mushman1017 said:

So what do you suggest growing them on? Agar plates and just scrape off the myc that grows on the agar?

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Why choose ORIVeDA 's PSP-50 ?
Oriveda PSP-50 is the most potent Turkey Tail extract commercially available. It is also the only fully certified extract worldwide, with guaranteed levels of the main bioactive and bioavailable compounds.

In Turkey Tail the main bioactive compounds are beta-glucans (2 different types) and polyphenols (anti-oxidants).

We can guarantee the presence of these compounds and their bioavailability. Check the Quality Control page on this website.

Click here to see our authorized 'Supplement Facts' label, which is based on those test reports.

PSP is an abbreviation of 'PolySaccharoPeptide': now in general known as 'proteo-glycan'. ORIVeDA's PSP-50 is identical to the original PSP as it was developed in China, over 25 years ago. In itself PSP is an improved version of the well-known Japanese PSK, which is even older. (See our FAQ for the differences / similarities between these two)

ORIVeDA's PSP-50 has been cultivated and extracted using the original methods. The only difference is a significant higher purity due to the more advanced 21st century pharmaceutical techniques. Only pure COV-1® mycelium (the 'roots' of the mushroom) was used for the extract, having the highest level of the desired bioactives.

According to the original research the most potent source of 'PSP' is that COV-1® mycelium strain (more details here)  which should ideally have been cultivated using so-called 'deep layer cultivation' (growing it in sterile laboratory tanks, in liquid substrate). This technique is standard in China but hardly used anywhere else, due to the high cost.

Cheap cultivation techniques are using rice/grains to grow mushrooms (solid substrate), but since it is impossible to isolate the spiderweb-like mycelium from the substrate in the end the final product is in fact 'biomass', not mushroom. It is contaminated with undigested substrate in the form of starch; levels can be as high as 80% (!).

Such products are not per definition without potential but in general their actual therapeutic effects are low and the value for money is poor. On top of that these products are in general not extracted, rendering them even less useful. They do not specify any bioactive compounds on their labels and a 2016 test report showed several of these product contained no beta-glucan at all, only starch. Research found that the immunological effects of mushroom extracts are up to 10 times higher when compared against non-extracted powders.

An objective and easy-to-follow mushroom supplement shopping-guideline can be found on our articles page. It explains facts like the above and others, good to know when shopping for mushroom supplements.

Recommended maintenance dosage: 3 capsules p/day. A leaflet with detailed instructions and background is included with every order.

Scientific research uses in general specialized, highly concentrated extracts to investigate the effects of medicinal mushrooms. ORIVeDA extracts are comparable in both composition and quality, so the research results you read about you can also expect from our extracts.

Extracted using hot water followed by alcohol precipitation - the main bioactives are water-solubles with a high molecular weight according to research. Alcohol precipitation is a purification process. It removes useless matter and low molecular weight compounds and thus increases the concentration of bioactives in the final product. The final product contains no alcohol.

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Why ORIVeDA 's L+ ?
Lion's Mane contains several unique bioactive compounds not found in other medicinal mushrooms; in particular the NGF- and BDNF-inducing compounds. Those are the main reason most people choose Lion's Mane as a supplement.

Those compounds are hericenones (only found in the fruiting body) and erinacines (only found in the mycelium). Both are part of the class of alcohol-soluble terpenes and meroterpenes (compounds which are part terpene and part polyphenol). Until now, not a single Lion's Mane supplement specifying and guaranteeing those compounds existed.

In Oriveda's L+ the emphasis is on exactly those compounds and their presence, percentage and bioavailability is guaranteed. Unlike other vendors we do not focus on beta-glucan or polysaccharides; for beta-glucan (immune-supporting compound) Oriveda has formulated a dedicated product; CCCE®.

Click here to see our authorized 'Supplement Facts' label with all relevant specifications.

If you buy a Lion's Mane supplement because it lists a high level of beta-glucans (or polysaccharides) you are not spending your money wisely. It makes more sense to choose a Lion's Mane supplement that specifies/guarantees Lion's Mane-specific compounds, right?

As said, in Lion's Mane the quality markers are 2 specific groups of bioactive terpenes; these contain the NGF- / BDNF-inducing compounds in Lion's Mane. Those compounds are known as hericenones (present in the fruiting body only - mero-terpenes) and erinacines (only found in the mycelium - di-terpenes).

Until now over 30 of these compounds have been identified in Lion's Mane. It is impossible to test for all of those individually. With only a few exceptions there's no standardised reference material available.

Quite a few research papers however describe in great detail how these compounds were discovered, isolated and quantified. The independent third party lab we use used this information to come up with a reliable way to measure / quantify these compounds. Check our COA. This level of detail makes L+ unique.

What also sets Oriveda's L+ apart as a unique product is that it is the first and only Lion's Mane alcohol extract. Only an alcohol extract contains a noteworthy amount of these compounds - they are strictly alcohol-soluble. When we were developing L+ we have tested dual extraction as well but this would have meant an unacceptable compromise. Levels of alcohol-soluble bioactives were low. In particular the mycelium had a very low yield of less than 0.1%.

Then there is the fact that Oriveda's L+ contains both fruiting body and pure mycelium. There are no other Lion's Mane products on the market containing pure mycelium, which is a major -and surprising- omission because the mycelium contains the most important NGF-inducers; erinacines (their NGF-promoting effect is up to 4 times stronger when compared against hericenones according to research).

The mycelium used was cultivated in liquid substrate, formulated using the latest research in order to produce a very high level of erinacines. It is the first time this technique was used succesfully outside a research facility. The results were excellent - at least 2 % erinacines are guaranteed.

After repeated alcohol extraction (to squeeze out all active compounds) the final product is 100% uncompromised Lion's Mane extract, free of additives or flow agents.

It should be obvious Oriveda's L+ is a better choice than a liquid alcohol 'tincture' because in such products the main element is alcohol, not Lion's Mane. If you would allow the alcohol to evaporate the remaining deposit equals maybe 1 gram of powdered extract. Such products also do not / cannot guarantee any bioactives. Also see our FAQ for more info about tinctures and such.

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