P.Zappatecorum said:

Not really, although a quadruple espresso or a couple red bulls is a good quick, legal start.  Mostly your brain has to be primed and then it doesn't take much to trigger it off, you're not going to be able to induce mania from a depression without something heavy.  One of the reasons I loved cocaine so much when I was younger was that I never really had a crash from it.  I could do it over a weekend session and that would send me off into a manic episode that would last several days, so even once the high wore off, my brain kept speeding.  Inertia has everything to do with it. 

Some of the nootropics, like piracetam and aniracetam as well as energy boosters like ginseng are good supplements to boost cognition and energy levels, and they do it in a much cleaner, healthier way, kind of like mania without the negative aspects, just quick minded alertness.

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