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Mushroom-Hut Shop: Liquid Cultures, Substrate Mix

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A new B-cell stimulator from Ganoderma Lucidum
    #1116291 -

story taken from mushworld site


A new B cell stimulator - GLIS from Ganoderma lucidum

Writer: Jingsong Zhang / Date :2002-09-18 / hits: 32
Jingsong Zhang1,2, Qingjiu Tang1,2, Martin Zimmerman-Kordmann1,
Werner Reutter1 and Hua Fan1
1Institut fur Molekularbiologie und Biochemie, Freie Universitat Berlin, Gemany.
2The edible fungi institute, Shanghai Academy of Agricultural Science, China.

Abstract: A bioactive fraction (GLIS) was isolated from the fruiting body of the fungus Ganoderma lucidum using successive chromatographic steps. GLIS is a proteoglycan and has a carbohydrate : protein ratio of 11.5 : 1. The carbohydrate portion is composed of seven different monosaccharides, predominantly D-galactose, D-glucose and D-mannose in the molar ratio of 1 : 3.8 : 1.
GLIS stimulated the proliferation of mouse spleen lymphocytes, resulting in a three to four-fold increase in the percentage of B cells. GLIS also activated mouse spleen lymphocytes, and most of the activated cells were B cells. The B cells were enlarged, expressed CD71 and CD25 on the cell surface, and showed a significant increase in the secretion of immunoglobulin. Lymphocytes also showed a slightly increased production of IL-2, whereas the secretion of IL-4 was not influenced by GLIS. Furthermore, GLIS did not influence the intracellular Ca2+ concentration of lymphocytes, but it enhanced the expression of protein kinase C and protein kinase C in B cells. According to our results GLIS is a new B cell-stimulating factor.

Keywords: B cell stimulator, GLIS, Ganoderma lucidum

* This paper is presented at 'The 2nd Meeting of Far East Asia for Collaboration on Edible Fungi Research'.





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The living ghost of Kykeon

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Re: A new B-cell stimulator from Ganoderma Lucidum [Re: kykeon]
    #1127916 -

I didn't know what B cells are so here are few links I found:
Understanding the Immune System
B and T cells

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Re: A new B-cell stimulator from Ganoderma Lucidum [Re: zeronio]
    #1128123 -

i read on Scientific American about dendrite cells... huh...


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The living ghost of Kykeon

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Mushroom-Hut Shop: Liquid Cultures, Substrate Mix

Mushrooms, Mycology and Psychedelics > Gourmet and Medicinal Mushrooms
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