dudefromaz said:

Wait... aren't they just more potent because they are made of more water, therefore when they are dry, they weigh less than cubes, and end up with more goodies per gram????

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dudefromaz said:

Wait... aren't they just more potent because they are made of more water, therefore when they are dry, they weigh less than cubes, and end up with more goodies per gram????

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Quote:

Active Compounds

The compounds responsible for the psychological effects of the Psilocybes are known as tryptamines.

Tryptamines are those compounds that contain an indole ring. These compounds resemble the neurotransmitter serotonin. They are thought to be competitive agonists of 5-HT2 receptors (a particular subtype of the serotonin receptor.) Psilocybin is the most abundant tryptamine in Psilocybe mushrooms and has been present in concentrations ranging from 0.36% in P. stuntzii to 0.98% in P. semilanceata . However, after ingestion it is rapidly dephosphorylated by the enzyme alkaline phosphatase in the intestine. Thus, it is the metabolite psilocin which is thought to be responsible for hallucinations and psychological effects.

Psilocin is the next most abundant compound, ranging from 0.12% in P. stuntzii to .60% in Psilocybe cubensis. Its bioavailability (the amount that is absorbed in the bloodstream from the intestines) was found to be around 50% in mice. Psilocin distributes uniformly in most body tissues, except for higher concentrations in the liver and adrenals. In rats, psilocin concentrates in specific areas of the brain: the neocortex, the hippocampus (involved in learning and memory), and thalamus (sensory processing). In rats, about 20% of psilocin is excreted unaltered in the urine, with the remainder excreted as polar conjugate metabolites such as glucoronides. It has been estimated that less than 4% of psilocin is degraded by monoamine oxidase, the enzyme that degrades endogenous monoamines like serotonin.

Baeocystin is usually present in concentrations of less than 0.1%. However, a few species, such as P. semilanceata (Liberty Caps) may have a content as high as 0.36%. Because few pharmacologic studies have been done with baeocystin, its potency relative to psilocin is unknown.

Some mushrooms of genera other than Psilocybe also contain psychoactive tryptamines, including Paneolus, Gymnopilus, and Inocybe.

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hope that helped.





tc