Memantine Log
I am attempting to use memantine to aid me in the process of tapering off of some psychotropic medications that I have been physically dependent on for many years. Specifically, I take Duloxetine (Cymbalta) 60mg 1xMorning, Topiramate (Topamax) 25mg 1xMorning 3xNightly, Gabapentin 800mg 3xDaily, Baclofen 10mg 4xDaily, and Mirtazapine (Remeron) 15mg 1xNightly. I have been dependent on Cymbalta for 8 years, Remeron for 6 years, Gabapentin for 4 years, and Baclofen and Topamax for 3 years. My goal is to, at minimum, eliminate all the medications other than Cymbalta and Gabapentin; however, if I am successful at eliminating the others, and feel okay, I will also attempt to taper off them as well.
2/15 8PM Ingested first dose of Memantine, 10mg oral. Took normally prescribed doses of medication at 9pm.
2/16 10 AM I feel very, very synthetically happy and over-energized, and there is a ringing in my ears. I suspect I have either overdone it with the Memantine dosage, or needed to go ahead and reduce the dosages of other medications.
9PM I take 5mg of Memantine. I decide to cut the dose of Remeron in half (7.5mg) and reduce my nightly dose of Baclofen by 5mg (I typically take two of the 10mg at night) and see how I feel. I typically depend on the Remeron to fall asleep, and I have trouble falling asleep, tossing and turning. I decide to take another 3.75mg of Mirtazapine and manage to fall asleep.
2/27 8AM I take 5mg memantine and my typical doses of morning medications. I feel okay. I definitely do not notice any issues related to reducing the dose of Baclofen, however I do notice a noticeable decline in cognitive sharpness, physical energy, and desire to socialize. This could either be attributable to the memantine or to a relative deficit in serotonin.
9PM I take 5mg memantine, 11.25mg of Mirtazapine again, and reduce the dosage of Baclofen by 5mg to 10mg. I have a bit of trouble falling asleep, but I just tough it out.
2/28 530AM I wake up feeling energized despite getting less sleep than usual. I take 5mg of memantine and typical doses of morning medications. I feel very happy, but the happiness feels less synthetic. I seem to be opening up to greater emotional depth and range. My thoughts are noticeably less “loopy”, presumably because memantine is an NMDA receptor. I have a lot of energy even though I have only one cup of tea.
I plan to continue taking this dose of Remeronfor another 2 nights, and then decrease it 7.5mg. I plan to take only 25mg of Baclofen tomorrow by reducing my afternoon dose by 5mg. . I plan to take only 25mg of Baclofen tomorrow by reducing my afternoon dose by 5mg. I know I have not made extreme changes yet, and there is a long way to go, but I am feeling optimistic about the results I’m getting so far.
7pm I take 12 grams of Kratom. I take Kratom every 10 days or so. I seem to have a naturally high tolerance for drugs that work through the opiate receptor (possibly related to me being a redhead).I typically take 15 grams or even sometimes 20 grams. However, the effect from 12grams tonight far exceeds the effect I’ve gotten from even 20 grams in a very long time. While this is not the reason I decided to take memantine, it makes me confident that the memantine is in fact working.
I will continue to keep this log and will post whenever I make serious progress. Wish me luck!
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