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Re: HPBCD complexed DMT made bioavailable sublingually under tongue, also improves oral bioavailability for pharmahuasca & Ay... [Re: idontknow1]
    #27384034 -

This should help answer your question idontknow1:

professor8 (from 11/1/2010 he writes like a poet w/special powers of imagination & expression):
Quote:
Tetrahydroharmine (THH) has the ability to raise your vibration in a most powerful, yet subtle way. It brings a crystalline prismy texture to spice and adds a super clear watery dimension to Aya, like looking down through 10meters of shimmering Caribbean Sea on clear blue day. It brings a dimension of pure light to the entheogenic experience and encourages entities & intelligences of only the Highest Order. If one is not accustomed to perceiving these experiences with a spiritual perspective most of the nuances & subtleties THH brings on are overlooked and remain unseen and one would better enjoy Harmaline as a house painter chooses a roller over a brush, its about preference & choice.



You are correct idontknow, 150 to 300mg oral THH 45 minutes ealier then 80mg sublingual HPBCD DMT is identical to around 600mg of mescaline, beautiful beyond belief.

New data has revealed that THH is not a 5-ht2a agonist at all, but rather a strong agonist at all three adrenal receptors, just like mescaline. It has around the same tolerance as that of mescaline, very short tolerance, you can use it again with just 4 days off if you want (not a good idea though, best to wait at least 7 days or more off in between use), whereas with LSD (5-ht2a agonist), there is a long tolerance, more like 2 weeks. Both mescaline and THH block serotonin strongly, therefore they are both potent 5-ht1a agonist. 5-ht1a agonism results in serotonin blocking, which make up over 80% of brain 5-ht. Ibogaine and THH have been shown to inhibit serotonin transporter (SERT) noncompetitively, in contrast to all other known inhibitors (LSD, mescaline, shrooms), which are competitive with substrate. I would say the main thing to get out of this is that DMT does not block serotonin on it's own, but requires teamwork with THH to do this, day to day normal survival filters (serotonin 5-ht) are then blocked and all barriers & doors are broken down as a result, divine transcendence results with the teamwork....ie music sounds incredible, beauty enhancement is infinite, real Ayahuasca visions appear, colors are neon and not subdued and dark, spiritual insights are powerful, etc.

When high dose THH and moderate dose DMT are combined, they form in my experience what is known as "super-mescaline", dirt-cheap experience which is identical to high dose mescaline in my experience, add in some harmine and it becomes Ayahuasca in feel.

INDOORS:

More on tolerance...due to my work schedule, I only have 2 weekends off, but have several midweek days off every other week, so I take a 300mg oral THH 45 minutes earlier + 90mg sublingual HPBCD DMT journey on Wed, 9 days later on a Friday have another journey, then 5 days later have another journey on a Wed, then 9 days later have another journey on a Friday, since I re-dose every 1.5 hour, I am taking total of 3 sublingual HPBCD DMT doses, giving me a 4.5 hour strong trip with super-long afterglow...so I basically use this stuff x 4 times a month, keeps me extremely happy and depression free.

I have ZERO tolerance using it like this, with extended time off from the journeys every other week, which makes up for the week when I use it again 5 days later due to not having every weekend off.

OUTDOORS:

Should I venture outdoors to the waterpark, where I get a pass every summer (former beach and deep-water waterpark lifeguard), also a lifeguard instructor for many years at the waterpark...

I will use outdoors instead: 3 x 12" long 2.5" wide or so PC san pedro cactus tea (PC san pedro probably accounts for 99% of all san pedro on this continent) this gives me around 350mg mescaline tea. Yes, you can still trip hard on PC san pedro if you use enough!

I will take this boiled down tea first. After the tea has sat in fridge several days in 1/2 pint tall jar for all the nausea causing sediment to fall and stick to bottom, just decant and drink only what is above the thin tiny sediment layer for ZERO nausea, or alternately simply filter tea brew thru a cotton ball in a funnel to eliminate the nausea causing sediment.

...then 45 minutes later take 250mg of THH, always stagger so the trace maoi's in cactus do not interact with the SRI which is THH at same time, which can cause unpleasant body symptoms.

The combination of the approx 350mg mescaline tea + 250mg THH gives me a trip identical to around 500mg of mescaline, trip my ass off outdoors at waterpark all day, super strong while completely relaxing and calm, can even hold normal conversations and complete control of all my faculties while tripping level 5 Shulgin strength outside. The beauty outdoors in nature is breathtaking and unbelievable.

Pic: waterpark nature fun

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Re: HPBCD complexed DMT made bioavailable sublingually under tongue, also improves oral bioavailability for pharmahuasca & Ay... [Re: tregar]
    #27387724 -

In conclusion...

7/15/2021 important update to the diary: After 3 months working with this stuff, I decided to try some experiments, taking as usual 300mg THH orally 45 minutes before taking the 90mg DMT complexed to 630mg plain HPBCD in 10 drops boiling hot water from a nearby coffee mug all stirred/mashed/scraped/kneaded together on a spoon using the end of another spoon for 2 minutes, stirring alone is not good enough, use scraping & mashing, as scientist form complexes with force mashing/kneading...then placing bottom of tongue on to spoon, the sticky gel-like complex all adheres. Held sublingually under tongue pressed down into the sublingual mucosa (only 100 microns thick) for 15 minutes (it all dissolves in 15 minutes).

In preparation for an evening's journey, I will often suck up the 0.5ml (10 drop complex) into a 3ml plastic syringe, pre-preparing 3 of these syringes, each with 90mg HPBCD complex so I can shoot one of these re-dose under my tongue every 1.5 hour without having to make more while I'm tripping. They can even be stored long-term in the freezer, and they de-frost quickly at room-temp when pulled out of freezer.

--> What I've been doing recently is experimenting with taking 200mg of harmine orally around an hour or more before using the sublingual HPBCD DMT. In other words, I'm taking the oral harmine at around the same time I'm taking the oral 300mg THH.

I have found this is especially useful in overcoming any developed tolerance to the sublingual HPBCD DMT, this use of oral harmine seems to completely reset any tolerance and drastically lower the body's overall MAO defenses for the entire evening, allowing for a sublingual HPBD DMT journey that is extremely powerful and very long duration when there is any sort of developed DMT tolerance.

The harmine seems to impart a very long 5 hour total in my experience "lowering of MAO defenses system wide in the body", so when I continue to take the sublinugal HPBCD DMT under my tongue x every 1.5 hour I continue this extremely powerful experience for 4.5 hours total with super-long afterglow.

--> Alternately, what one can do is use 30mg sublingual harmine (no complexing to HPBCD needed) taken 1/2 hour before using the sublingual HPBCD DMT, this could prove nearly identical to using 200mg oral harmine, I will experiment with this in the future in place of the oral harmine.

--> I know that I had developed a strong tolerance as when I tried sublingual 90mg HPBCD DMT earlier in the day, it did not work at all, until after I had taken the harmine...which completely reset my tolerance, then a couple hours after taking the harmine the sublingual 90mg HPBCD DMT worked with full force, stronger than anything previously encountered.

I recently experienced the most powerful journey out of all the many journeys I have taken in 3 months, by experimenting as written above...this taking first of 300mg THH 45 minutes before then of 200mg harmine around an hour or more in the evening before using the sublingual HPBCD DMT x 3 total sublingual re-doses during the evening (every 1.5 hour) really turbo-charged the experiences...just completely blown away.

The open-eyed visuals were extremely powerful, Shulgin level 5 strength easily, impossible not on this earth neon-colors on all the walls constantly shifting into other colors, with mind-bending geometrics, beauty-enhancement so over the top & infinite, music so incredible, actresses on the movies again looked like super-beautiful glowing dazzling cartoon caricatures of themselves, felt identical to 700mg of mescaline, but this was with a developed tolerance.

I have been completely able to maintain this level 5 shulgin strength level for 4.5 total hours with no weakness or lowering of strength even on the 3rd re-dose, completely awestruck, and this has been accomplished when I had a tolerance on monday, after having taken this stuff only 4 days earlier, I wanted to see if harmine would make a difference in lowering the developed DMT tolerance, and it did drastically.

I can only imagine what it might do when one does not have a tolerance, waiting normal 7 days or longer before using the sublingual HPBCD DMT again, which is the way I normally use it.

Based on these findings, I encourage other future psychonauts to experiment with adding in some 200mg harmine either orally or alternately 30mg harmine used 1/2 hour sublingually before using the sublingual HPBCD DMT...to lower the body's overall MAO system defenses for the entire course of these sublingual HPBCD DMT re-doses all evening long, as this single taking of only 1 dose harmine works incredibly well for the entire evening, a good 5 hours total in my experience. I am able to maintain Shulgin level 5 strength for each of the 3 re-doses with ease, even with a developed tolerance, even though I plan to go back to my normal zero tolerance 7 to 9 day time-frame between doses. I will again experiment with usage of the single dose harmine even without a developed tolerance in the future.

This single usage of either one-time dose 200mg oral harmine or one-time dose sublingual 30mg harmine is ground-breaking in my experience in lowering any developed DMT tolerance, and further in potentiating the strength levels of these already powerful sublingual HPBCD DMT doses by lowering the body's system-wide MAO defenses for a good 5 hours total during the evening of every 1.5 hour HPBCD DMT re-doses, even when there is no tolerance in play.

I am especially thankfull to Loveall and downwardsfromzero for mentioning to me months ago about the potential inclusion of 25 to 30mg sublingual harmine experimentation beforehand. It just took me a while to finally implement it properly, and especially glad I did finally.

Pic1: 3ml syringe and puppy dog sunglasses storage case for syringes. The syringe's liquid complex becomes re-flowable again after sitting at room temp for a short while, in case it has been pulled from freezer storage.

Pic2: Woman sitting on the Eleusis ruins of ancient Greece where the sacred Kykeon entheogenic beverage was drank in ritual for nearly 2,000 years. In its heyday, up to 3,000 initiates could be received at a time.

pic3: Spirit animals watch on & guide the process as 2-step HPBCD DMT for sublingual use with oral THH Ayahuasca is prepared with meditation, prayer & intentions. Table showing subjective DMT strength from 20 to 80mg.

pic4: 3ml syringe filled with 10 drop (0.5ml) of the HPBCD liquid complex (80mg DMT complexed to 560mg plain HPBCD, use 640mg if using 2-hydroxy propyl beta cyclodextrin, 1:1 molar ratio = 1:7 weight gram ratio if using plain HPBCD from China, 1:8 weight ratio if using more common 2-hydroxy PBCD).


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Re: HPBCD complexed DMT made bioavailable sublingually under tongue, also improves oral bioavailability for pharmahuasca & Ay... [Re: tregar]
    #27389194 -

I noticed on the Nexus that you've started taking harmine in the complex sublingually. What are your thoughts about taking THH sublingually as well (possibly at the same time as the harmine?


--------------------
It’s not personal

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Re: HPBCD complexed DMT made bioavailable sublingually under tongue, also improves oral bioavailability for pharmahuasca & Ay... [Re: idontknow1]
    #27389942 -
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idontknow1 said:
Quote:
I noticed on the Nexus that you've started taking harmine in the complex sublingually. What are your thoughts about taking THH sublingually as well (possibly at the same time as the harmine?



Yes idontknow, see update 7/16/2021 below.

The end. Complete summary of this entire paper in 2 pages. Includes everything I've learned in 3 months working with this new discovery:

DMT molecular weight = 188 g/mol
HPBCD molecular weight = 1300 g/mol
2-hydroxy PBCD molecular weight = 1500 g/mol

1:1 molar ratio dmt to HPBCD = use 1:7 gram weight ratio dmt to HPBCD
1:1 molar ratio dmt to 2-hydroxy PBCD = use 1:8 gram weight ratio dmt to 2-hydroxy PBCD

1. put 60mg DMT freebase on a spoon

2. cover with 480mg of the 2-hydroxy PBCD powder (1:1 molar ratio), use 420mg if using plain HPBCD (hydroxy propyl beta cyclodextrin), a kilo is dirt cheap from China, cost of 4 movie tickets), and will last a lifetime for yourself and friends.

3. add 10 drops of near boiling hot water from a coffee mug

4. stir, scrape, and mash it all together for 2 minutes...knead/mash/scrape using end of another spoon...Use your muscles to scrape/mash it all together, just stirring or mixing alone is not good enough. It will form a liquid sticky gel-like complex that can even be sucked up into a 3ml syringe and stored in freezer. 10 drops complex will fill it up to the 0.5ml line. I pre-prepare x 3 of these syringes ahead of time for the evening so I don't have to stop and make one every 1.5 hour while I'm tripping.

5. dry bottom of tongue and top of sublingual mucosa with a tissue.

6. put bottom side of tongue onto spoon, it will all adhere to bottom of tongue, or you can shoot a syringe under tongue.

7. Hold in sublingual mucosa under tongue for 15 minutes, it will all dissolve, I've done this enough times to notice it all dissolve in 15 minutes, even 110mg complexed DMT dissolves in 15 minutes sublingually. Spit out any saliva after 15 minutes instead of swallowing it. If it's too uncomfortable before the 15 minutes is over, tilt forward & gently relieve the saliva into a cup while still holding what's under your tongue without releasing it.

There is a mild to moderate sting during the 15 minutes, but I actually like it and it does not bother me at all. If you find this too much, you can always just add the HPBCD DMT from off the spoon to a 1 oz hot water tea which already has 200mg harmine and from 150mg to 300mg THH already dissolved into it, use 100mg of crushed vitamin C to help dissolve the harmals should they be in freebase form. Drink it all at the exact same time just as the Shaman's do for an experience that is many factors stronger than plain freebase DMT or DMT salts, the HPBCD DMT is just like using 30 to 40g of Hawaiian psychotria, it is all encompassing just like the leaf and very strong.

8. 22 minutes after you begin all this, (1/2 the time of an oral dose) you will go from baseline to full throttle, 60mg DMT will take you to a level 3.5 on Shulgin strength scale.

9. So long as you took 150mg to 300mg of tetrahydroharmine 45 minutes earlier, it will double the half-life of the DMT, so you get a full strong 90 minutes out of it. Update 7/16/2021: Take sublingual 35mg freebase harmine complexed to 210 HPBCD (use 280mg if using 2-hydroxy PBCD) in 10 drops boiling hot water, mixed/crushed then held under tongue for 15 minutes around the same time you take the THH to "super-turbo" charge the strength of all 3 HPBCD DMT sublingual doses for the evening. Just one single harmine dose early on will last for 5 to 6 hours. Alternately, you can take 200mg of oral harmine instead around the same time you take the THH.
------------------------------------------------------------
From 5-19-21: 60mg DMT complexed to 420mg HPBCD sublingual report dosed x 3 times every 1.5 hour

Full Journey trip report:

Keep in mind using DMT salts sublingually does not work. The HPBCD complexed DMT works extremely well, the outer water soluble sugary like tasting HPBCD keeps the freebase DMT trapped inside it's non-polar cone, so as the complex sits under the tongue for 15 minutes...

...you feel a mild to moderate sting for around 15 minutes as the HPBCD releases the DMT directly into the bloodstream from the mucosa membrane under the tongue (only 100 microns thick) as the freebase, only as the freebase will it reach from the bloodstream to the brain with maximum effects. I don't have all the answers, I only know it works extremely well. The tongue is completely fine after, and it's as if nothing happened the next day, 100% no scarring or burning, totally normal.

Be sure to press down with tongue the whole time to trap the sticky complex in the sublingual mucosa.

Give this a try...follow 2 step instructions, 60mg DMT complexed to 420mg HPBCD (use 480mg if using the 2-hydroxy PBCD) with 2 minutes stirring, mashing & kneading all of it hard (to force the DMT into the tornado like HPBCD cone) using your muscles on a spoon with 10 to 12 drops very hot water, put bottom of tongue on to spoon, it will all adhere...and hold for 15 minutes in the sublingual mucosa, begins to work in 22 minutes...at the end of the 15 minutes, I spit out any saliva that's collected in mouth into a cup instead of swallowing, for me this has been less than 1/4oz or around less than 15ml saliva. As I gently spit out the saliva, I will keep any tiny residual amount still trapped or pressed down under tongue for another 5 minutes usually, but I have noticed most of the time, it all dissolves within 15 minutes.

...and is VERY STRONG...I experienced 90 minutes of very strong effects, pupil dilation maxed out, strong tryptamine body buzz high frequency, heavy CEV imagery, open eyed beauty profound, music sounds incredible...feels identical to if I had taken 60mg DMT complexed to HPBCD orally with 200mg harmine with 300mg THH, of course I always take 300mg THH orally any time I do this using the sublingual DMT.

I recommend not using more than 250mg of THH if it is your first time. 250mg of THH causes zero dizziness and ZERO nausea, but 300mg will cause a tiny bit of dizziness for a short time if you are not used to it. I am used to it, so I get no dizziness at 300mg.

The effects were so INCREDIBLE, I RE-DOSED 60mg of DMT complexed to 420mg HPBCD x two more times the same night, every 1.5 hours...it was the bomb...I was in 7th heaven.

...never before have I had such insane visuals all night long...all the way till 5am in the morning I was seeing closed eye visions of slow and high speed movies...I saw brightly colored serpents, dungeons I traveled thru, many Mesoamerican pyramids, women of incredible beauty, Japanese landscapes, dancing geometrics, many different animals on a rotating globe, walking on the planet-like globe as it spun, hundreds of visions like slow and high-speed movies over the course of many hours.

I saw the interiors of many magnificent homes, exposed like a camera flash went off, then off to the next home interior, bizarre alien looking creatures, I saw ancient ruins but they were seen as they were before they fell apart. All sorts of architectural wonders appeared that I could not make out exactly what time period they were from.

All the visions were enchanting & manifested incredible beauty. The multi-colored beautiful serpents kept appearing several times in different forms, as if they have some prominence to do with it all, two of them had shining skin covered in gold scales and intertwined like DNA, reminds me of the Aztec quetzalcoatl myth, the "serpent of precious feathers."

...all of these visions were brightly colored due to the DMT and THH combo all night long..it was one of the most powerful psychedelic experiences of my life...and I've taken Ayahuasca x 70 times, cactus 200 times, etc...I have never had over 5 hours of non-stop CEV visions anything close to what I saw the other night...I was blown away, and will be thinking about this for a very long time...this sublingual DMT along with 300mg THH taken orally 1 hour before is my absolute favorite...there is no nausea...I wore headphones and listened to music the whole time, as the music sounded just like if I had taken a very strong cactus tea...out of this world good...I had non-stop closed eye visions all night long, insane visions...totally blown away.

I love the "oral 250 to 300mg THH + sublingual 420mg HPBCD complexed to 60mg DMT administration" as there is a complete lack of "queasiness feeling during the journey", perhaps because there is no harmine/DMT going thru the stomach & intestines...I don't know the answer for sure, but I like it.

Remember, I took 300mg of THH once early on, then every 1.5 hour I took 60mg of DMT complexed to 420mg of HPBCD sticky liquid under my tongue for 15 minutes held...so I took it x 3 times...one of the most visionary entheogenic experiences of my life.
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Update 7/16/2021:

How to turbo-charge the strength of each 3 sublingual HPBCD DMT doses for the evening, beyond level 5 Shulgin strength, in other words "super-strong", simply by using a single dose of harmine early on, lasts a good 5 to 6 hours.

DMT molecular weight = 188 g/mol
Harmine molecular weight = 212 g/mol
HPBCD molecular weight = 1300 g/mol
2-hydroxy PCD molecular weight = 1500 g/mol

1:1 molar ratio harmine to HPBCD = use 1:6 gram weight ratio harmine to HPBCD
1:1 molar ratio harmine to 2-hydroxy PBCD = use 1:7 gram weight ratio harmine to 2-hydroxy PBCD

If you browse the search for "sublingual harmine" there are a number of topics in which psychonauts have used around 35mg sublingual harmine to potentiate DMT to very strong levels. I used this same technique twice already, this week and the week before to potentiate the already strong sublingual HPBCD DMT to the "very strong" category, like walking thru a curtain of visuals when moving from room to room, and everything surrounded by neon colored rainbow auras and colored sparkles, with high-powered tracers, just incredibly visual open-eyed, very euphoric while still relaxing and calm just like with high dose cactus tea. Music so incredible sounding.

Never take the HPBCD harmine and HPBCD DMT sublingually all at the same time, I found out months ago the harmine interferes with the absorption of the HPBCD DMT, and the result is weak trip, always stagger.

This is the only way I will be using the sublingual HPBCD DMT from now on, by taking sublingual 35mg freebase harmine complexed to 210mg HPBCD in 10 drops boiling hot water mixed/mashed all together for 2 minutes on a spoon, then place bottomside of tongue onto spoon, it will all ahdere and held under tongue for 15 minutes, taking this 30 minutes before I take the sublingual 90mg HPBCD DMT, or alternately, one can use 200mg oral freebase harmine instead, with of course taking 300mg THH orally 45 minutes before the sublingual process as always. Only freebase harmine can be complexed to HPBCD.

I'm blown away by the strength of the sublingual HPBCD DMT this way. It's like taking it to the next level strength, beyond the Shulgin level 5 strength. Taking the sublingual 35mg HPBCD harmine just once (one dose early on) is enough to make all three sublingual HPBCD DMT doses for the evening extremely powerful, with each strong dose lasting 1.5 hour...but the HPBCD complexed harmine seems to leave this lasting effect for a good 5 hours. I attribute this to the harmine's power to "lower all the body systems MAO defenses" for an extended 5 hour period of time.

Dr. Narang in the attached paper on page 1 explains how the "sublingual route can be up to 3 to 10 times greater than oral route", I think this is what is making the sublingual 35mg harmine x 6 average (3 + 10 divided by two) seem to have the strength of around 200mg of oral harmine. I highly recommend this approach for really phenomenal journeys.

Always remember, colors will only be neon-colorful, music will only sound bad-ass incredible, beauty enhancement will be "over the top" and actresses on TV will look like dazzling glowing super-colorful cartoon versions of themselves (just like with high dose cactus tea) only if you include the THH. Important teamwork takes place with THH + DMT. In my experience, THH also doubles the half-life of the DMT, so you get a full 90 minutes out of each HPBCD DMT dose. THH has numerous similarities to mescaline, and has a 10.5 hour half-life with peak at 5 hours. You can even re-dose more sublingual HPBCD DMT x 2 more times (every 1.5 hour) at night for a 4.5 hour total strong experience with long afterglow.

You can either take a sublingual 35mg HPBCD harmine dose or take an oral 200mg harmine dose around 1/2 to 1 hour before beginning all this (around the time you drop the oral THH), either way, you are in for a treat.

Not only does harmine increase the strength of the 1st and two subsequent sublingual HPBCD DMT re-doses every 1.5 hour, but it adds a unique signature in this context which I find most magical, a feeling that the protective allies are smiling down on me, a feature I've always experienced in the past with cactus tea just like DM Turner. Also makes one feel as if they are relaxing in a hot tub.

Stay true to yourself. Peace, Love & music.
www.friskyradio.com

Pic1: Neon colored rainbow auras and colored sparkles surround everything.

Pic2: 3ml syringe and puppy dog sunglasses storage case for syringes. The syringe's liquid complex becomes re-flowable again after sitting at room temp for a short while, in case it has been pulled from freezer storage.

Pic3: Woman sitting on the Eleusis ruins of ancient Greece where the sacred Kykeon entheogenic beverage was drank in ritual for nearly 2,000 years. In its heyday, up to 3,000 initiates could be received at a time.

pic4: Spirit animals watch on & guide the process as 2-step HPBCD DMT for sublingual use with oral THH Ayahuasca is prepared with meditation, prayer & intentions. Table showing subjective DMT strength from 20 to 80mg.

pic5: 3ml syringe filled with 10 drop (0.5ml) of the HPBCD liquid complex (80mg DMT complexed to 560mg plain HPBCD, use 640mg if using 2-hydroxy propyl beta cyclodextrin, 1:1 molar ratio = 1:7 weight gram ratio if using plain HPBCD from China, 1:8 weight ratio if using more common 2-hydroxy PBCD).

attached paper 1: sublingual route can be up to 3 to 10 times greater than oral route.

attached paper 2: When vegetals (UDV, Santo Daime, native Shuar Indian) are consuming one cup of Ayahausca tea, they are getting 150mg average THH dose, when 2 cups are drank for evening (very common), they are consuming 300mg THH. Dennis Mckenna Ph.D: page 115: "Thus, tetrahydroharmine may prolong the half-life of DMT by blocking it's intraneuronal uptake, and hence, its inactivation by MAO, localized in mitochondria within the neuron." In my experience, THH doubles the half-life of the dmt.




Edited by tregar (07/17/21 08:22 AM)

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Re: HPBCD complexed DMT made bioavailable sublingually under tongue, also improves oral bioavailability for pharmahuasca & Ay... [Re: tregar]
    #27391125 -

Summarized this entire paper above in 2 pages with everything I've learned over 3 months, even how to take this 90mg sublingual HPBCD DMT to "the next level strength" above Shulgin level 5 strength, which is how I use it from now on. Potentiates the already strong sublingual HPBCD DMT to the "very strong" category, like walking thru a curtain of visuals when moving from room to room, and everything surrounded by neon colored rainbow auras and colored sparkles...with high-powered tracers, just incredibly visual open-eyed, it hits extremely strong like out of nowhere at the 22 minute point, often sooner, very euphoric while still relaxing and calm just like with high dose cactus tea. Music so incredible sounding, this is of course with taking 300mg THH orally 45 minutes before hand, feels like 700mg plus of super-mescaline, so if you need something to print out to follow, post above would be the one.

Pic: Ancient ruins & 10mg pure THH grabbed with a wet cue-tip used to draw on a paper plate under blacklight, blue glow.


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Re: HPBCD complexed DMT made bioavailable sublingually under tongue, also improves oral bioavailability for pharmahuasca & Ay... [Re: tregar]
    #27395502 -

One thing I should mention is that I don't smoke DMT, so it could be that if anyone is trying to experience this within days of smoking DMT, you are most likely in for an extremely weak journey due to DMT immunity or tolerance.

300mg oral THH 45 minutes before then sublingual 60mg DMT complexed to 420mg plain HPBCD (480mg if using 2-hydroxy PBCD) in 10 drops boiling hot water always gives me a strength level of around 450mg of mescaline or 150 mics of acid (but way more aesthetic and beautiful than acid). It lasts for 1.5 hour.

My dosage is 300mg oral THH 45 minutes before then sublingual 90mg DMT complexed to 630mg plain HPBCD in 10 drops boiling hot water mashed together for 2 minutes...gives me a strength level of 700mg of mescaline for 1.5 hour, then I re-dose x two more times every 1.5 hour with more sublingual 90mg HPBCD DMT.

You said last time you used 244mg of THH so it could be that when you sent it to 300mg THH and 200mg harmine, your body just said "can't do this, too much." Yes, drop the harmine and just use the THH and sublingual HPBCD DMT in the future.

When I added in the 200mg of harmine taken at the same time as the 300mg of THH, I had zero nausea, but I am used to these kind of dosages...then I dosed sublingual 90mg DMT complexed to 630mg plain HPBCD, it was beyond the strength of 700mg of mescaline, when walking to another room, there was a curtain of visuals along the way, alternating neon colors on all the walls, neon colored rainbows and colored sparkles surrounding everything and geometrics with open or closed eyes, insane open eyed beauty, wild tracers & music very incredible sounding, just blown away. I watched movies all night and was in Heaven, powerful euphoria and enjoyment of it all, actresses on screen looked like dazzling, glowing super-colorful cartoon caricatures of themselves, the beauty was breath-taking.

A beginner at this is going to want to use 150mg THH orally and 150mg harmine orally, then slowly advance up to 150-300mg THH and 150-200mg harmine if desired, or just stay at the lower doses. Delete the harmine or include it, it's up to you. I'm at the advanced point where I'm using the harmine to rocket fuel the journeys.

It hit extremely hard out of nowhere at the 22 minute point, went from sober to full throttle in an instant and stayed there 1 and 1/2 hour...I was not expecting this kind of strength, but even did this on a second week, and again same effect... I had no idea the harmine would lower the overall body mao defenses this powerfully for a full 6 hours...honestly, I was blown away, and still trying to figure out how this strength is possible. I kept re-dosing every 1.5 hour and still the same mind-blowing strength and 1.5 hour duration.

It was beyond anything I've experienced when using the HPBCD DMT orally with 200mg harmine and 300mg THH...the sublingual 90mg HPBCD DMT was immensely powerful, I will be satisfied with this for the rest of my life to replace high dose cactus tea at home, which has become very expensive and rare. This is dirt cheap and identical to me to high dose mescaline.

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Re: HPBCD complexed DMT made bioavailable sublingually under tongue, also improves oral bioavailability for pharmahuasca & Ay... [Re: tregar]
    #27395684 -

I need to read this thread in it's entirety and I'm sure it's been asked, but how does one obtain THH and the HPBCD?  I did a quick search to no avail...but I admittedly feel like a fkn retard trying to wrap my head around it.  I'm highly intrigued, I've never orally dosed DMT but from what I've read about the standard approach with harmalas this seems more straightforward.  And thank you, for putting this all out there.


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Re: HPBCD complexed DMT made bioavailable sublingually under tongue, also improves oral bioavailability for pharmahuasca & Ay... [Re: seldom seen] * 1
    #27395769 -

My HPBCD came in. I don't have any THH at the moment, only harmine and harmaline. I'll have to go through the conversion( https://www.dmt-nexus.me/forum/default.aspx?g=posts&t=29210 ) soon.

I am a big fan of whole rue, maybe I'll give it a try on that before I get around to making some THH.


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I felt.

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Re: HPBCD complexed DMT made bioavailable sublingually under tongue, also improves oral bioavailability for pharmahuasca & Ay... [Re: Abyssinian] * 1
    #27441054 -

Update 9.2.2021:

Oral Tetrahydroharmine + sublingual HPBCD DMT journeys, very similar to mescaline:
https://www.shroomery.org/forums/showflat.php/Number/27453370

(1) On the importance of tetrahydroharmine (THH)
(2) 300mg oral THH + 60mg sublingual HPBCD DMT re-dose every 1.5 hour, 5 hours of brightly colored CEV visions: example of the importance of THH to the journey, brightly colored snake visions.
(3) Post #3 on-wards, additional journeys diary

These high-dose profoundly beautiful trips are identical in effects to me as taking from 600 to 700mg of the infinitely beautiful mescaline. :heart: The trips feel like "super-mescaline", but are dirt cheap in comparison to the rare and expensive cactus.

MUSIC SOUNDS INCREDIBLE for hours on end. :heart: And beauty enhancement is way over the top.

----------------------------------------------
----------------------------------------------


The 2 minute formed HPBCD DMT liquid very bioavailable sublingually under tongue & outperforms DMT salts orally by many factors in personal trials, combo with tetrahydroharmine, Ayahuasca.

https://www.dmt-nexus.me/forum/default.aspx?g=posts&t=96861

Part 1: HPBCD complexed DMT experimental dosage, effects & duration
Part 2: receptorome chart & explanation
Part 3: Tetrahydroharmine (THH) effects
Part 4: Tetrahydroharmine receptorome similarities to mescaline; potentiates cactus & safety note
Part 5: chemist Patrick Arnold's HPBCD prohormones & bloodwork studies
part 6: Dr. Narang: "with sublingual" or "under the tongue" better than buccal, gingival & palatal
part 7: a little bit on my 70 Ayahuasca experiences, doses & visions
part 8: New research: Morning glory contains 5 stimulating LSD-like drugs, soluble only in wine/alcohol, only sparingly soluble in water.
part 9: 20 minute visionary visit from a dead Aztec Shaman
part 10: One way to make tetrahydroharmine
part 11: How to easily extract 2.3g DMT from 170g bark using a 2 liter Erlenmeyer flask

Continuation:

Update: 8-24-2021:
Oral Tetrahydroharmine + sublingual HPBCD DMT journeys, very similar to mescaline

https://www.dmt-nexus.me/forum/default.aspx?g=posts&t=97557

These high-dose profoundly beautiful trips are identical in effects to me as taking from 600 to 700mg of the infinitely beautiful mescaline. :love: The trips feel like "super-mescaline", but are dirt cheap in comparison to the rare and expensive cactus.

Here is 2.4 grams brand new DMT extracted from 170g bark for use in some more HPBCD DMT Ayahuasca experiments. See post #19 here: https://www.dmt-nexus.me/forum/default.aspx?g=posts&t=96861 if you need help on how to do this. Always get from 2.4 to 2.5 grams from 170g bark. I really love this orangish/yellowish colored DMT, it is very potent and other-worldly.


Edited by tregar (09/02/21 10:09 AM)

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Re: HPBCD complexed DMT made bioavailable sublingually under tongue, also improves oral bioavailability for pharmahuasca & Ay... [Re: tregar]
    #27441931 -

a simple starter kit would be a great christmas gift.


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:brainfart: _ :finger:

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Re: HPBCD complexed DMT made bioavailable sublingually under tongue, also improves oral bioavailability for pharmahuasca & Ay... [Re: redgreenvines] * 2
    #27441934 -

HPBCD complexed Salvinorin :awecid:


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Omnicyclion.org
personal empowerment for the world

:nyan: LGBT - Love God Before Tradition :nyan:

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Re: HPBCD complexed DMT made bioavailable sublingually under tongue, also improves oral bioavailability for pharmahuasca & Ay... [Re: Asante]
    #27443459 -

:wink:


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:brainfart: _ :finger:

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Re: HPBCD complexed DMT made bioavailable sublingually under tongue, also improves oral bioavailability for pharmahuasca & Ay... [Re: redgreenvines] * 1
    #27444809 -

Those were the days :sun:


RGV if you're still into that plant and have some S-A set aside, if you'd like e few grams of HPBCD in the mail, drop me a secure PM, I literally have a kilo of the stuff for experimentation with cycloastragenol to lengthen my telomeres some (look into that!), and HPBCD is a food ingredient without problematic properties, basically high tech starch.

Only thing I ask in return is that you report your findings, because sublingually improved S-A would show amazing promise, since sublingual is the ideal way to derive benefit from salvia, were it not for the horrid low bioavailability. HPBCD for sure would change that.

You'd literally advange the frontier of human knowledge, that's worth a postage stamp.

Just throwing that out here :P


--------------------
Omnicyclion.org
personal empowerment for the world

:nyan: LGBT - Love God Before Tradition :nyan:

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Re: HPBCD complexed DMT made bioavailable sublingually under tongue, also improves oral bioavailability for pharmahuasca & Ay... [Re: Asante]
    #27465652 -


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Re: HPBCD complexed DMT made bioavailable sublingually under tongue, also improves oral bioavailability for pharmahuasca & Ay... [Re: tregar] * 1
    #27471256 -

Should add that once you have these very fresh just extracted and complexed pre-made frozen syringes made, each with 0.6ml (110mg HPBCD DMT) that they can not only be used under the tongue sublingually, but can just as easily be used in an Ayahuasca tea...

What I have done before is squirt all 110mg HPBCD DMT directly into a 1oz black coffee that already has 140mg of harmine freebase dissolved into it with a bit of crushed vit C, so the harmine freebase dissolves. YES! I have used as little as 140mg harmine freebase to activate the dmt, just as Jonathan Ott found out works (1.5mg/kg threshold activating dose). He found 120mg worked just fine for him, he weighs 175lbs (80kg), I weigh 200lbs (90kg).

I take a capsule of from 150mg to 300mg THH orally around the same time. You can re-dose again later with sublingual HPBCD DMT under the tongue every 1.5 hour, the oral harmine continues to work for 5 hours, to slow down the deamination or oxidation of the DMT in the mitochondria in the brain. I have tripped very hard all evening long (4.5 hours) this way.

There are options is all I'm saying: sublingual or oral.
--------------------------------------------------------
The end summary. Bon Voyage.

pic5: 2.2g fresh new extracted DMT from 170g bark & 20 x 3ml syringes each getting ready to be loaded with 0.6ml = 110mg HPBCD DMT
pic6: 20 syringes each holding 110mg HPBCD DMT for sublingual or oral use, storage in freezer will keep potent indefinitely. I like to use 3 for the evening, 300mg oral THH 45 minutes before, then pull out one syringe holding 110mg HPBCD DMT original dose, squirt under tongue and hold for 15 minutes, and re-dose every 1.5 hour, for 3 total doses = 4.5 hour of very strong effects, identical to 500 to 700mg long lasting mescaline.
pic7: store 20 syringes in freezer in a protein shaker bottle, "syringe tip caps", 1000 for dirt cheap, go on the end to seal syringe, so no leak.

Or can be used by taking from 150mg to 300mg THH in a capsule, then take an Ayahuasca tea made with 1oz hot coffee holding from 140 to 180mg harmine freebase with a bit of vitamin C added to help the harmine absorb should it be in freebase form, then squirt the syringe dosage into the hot 1oz coffee, mix and drink all at the exact same time, just as the Shaman's do. The oral HPBCD DMT is very potent, much stronger than normal DMT freebase or salts used orally, and just as strong as actual 30 to 40g Hawaiian psychotria.
-------------------------------------------------------------------
How to:

110mg fresh just extracted DMT is put onto a spoon, covered with (1:7g ratio to keep at a 1:1 molar ratio) 770mg plain HPBCD, if using instead the 2-HPBCD, then use a 1:8g weight ratio or 880mg 2-HPBCD in order to keep a 1:1 molar ratio.

Then 12 drops of near boiling hot water from a nearby coffee mug is added, mix, mash & scrape it all back and forth on the spoon, using the end of another spoon really hard using your muscles for 2 minutes, then suck up the 0.6ml (12 drop complex) into a 3ml syringe for storage in a freezer, keeps the fresh potency forever, the DMT protected within the HPBCD cavity, and frozen solid, never oxidizes this way, stays as fresh as the day you extract it.

So on the day I extract 2.5g from 170g bark, I go ahead and right after scraping it all up, and allowing it to dry, pre-prepare many individual syringes, and freeze all of them, each with a 0.6ml 110mg HPBCD DMT dose.

If you take a look at the 3ml syringe picture, notice 12 drops fills it up to 6th click mark.

tic mark 1 = 2 drops = 18.3mg HPBCD DMT (0.1ml)
tic mark 2 = 4 drops = 36.3mg HPBCD DMT (0.2ml)
tic mark 3 = 6 drops = 54.9mg HPBCD DMT (0.3ml)
tic mark 4 = 8 drops = 73.2mg HPBCD DMT (0.4ml)
tic mark 5 = 10 drops = 91.5mg HPBCD DMT (0.5ml)
tic mark 6 = 12 drops = 110mg HPBCD DMT (0.6ml)

This is how I measure my dosage out for sublingual or oral Ayahuasca use, once I pull the syringe from the freezer, it will quickly defrost at room temp. You can either shoot the dose directly under your tongue, or measure out the dose onto a spoon, then place the bottom side of your tongue onto the spoon, and it will all adhere. Then simply hold dose under tongue, and press it into the sublingual mucosa, it will all dissolve in 15 minutes or less.

1st paper: https://www.dmt-nexus.me/forum/default.aspx?g=posts&t=96861
2nd paper: https://www.dmt-nexus.me/forum/default.aspx?g=posts&t=97557&p=1

Stay true to yourself. Love, Peace & Music
http://friskyradio.com




Edited by tregar (09/22/21 04:54 PM)

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Re: HPBCD complexed DMT made bioavailable sublingually under tongue, also improves oral bioavailability for pharmahuasca & Ay... [Re: tregar] * 1
    #27472913 -
Log in to view attachment

THH + DMT is divine, the main course.

From much experience, can indeed say that THH is very euphoric and creates open-eyed visual "over the top visual beauty enhancement". Hours of closed eye teaching visions when I reach 300mg of pure THH. Note the 300mg dosage entry for THH or tetrahydroharmine in TIHKAL was not done by Dr. Shulgin but by an inexperienced person who equated it to 100mg harmaline. Tetrahydroharmine is nothing like harmaline, it is not sedating or nauseating or even dizzying, but rather stimulating, euphoric, very mescaline-like with diamondlike open eyed beauty enhancement, music enhancement, closed eye way beyond 4k teaching visions for hours on end, it's in the same beta-carboline family as ibogaine.

THH has 10.5 hour half-life with peak at 5.25 hours. When 150mg to 200mg THH is combined with DMT either sublingually or in an Ayahuasca tea with from 140 to 180mg harmine fb, the effects are absolutely stunning, very much identical to high dose mescaline, mescaline like euphoria for hours on end, deep head space, powerful music enhancement, powerful spiritual insights and visions, etc.

THH is an isomer of a hormonal-like substance found in the brain already, and is responsible for the teaching visions and Ayahuasca's telepathic or telepathine properties. I believe it is the "main course" of the Ayahuasca session, it is also able to bring out the "essence" of other plants, and combines extremely well with all sorts of psychedelics to bring out there "essence".

Historical note: one month ago combined 300mg of THH or tetrahydroharmine with 250mcg of acid paper that had been soaked in 1 shot of cold sherry wine for 3 hours in the fridge with hand stirring once an hour in the fridge, to help theoretically or hypothetically convert the LSD to the more colorful & visual and head-space gentle ALD-52 by adduction of the acetaldehyde from the sherry wine to the NH bottom indole position on the LSD (don't try this at home unless you are really advanced, and sure you have very pure THH) and had closed eye bright colored teaching visions all the way from 8pm till midnight.

Much more powerful than LSD visions alone, these were brightly colored Ayahuasca visions. One of the sequence of visions were of a variety of stone carvings with very elaborate artwork and a beautiful woman who stretched out her hand to me to show me magic.

I would need a tape recorder going as I lie in bed for hours to talk into in order to record the hundreds of non-stop animated and static colored visions.

Then at midnight took another 100mg of THH, it brought the visions all back until 4am in the morning! It was almost too much, non-stop hundreds of Ayahuasca visions for hours and hours, I was completely blown away, reminds me of the time I took 300mg THH combined with 60mg sublingual HPBCD DMT every 1.5 hour and had visions from midnight all the way till 5am in the morning also. I would lie in bed watching the colored visions for hours on end listening to music on my headphones, which sounded as if I had taken a high dose cactus tea, very remarkably enhanced, just Heavenly.

The combo of 300mg THH + LSD also makes the beauty & aesthetic enhancement way stronger than LSD alone, and the music sounds much better than LSD alone, it feels very much like when you combine mescaline with LSD, as THH is like the beta-carboline version of mescaline. Very beautiful combination.

Please note: all beginners only use around 150mg to 200mg THH which is what is found average in 1 cup of Ayahuasca tea, only advanced members of the UDV, Santo Daime, Shuar Indian and people like myself drink 2 cups of Ayahausca tea for the evening, which then contains around 300mg THH average.

P.S. Will be able to determine in future whether coffee filters or a cotton ball stuffed into a funnel will work in place of normally used vacuum pump with #101 filtration disc to filter out the remaining floating zinc dust (only around 10% left floating) after the spun solution sits for 1 hour as 90% of the zinc dust falls to very bottom, so solution above it can be decanted off. This would make it very cost efficient and easy for anyone to convert harmaline to THH without all the fancy equipment (buchner filtration flask and cup/filtration paper, vacuum pump).

Harmaline to THH in 1.5 hour, way a chemist does it, see post #12: https://www.dmt-nexus.me/forum/default.aspx?g=posts&t=96861

2nd paper: Oral Tetrahydroharmine + sublingual HPBCD DMT journeys, very similar to mescaline:
https://www.dmt-nexus.me/forum/default.aspx?g=posts&t=97557&p=1

--------------------------------------------------------

Update: Now we know why polysaccharides like those in aloe vera leaf and gel or the man-made polysaccharides like HPBCD increase the oral and sublingual absorption of DMT freebase by many factors:

Downwardsfromzero said a while back:
Quote:
This combined with the HPBCD complexation results (which we really ought to replicate and confirm) makes me wonder whether there are saccharides in leaf brews which perform a similar effect to HPBCD. There is still so much scope for really interesting research here - thanks for posting.




It just so turns out that you were absolutely right! Cyclodextrins such as HPBCD (hydroxy propyl beta cyclodextrin) are naturally occurring polysaccharides obtained through the enzymatic degradation of starch.

This explains how when HPBCD is complexed to freebase DMT, it is able to not only make it water soluble, but also make it absorb MANY FACTORS BETTER orally than normal DMT freebase or DMT salts.

This is why in my experience, the Ayahuasca tea made with HPBCD DMT is many factors stronger than normal DMT, easy to reach +5 Shulgin strength levels, just like the Hawaiian psychotria made Ayahuasca tea, which in all likely hood may also contain polysaccharides just like aloe vera leaf which explains why the Hawaiian psychotria leaf contained DMT easily reaches +5 Shulgin strength: all encompassing and super-strong. I've taken Hawaiian psychotria over 70 times in Ayahuasca made Caapi tea, and it's always been super potent, much more potent than freebase used DMT or salts in my experience. A world of difference, no comparison. The HPBCD DMT is the same, super potent just like the Hawaiian leaf.

Example from the scientific literature: HPBCD improves oral absorption profile for Ofloxacin, a second generation fluroquinolones by 54 to 89 percent.

Guess what else also contains polysaccharides: Aloe vera gel and leaf. Aloe vera gel caused a 3.7 fold increase in the bioavailability of vitamin C in comparison to control (vitamin C administered in water).

The polysaccharide fraction from dehydrated Aloe vera gel (datonmax 700) material could enhance the transport of many drugs across the intestinal rat tissue many factors over, and was statistically significant compared to control.

Aloe vera leaf and gel, due to the polysaccharides open tight junctions and consequently enhance paracellular transport of hydrophilic molecules.

Polysaccharides are the component of aloe vera gel and leaf that is the biologically active component responsible for the greatly increased modulation of drug pharmacokinetics and absorption -- this is concentrated in the polysaccharide components of the aloe vera gel and material.

The paper also shows that Aloe vera has also been shown to significantly enhance the sublingual and buccal permeability of drugs. HPBCD complexed freebase DMT does the same thing, it not only makes the DMT water soluble until it crosses the sublingual membrane, where it is released into the bloodstream as the potent freebase, where it reaches the brain intact in my experience, very potent indeed...

...but HPBCD, being a polysaccharide just like aloe vera gel or leaf, greatly enhances the penetration of the DMT thru the sublingual mucosa under the tongue due to it's potent disruption capabilities of the epithelium layer (only 100 to 200um thick), also discussed in the attached paper.

All of this is covered in the attached paper "Drug Bioavailability Enhancing Agents of Natural Origin (Bioenhancers) that Modulate Drug Membrane Permeation and Pre-Systemic Metabolism" by Bianca Peterson, Morné Weyers , Jan H. Steenekamp, Johan D. Steyn, Chrisna Gouws and Josias H. Hamman.

Last pic: The absorption of drugs through the sublingual mucosa route is 3 to 10 times greater than oral route according to Dr. Narang.


Edited by tregar (09/18/21 06:39 PM)

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Re: HPBCD complexed DMT made bioavailable sublingually under tongue, also improves oral bioavailability for pharmahuasca & Ay... [Re: tregar]
    #27477807 -

Quick note On safety:

Yes, I have read many studies, Thanks for bringing this to our attention. Cyclodextrin has been linked to some studies in mice at very high doses of 8000 mg/kg s.c. We are not using doses anywhere near that here. I have used HPBCD complexed to pro-hormones for years when pro-hormones were legal and never had any side effects at low level like we are using. Patrick Arnold is the chemist who created hydroxypropyl-beta-cyclodextrin complexed diols such as Cyclo-Diol(TM) and Cyclo-Nordiol(TM) and sold them for nearly 10 years thru his company ERGOPHARM, never any complaints of hearing loss. See part 5 of my paper on his story and bloodwork results. I've used the stuff over 44 times now if you include the number of times I've re-dosed in an evening = 3 total doses for an evening. Had my hearing checked earlier this month as I wanted to see myself if any problems with the low doses I have been using, no different than years ago. If you are concerned, then simply don't use it. Proceed with caution. Use aloe vera gel or leaf instead, or even chitosan, many alternatives, see paper above: File Attachment(s): "Pharmaceutics drug bioavailability enhancing agents", example: Aloe vera gel caused a 3.7 fold increase in the bioavailability of vitamin C in comparison to control (vitamin C administered in water).

2-Hydroxypropyl-β-Cyclodextrin Raises Hearing Threshold in Normal Cats and in Cats With Niemann-Pick Type C Disease

https://www.nature.com/articles/pr2010130

Cats with NPC disease cats showed no increase in hearing threshold after weekly administration of 1000 mg/kg HPβCD (group 7; n = 5) compared with untreated affected cats [group 6; n = 8]. Both cats treated with weekly 4000 mg/kg (group 8; n = 2) showed an increase in hearing threshold and cats treated with weekly 8000 mg/kg (group 9; n = 5) had a statistically significant (p < 0.05) increase in threshold. No waveforms were evoked at the maximum stimulus intensity of 125 dB from two cats treated with every other week intrathecal HPBCD (group 10).

Pic: Cats with NPC disease cats showed no increase in hearing threshold after weekly administration of 1000 mg/kg HPβCD (group 7; n = 5) compared with untreated affected cats [group 6; n = 8].


Edited by tregar (09/22/21 06:03 AM)

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Re: HPBCD complexed DMT made bioavailable sublingually under tongue, also improves oral bioavailability for pharmahuasca & Ay... [Re: tregar]
    #27477963 -

GordoTEK said:
"HPBCD is generally considered safe to eat because it gets destroyed in the gut before it can get into your bloodstream."

This is the same as I have read in the article you linked, which I have read twice now. Based on this orally safe profile, I will only use HPBCD complexed DMT orally from now on mixed into a 1oz hot coffee with from 140 to 180mg harmine fb, a bit of crushed vit C to help the freebase harmine absorb, and a capsule of from 150mg to 300mg THH taken orally at same time. I have done this x 4 times now over a period of 5 months using from 70mg to 110mg HPBCD DMT with impressive results.

As little as 1.5mg/kg harmine fb can be used as a threshold dose to orally activate DMT, just as Jonathan Ott found worked just fine, he weights 175lbs (80kg), he found 120mg harmine fb to work, I weigh 200lbs (90kg), I found 140mg harmine fb to work. Up this amount to 160mg harmine fb for an 80kg individual, or 180mg for a 90kg individual for very strong activation. 

Re-dosing can be even be done 1 hour to 1.5 hour later after feeling effects as half life of harmine is from 1 to 3 hours, using only 1/2 the dose of harmine combined with another dose of HPBCD DMT. I have found this to work very well.

Just as aloe vera gel has been shown to increase the oral bioavailability of vitamin C administered in water x 3.7 fold, HPBCD has been shown to improve oral absorption profile for Ofloxacin, a second generation poorly absored fluroquinolones by 54 to 89 percent. Both aloe vera gel and HPBCD are able to increase the absorption of many poorly absored drugs many factors over.

I have no problem using the HPBCD DMT orally, as I've found it many factors stronger and all-encompassing than normal poorly absorbed DMT freebase or salts used orally (never been able to get over +3 Shulgin level mild effects in over a dozen trials using from 70 to 120mg), in fact, the HPBCD DMT is just as potent and super-strong as using actual 30 to 40g Hawaiian psychotria, easy to achieve +5 Shulgin level strength.

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Re: HPBCD complexed DMT made bioavailable sublingually under tongue, also improves oral bioavailability for pharmahuasca & Ay... [Re: tregar]
    #27481612 -

I prefer using the harmine sublingually myself, I complex 30mg to 180mg HPBCD in 3 drops hot water, (1:6g ratio to keep at 1:1 molar ratio) hold under tongue, there is zero taste thanks to the HPBCD masking the nasty harmine freebase taste. it all dissolves in only 5 minutes or so as it is such a low dose, and the HPBCD helps the fb harmine to absorb way better in my experience. I sometimes take this around 10 minutes before I take my sublingual 110mg HPBCD DMT, I way prefer this to oral harmine.

Oral harmine sketches me out, everytime I take it, I repeat to myself "I just don't like the feeling", and can't wait for it to end. I just don't like it. I won't use it anymore, unless I take a 30mg dose sublingually, this is way more pleasant to me and shorter lasting, it acts more as a facilitator of the dmt this way than a participant.
-----------------------------------------------------------------------
For Reference: How to:

Important Reference notes:

HPBCD = Hydroxypropyl-beta-cyclodextrin
2-HPBCD = 2-hydroxypropyl-beta-cyclodextrin

Note: Molecular weight of harmine = 212g/mol, plain HPBCD molecular weight = 1300g/mol, therefore use a 1:6g weight ratio in order to keep a 1:1 molar ratio. 2-HPBCD = 1500g/mol, therefore use a 1:7g weight ratio in order to keep a 1:1 molar ratio.

Note: Molecular weight of DMT = 188g/mol, plain HPBCD molecular weight = 1300g/mol, therefore, use a 1:7g weight ratio in order to keep a 1:1 molar ratio. 2-HPBCD = 1500g/mol, therefore use a 1:8g weight ratio in order to keep a 1:1 molar ratio.

Dennis Mckenna Ph.D:
Quote:
Thus, tetrahydroharmine may prolong the half-life of DMT by blocking it's intraneuronal uptake, and hence, its inactivation by MAO, localized in mitochondria within the neuron.




Jamie, posted : 11/23/2012 8:29:28 PM:
Quote:
You can't compare sublingual or oral either..20-30mg sublingual harmine is enough to activate sublingual DMT and cause effects on it's own. 20mg sublingual is probably comparable to 200mg oral.




One quick note: I would recommend if you take 25mg sublingual HPBCD harmine, to take it 10 to 15 minutes before beginning the evening of sublingual HPBCD DMT dosing, of course taking from 150mg to 300mg pure thh orally 45 minutes before all this.

I have found the HPBCD DMT absorbs much better on it's own without any sublingual harmine in the mix at the same time, so keep them separate is all I'm saying.

Dr. Narang and Sharma mention in their 2010 sublingual paper (attached on post #1) that under the tongue pharmaceuticals can be 3 to 10 times more bioavailable than oral.

Wikipedia on sublingual administration: https://en.wikipedia.org/wiki/Sublingual_administration
Quote:
"many drugs are much more potent taken sublingually"

"this route translates the chemical directly to the brain, where most psychoactives act."



110mg fresh just extracted DMT is put onto a spoon, covered with (1:7g ratio to keep at a 1:1 molar ratio) 770mg plain HPBCD, if using instead the 2-HPBCD, then use a 1:8g weight ratio or 880mg 2-HPBCD in order to keep a 1:1 molar ratio.

Then 12 drops of near boiling hot water from a nearby coffee mug or pyrex pot on a hotplate is added, mix, mash & scrape it all back and forth on the spoon, using the end of another spoon really hard using your muscles for 2 minutes, then suck up the 0.6ml (12 drop complex) into a 3ml syringe for storage in a freezer, keeps the fresh potency forever, the DMT protected within the HPBCD cavity, and frozen solid, never oxidizes this way, stays as fresh as the day you extract it.

So on the day I extract 2.5g from 170g bark, I go ahead and right after scraping it all up, and allowing it to dry, pre-prepare many individual syringes, and freeze all of them, each with a 0.6ml 110mg HPBCD DMT dose.

If you take a look at the 3ml syringe picture in above post, notice 12 drops fills it up to 6th click mark.

tic mark 1 = 2 drops = 18.3mg HPBCD DMT (0.1ml)
tic mark 2 = 4 drops = 36.3mg HPBCD DMT (0.2ml)
tic mark 3 = 6 drops = 54.9mg HPBCD DMT (0.3ml)
tic mark 4 = 8 drops = 73.2mg HPBCD DMT (0.4ml)
tic mark 5 = 10 drops = 91.5mg HPBCD DMT (0.5ml)
tic mark 6 = 12 drops = 110mg HPBCD DMT (0.6ml)
----------------------------------------------------------------------------
Experience #45: 9.24.2021 Friday night Journey.

300mg oral THH, 30mg sublingual HPBCD harmine, 110mg sublingual HPBCD DMT

Harmine sketches me out, I just don't like it unless say 30mg is used sublingually, but not orally.

6pm: 1st I took 300mg +R-ALA, 1g vit C, and vitamin E, three potent antioxidants I always take anytime I take the sublingual HPBCD DMT. These anti-oxidants prevent any unknown oxidative stress on the body, and drink plenty of lukewarm water.

6pm: took oral 300mg pure THH in a capsule

6:30pm took 30mg harmine fb complexed to 180mg plain HPBCD in 3 drops boiling hot water, mixed and mashed for 2 minutes, placed under tongue, it all dissolved in around 5 minutes, no taste as the HPBCD masked the nasty taste of the fb harmine.

6:40pm So I went back to my preferred method of just taking oral 300mg pure THH in a capsule 45 minutes before I took 110mg HPBCD DMT under tongue (3ml syringe full of 0.6ml 110mg DMT complexed to 770mg plain HPBCD in 12 drops very hot water), and held for 15 minutes, it all dissolved...had an amazing time, this always feels just like high dose mescaline to me, yesterday felt like around 500mg mescaline.

I will take one of my 110mg HPBCD DMT syringes out of protein shaker bottle in freezer, it has a locking syringe tip to prevent leakage, dunk the syringe into a mug of hot water for 1 minute, it all defrosts and becomes flowing homogenous liquid again, and then place warm liquid under tongue.

I made 20 of these syringes each with 110mg HPBCD DMT last time 2.2 grams dmt was extracted from 170g bark.

First I watched a movie that had amazing beach scenery and beautiful actresses, the beauty enhancement was way over the top, deep head space, powerful spiritual insights. Visual acuity very strong, the actresses on screen looked again like glowing, dazzling, super-colorful cartoon versions of themselves, walls filled again with gentle neon colors, high powered open-eyed tracers like lightening flashes when I shifted my gaze quickly or moved my hands in mid-air, CEV's of slow moving geometrics.

In between watching the movie I closed my eyes and watched gentle colored geometrics spin and dance for an hour, beautiful blue and pink colors, the geometrics would constantly morph into other colors, just amazing.

Then 1.5 hour later, I took another dose of 110mg HPBCD DMT under tongue, again the geometrics came back, due to the THH and DMT combo, the geometrics then went away and lead to a different phase: then I saw for a good 2 hours while laying in bed fantastic realistic scenery...static and animated imagery: fantastic grand archaic architecture, Mayan and Aztec pyramids, and the steps leading up to them, landscapes I traveled down leading to a city in the Jungle, hundreds of amazingly beautiful dream-like imagery but way beyond 4k, the detail way beyond anything an artist could draw, had a fantastic time. Love

I wore headphones the whole time and listened to music, which again sounded remarkably enhanced, just like high dose cactus tea, same powerful music enhancement.

Pic: with closed eyes, the step pyramids of Chichen Itza were seen, but seen brand new as if newly created.


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Re: HPBCD complexed DMT made bioavailable sublingually under tongue, also improves oral bioavailability for pharmahuasca & Ay... [Re: tregar]
    #27493235 -

Note on safety: I am not worried about using HPBCD sublingually, as noted earlier we are using doses that are very similar to what chemist Patrick Arnold sold for 10 years as cyclodiol and cyclonordiol by his sports supplement company: Ergopharm. He made millions selling his very effective sublingual HPBCD pro-hormone supplements until they were made illegal 9 years later, never any complaints of hearing loss. I used his sublingual HPBCD pro-hormone supplements for many years.

I had my hearing checked after using this stuff 44 times (1 original dose + 2 re-doses each evening) after 6 months of use and still my hearing was excellent. We are using very, very low doses: 770mg HPBCD compared to 4000 to 8000mg/kg in cats and mice, yes, that is 4000 to 8000 mg per kilogram injections, again we are not using anywhere near the insane mega-doses like they were using to treat Niemann–Pick disease in the studies.

Niemann-Pick disease type C (NPC) is a rare progressive genetic disorder characterized by an inability of the body to transport cholesterol and other fatty substances (lipids) inside of cells. This leads to the abnormal accumulation of these substances within various tissues of the body, including brain tissue. The accumulation of these substances damages the affected areas.

I also had a full complete labwork done, and it was excellent as well, liver and kidney functions completely normal. Doctor was very happy, all in the green, no red.

I also prefer the sublingual route, as I find it many times stronger than oral, it's much more potent than taken orally, and it comes on in only half the time of an oral dose (22 minutes instead of 45 minutes) yet it still lasts as long as an oral dose: 90 minutes. It's easy to achieve +5 Shulgin level strength using the powerful sublingual HPBCD DMT doses.

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