shroomery

https://soundcloud.com/cyberhops

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Re: Types of LSD ~ Difference between LSD-25, needlepoint, white fluff [Re: epilectric] * 2
    #29410040 -

Tell me what you think about another David, David Nutt.


Credible drugscienceman, or:



lying charlatan?!
It's just so hard to tell nowadays when folk are sometimes laughing.

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Re: Types of LSD ~ Difference between LSD-25, needlepoint, white fluff [Re: Lithop]
    #29410046 -

true. i'm not sure. my intuition would guide me towards: yes, charlatan. don't believe a word

but i guess he still has something to say...


--------------------
i :heartpump: shroomery

https://soundcloud.com/cyberhops

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Re: Types of LSD ~ Difference between LSD-25, needlepoint, white fluff [Re: epilectric] * 3
    #29410062 -

:takingnotes:
Hmm, interesting.
:lsdabc:

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Re: Types of LSD ~ Difference between LSD-25, needlepoint, white fluff [Re: Lithop] * 1
    #29410067 -



--------------------
i :heartpump: shroomery

https://soundcloud.com/cyberhops

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Mushrooms, Mycology and Psychedelics > The Psychedelic Experience
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