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It remains unclear how these drugs exert their action in the brain, but anecdotal evidence and some earlier studies indicate they may help a variety of psychiatric conditions, says David E. Nichols, founder of the Heffter Institute, in Santa Fe, and professor of medical chemistry and molecular pharmacology at Purdue School of Pharmacy in West Lafayette, Ind.

Nichols says there is some indication these drugs work on the serotonin pathway in the brain, the same target of the selective serotonin reuptake inhibitor drugs Prozac, Paxil and Zoloft, used to treat depression, anxiety and obsessive compulsive disorder.

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The study authors note that this may be due to the drugs' effect on patients' altered brain circuits and neurotransmitter systems, including serotonin and glutamate systems, according to recent neuroimaging data.

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# A recent review of studies conducted in the 1960s found that psilocybin and LSD are effective treatments for OCD, and a current study showed that psilocybin significantly reduced symptoms of OCD in treatment-resistant patients within an average of 2 hours and lasted up to 24 hours.
# Several studies are currently looking at psilocybin and LSD as treatments for anxiety and depression in patients with terminal cancer, with 1 recently completed trial finding that psilocybin improved mood and reduced anxiety and lasted between 2 weeks and 6 months.

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zergroz said:

yeah but i take like 5 grams... it makes a big difference

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wyldeman007 said:

You can get St. John's Wort supplement to treat mild to moderate depression. For one, it is a lot cheaper than any cubensis dose, it's legal and it has scientific literature to back up my claims.

http://www.bmj.com/content/330/7490/503.abstract

Let me know what you think.

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St. John's Wort never worked for me, I gave it a good try too

If you're going to do the shrooms thing - consider that long term benefits are only going to come about through a change in perspective or constant low/mild dosing. A single high dose however, can be the catalyst for a permanent change in perspective.