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Making this thread so that I can post my thoughts on the dosing method described in this thread
https://www.dmt-nexus.me/forum/default.aspx?g=posts&t=96861
hxxps://www.dmt-nexus.me/forum/default.aspx?g=posts&t=96861
My few experiences have consisted of about 60 mg of freebase DMT dissolved in 500 mg of HPBCD, with 250-300 mg of THH, and about 35 mg of sublingual harmala/harmaline

From the start I want to say that sublingual DMT with oral THH is everything I wanted ayahuasca/pharmahuasca to be. And I think it is also the best way for someone to be introduced to DMT
Where do I start with the pros
- no nausea at all, even if you take sublingual harmine/harmaline with it. It is such an odd and pleasant feeling to not have to fight constant nausea and vomit inducing dizziness. I literally don't have to worry about having a handy throwup bucket like I did with typical oral DMT.
- just the right kind of duration, it never overstays it's welcome, in about an hour you will get whatever you had to receive. No need for a bedridden 2+ h long comedown
- crisp, clear headspace. Previous oral DMT experiences have always given me this pinch of delirium and sleepiness to my mental state. But with this combo and I am fully present in it
- no come-up anxiety, the transition is gradual and smooth
- the DMT visuals are there, and in one experience they seemed even more glowing, or with actual real-life landscapes or persons assembling before my vision instead of the usual DMT geometry
- your body will love to move to the music you are listening
- let's say you accidental swallow the DMT solution or the saliva build-up becomes unbearable - you will still have a pharmahuasca experience with less if not any nausea. And also this form of oral DMT seems to absorb way better than a typical pharmahuasca
- you need less DMT than the typical pharmahuasca
- if you aborted the experience (saliva build-up that you spit out) you will now in about 25-30 minutes for sure, and then you can try again with the same DMT dosage, it won't stack like in pharmahuasca where it can sometimes take even 2 hours to enter fully

Now the cons:
- the saliva build-up can abort your start or break it's knees. Now if you swallow the solution you will still get a top-tier pharmahuasca trip, I repeat again, with barely any nausea. I tried with some cotton rolls in my mouth to stop the saliva pooling around the DMT solution but it was useless. Next thing I want to try are some saliva pads dentists use: either I trap the solution between the pad and the mouth floor, or I infuse the pads with the DMT solution, put the pad to the cheek mucosa or sublingual mucosa, and enjoy the slow release of DMT (even your lips can absorb this stuff pretty well, one of these days I will use the solution as ointment only for the lips to test it)
- and that is pretty much it, I can't think of any other cons of this way of taking DMT

With that in mind here are some questions that could be explored in the future
- how to get consistently the neon-glowing visions, they feel like such an eye-candy that your eyes feel compelled to see in all their beauty; is it a certain THH treshhold? less harmine/harmaline or more sublingual harmine/harmaline?
- do we really need the mouth floor? can I just smear this on my lips, inner cheek, upper gums or mouth top since with these there is not saliva problem?

I still can't believe people aren't all over this method, especially beginners. It is so versatile and maybe even "comfortable". It is worth experimenting only on it for me, goodbye throw bucket and tissues next to my bed, goodbye retching and holding in the taste of earthy vomit, goodbye 5 hour long sedation and diziness that takes up your entire day.
I predict in a short time sublingual DMT will have it's separate section on the Nexus.

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Hey tregar, have you tried alcohol in a sublingual DMT preparation? Perhaps a tincture can help with faster absorption and overcome some of the issues caused by the fast metabolism of DMT.

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My procedure:
1) place 60mg of DMT onto a spoon
2) add 1:1 molar ratio of host drug to HPBCD powder, this means 1:7 mg ratio DMT to HPBCD, use a 1:8 mg ratio DMT to HPBCD if you are using the 2-Hydroxypropyl-β-cyclodextrin.
3) this means 60mg dmt placed on spoon, then add 420mg of HPBCD on top DMT, use 480mg HPBCD if you are using the 2-Hydroxypropyl-β-cyclodextrin.
4) add 10 drops of very hot near boiling water to the mix from a nearby microwaved coffee mug for DMT doses of 90mg or below, use 12 drops of boiling hot water to mix DMT doses over 90mg (such as 100 to 120mg). 60mg DMT = +3 Shulgin level strength, 90 to 120mg = +5 Shulgin level life changing strength.
5) Knead or crush the HPBCD powder into the dmt using the end of a spoon for 2 minutes, scrape & mix everything back and forth hard using your muscles. This is how scientist pre-pare these complexes by kneading.
6) Hold a lighter under the spoon to heat up spoon for around 20 seconds or so, until the solution just starts to boil, then pull flame away, so that complete dissolution or dissolving takes place, after heating up, mix the contents a little bit more before using, see pics.
7) Take 150 to 300mg tetrahydroharmine orally around 45 minutes before. Place 35mg of freebase harmine under your tongue. Then place bottom of your tongue onto HPBCD complexed DMT spoon, the HPBCD DMT glob will all adhere as HPBCD powder forms sticky complexes. Be sure to take the 35mg harmine and HPBCD DMT under tongue all at the exact same time in order to activate the DMT strongly.

Hold under tongue for 10 to 12 or 15 minutes depending on dosage, press down with bottom of tongue the whole time to trap sticky liquid complex in the sublingual mucosa. Be sure to use bottom end of tongue to lick any off spoon that is left behind, you want to get it all.

At end of 15 minutes, spit out any saliva into a cup instead of swallowing. Gently relieve any saliva during the 15 minute period as comfort dictates by leaning your head forward and spitting into a cup, but keep your tongue pressed down any time you relieve saliva. There is a mild to moderate sting felt but it's so worth enduring for the effects in 22 minutes. The sting does not bother me at all. The tongue is completely fine afterwards (no burn), and it's as if nothing happened the next day.
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The combination of THH + DMT simulates true Ayahuasca, but there is zero nausea, zero dizziness, zero queasiness since there is no harmine or DMT going thru stomach and intestines. 22 minutes in there are heavy CEV's of spinning colored geometrics, visions of ancient architecture, animals, aliens, you name it, She seems to tap into the Akashic record of the ether in the Universe, where all past, present, and future is known. Open eyed profound beauty, music sounds incredible.

This all lasts for 90 minutes. You can re-dose more HPBCD DMT by two more times, around every 1.5 hours if you want. It remains just as effective as the first dose. The sublingual application is several factors stronger than oral DMT, and I've used oral DMT dozens of times.

Oral 300mg THH taken 1 hour earlier + sublingual 60 to 140mg HPBCD DMT journeys (over 44 of them over a year's time). This counts the two subsequent re-doses every 1.5 hour for the evening, for a 4.5 hour total strong journey with super-long afterglow.

With oral 150 to 300mg THH + sublingual 60-120mg HPBCD DMT + sublingual 35mg harmine fb, there is zero nausea, zero dizziness, zero un-easy feelings or anxiety, I tolerate this very well compared to oral DMT, extremely pleasurable experience, high spiritual euphoria.

First of all there was a deep head space, profound spiritual insights and revelations. I was seeing curtains of visuals in the doorway, closed eye neon spinning & dancing geometrics, music enhancement incredible, out of this world impossible neon colors (like neon yellow-purple) flashing on the walls, some times these colors on the walls would break up into fine lines like lazer beams, and paste themselves like hundreds of beams broadcast on the walls, concentric circle rings in the air, powerful lightening like tracers.

Open eyed beauty so over the top & infinite, actresses in movies looked like glowing, dazzling, super-colorful, cartoon versions of themselves, just like with high dose cactus tea, also zero anxiety just like mescaline. Euphoria was powerful, just like with high dose cactus tea.

Again with the sublingual: pupil dilation maxed out, strong tryptamine body buzz high frequency, heavy CEV imagery, open eyed beauty profound, music sounds incredible.

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Instead of the harmine sublingual, have you tried orally ingested harmine, maybe at the same time as THH, 45 minutes before the sublingual HPBCD-complexed DMT?

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- how to get consistently the neon-glowing visions, they feel like such an eye-candy that your eyes feel compelled to see in all their beauty; is it a certain THH treshhold? less harmine/harmaline or more sublingual harmine/harmaline?

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Always test any THH you may acquire elsewhere. For example, there is a THH many are using that is made in China, with several reports of it not glowing blue when a bit is rubbed on a wet q-tip and smeared on a paper palate, and the plate held under blacklight. Pure tetrahydroharmine glows light blue like LSD under UV light, any green in the glow indicates unconverted harmaline. Five reports so far from nexus people saying it glows green instead of blue like pure THH even though the paperwork indicates over 98% pure. THH never converts back to harmaline once made and remains stable indefintely, so this tells me the initial synthesis on those particular batches was incomplete.

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The THH I have does not glow blue (it did not come with a purity certificate), but it definitely is not harmine or harmaline since it does not give nausea at all. Taking more than 300 mg of it makes me a bit dizzy and that's it. And post experience I do feel the typical calmness or composure I got from previous aya drinks.

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Had another try today.
Ava was not kidding with the images of beautiful women. Today I had a vision of a naked blonde with the body of a literal Goddess opening my mind's eye like you would a zipper at the beggining. The perfection of the female form in full display with a glistening astral skin. And it wasn't any libido increase, just a sense of witnessing beauty. This effect is so peculiar to me, ava mentioned about certain adrenergic receptors that THH touches like mescaline does, but I could not find a source on how these receptors are actually involved in "Aesthetic perception"

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In my trip diary this June night, I documented this oral 200mg harmine + oral 300mg THH + 90mg sublingual HPBCD dmt around 1 hour later as the most powerful sublingual experience of my life. Not only was there no dizziness or nausea or delirium, but no anxiety as well, very impressed. For reasons posted by Dr. Narang on post #1, the sublingual HPBCD DMT was many factors more powerful than any dosage of oral HPBCD DMT. It was many factors stronger, around x5 times.

It was so powerful that I saw curtains of neon-colored visuals in the open doorway when I looked to my right. Everything in all directions was surrounded by brilliant neon-colored rainbow reflections, the euphoria and music enhancement was very powerful.

Open-eyed beauty was beyond belief, divine and infinite. The tracers were so powerful, that they went on forever like a hall of mirrors into the distance, and instead of there just being multiples of my hands when I waved them, there were beautiful colored fractals inside the tracer smears. One hour after the sublingual HPBCD DMT started to work, it was still as strong visually & transcendence wise as when it started. Only at the 1.5 hour point did the DMT ween down in strength several levels.

The 200mg of harmine was so powerful, that I continued by taking a 2nd dose of sublingual 90mg HPBCD DMT again 2 hours later after the 1st dose, and it again worked just as strong as the first dose. With closed eyes were seen brightly colored Ayahuasca visions, in my diary I note that I saw close to a hundred rapidly changing visions from incredibly beautiful women, birds, gardens, palaces, temples, inner decorations of these palaces, artwork of an entire culture, ancient pristine & perfect architecture to elaborate art carvings in stone, way beyond 4k in detail. The visions never repeat, of a beauty that defies comprehension. This resulted in a +5 strength Shulgin level journey with life changing consequences.

The harmine having a half-life of from 1 to 3 hours, did not die off until around 5 hours later, so each time I took a re-dose of sublingual HPBCD DMT for the evening, it continued to work very strongly. I highly recommend this approach, and plan to use the oral harmine again with the oral THH many times again in the future, but only using the HPBCD DMT sublingually as noted above.

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Stay true to yourself, Love, Peace and Music
http://www.friskyradio.com

Pic: Psychedelic Tolerance chart

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I seem to remember from a previous post that you very much disliked oral harmine due to the dizziness it produced and preferred  sublingual administration.  What made you change your mind?

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Why do you think it is that you are gaining tolerance to these substances? Typically DMT does not induce a tolerance and harmala alkaloids induce sensitivity rather than tolerance with regular use.

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I want to give this a try, the last time I orally took the hcl I barely got any effects with it, even took it with 10g Syrian rue seed tea.

When doing this are you swallowing the tetrahydroharmine or under the tongue?

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Does ayahuasca produce tolerance?
Ayahuasca tolerance is very mild and you can take another dose within a day without significantly reduced effects. It also does not produce tolerance to other psychedelics.

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There is an average of 160mg harmine per dose in Caapi potions. In the course of some three dozen psychonautic bioassays (self-experiments) with crystalline samples of DMT and harmine (which I myself had isolated from appropriate plants), we substantiated an verified the theory of the "ayahuasca-effect," that doses as low as 120mg (below the average amount found in analyzed doses of the potions) could render minuscule doses of DMT psychoactive and visionary (between 25 and 30mg).

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Modern day researchers, spearheaded by people such as myself, have realized that Jonathan Ott's calculations fall short of what most explorers need for a truly visionary experience. Even with a strong harmine/Banisteriopsis caapi dosage, 30-60mg of dmt is not sufficient to produce significant visionary effects in most people. So if fact, a dosage of 30-40mg of dmt is where tryptamine-like effects just begin to occur for most people, and 10-25mg dmt is not really noticeable above the gentle psychoactive effects of the harmine.

Each person is different and for some rare individuals, 30-40mg may be about as much dmt as they wish to take--but most people need at least 60-80mg for sufficient psychoactive effects and even at this dosage, you generally cannot expect a full-blown visionary experience, even when using a strong dose of 4 grams of syrian rue or 100 grams of strong caapi vine. Also, it should be pointed out that going beyond 4 grams of syrian rue (around 200-280mg of harmaline) or 100 grams of strong caapi vine (150--250mg of harmine) can increase the negative effects of these beta-carbolines--which include a feeling of heaviness, pressure in the head, inability to walk properly, more purging and perhaps more of an emphasis on bodily processes.

An oral dosage of 100mg of dmt is where the visionary qualities really begin to occur, for most people say when they are taking 3 grams of syrian rue or 80 grams of strong vine, and in context, 40-60 grams of strong vine is enough to fully mao inhibit most people.

I would say to neophyte explorers to tread carefully, and to slowly increase your dmt dosage in increments: perhaps starting at 60mg, going to 100mg, then 150mg. Some people are going to find 100mg of dmt to be exceedingly strong, and it will perhaps give them an experience they did not feel ready for.

--> It came to my attention after an embarrassing number of years, that taking freebase crystal DMT orally was not as potent, colourful, or clear as taking the equivalent amount of DMT in a tea that was brewed from the plant. For many years, I couldn't see how there could be a difference, but after doing some comparisons, it was obvious that the tea was much better, and the experiences resulting from the crystalline extract were inferior.

You could take twice or even three times as much DMT crystal as the equivalent in brew, and the experience from the crystal would never be as bright or full as that from the tea. Why could this be?

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Clearlight experiments that involved several people found the leaf brew form superior to extracted actives, they found the leaf brews very strong and powerful & clairavoyant (+5 Shulgin scale), while they mentioned that the extracted actives were mild (+3 Shulgin scale) at best, even up to 100mg. Again, this is poorly understood.

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Cyclodextrins can be used to reduce or prevent gastrointestinal and ocular irritation, reduce or eliminate unpleasant smells or tastes.

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Cyclodextrins at high doses can increase drug permeability by direct action on mucosal or intestinal membranes and enhance drug absorption and/or bioavailability. These effects are possibly caused by solubilisation of membrane lipids through inclusion complexation with cyclodextrins and the ability of cyclodextrins to cause perturbation of membrane integrity. However, unlike detergents, cyclodextrins solubilize membrane components without entering into the membrane, therefore the perturbing effects of cyclodextrins are mild and reversible [7].Cyclodextrins are absorbed poorly via mucosal membranes.

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The oral bioavailability of cyclodextrins is very low in adult animals and humans (0.1–3%), except for RM-β-CD, which has a bioavailability of 12% in rats. Because of their bulky and hydrophilic nature only insignificant amounts of cyclodextrins are absorbed from the gastrointestinal tract by passive diffusion [33, 27].

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Note: music lovers like myself will love this Ayahuasca formula high in THH, as there is very strong music enhancement (similar to high dose mescaline) in combo with the DMT...and you can re-dose after the DMT effects wear down to continue not only the strong music enhancement, but open eyed profound beauty, neon colors, open eyed visuals, closed eye geometrics which progress into full fledged colored Ayahuasca visions. The THH has a half life of 10.5 hours with peak at 5.25 hours, so you never have to re-dose the THH for the evening, only the harmine and DMT to continue the divine journey. One of my favorite things to do is listen to music for hours on end while I enjoy the profound open eyed beauty and visuals. Watching 4k movies is also a blast, extremely enjoyable.

Ayahuasca is strong medicine and VERY TRIPPY, but like Benny shanon said in his book "Antipodes of the Mind", "many people enjoy Ayahuasca as if going to the theatre and watching a good movie". Even Jonathan Ott remarked on his euphoric Ayahuasca trips being a source of intense enjoyment & pleasure, same here. Sometimes divine spiritual transcendence is just the medicine we need. Ayahuasca is a great way to stay Psychedelic for the rest of your life.

P.S. Don't forget to visit your local waterpark this summer, former beach & waterpark deep water lifeguard, we get a summerpass and go all spring, summer & fall at least twice a week, lots of fun! I sometimes take a bridgesii cactus tea with 200mg THH combo together in the morning before I go (taking the THH 1 hour after the cactus), unbelievable fun, all of nature looks like a fairytale land full of neon colored bikinis & the music sounds great being played over the outdoor speakers.

Pic 1: attached chart of harmine and DMT strength from Jonathan Ott's "Ayahuasca Analogues"

Pic 2: Serpents are the manifest spirit of Ayahuasca, have seen them multiple times on many Ayahuasca journeys.

Top left: Egyptian Goddesses Isis (Cobra) & Serapis: depicted as Sacred Serpents

Top middle: Shipibo Ayahuasca Tapestry: The Vase representing the Amazonian Medicine, The Serpents that of the Grandmother Spirit of Ayahuasca

Top middle: Cosmic Serpent: Book by Jeremy Narby

Top right: Mayan ruins

Bottom left: Priestess of Quetzalcoatl

Bottom middle: Aztec Serpent Moon Goddess (Coyolxauhqui). Other Aztec Serpent Symbols include: Quetzalcoatl (Feathered Serpent), Xiuhcoatl (Fire Serpent), Mixcoatl (Cloud Serpent), and Coatlicue (She with Serpent Skirt)

Bottom right: Kundalini Serpent Pathway

Bottom right: Shiva & Shakti: Siddhi Level of Divine Masculine & Feminine Balance

Icon said:

You could probably isolate it, though I don't think you'd want to. THH is technically an SSRI. Still a very special harmala, but you also want some harmine for mao inhibition.

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