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Mushrooms, Mycology and Psychedelics > The Psychedelic Experience
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Re: Grapefruit juice and shrooms??? [Re: John]
    #2305135 -

hmmm...
milk has lotsa protein (esp rich in the amino acid tryptophan); it is possible that trhis amino acid may compete with the structurally similar psilocin at some receptor sites, thus somewhat inhibiting absorption/psychedelic activity...
vitamin C - well, since vitamin C is a fairly good free-radical quencher, it is possible that doing up vitamin C while tripping helps to eliminate free-radicals molecules (& thus making the trip fell "cleaner")...
as to things which may help absorption - some drugs exhibit increased bio-availablity when taken with black pepper, or with ginger, or cayenne pepper... something to consider...
& of course, other plants & drugs may alter absorption, metabolism, CNS effects, etc... (MAOIs, SSRIs, uppers, downers, whatever...)
~
gee it's too bad study of psychedelics has been marginalized since the 60s (lyndon & tricky dick, too, for sure...)(if JFK hadn't been blown away in '63 ---> well, jack & bobby prolly both did pot & tripstuff, do ya think they would have been nearly as "anti" as LBJ & RMN ???)
~
~


--------------------
old enough to know better
not old enough to care

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Re: Grapefruit juice and shrooms??? [Re: gnrm23]
    #2305843 -

The Aztecs always served their shrooms to visiting dignitaries with chocolate and honey drinks. Why , we do not know, but i myself have, for thirty years always eaten my shrooms with chocolate mild and I get off perfectly fine. Also, one should take up to 15 minutes or more to eat a dose, as the Indians do. I image that since they have been eating them that way for more than 3 millenia that there must be a reason for that.

And getting off faster is not what the high is about. When eaten slow over a period of time, the come on comes on in waves and ripples and peaks slowly and the high is smoother for the CNS and makes the trip more comfortable with out any anxiety or panic attacks often associated with tea or eating them fast to get them down in order to allievate the sometimes nauseating gagging associated with their consumption.

Anyway, I know people will want to do them any way they like so go ahead.

mj

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Re: Grapefruit juice and shrooms??? [Re: mjshroomer]
    #2306710 -

chocolate is pretty intersting in what it contains

Pharmacologically active ingredients of chocolate 
Compound  Amount
(%W/W) 
Neurotransmitters:   
Serotonin  0.62 - 5.82 
Histamine  0.04 - 0.13 
Methylxanthines:   
Theobromine  <1.3 
Caffeine  ND 
Tetrahydroisoquinolines:   
Salsolinol  High 
Methyltetrahydroisoquinoline  <0.01 
Amines:   
Phenylethylamine  0.02 - 2.20 
Tele-methylhistamine  0.01 - 1.54 
Spermidine  0.05 - 1.15 
p-tyramine  0.02 - 0.35 
3-methyloxytyramine  0.02 - 0.33 
Tryptamine  0.03 - 0.18 
Spermine  0.00 - 0.13 
ND = not detected 
Source: Biochemist, Apr/May 1993, p 15. 

also this intersting quote
Quote:
The researchers found that cocoa and chocolate fats include substances that are chemically and pharmacologically related to the brain lipids anandamide (N-arachidonoylethanolamine), N-oleoylethanolamine and N-linoleoylethanolamine. (The word anandamide is derived from ananda, Sanskrit for 'bliss'.) These N-acylethanolamines target the endogenous cannabinoid system of the brain, mimicking the psychotropic effects caused by plant-derived cannabinoid drugs either directly (by activating cannabinoid receptors) or indirectly (by increasing anandamide levels in the brain).

Earlier research, in which anandamide was isolated from pig brain and then administered to mice, resulted in hypothermia, decreased pain perception and hypomobility - similar responses to marijuana.



from here http://www.chemsoc.org/chembytes/ezine/1997/chockie.htm :thumbup:


--------------------
There's a thin line between sanity and insanity... and I just snorted it.

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Re: Grapefruit juice and shrooms??? [Re: John]
    #2307662 -

Well, it seems to be a restart, look what is going on....

Cancer Study Seeks Patients for Psilocybin Research

Quote:
The Research & Education Institute at Harbor-UCLA Medical Center is conducting a study designed to measure the effectiveness of the novel psychoactive medication psilocybin on the reduction of anxiety, depression, and physical pain. 



novel ? not really  :grin:
have in mind that when dealing with chemical interactions , pure psilocybine might not be the same as the whole mushroom.

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Re: Grapefruit juice and shrooms??? [Re: Hermes_br]
    #2311212 -

When I get my script of valium my doc allways tells me not to drink grapefruit juice as it will make the valium that normally last 4 hours will last 6 hours now this is from a pharmasist and he stresses this and I have no clue if it effects mushrooms but I know for a fact it does have an effect on valium

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Re: Grapefruit juice and shrooms??? [Re: fee]
    #2311237 -

I have no clue if it effects mushrooms...

I too have no clue...

I was speaking more in general, not really focusing the grapefruit vs. mushrooms.

Edited by Hermes_br (02/07/04 01:39 PM)

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Re: Grapefruit juice and shrooms??? [Re: Psilocybeingzz]
    #11110512 -

Grapefruit juice will affect metabolism of any drugs that are metabolized by the P450 Enzyme 3A4. reference http://findarticles.com/p/articles/mi_qa3804/is_200201/ai_n9083616/ ; Depending on what drug it is, if you are taking it, it could affect how you trip.  For example an antipsychotic that is metabolized by 3A4 might be potentiated by grapefruit juice and you wouldn't trip as hard, etc.  you'll have to do your own research on this because this is a fucking complicated topic, people do doctoral dissertations on stuff like this.


--------------------
If the neighbors complain 'cause the music is too loud, turn it up so you can't hear them bitch. ~ I'm blowing my mind....one ass-kicking trip at a time.... :cool:

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