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280-400 nm blue light to induce production of psilocin, psilocybin and other tryptamines in myc
    #26189029 -

This is kind of crazy.

Inventor: Paul Edward Stamets US20180021326A1

Using blue light stimulation in the 280-400 nm wavelength range, precursor molecules to psilocybin and psilocin production can be elicited from the mycelium, primordia or fruitbodies of psilocybian or their close non-psilocybian relatives, to induce the formation of neurogenic compounds, including those that are not illegal, and therefore would not violate statutes in the United States or other countries. The goal here is to employ legal neurogenic precursor, congener or analog compounds related to psilocybin and psilocin.


Induction of bioactive compounds from mycelium through light stimulation is a method that can be used for discovering synergistic neurogenic compounds. Blue light activates shikimic acid production in mycelium, and antioxidant polyphenols, while also stimulating tyrosinase leading to melanization while inhibiting laccase and other enzymatic pathways, simultaneously inducing the production of psilocin, psilocybin and other tryptamines from mycelium in psilocybin active mushrooms and their relatives. Modifying the wavelength (i.e. blue light for 12 hours, red light for 12 hours, per day) and frequency of light exposure, including “pulsing” of the light, can help articulate the expression of active neurogenic ingredients. The shikimic acid pathway gives rise to aromatic amino acids (phenylalanine, tyrosine and tryptophan), which are precursors for the formation of ergot alkaloids, lysergic acid, psilocybin and psilocin (Isaac, Fungal-Plant Interactions, Springer Netherlands, 1992). The inventor postulates that light stimulation evoking the transformation of ergosterol to vitamin D will also influence the pathways where light induces neurogenic compounds from mycelium. These pathways are interrelated and can be used for creating medically significant novel compositions whose synergy is useful for repairing the neuropathic damage by promoting neurogenesis and synaptic integrations. Exposure of mycelium to select wavelengths of light, especially blue and red spectra, may induce indole alkaloids related to psilocin analogues that have distinct antiviral and neuroprotective properties.

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Re: 280-400 nm blue light to induce production of psilocin, psilocybin and other tryptamines in myc [Re: murderlabz] * 1
    #26189439 -

Look who the author is :shrug:

Then do some research


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Welcome to the Advanced Mycology Forum

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Re: 280-400 nm blue light to induce production of psilocin, psilocybin and other tryptamines in myc [Re: bodhisatta]
    #26189463 -

bodhisatta said:
Look who the author is :shrug:

Then do some research


Haha, not a fan Bod?

I remember back in the day zapping subs with UV blubs for the hell of it.
I don't recall the outcome if any. Did you ever play around with UV-a/b/c?

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Re: 280-400 nm blue light to induce production of psilocin, psilocybin and other tryptamines in myc [Re: murderlabz] * 2
    #26189473 -

No, hundreds of people already have. They are plenty strong as normally grown when grown in the dark aside from shit yields. Show me something he's researched or done with efficacy. Host defense is made from mycelium extract and propped up by his own "research" that mycelium is full of the goods. Despite all the research saying fruits are far more medicinally useful and that also most mushroom medicinals are pretty overblown anyway. I personally think it's distasteful to say mushrooms cure cancer and give people false hope. His mother's doctors said she was cured from her treatment and had no idea Paul fed her mushroom extracts. Maybe it's because he's a tinfoil hat man and there's a cancer conspiracy... it's intellectually shameful to go about doing things that way then reporting on them as miracles. Laypeople eat it up.


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Edited by bodhisatta (09/15/19 10:30 AM)

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Re: 280-400 nm blue light to induce production of psilocin, psilocybin and other tryptamines in myc [Re: bodhisatta]
    #26189526 -

Bod, I'm with ya on the Cancer stuff It's fucked up. Help me with this, he has stated a few times that UV is needed to trigger biosynthesis but I can't find anything to back that up. The closet I can find is in the use of HPLC-UV for detection.

https://pdfs.semanticscholar.org/97a6/5b43b6ada96a38671aa33e9b5e07ee89bb12.pdf

Edited by murderlabz (09/15/19 10:49 AM)

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Re: 280-400 nm blue light to induce production of psilocin, psilocybin and other tryptamines in myc [Re: murderlabz] * 1
    #26189609 -

Every pathway ive seen doesn't show light at all as a step or even a catalyst for any of the steps in biosynthesis


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Welcome to the Advanced Mycology Forum

Bod's Library    Article behind a paywall? I can try to get it for you

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Re: 280-400 nm blue light to induce production of psilocin, psilocybin and other tryptamines in myc [Re: bodhisatta]
    #26190782 -

From personal experience having a family member (my dad) that started using Pauls products (not sure which one) after being on radiation for a few weeks and was told about it from a fellow patient (not as a cure) it doesnt seem to be snake oil really imho. His antibodies and other immunity factors had improved dramatically along with his symptom tolerance just a couple dr visits after starting it for its natural anti biotic properties. Even his dr said that polysaccharides in mushrooms can help white blood cells and overall immunity And i don't think Paul ever said it cured her cancer but that it saved her life by boosting her immune system that greatly needed improving as she was undergoing conventional cancer that people very rarely recover from such a chronic stage. Plus the research hes doing with the bees is super solid and beneficial and from what i here is promising and going to be released to the public to help apieries for free.... I love Paul lol sorry


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Re: 280-400 nm blue light to induce production of psilocin, psilocybin and other tryptamines in myc [Re: Psonic]
    #26190792 -

I also don't understand what hes getting at with the vitamin d-psilocin analogues but i think he means that the phototropism reactions mushrooms use blue light 320-400nm to induce vitD and fruiting are tied to psilocybin production. I remember him referring to an old experiment showed that p cubensis mycelium doesnt produce psilocin unless exposed to far blue/uv light. But idk what that is clipped from.

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Re: 280-400 nm blue light to induce production of psilocin, psilocybin and other tryptamines in myc [Re: Psonic]
    #26192754 -

Psonic said:
From personal experience having a family member (my dad) that started using Pauls products (not sure which one) after being on radiation for a few weeks and was told about it from a fellow patient


I'm not a Paul hater, I have learned so much from his early work. But Bod might be like me and lost some one close to Cancer. It's a touchy subject. I'm interested in what you dad was taking and how much. Can you please find out and let me know?

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Re: 280-400 nm blue light to induce production of psilocin, psilocybin and other tryptamines in myc [Re: murderlabz] * 1
    #26193462 -

I see a lot of big flowery words, many claims and presumptions but very little evidence or research.

For as long as the whole “blue light increases potency” thing has been around you would think someone would come up with a solid study to show it.  I believe in recent years there has been one study that showed many mushrooms enjoy blue light, but nothing to suggest it has anything to do with psilocybin production.

On the other hand we do know it has little to do with psilocin production and if it did that would be bad, as the pathways discovered show phosphorylation first and if we were going in steps, it would be best to call Baeocystin methylated norbaeocystin and psilocybin methylated baeocystin. So if blue light is causing psilocin production, it’s causing the dephosophorylation of psilocybin, which is bad and if the phosphorylating enzymes find it, they will spend energy to turn it back.  Increasing psilocin production seems like a potential stress to the mushroom and not a benefit.

Additional that if it’s being produced in a manner similar to vitamin D or melanin we should find a higher concentration at the surface, just like we do melanin, and a more average concentration in the core, as not being exposed to light the core doesn’t need to tan.

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Re: 280-400 nm blue light to induce production of psilocin, psilocybin and other tryptamines in myc [Re: StygianKnight]
    #26194597 -

The carrot dangles! Reminds me back when everyone was trying to find and stuff brassinosteroid in their subs to recreate the Jochen Gartz research.

Growth-Promoting Effect of a Brassinosteroid in Mycelial Cultures of the Fungus Psilocybe cubensis

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Re: 280-400 nm blue light to induce production of psilocin, psilocybin and other tryptamines in myc [Re: murderlabz] * 1
    #26197668 -

I know lions mane was one, particularly whole powder in smoothies. And i believe one of the earlier blends paul had. I will ask he has started growing his own reishi, lions mane, oysters and is having me help setup a wood pile with portabella mushrooms. He also stopped eating meat or preservatives. I still do all that horrible shit hes like the world's strongest man compared to me lol and hes 72! Im not contributing it all to the products Paul has but they do help and i think its significance is great enough to cause a lot of people to look into what other ways they can clean up their intake and start seeking better living habbits as they realize the benefit in them. It was like the first good news he heard and i feel it helped him just in that regard alone to keep pushing. But i do understand there is nothing worse than hearing someone promote any product as a cure in any way even if it does dramatically help a subset group of people. Because the expectations of most will be crushed. Similar to how they promote CBD as a cure all yet even for what it's best at seizures it only decreases epileptic attack frequency and or intensity in less than 40% of epilepsy patients... But i also see how its hard to market it without giving false hopes yet still having enough incentive to buy it or grow it eventually so it gets in as many peoples hands as possible..


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Re: 280-400 nm blue light to induce production of psilocin, psilocybin and other tryptamines in myc [Re: murderlabz]
    #26197698 -

murderlabz said:
The carrot dangles! Reminds me back when everyone was trying to find and stuff brassinosteroid in their subs to recreate the Jochen Gartz research.

Growth-Promoting Effect of a Brassinosteroid in Mycelial Cultures of the Fungus Psilocybe cubensis


Originally i was like "no way" then i read it now i got 50$ of B-Roids in the mail thank you ebay. Unfortunately they call for an insane amount of 5g per liter of substrate so that is expensive but not too expensive to test it!


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Re: 280-400 nm blue light to induce production of psilocin, psilocybin and other tryptamines in myc [Re: Psonic]
    #26198170 -

Psonic said:
Originally i was like "no way" then i read it now i got 50$ of B-Roids in the mail thank you ebay. Unfortunately they call for an insane amount of 5g per liter of substrate so that is expensive but not too expensive to test it!


On no what I have done! Well, please post a side by side with a good isolate to compare. Thanks for the details on Paul's stuff. I'll read up on it.

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Re: 280-400 nm blue light to induce production of psilocin, psilocybin and other tryptamines in myc [Re: murderlabz] * 1
    #26198565 -

I’ve met Paul. He’s a down to earth guy that is literally obsessed to the teeth with all things remotely mycology related up to and past his ears, radiating into fucking space...and he’s not stopping. He’s got a lot of science to back up what’s in his books and that’s going back to the 70’s. He emerged out of the company of people like Weil, McKenna, Pollock, & a bunch more of the classic early psilo-folk type people like that. His latest “Fantastic Fungi”, is just beautiful, and apparently has a film complement that has been in the works for over a decade. The trailer looks great anyway. I also know he’s been contracted for work by the US government for something called the Bioshield program (some anti-terrorism related endeavor) specifically for his knowledge on fungi as pertains to warfare/defense.

I’ve never bought anything from him except books indirectly over the years, so I cannot speak personally regarding his products, nor would I if I had, since I do not posses any remote way to even begin assess it, whether it be people/peers, technology, or what have you.

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Re: 280-400 nm blue light to induce production of psilocin, psilocybin and other tryptamines in myc [Re: Psilotyl] * 1
    #26198570 -



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‎שלום וְאור | PEACE & LIGHT

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Re: 280-400 nm blue light to induce production of psilocin, psilocybin and other tryptamines in myc [Re: Psilotyl] * 1
    #26198993 -

Yea started over after years of just doing a cased grain jar in my dresser once or twice a year for headaches. Recently i decided they need to be my new old hobby and i plan on getting a new flow hood soon but going to start working agar in a SAB once i get my first flushes of PE, PEU, APE, AA+,Huautla, and p. tropicalis. Also plan on starting subaeruginosa to have chips in time for next spring.


But yea I'm interested in seeing small amounts of the brassinosteroid are effective enough to warrant use it is possible the amount they use is unnecessarily excessive since they only tested one concentration of it.


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Re: 280-400 nm blue light to induce production of psilocin, psilocybin and other tryptamines in myc [Re: Psonic]
    #26199013 -

Hey you guys only need to add gas that costs $20 a gallon to get to 37 mpg. Hey well i get 32 mpg on $4 a gallon gas. That's like this additive. If it doesn't even pay for itself in returns its pretty dumb imo


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Welcome to the Advanced Mycology Forum

Bod's Library    Article behind a paywall? I can try to get it for you

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Re: 280-400 nm blue light to induce production of psilocin, psilocybin and other tryptamines in myc [Re: bodhisatta]
    #26199726 -

bodhisatta said:
Hey you guys only need to add gas that costs $20 a gallon to get to 37 mpg. Hey well i get 32 mpg on $4 a gallon gas. That's like this additive. If it doesn't even pay for itself in returns its pretty dumb imo


My bad I shouldn't of posted that. I was trying to make a joke about everyone running out trying the latest thing to super charge their grows. But the nerd in me whats to see the side by side now haha. I don't recall anyone pulling off a good compare.

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Re: 280-400 nm blue light to induce production of psilocin, psilocybin and other tryptamines in myc [Re: murderlabz] * 1
    #26202872 -

murderlabz said:
bodhisatta said:
Hey you guys only need to add gas that costs $20 a gallon to get to 37 mpg. Hey well i get 32 mpg on $4 a gallon gas. That's like this additive. If it doesn't even pay for itself in returns its pretty dumb imo


My bad I shouldn't of posted that. I was trying to make a joke about everyone running out trying the latest thing to super charge their grows. But the nerd in me whats to see the side by side now haha. I don't recall anyone pulling off a good compare.



I totally agree looking at the prices available with a quick google search its insane but i think the lower amounts of it will probably produce statistically significant difference in speed and pin set. It would have been nice if they didn't do invitro fruiting or if the did something like a grow bag etc that way we could have seen the fruits unsquished. Also curious if would help slow Panaelolus species fruit within a month from spore! Then it may be worth the cheddar lol when i get it i will start a new thread and post the link here. Tho im at least 6 weeks from having an isolate that would be suited for side by side. Started fresh just 3 weeks ago.


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