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Soaking a tab of LSD in vape liquid
    #29436640 -

Josie Kins, the founder of PsychonautWiki and an employee of Mindstate Design Labs, stated that she soaked a tab of LSD in vape liquid and vaped it.

"the onset was instant, rose over a few minutes, then lasted a couple hours before dropping off."


"I am a professional psychedelic researcher. I tried vaping LSD and it worked. The psychedelic subculture has a big problem with just saying things don't work, without ever trying it for themselves. Then they repeat it to others, who spread it further... without trying it..."[ 1 ]

"oh and to clarify, the onset was instant, rose over a few minutes, then lasted a couple hours before dropping off."[ 2 ]


She soaked LSD in vape liquid for one or two days.[ 3 ]


Quote:
At least 50% of LSD-25 remained in the active form even after baking the LSD-25 in a batter made from Commercial Bisquick at 300°F for one hour and freezing it for several weeks (36). Boiling a solution of 1.0mg/ml of LSD-25 in the dark up to 4 hours did not lead to a significant destruction of the LSD-25. However, LSD-25 is very sensitive to light. Its photodecomposition has been described by Niwaguchi and Inoue. Further details of the destruction of LSD-25 by ultra-violet light is described in the section under assay of LSD-25.

36. Gettner, H.H., Rolo, A. and Abramson, H. A. J. Psych. 75, 35 (1970).

39. Inoue, T., Nakahara, Y. and Niwaguchi, T. Chem. Pharm. Bull. 20, 409 (1972).




LSD: A Total Study. D.V. Siva Sankar. 1975. PJD Publications Ltd.: Westbury, NY. INTRODUCTION / EARLY HISTORY OF LSD, page 50


1. Josikinz. 2025-09-10. https://x.com/Josikinz/status/1965879102528958956

2. Josikinz. 2025-09-10. https://x.com/Josikinz/status/1965882600008163429

3. FatherMcKennaa. 2025-09-11. h‍ttps://x.com/FatherMcKennaa/status/1965479494648823886

Edited by s240779 (12/22/25 11:29 AM)

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Re: Soaking a tab of LSD in vape liquid [Re: s240779] * 1
    #29436644 -

I dont trust the vape juice


--------------------
Life is demanding,
Without understanding

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Re: Soaking a tab of LSD in vape liquid [Re: Spira] * 2
    #29436648 -

Doesn't sound very appealing to me either. I'd rather enjoy my tabs the old fashioned way.

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Re: Soaking a tab of LSD in vape liquid [Re: RiPpLeZzZ]
    #29436650 -

RiPpLeZzZ said:
Doesn't sound very appealing to me either. I'd rather enjoy my tabs the old fashioned way.

I agree LSD is smokable though.




Edited by s240779 (12/22/25 10:32 AM)

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Re: Soaking a tab of LSD in vape liquid [Re: s240779] * 1
    #29436653 -

Maybe try the tab rectally then and see how that evaporates :shrug:


--------------------
i :heartpump: shroomery

https://soundcloud.com/cyberhops

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Re: Soaking a tab of LSD in vape liquid [Re: s240779] * 1
    #29436669 -

s240779 said:
RiPpLeZzZ said:
Doesn't sound very appealing to me either. I'd rather enjoy my tabs the old fashioned way.

I agree LSD is smokable though.







:kummeli:

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Re: Soaking a tab of LSD in vape liquid [Re: s240779]
    #29438038 -

The first post contains info about two heat resistance experiments that were carried out by professionals that were reported on in this article:

Lysergic Acid Diethylamide (Lsd 25) : XXXIX. The Effect of High Temperatures on Stability. Gettner, H. H., Rolo, A., Abramson, H. A. 1970. The Journal of Psychology, 75(1), 35–40. 10.1080/00223980.1970.9916802

This is what Claude Opus said after being presented with the information in the first post and the above study:

Evaluation of the Vaping LSD Claim

What the Gettner et al. (1970) Study Supports

The thermal stability data provides partial plausibility for Josie Kins' claim:

212°F for 4 hours → No appreciable degradation

300°F for 1 hour → ≥50% activity retained

Vaping involves brief exposure (seconds) rather than sustained heating. If LSD survives 300°F for a full hour, brief vaping temperatures might preserve a meaningful fraction.

What the Study Does Not Address
  • Whether LSD actually vaporizes (vs. merely surviving heat without volatilizing)
  • Pulmonary absorption of LSD
  • Stability in propylene glycol/vegetable glycerin (vape liquid carriers)
  • Temperatures exceeding 300°F (many vape coils reach 400–600°F)

Notable Observation

The reported effect duration ("a couple hours") is substantially shorter than typical oral LSD (8–12 hours). This could reflect partial degradation, different pharmacokinetics via pulmonary absorption, or incomplete extraction.

Conclusion

The thermal stability evidence makes the claim more plausible than conventional wisdom would suggest, but remains a single anecdotal report, not confirmation of efficacy or safety.

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Re: Soaking a tab of LSD in vape liquid [Re: s240779] * 1
    #29440326 -

𝚀𝚞𝚘𝚝𝚎:

I think it's important to distinguish between vaporization (think meth in a lightbulb) and nebulization (propylene glycol in a vape cannister.)

When you nebulizer, you're basically just aerosolizing a carrier liquid. In practical applications such as e-cigarettes, nebulization occurs at much lower temperatures (e.g., around 65°C) because nebulization does not require boiling. Partial nebulization is enough, and occurs as the vapor pressure increases with temperature.

So if LSD is soluble in the carrier liquid, and if that liquid partially aerosolizes at a low enough temperature, then I see no reason why it wouldn't work. The LSD would be floating through the air, dissolved in little liquid droplets at less than the solvent's boiling point.

Pfafffed, 2025-12-26, https://www.bluelight.org/community/threads/soaking-a-tab-of-lsd-in-vape-liquid.951010/post-16366284

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Re: Soaking a tab of LSD in vape liquid [Re: s240779] * 1
    #29440432 -

ok and who would want to do that? seems like a pretty useless idea


--------------------
i :heartpump: shroomery

https://soundcloud.com/cyberhops

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Re: Soaking a tab of LSD in vape liquid [Re: epilectric]
    #29441017 -

The decreased duration is enticing, generally an oral dose of LSD lasts much longer than 12 hours for me personally.


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"Blow up your TV, throw away your paper.  Go to the country, build you a home."

- John Prine

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Re: Soaking a tab of LSD in vape liquid [Re: schmutzen]
    #29441219 -

Why would vaporizing LSD significantly decrease the duration of effect?

There is a reason why oral, sublingual, rectal and IV all have similar duration of action, because it takes a series of cascade effects to actually get the ball rolling. From binding to the 5ht2a receptors and activating them, to activating and agonizing d2 receptors and much much more.

As far as I am aware, IV doesn't even reduce the duration nor does it significantly increase the onset in comparison to say sublingual. It might be slightly faster but the onset time is not drastically different between the two.

I can't imagine vaping LSD is somehow significantly faster than IV, because again, it takes a cascade of effects going on in the brain for the effects to actually begin. So somehow getting LSD in the lungs somehow speeds up the onset to instant because it's right there in the bloodstream? Why would IV not have the same impact then, because there's literally nothing faster than getting something directly in your bloodstream.

Even the most insane doses I've ever done, it's been a minimum of 20-30 minutes for the comeup to occur and about double the time if it's just eaten and not taken sublingual. I can't speak for IV, but reading reports on it make these claims suspicious.

I have no interest in shortening the trip though. I actually love the length of LSD. I can see why someone would prefer to have it shortened some, but then again, there's ways to boot off the tail end of a trip forcibly and go to sleep or whatever if that's what you want.


--------------------
Lead by example, words mean little when your actions don't reflect what you say.

Spread kindness, love, empathy, compassion.

Learn from mistakes. Try and do better. Each day is a new day, try to make it a better one.

Coconut and Avocado is awesome for the skin.

MIND OVER MATTER

:mushroom2::lsd:

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Re: Soaking a tab of LSD in vape liquid [Re: TrancedOutBrah]
    #29441222 -

Nebulizing makes sense to me.
and an effective lsd vape could be a very good friend
one could learn to obtain the amount and duration that they want from a few uses.


--------------------
:brainfart: _ :finger:

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Re: Soaking a tab of LSD in vape liquid [Re: s240779]
    #29441336 -

It might be possible, the heat probably isn't a big deal, but there are potential downsides. Its active in such small amounts that you might accidentally dose someone else nearby if you had LSD suspended in the air. Another downside is that if the LSD in the air landed on a surface, and someone else later touched the surface and then touched their mouth...

I'm not sure if the duration would be affected. Lowering the duration of LSD is definitely desirable. The biggest blocker to using LSD in a medical context is its duration, but I would think IV would lower the duration by the most if duration is affected. A confirmed lower duration would have advantages in a medical context though.

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Re: Soaking a tab of LSD in vape liquid [Re: nooneman]
    #29441392 -

aerosols dissipate too much to worry about, but inhaling a well dosed stream should be effective


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:brainfart: _ :finger:

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Re: Soaking a tab of LSD in vape liquid [Re: redgreenvines] * 3
    #29441440 -

Lost me at the AI-generated avatar on her website. Most of the rest of the text there (and here) feels far too AI-generated and AI-adjacent for me to waste my time digesting it. I'll proudly remain in the part of the "psychedelic culture" that's "all too quick to declare that things don't work."

As for the efficacy of vaping LSD, yeah. My response is a simple "why the fuck would I want to do that?" It's right up there with boofing hash oil for me. Don't really care if it works. Just strikes me as pointlessly complicated and unreliable.

On a slightly related note: why on earth do people think that, in basic etiquette/respect terms, it's OK to generate long texts with AI and then expect other people to read them without it? Do they just assume that their intellect is so superior that their chatGPT prompts and resultant output demand biology-based analysis from the plebes? Or are they just too far up their own asses to care?


--------------------


ACAB  🖕🧊


Edited by B Traven (12/28/25 10:06 PM)

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Re: Soaking a tab of LSD in vape liquid [Re: B Traven] * 1
    #29441614 -

B Traven said:
...

On a slightly related note: why on earth do people think that, in basic etiquette/respect terms, it's OK to generate long texts with AI and then expect other people to read them without it? Do they just assume that their intellect is so superior that their chatGPT prompts and resultant output demand biology-based analysis from the plebes? Or are they just too far up their own asses to care?



etiquette dissolves in conformity, and the current fashion is to put out your best AI pompidour masque while waving your fan at the odorous verbosities - another canape perhaps?


--------------------
:brainfart: _ :finger:

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Re: Soaking a tab of LSD in vape liquid [Re: s240779] * 2
    #29441726 -

Interesting :thatsinteresting:

I see no reason that lsd in a carrier wouldn't be absorbed via the lungs and act in a similar fashion to sublingal.

I find the claims of shortened duration very dubious. As others pointed out there have been clinical studies including IV administration that showed no change in duration. Further there is the well documented edgewood arsenal experiments which involved aerosolized LSD declassified document link that showed the same duration as every other ROA.

It is also worth noting that the govt found inhalation was a 70-75% less effective ROA as compared to oral or IV.  This last point implies that soaking a tab in vape juice and vaping would mean a significantly lower dose was absorbed which could be the reason they perceived a shorter duration.

So not dismissing blindly because I didn't try it, but pointing to the documented evidence that overwhelms the antedotial claim of shortened duration by this one person.

The only other plausible explanation would seem to be some type of conversion to a different compound.


--------------------
:elmo::rebeccablack::cookiemonster:
:catfrog::snickers:

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Re: Soaking a tab of LSD in vape liquid [Re: Sugabearcrisp] * 1
    #29441747 -

Some excerpts from the declassified doc via pdf > image > ocr

Quote:
C,
Technique of Exposure.

Subiects were trained to breathe in conformity with a standard
pattern that assured a rate of 1 5 breaths per minute and a minute volume of
approximately l0 liters. The method, developed previously for BZ inhalation
studies, employs an oscilloscopic display of the respiratory activity. The
subject endeavors to make the beam track a prescribed curve of inspizarion
and expiration superimposed on the oscilloscope screen. Rate is established
by sweep time of the beam. Vertical deflection is produced by air flow across
a detector situated in the orifice of the face mask, With minimal practice,
stable breathing patterns are easily achieved.

Because of the possibility that coughing might occur during inha-
lation, subiects were instructed in all cases that if the urge to cough occurred,
they should in no case break contact with the mask, but cough into the system
if nscessary.

The agent, both maleate and free base, was generated as a water
solution in droplet form; average particle size being 0.8u. Concentration in
air was usually less than 20 ug/liter, and exposure time from 1 to 4 min.
Retention was calculated by direct measurement of concentration differences
between inspired and expired air. This difference was multiplied by the tota.
volume breatred, Drug retained in apparatus was then subtracted to give
total retained dose per man.





Quote:
B. (C) What are the Onset Times, Peak Times, and Durations of Action of the Effective Inhalation Dose?
<
Onset time is defined here as that time at which performance on the NF test fell below 75% of baseline. Clinically, this represents definite impairment in mental efficiency.
Employing this criterion, the onset time for the effective dose may be interpolated to approximately 15 min (figure 3). Peak time is about 1-1 /2 hr. Partial recovery time (time at which scores return to 75% or higher) is about 5-1/2 hr, and "full" recovery time (100% or higher) is betweer 8 and 12 hr.
As shown in figure l, the half-life of the drug following intravenous injection is about 3 hr. The percent decrease from I to 2 hr is 22%. In the inhalation cases, blood levels were measured at 1 and 2 hr, and with the maleate, the blood level dropped an average of 23% from the first to the second hour, while the average decrease for the frce basc was 28%. This would indicate a Þalf-life of 155 and 130 min, respectively, for the maleate and the free base. It seems unlikely that the half-life for the free base would be
D
) i2.cdn.turner.com/cnn/2012/images/02/15/human.test.subjects.-.edgewood.






--------------------
:elmo::rebeccablack::cookiemonster:
:catfrog::snickers:

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Re: Soaking a tab of LSD in vape liquid [Re: Sugabearcrisp] * 2
    #29441871 -

Yes the only thing that would make sense is getting a much lower dose than expected and thus a perceived dec in duration. The instant onset is total BS though. If IV isn't instant there's no way inhalation is. Id bet both my nuts on it.


--------------------
Lead by example, words mean little when your actions don't reflect what you say.

Spread kindness, love, empathy, compassion.

Learn from mistakes. Try and do better. Each day is a new day, try to make it a better one.

Coconut and Avocado is awesome for the skin.

MIND OVER MATTER

:mushroom2::lsd:

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Re: Soaking a tab of LSD in vape liquid [Re: TrancedOutBrah] * 3
    #29442142 -

When I IV'd acid I was extremely disappointed it didn't hit like a massive psychedelic rush. This was back in the days before the internet though, there was no one to ask what would happen.


--------------------
The nearest we ever come to knowing truth is when we are witness to paradox.

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