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Offlineincubaby_421
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Re: *** BLACK CURRANT JUICE is a MAO inhibitor *** + Lemon Juice = 10X Effects?? [Re: HeavyToilet]
    #4958010 - 11/20/05 12:45 AM (15 years, 11 months ago)

no, but what the hell...
worth a shot right?
i can always buy more juice another time,
and i always buy more shrooms


--------------------
"yet the more i dig, the more i consume, the more i unfold... the less protected i feel.
i am the spit on the hair of the son of an electron, swimming around the nucleus of a cell inside the sperm of a killer bee, and my purpose is as nebulous as why weve been bestowed with the capacity to give a shit" Brandon Boyd



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Offlineincubaby_421
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Re: *** BLACK CURRANT JUICE is a MAO inhibitor *** + Lemon Juice = 10X Effects?? [Re: incubaby_421]
    #4958103 - 11/20/05 01:11 AM (15 years, 11 months ago)

ITS BEEN DONE!
IM OFF!
more tomorow


--------------------
"yet the more i dig, the more i consume, the more i unfold... the less protected i feel.
i am the spit on the hair of the son of an electron, swimming around the nucleus of a cell inside the sperm of a killer bee, and my purpose is as nebulous as why weve been bestowed with the capacity to give a shit" Brandon Boyd



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Offlineincubaby_421
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Re: *** BLACK CURRANT JUICE is a MAO inhibitor *** + Lemon Juice = 10X Effects?? [Re: incubaby_421]
    #4958558 - 11/20/05 03:12 AM (15 years, 11 months ago)

wooooooooooooooooooooooooooooow
:freakybirdthing:


--------------------
"yet the more i dig, the more i consume, the more i unfold... the less protected i feel.
i am the spit on the hair of the son of an electron, swimming around the nucleus of a cell inside the sperm of a killer bee, and my purpose is as nebulous as why weve been bestowed with the capacity to give a shit" Brandon Boyd



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Offlineincubaby_421
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Re: *** BLACK CURRANT JUICE is a MAO inhibitor *** + Lemon Juice = 10X Effects?? [Re: incubaby_421]
    #4960140 - 11/20/05 04:09 PM (15 years, 11 months ago)

holy jesus fucking christ
i just want to say
i love you guys
i needed that... and it comes highly recomended...
it works.... it all works


--------------------
"yet the more i dig, the more i consume, the more i unfold... the less protected i feel.
i am the spit on the hair of the son of an electron, swimming around the nucleus of a cell inside the sperm of a killer bee, and my purpose is as nebulous as why weve been bestowed with the capacity to give a shit" Brandon Boyd



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OfflineMxIndustry
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Re: *** BLACK CURRANT JUICE is a MAO inhibitor *** + Lemon Juice = 10X Effects?? [Re: incubaby_421]
    #4960318 - 11/20/05 04:49 PM (15 years, 11 months ago)

i know this may sound stupid but what are MAOI's?


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Invisibleinfinitedot
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Re: *** BLACK CURRANT JUICE is a MAO inhibitor *** + Lemon Juice = 10X Effects?? [Re: incubaby_421]
    #4960357 - 11/20/05 05:01 PM (15 years, 11 months ago)

Quote:

incubaby_421 said:
holy jesus fucking christ
i just want to say
i love you guys
i needed that... and it comes highly recomended...
it works.... it all works




Incubaby, DID IT WORK that amazingly GOOD!??

You seem like an experienced tripper then, GOOD.

Can you please write a report for us like this?

Thanks mate!  :thumbup:

Black Currant Juice brand: Really Light Blackcurrant Squash
Juice Quantity: 750 gr. = 24 oz.(cc. if we assume 1 gr roughly = 1 cc.)
Mushrooms species: Psylocybe Cubensis
Mushrooms Quantity: 3 gr. dry
Did you know the potency of the mushrooms beforehand? (Y/N): Yes, ate from the same crop twice before.
Hours since last meal: 12 h.
Description of effects compared vs. no juice:
Description of effects compared vs. Lemon/Lime juice:
Are you positively sure that there IS definitely an improvement in potency? (Y/N):
Estimated potency compared vs. no juice: 4X-5X
Estimated potency compared vs. Lemon/Lime juice: 1.5X-2X
Time to "first alert" (aka, "whoa, something's definitely going to happen"): 20 mins.
Time to onset of visual disturbance: 45 mins.
Time to peak (rough estimate): 2 hours
Time to first sign of diminishing effects: 5 hours
Time to baseline (indiscernable effects): 7 hours



Edited by infinitedot (11/20/05 07:45 PM)


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Invisibleinfinitedot
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Re: *** BLACK CURRANT JUICE is a MAO inhibitor *** + Lemon Juice = 10X Effects?? [Re: MxIndustry]
    #4960386 - 11/20/05 05:11 PM (15 years, 11 months ago)

Quote:

MxIndustry said:
i know this may sound stupid but what are MAOI's?




Don't worry MxIndustry. It's a good question.

I'm going to update the first post with further links. Check these:

http://en.wikipedia.org/wiki/Monoamine_oxidase_inhibitor - Wikipedia
http://www.erowid.org/chemicals/maois/maois.shtml - MAOIs, Erowid
http://www.maps.org/news-letters/v06n1/06158mao.html - MAOI Contraindications
http://peyote.com/jonstef/maois.htm - Harmala in Syrian Rue as MAOI
http://www.acacialand.com/syrian.html - "Leonardo da Vinci and Michelangelo both claimed that, owing to rue's metaphysical powers, their eyesight and creative inner vision had been improved."


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Invisibleinfinitedot
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Re: *** BLACK CURRANT JUICE is a MAO inhibitor *** + Lemon Juice = 10X Effects?? [Re: HeavyToilet]
    #4960629 - 11/20/05 06:20 PM (15 years, 11 months ago)

Quote:

HeavyToilet said:
I guess you probably wont be able to accurately judge if it is an MAOI or not, huh?




Just a minor clarification. There are no brands that are or are not MAOI. ALL Black Currant juices brand are MAOIs, it's the concentration of the juice that determines the potency of it.

Just thought I'd clarify that. Be safe guys.


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InvisibleHeavyToilet
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Re: *** BLACK CURRANT JUICE is a MAO inhibitor *** + Lemon Juice = 10X Effects?? [Re: infinitedot]
    #4960691 - 11/20/05 06:51 PM (15 years, 11 months ago)

I'd like to see more experiences with it. Seems too good to be true.


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OfflinePsiloman
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Re: *** BLACK CURRANT JUICE is a MAO inhibitor *** + Lemon Juice = 10X Effects?? [Re: infinitedot]
    #4960976 - 11/20/05 08:04 PM (15 years, 11 months ago)

To tell you the truth first time i hear about Black currant's MAOI properties if indeed they exist...

Some question that either noone thought to ask or noone bothered so far to do so....

IF blackcurrant juice has MAOI properties then :

a) What type of MAOI does it contain? Irreversible? Reversible? Selective? Non-Selective? And which form of MAO enzyme does it inhibit

b) Has the specific compound reputed to exert such an action in this juice been indentified? IF so what is its name?


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OfflinePsiloman
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Re: *** BLACK CURRANT JUICE is a MAO inhibitor *** + Lemon Juice = 10X Effects?? [Re: Psiloman]
    #4961023 - 11/20/05 08:15 PM (15 years, 11 months ago)

By the way here is a chemical analysis of the plant : http://sun.ars-grin.gov:8080/npgspub/xsql/duke/plantdisp.xsql?taxon=858

Looking up the activities of the plant two compounds show up that Dr Duke assigns them MAO-A inhibitor properties : Quercetin and Quercitrin.Also an extra one is listed as "MAO Inhibitor" (without further specification) : Kaempferol

So... i will run some searches on them to see what they are exactly.Feel free to do the same


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Invisibleinfinitedot
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Re: *** BLACK CURRANT JUICE is a MAO inhibitor *** + Lemon Juice = 10X Effects?? [Re: Psiloman]
    #4961044 - 11/20/05 08:21 PM (15 years, 11 months ago)

Quote:

Psiloman said:
By the way here is a chemical analysis of the plant : http://sun.ars-grin.gov:8080/npgspub/xsql/duke/plantdisp.xsql?taxon=858

Looking up the activities of the plant two compounds show up that Dr Duke assigns them MAO-A inhibitor properties : Quercetin and Quercitrin.Also an extra one is listed as "MAO Inhibitor" (without further specification) : Kaempferol

So... i will run some searches on them to see what they are exactly.Feel free to do the same




Everything is in the patent.
http://tinyurl.com/aun6x

Test 1--Demonstration of MAO-Inhibiting Action In Vitro

The test was carried out using a concentrate of black currant juice in 5.5-fold concentration. After adjustment of the pH to 7.2, one aliquot (40 .mu.l) was pre-incubated with the enzyme (1 mg mitochondrial protein, rat liver) for 20 minutes at room temperature. For determination of monoamine oxidase (MAO) type A and B activity, the reaction was started by adding 50 nmol @14 C benzylamine or @14 C serotonin. After one minute of incubation in a shaking water bath (37 DEG C.), the reaction was stopped (1 ml perchloric acid, 0.5M), the acidic and neutral deaminated products being determined after separation by ion-exchange chromatography.

The effect of the juice concentrate is described in percent of inhibition, related to a similarly-incubated buffer control.

Result

The black currant concentrate effects a 61% inhibition of MAO type B, and an 37% inhibition of MAO type A.


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Invisibleinfinitedot
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Re: *** BLACK CURRANT JUICE is a MAO inhibitor *** + Lemon Juice = 10X Effects?? [Re: Psiloman]
    #4961054 - 11/20/05 08:23 PM (15 years, 11 months ago)

Quote:

Psiloman said:
By the way here is a chemical analysis of the plant : http://sun.ars-grin.gov:8080/npgspub/xsql/duke/plantdisp.xsql?taxon=858




Interesting info indeed. I'll see what do I come up with too. Thanks psiloman.


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Invisibleinfinitedot
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Re: *** BLACK CURRANT JUICE is a MAO inhibitor *** + Lemon Juice = 10X Effects?? [Re: infinitedot]
    #4961125 - 11/20/05 08:37 PM (15 years, 11 months ago)

I found something interesting.

"the glycoside quercetin in GB has been shown to increase cerebral blood flow and augment cerebral function"

http://www.iamse.org/jiamse/volume12/12_19-27.pdf

And even more, this seems to be present on GINKGO BILOBA too (Maidenhair tree, Kew tree).

Ginkgo biloba + mushrooms =  :mushroom2:

Never heard of anybody trying that before.

Also present on ST. JOHN?S WORT, the popular Hypericum.

"SJW components appear to be free of the side effects associated with TCA or MAOI (MAO inhibitor)classes of drugs."

We might be onto a new way of tripping on mushrooms.


Edited by infinitedot (11/20/05 08:53 PM)


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OfflinePsiloman
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Re: *** BLACK CURRANT JUICE is a MAO inhibitor *** + Lemon Juice = 10X Effects?? [Re: infinitedot]
    #4961150 - 11/20/05 08:41 PM (15 years, 11 months ago)

Back with some more info

On Qercetin :Apparently its a bioflavonoid ,which amongst others exhibits free radical scavenging activities (antioxidant).It exists even in apples (dont know what quantities) and in Ginko biloba. Its MAO activities have been documented also it was found to cause COMT inhibition.

Some refferences on it :

http://www.ncbi.nlm.nih.gov/entrez/query...1835&query_hl=4

http://www.ncbi.nlm.nih.gov/entrez/query...358&query_hl=13

A less informative but more "pop" source on it : http://www.wholehealthmd.com/refshelf/substances_view/1,1525,10053,00.html

And some more : http://www.umm.edu/altmed/ConsSupplements/Quercetincs.html

And lets not forget Kaempferol...Antioxidant with neuroprotective action (at least in the way used in the refference i provide) plus some MAO inhibition properties : http://www.ncbi.nlm.nih.gov/entrez/query...3558&query_hl=4

EDIT:

Also what the "layman" should keep in mind: Its not only the presence of a substance that guarantees or denies a resutl.Its also the concentration that it is present. For example DMT could be found in lets say...tomatoes.But it could be found in lets say a microgram per kilo of tomatoes,so its not of use.So in the case talked here one should see what is the active dose for the compounds discussed here and the concentrations in the plants in question.


Edited by Psiloman (11/20/05 08:45 PM)


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Re: *** BLACK CURRANT JUICE is a MAO inhibitor *** + Lemon Juice = 10X Effects?? [Re: Psiloman]
    #4961182 - 11/20/05 08:45 PM (15 years, 11 months ago)

Nice research psiloman! Apples. Now apple juice might come next if this is confirmed to be active there in enough quantities too.

I'll keep on researching. Nice job.  :thumbup:


Edited by infinitedot (11/20/05 08:47 PM)


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Re: *** BLACK CURRANT JUICE is a MAO inhibitor *** + Lemon Juice = 10X Effects?? [Re: infinitedot]
    #4961221 - 11/20/05 08:52 PM (15 years, 11 months ago)

Another study on Hypericum as MAOI.

Hypericum perforatum extracts as potential antidepressants.
http://www.ncbi.nlm.nih.gov/entrez/query...9&dopt=Abstract


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Re: *** BLACK CURRANT JUICE is a MAO inhibitor *** + Lemon Juice = 10X Effects?? [Re: infinitedot]
    #4961258 - 11/20/05 08:58 PM (15 years, 11 months ago)

"Experts Reconfirm Safety and Benefits of St. John's Wort for
Combating Mild to Moderate Symptoms of Depression"
http://www.crnusa.org/pdfs/crnsjwtranscripts062501.pdf


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Re: *** BLACK CURRANT JUICE is a MAO inhibitor *** + Lemon Juice = 10X Effects?? [Re: infinitedot]
    #4961282 - 11/20/05 09:03 PM (15 years, 11 months ago)

Siberian Ginseng, Ginkgo Biloba, 5HTP, SAMe and St. John's Wort as natural MAOIs.
http://www.depressionremedy.com/herbal_and_natural_remedies.php


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Re: *** BLACK CURRANT JUICE is a MAO inhibitor *** + Lemon Juice = 10X Effects?? [Re: infinitedot]
    #4961301 - 11/20/05 09:07 PM (15 years, 11 months ago)

"In November of 1997, the Minneapolis Star-Tribune published
an editorial from physician Mary Arneson reporting a stroke
in an elderly woman who was using St. John's wort."
http://www.adbiotk.com/wort.html

I'd be willing to bet that mushrooms + St. John's wort tea would improve its potency too.


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