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Mushrooms, Mycology and Psychedelics > The Psychedelic Experience
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Psilocybe dosing from grams to milligrams.
    #19294797 -

According to Dr. Carhart-Harris, they dosed their participants with 2 milligrams intravenously, which, he says, is the equivalent to 50 milligrams orally.

So, if psilocybe cubensis is approx. 1% psilocybin, that would mean that one gram of dried cubes would equal .01 grams psilocybin, which equals 10 milligrams.

So, I'm guessing this means, regarding cubes, that a heroic dose (McKenna's phrase for 5 dried grams), would mean 50 milligrams pure psilocybin.

Does this seem right to everybody else?


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Re: Psilocybe dosing from grams to milligrams. [Re: treid2]
    #19294803 -

50 mg is a ridiculously high dose.  If my memory serves me correctly, 25 mg is a sizable dose.

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Re: Psilocybe dosing from grams to milligrams. [Re: treid2]
    #19294947 -

First, there's no such thing as a "heroic" dose. There is absolutely nothing "heroic" about taking large doses. In fact, lots of stupid teenagers take stupidly large doses all the time.

Physicist is right, 50mg is an outrageously large dose. 25mg is a good sized dose. 30+mg is a large dose.

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Re: Psilocybe dosing from grams to milligrams. [Re: nooneman]
    #19295053 -

Think about it... when you`re taking iv for any other drug you are almost 100% certain there is no bacteria or mold in the syringe. (ex. you put a flame under heroin to make sure it`s not contaminated)

With mushrooms, a flame would kill the psilocybin and mushrooms can easily have bacteria and mold on it. It`s different if you eat mold, in which your stomach can easily recover by eliminating the bacteria by things such as throwing up, but you could get a serious infection on your body if you inject it.


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Re: Psilocybe dosing from grams to milligrams. [Re: SkeletalSpore]
    #19295459 -

I think you've misunderstood the question, Skeletal.  They're comparing IV and oral doses of pure psilocybin / psilocin to oral doses of mushrooms.  I don't think anybody is considering injecting fungal matter or a crude extract thereof.  :pipesmoke:

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Re: Psilocybe dosing from grams to milligrams. [Re: treid2]
    #19295524 -

treid2 said:
According to Dr. Carhart-Harris, they dosed their participants with 2 milligrams intravenously, which, he says, is the equivalent to 50 milligrams orally.

So, if psilocybe cubensis is approx. 1% psilocybin, that would mean that one gram of dried cubes would equal .01 grams psilocybin, which equals 10 milligrams.

So, I'm guessing this means, regarding cubes, that a heroic dose (McKenna's phrase for 5 dried grams), would mean 50 milligrams pure psilocybin.

Does this seem right to everybody else?


if i remember correctly 5 grams of cubes should have about 30mg of psilocybin


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Re: Psilocybe dosing from grams to milligrams. [Re: allseeingike]
    #19296743 -

I think that comparison is off. I cant believe 2mg IV is the same as 50mg orally. I know it'll hit harder and faster but I think it would be more along the lines of smoking DMT compared to drinking aya.


McKennas "heroic" dose is a generalisation and aimed at rec trippers eating a couple grams to giggle and see walls shift in the corner of their eyes. its not some quest to be accepted as a brave psychadelic knight. Its an approximate dose that will separate fun time from balls dipping in  eternity. He recommended high doses but "rarely".


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Re: Psilocybe dosing from grams to milligrams. [Re: hmmn]
    #19298952 -

hmmn said:
I think you've misunderstood the question, Skeletal.  They're comparing IV and oral doses of pure psilocybin / psilocin to oral doses of mushrooms.  I don't think anybody is considering injecting fungal matter or a crude extract thereof.  :pipesmoke:


thanks for the clarification :glittershitz:


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Re: Psilocybe dosing from grams to milligrams. [Re: SkeletalSpore]
    #19329146 -

Interesting.

I wasn't sure if we could figure out some algorithm to figure out the oral dose compared with IV dose, and then give the number of grams one would have to eat in dried material (cubes) to reach a certain approx. mgs.

As I said in the original post, Dr. Carhart-Harris said 2 mgs IV was equal to 50 mgs orally, and as for the term "heroic dose" I was just using it as a point of reference. Arguing the semantics of "Heroic dose" was not what I intended, it's just that everyone knows what I mean when I say "heroic dose."

Nevertheless, thanks for the feedback, but with all due respect, nobody actually offered any proof to debate the claim, which is all I want to find. I'm honestly interested in figuring this out. If it's 30 mgs for each 5 grams dried cubes, show me how to figure this out, or where you found the info.


--------------------

"Now, gods, stand up for bastards!"
— King Lear Act 1, scene 2.

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Mushrooms, Mycology and Psychedelics > The Psychedelic Experience
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