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Re: Gabapentin and Pregabalin may cause serious brain deterioration, also possibly birth defects [Re: eeso]
    #24028413 -

eeso said:
There's still no link to the *actual journal article* in this thread.. Even the Stanford 'news' link Asante posted lacks one.

But I used to be prescribed 1.2g of gabapentin per day. So it's concerning to me.


1.2g a day? shit. I can't imagine. The most I took was 300mg a day of gabapentin, for about three months, and then 75 mg of pregabalin for three weeks.

Did you get the dry mouth and mood swings? My "swings" went from giggling like a schoolgirl at nothing, to a spitting rage. Yet some people want to abuse these drugs, in prison!

OK, I can understand the giggling being a bit of light relief when your in prison, but if it's followed by the spitting rage... :nonono:


--------------------
whether low pressure sucks or high pressure blows...
it's a bugger to cycle in.

even though I'm feeling good
Something tells me I'd better activate my prayer capsule

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Re: Gabapentin and Pregabalin may cause serious brain deterioration, also possibly birth defects [Re: musiclover420]
    #24028430 -

musiclover420 said:
...if a pregnant woman had been taking antibiotics and not balancing it with pro biotic supplements she could give birth to a baby lacking many beneficial organisms that could lead to various complications.


Or...Better yet, she could get into some 'scissor sister' action with a friend. :naughty:

Oops,double post. I thought there would be a dozen posts by the time I replied.


--------------------
whether low pressure sucks or high pressure blows...
it's a bugger to cycle in.

even though I'm feeling good
Something tells me I'd better activate my prayer capsule

Extras: Filter Print Post Top
Re: Gabapentin and Pregabalin may cause serious brain deterioration, also possibly birth defects [Re: deucedbi9]
    #24028439 -

deucedbi9 said:
musiclover420 said:
...if a pregnant woman had been taking antibiotics and not balancing it with pro biotic supplements she could give birth to a baby lacking many beneficial organisms that could lead to various complications.


Or...Better yet, she could get into some 'scissor sister' action with a friend. :naughty:

Oops,double post. I thought there would be a dozen posts by the time I replied.


Where did that come from? :lol:


--------------------
Don't worry about me, I've got all that I need. And I'm singing my song to the sky

You know how it feels, With the breeze of the sun in your eyes. Not minding that time's passing by

I've got all and more, My smile, just as before. Is all that I carry with me

I talk to myself, I need nobody else. I'm lost and I'm mine, yes I'm free


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Re: Gabapentin and Pregabalin may cause serious brain deterioration, also possibly birth defects [Re: musiclover420]
    #24028486 -

musiclover420 said:
deucedbi9 said:
musiclover420 said:
...if a pregnant woman had been taking antibiotics and not balancing it with pro biotic supplements she could give birth to a baby lacking many beneficial organisms that could lead to various complications.


Or...Better yet, she could get into some 'scissor sister' action with a friend. :naughty:

Oops,double post. I thought there would be a dozen posts by the time I replied.


Where did that come from? :lol:


You know how women are. They'll have babies for each othe if need-be what's a little scissoring compared to that.

Or...They could make their own pro biotic:
The friend gets a pot of natural yoghurt stirs it with a nice wet 'sticky finger' leave it in a warm place for a day and gives it to her pregnant friend as a present with instructions to "dip your finger in the yoghurt pot and slide it up ya honey pot." Simples.


--------------------
whether low pressure sucks or high pressure blows...
it's a bugger to cycle in.

even though I'm feeling good
Something tells me I'd better activate my prayer capsule

Extras: Filter Print Post Top
Re: Gabapentin and Pregabalin may cause serious brain deterioration, also possibly birth defects [Re: deucedbi9]
    #24028785 -

The fuck is this!:puke:

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Re: Gabapentin and Pregabalin may cause serious brain deterioration, also possibly birth defects [Re: deucedbi9]
    #24029966 -

deucedbi9 said:
eeso said:
There's still no link to the *actual journal article* in this thread.. Even the Stanford 'news' link Asante posted lacks one.

But I used to be prescribed 1.2g of gabapentin per day. So it's concerning to me.


1.2g a day? shit. I can't imagine. The most I took was 300mg a day of gabapentin, for about three months, and then 75 mg of pregabalin for three weeks.

Did you get the dry mouth and mood swings? My "swings" went from giggling like a schoolgirl at nothing, to a spitting rage. Yet some people want to abuse these drugs, in prison!

OK, I can understand the giggling being a bit of light relief when your in prison, but if it's followed by the spitting rage... :nonono:


Yep, Gabapentin (300mg capsules) 300mg at wake up, 300mg at lunch, 600mg at bedtime. I can't remember any unwanted effects now, nothing stands out to me, this was more than a few years ago now. I've never used it recreationaly so I don't know how that is, though I knew it was used that way when I was prescribed it.

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Re: Gabapentin and Pregabalin may cause serious brain deterioration, also possibly birth defects [Re: eeso]
    #24030044 -

I've been taking a high dose of gabapentin for four years and my cognition and memory seem to be extremely good. I mean, who knows if they would have been even better had I never taken it. I certainly wish I'd never started taking it.

I take 2400mg a day of gabapentin. I can def see how taking a Gaba-ergic substance could block synaptic growth. I think in my own case that might have been blocked by the fact that I also take an SNRI :sad:

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Re: Gabapentin and Pregabalin may cause serious brain deterioration, also possibly birth defects [Re: morrowasted]
    #24030419 -

Me too, Effexor and Lyrica.  Wish I never started, the SNRI causes violent withdrawal (brain zaps aka sensation of electric currents surging through crainium).  Easily the most addictive substances I've encountered.

I've been shunned for stating that Lyrica rots the brain.. sure feels like it sometimes.


--------------------

From all I may be, or have been before,
To mingle with the Universe, and feel
What I can ne’er express, yet cannot all conceal.

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Re: Gabapentin and Pregabalin may cause serious brain deterioration, also possibly birth defects [Re: birdeatingspider]
    #24030464 -

The severe cognitive impact of depression is well documented. If left untreated I would guess that the ensuing mental fog (and urge to kill oneself) would be worse than any side effect associated with Lyrica...


--------------------
"What appears impenetrable to us does exist, manifesting itself in the deepest wisdom and the most radiant beauty" Einstein

"The conservatives of 70 years ago would be outraged at what has come to pass. It embodies everything they took up arms for to defeat"Asante


:kratom:

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Re: Gabapentin and Pregabalin may cause serious brain deterioration, also possibly birth defects [Re: pslyke]
    #24030713 -

Very true story, speak for Effexor, as well.  My true story, why I've stayed on.


--------------------

From all I may be, or have been before,
To mingle with the Universe, and feel
What I can ne’er express, yet cannot all conceal.

Extras: Filter Print Post Top
Re: Gabapentin and Pregabalin may cause serious brain deterioration, also possibly birth defects [Re: birdeatingspider]
    #24032719 -

I've been on Effexor before. And even having experienced the horrible withdrawal from it I want to be back on it. It's the only anti-depressant that has ever "worked" on me, and I've been on too-many to remember.

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Re: Gabapentin and Pregabalin may cause serious brain deterioration, also possibly birth defects [Re: PatrickKn] * 1
    #24032964 -

PatrickKn said:
musiclover420 said:
Not to mention modern antibiotics have their downsides too such as being indiscriminate and killing many beneficial organisms in the body that can take a while to replenish.


Good points. I hadn't considered the idea that enough decades haven't passed to see the real downsides of antibiotics in the long term when I made the post either. Downsides aside, they have increased mortality quite a bit and it would be needless to not trust them if you have a bad infection.


Antibiotics is a very good example as to why one should use caution with medicine. Yes they are miracle drugs. But using them when they're not needed is a huge problem. Using them long term is a massive problem for both an individual and a society.


And for decades it was hailed as miracle drugs, as near cure alls, without regard to the potential long term consequences.


Which is also why I personally don't trust new drugs and I'd put my "safe or not" time period as a little over 50 years and thousands of patients. There's a good chance that if there is serious long term consequences for an individual it will develop within 40-50 years and beyond that, say causing Alzheimer's in one's late 70s, I don't really care cuz we're all supposed to start dying a little after our 60s anyway.



As far as this drug class specifically, the least understood and most important organ in the entire human body is the brain. And these treatments and potential consequences come from theory, not long term studies than represent truth. There are very few chemicals you can manipulate in the brain and not run the risk of seriously fucking something up. Especially when everyone's brain chemistry varies and there's no way to determine what will happen to someone unless they just take the drug.

Some people have no side effects.
Some people get nausea or diarrhea.
Some people have seizures and die.

And how they react long term can vary as well. Demographic body chemistry differences puts African Americans at higher risk for hypertension and Caucasian Americans at higher risk for skin cancer. Manipulating certain chemicals in the body can dramatically increase the chances of developing a predisposed disease like that.

I think unwillingness to appropriately survey an individual and accurately gauge risk is the biggest flaw in modern medicine right now.


--------------------
          :dancingbear: Free time is the only time :dancingbear:                    :thatsinteresting:

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Re: Gabapentin and Pregabalin may cause serious brain deterioration, also possibly birth defects [Re: CookieCrumbs]
    #24046949 -

CookieCrumbs said:
PatrickKn said:
musiclover420 said:
Not to mention modern antibiotics have their downsides too such as being indiscriminate and killing many beneficial organisms in the body that can take a while to replenish.


Good points. I hadn't considered the idea that enough decades haven't passed to see the real downsides of antibiotics in the long term when I made the post either. Downsides aside, they have increased mortality quite a bit and it would be needless to not trust them if you have a bad infection.


Antibiotics is a very good example as to why one should use caution with medicine. Yes they are miracle drugs. But using them when they're not needed is a huge problem. Using them long term is a massive problem for both an individual and a society.


And for decades it was hailed as miracle drugs, as near cure alls, without regard to the potential long term consequences.


Which is also why I personally don't trust new drugs and I'd put my "safe or not" time period as a little over 50 years and thousands of patients. There's a good chance that if there is serious long term consequences for an individual it will develop within 40-50 years and beyond that, say causing Alzheimer's in one's late 70s, I don't really care cuz we're all supposed to start dying a little after our 60s anyway.



As far as this drug class specifically, the least understood and most important organ in the entire human body is the brain. And these treatments and potential consequences come from theory, not long term studies than represent truth. There are very few chemicals you can manipulate in the brain and not run the risk of seriously fucking something up. Especially when everyone's brain chemistry varies and there's no way to determine what will happen to someone unless they just take the drug.
I think unwillingness to appropriately survey an individual and accurately gauge risk is the biggest flaw in modern medicine right now.


Good post.

I agree, physicians who undermine clues to the individual profile that is the patient are foolish and poor clinicians.

Food for thought- my hard to tame HBP was caused by heavy antibiotic prescribing from when I got sick last year.


--------------------

From all I may be, or have been before,
To mingle with the Universe, and feel
What I can ne’er express, yet cannot all conceal.

Extras: Filter Print Post Top
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