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Mushrooms, Mycology and Psychedelics > The Psychedelic Experience
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MAO inhibitor Acquisition in America
    #20787202 -

Admin, if there is a better spot for this where it can be enjoyed by all I'd appreciate a move to that spot!

Where can I get MAO inhibitors such as Sryian rue or better in the US>? I ask here because experience is better than google.

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Re: MAO inhibitor Acquisition in America [Re: Cryptology]
    #20787210 -

Our experience IS Google.

That being said, some vendors affiliated with this forum sell those products. If you want a purified product, Avalon Magic Plants sells harmine HCL, and possibly harmaline HCL as well. Been a while since I was on there.

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Re: MAO inhibitor Acquisition in America [Re: larry.fisherman]
    #20787240 -

XLCaps said:
Our experience IS Google.

That being said, some vendors affiliated with this forum sell those products. If you want a purified product, Avalon Magic Plants sells harmine HCL, and possibly harmaline HCL as well. Been a while since I was on there.



Google may be your experience, but I am hoping for the good back to narrow it down. And those MAO's you listed.. how powerful at they? I am not too familiar with MAO

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Re: MAO inhibitor Acquisition in America [Re: Cryptology]
    #20787278 -

Westerners lately are all about using rue, because rue is cheap. However, rue also contains toxins. You can overdose and are doing damage to your body unless you do some kind of extraction to filter out all of the toxins. Not worth being cheap to me.

The best MAO-I to use for ayahuasca is a Caapi. It is completely safe and also contains many more different good psychedelic alkaloids than rue. The Caapi plant is also named "ayahuasca". It is THE plant to use. The shamans believe that this plant has spiritual powers.

These plants are legal in the U.S. and you can find them easily on dozens of shaman-themed websites on Google. You can just use your credit card and have it shipped in days.

I don't think I could give you a specific site because it might be called 'sourcing' here even though it's legal. It's not legal in every country either.

There are also other MAO-Is you can buy from the pharmacy or a health food store.


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Edited by PsychoKinesiS (11/03/14 09:25 AM)

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Re: MAO inhibitor Acquisition in America [Re: PsychoKinesiS]
    #20787337 -

PsychoKinesiS said:
Westerners lately are all about using rue, because rue is cheap. However, rue also contains toxins. You can overdose and are doing damage to your body unless you do some kind of extraction to filter out all of the toxins. Not worth being cheap to me.

The best MAO-I to use for ayahuasca is a Caapi. It is completely safe and also contains many more different good psychedelic alkaloids than rue. The Caapi plant is also named "ayahuasca". It is THE plant to use. The shamans believe that this plant has spiritual powers.

These plants are legal in the U.S. and you can find them easily on dozens of shaman-themed websites on Google. You can just use your credit card and have it shipped in days.

I don't think I could give you a specific site because it might be called 'sourcing' here even though it's legal. It's not legal in every country either.

There are also other MAO-Is you can buy from the pharmacy or a health food store.



Could you PM with a source you trust?

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Re: MAO inhibitor Acquisition in America [Re: Cryptology]
    #20787362 -

Syrian rue is legal as is b caapi
You can buy either one from on-line retailers
Can find Syrian rue sometimes in large health food stores or head shops

But.. They are legal... So... Not sure I see your paranoia

The Shroomery Sponsors are good sources

I suggest you start there

And yes... Rue is cheap


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Mushroom hunting:  One bad mushroom can ruin your day! Know it or throw it.

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Re: MAO inhibitor Acquisition in America [Re: PsychoKinesiS]
    #20787390 -

PsychoKinesiS said:
There are also other MAO-Is you can buy from the pharmacy or a health food store.



No, read about the criticism of the bioavailability of those MAOIs here: http://www.bluelight.org/vb/threads/660439-Mixing-MAOI-with-cacao?p=11923528&viewfull=1#post11923528

They've made extra-bioavailable forms of curcumin, though, so that's something to look into: http://emediahealth.com/2011/07/02/high-bioavailability-curcumin-supplements-from-indena-dolcas-biotech-and-verdure-sciences/

Evidence for curcumin's MAO-A inhibiting activity:

Anti-depressant like effect of curcumin and its combination with piperine in unpredictable chronic stress-induced behavioral, biochemical and neurochemical changes
Mohit Kumar Bhutani, Mahendra Bishnoi, Shrinivas K. Kulkarni
Pharmacology Biochemistry and Behavior - PHARMACOL BIOCHEM BEHAV , vol. 92, no. 1, pp. 39-43, 2009
DOI: 10.1016/j.pbb.2008.10.007
DOWNLOAD (thanks to libgen.org)


Allegations of curcumin toxicity, though: The dark side of curcumin. Burgos-Morón et al. 2010. Int. J. Cancer: 126, 1771–1775


I agree with you about rue, PsychoKinesiS, based on others saying the same thing and my own experience; however perhaps the crude chemical extractions* that the average person can do succeeds in filtering those toxins out? Here's some info on the toxins in rue:

I only have copies of the first three, which you can download here.

Peganum harmala intoxication, a case report. M. Moshiri, et al (2013)

A case of β-carboline alkaloid intoxication following ingestion of Peganum harmala seed extract. Frison G, et al (2008).

Toxicity of Peganum harmala: Review and a Case Report. M. Mahmoudian, et al (2002)

A case of overdose with Peganum harmala L. Ben Salah, N., Amamou, M., Jerbi, Z., Ben Salah, F., Yacoub, M., 1986. J. Toxicol. Clin. Exp. 1986, 319–322.


Quote from the first one:

However, it must be emphasized that peganine and deoxypeganine, reportedly present in P. harmala seeds, were for the first time detected in an infusion-like preparation and in the patient’s urine. These two quinazoline alkaloids are reported to cause a pronounced depression of cholinesterase activity in animals, with desoxypeganine showing an anticholinesterase activity being 10 times superior than peganine. In the experiments on anesthetized cats, desoxypeganine eliminated blockade of neuromuscular conductivity induced by diplacine and conversely enhanced blockade induced by ditilin[40]. Their role in producing some of P. harmala intoxication symptoms should be kept in account.

[40] N. Tuliaganov, F.S. Sadritdinov, G.A. Sulemanova, Pharmacological characteristics of desoxypeganine hydrochloride, Farmakol. Toksikol. 49 (1986) 37–40.


*A new level of harmala purity with this extraction


Synthetic MAOIs shouldn't be dismissed either. A user on Bluelight is a big fan of using moclobemide in combination with DMT. Search it under his name, Ismene, and you'll see loads of posts. There's even a whole article on it called "the Moclobemide Report":

The Moclobemide Report supplies information about this short-term, reversible, medical MAOI. Learn about the benefits of this drug (over Peganum harmala and other herbal MAOI drugs) when used in pharmahuasca experiments. Moclobemide is fast becoming the MAOI of preference amongst in-the-know psychonauts. Educate yourself today! (3 pages)

Jon Hanna. http://www.erowid.org/library/books_online/psychedelic_resource_list.pdf


All the MAOIs should be up for consideration though. The following report about the drug, selegiline is questionable because of how low the dose is (read more about selegiline's dose in this post), but it's very intriguing:

Taking 5mg of selegiline and 4-5+ grams (dried) of shrooms, often lead to overwhelming experiences, more profound and more beautiful, longer, and more of a too long DMTish feel; with the "into the void and piercing the veil" type trips. And if I could get brave enough to "let go" I would experience constant Ego Loss over and over again while being overwhelmed with epiphanies of myself, surroundings, and my little social web and life.

04/29/14  BayerPhi  http://www.shroomery.org/forums/showflat.php/Number/19914585#19914585


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AI Thread

Northerner said:
I agree psilocybin is smokable though.

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Re: MAO inhibitor Acquisition in America [Re: s240779]
    #20787509 -

Da2ra said:
PsychoKinesiS said:
There are also other MAO-Is you can buy from the pharmacy or a health food store.



No, read about the criticism of the bioavailability of those MAOIs here: http://www.bluelight.org/vb/threads/660439-Mixing-MAOI-with-cacao?p=11923528&viewfull=1#post11923528

They've made extra-bioavailable forms of curcumin, though, so that's something to look into: http://emediahealth.com/2011/07/02/high-bioavailability-curcumin-supplements-from-indena-dolcas-biotech-and-verdure-sciences/


04/29/14  BayerPhi  http://www.shroomery.org/forums/showflat.php/Number/19914585#19914585



Great post. Now, this is something I can sink my teeth into. Thank you for the small volume, I'll study religiously until I get it. :smile:

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Re: MAO inhibitor Acquisition in America [Re: s240779]
    #20787547 -

Your welcome!

In regard to naturally-occurring MAOIs, resveratrol is something to look into as well: http://www.shroomery.org/forums/showflat.php/Number/17591264#17591264

There are also many other plants that contain chemicals closely related to rue & caapi's harmine/harmaline. These are addressed in Christian Rätsch's 'The Encyclopedia of Psychoative Plants', in the chapter entitled 'Ayahuasca Analogs and Pharmahuasca', on page 716. You can download this book here.

Someone recently started a discussion on one of these plants, which is what lead me to that entry in the book: Russian Olive: MAOi in Our Backyards


Technical data on harmala chemicals:

Udenfriend S, Witkop B, Redfield B, Weissbach H. 1958. Studies with reversible inhibitors of monoamine oxidase: Harmaline and related compounds. Biochemical Pharmacology, 1(2):160-165. DOI:10.1016/0006-2952(58)90025-X  DOWNLOAD

Buckholtz NS, Boggan WO. 1977. Monoamine oxidase inhibition in brain and liver produced by beta-carbolines: structure-activity relationships and substrate specificity. Biochemical Pharmacology, 26(21):1991-6. DOI:10.1016/0006-2952(77)90007-7  DOWNLOAD


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AI Thread

Northerner said:
I agree psilocybin is smokable though.

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Re: MAO inhibitor Acquisition in America [Re: s240779]
    #20787598 -

Wow I just read about reservatrol as a brain enhancement supplement and was about to start using it and didn't even know it was an MAO_I

Same thing happened with Turmeric. I started using it as a health supplement and then found out Circumin (in turmeric) is a MAO_I.

Is everything good an MAO_I?


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Edited by PsychoKinesiS (11/03/14 10:56 AM)

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