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Neurotech said:
Real LSD is LSD. It’s either that molecule or it’s not. “Bad” LSD is either weak or research chemicals. So yes, more, if real, would be the exact same substance. However, we all know the impact of set and setting. The 2020’s are not the 1960’s when acid was newly discovered by the masses, and an integral part of a seismic cultural shift. That’s a unique set and setting.

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Typerwritermonky said:

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Neurotech said:
Real LSD is LSD. It’s either that molecule or it’s not. “Bad” LSD is either weak or research chemicals. So yes, more, if real, would be the exact same substance. However, we all know the impact of set and setting. The 2020’s are not the 1960’s when acid was newly discovered by the masses, and an integral part of a seismic cultural shift. That’s a unique set and setting.

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Actually, that's not true at all.  You can have batches of LSD crystal that is 60% LSD-25 and 40% impurities.. that means if you lay 100ug per tab, there would only be 60ug of LSD on that tab (40ug impurities).  If you had 97% pure crystal, thats 97% LSD and 3% impurities.  That means there would be 97ug of LSD on that tab if you laid it at 100ug per tab.

If you take 3 tabs, you're absolutely gonna notice a huge difference between 180ug LSD and 292ug LSD.  Even with two tabs, 120ug vs. 198ug.  That's a big difference too.

So there is a huge difference.  One time I got a batch that was like 40% pure, like the concentrate liquid was black.  Me and my friend accidently took like 1.2mg and 1.4mg.  The only thing that saved our asses was it was so impure, we each took more like 500ug and 600ug.  Still an insane trip though.  If that stuff was 95% pure we would've been in real trouble.

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Azure Essence said:
LSD is LSD is LSD. Anything else is marketing. Even if you're getting something like 99% pure LSD in 100ug blotters("needlepoint"), you're getting 99ug LSD.

If you have 85% purity on 100ug blotters, you're getting 85ug of LSD. Now make no mistake, that dosage difference, along with set, setting, diet, mood, etc of your recent week can have profound effects, but this is not different LSD.

I emailed David Nichols about this a few years ago, and this is what he said:

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If LSD is purified, usually by chromatography of some kind, it should always be the same.  The original synthesis method is not crucial, although some methods may make it harder to purify the LSD than others.

Because LSD is so potent, there is no impurity potent enough to fit on a blotter that would affect the psychopharmacology of LSD.  Years ago, realizing that a major impurity might be isoLSD, we examined the pharmacology of isoLSD.  It had  no significant effect at any receptor system we examined.  If the LSD comes in a capsule, or tablet, then all bets are off because you could put all kinds of things in something that size.

Variability in effects is most often related to set and setting.  For example, if someone buys a blotter and is told that it is standard commercial blotter, and then is sold another blotter (for much higher price!)  and is told, “This blotter contains LSD originally synthesized by Hofmann himself at Sandoz laboratories”  it is a safe bet that the “Hofmann LSD” will be given rave reviews compared to the conventional blotter.  Most people in the street would not realize that it is not possible to get Sandoz LSD.  I read years ago where someone said that they bought a particular psychedelic that “came out of Sasha’s lab.” I wrote to them that Sasha never put his compounds on the street, and that it was purely a marketing gimmick.

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