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OfflineSouthPArk
C'est La Vie
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Posts: 740
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.
    #4551462 - 08/18/05 02:06 PM (11 years, 3 months ago)

.


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Live as if you were to die tomorrow. Learn as if you were to live forever.


Edited by SouthPArk (04/18/08 07:13 PM)


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InvisibleYarry
Old Timer
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Registered: 01/05/04
Posts: 23,740
Re: Got E???? [Re: SouthPArk]
    #4551466 - 08/18/05 02:08 PM (11 years, 3 months ago)

weaksauce.


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Grumpy Old Man.


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OfflinePS_Cubes
Searching...
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Registered: 01/30/05
Posts: 393
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Re: Got E???? [Re: SouthPArk]
    #4551470 - 08/18/05 02:09 PM (11 years, 3 months ago)

:cuss:


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OfflineFospher
Crime FightingMaster Criminal
Male

Registered: 02/09/05
Posts: 2,033
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Re: Got E???? [Re: PS_Cubes]
    #4551489 - 08/18/05 02:14 PM (11 years, 3 months ago)

who gives a fuck


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InvisibleVvellum
Stranger

Registered: 05/24/04
Posts: 10,920
Re: Got E???? [Re: Fospher]
    #4551496 - 08/18/05 02:15 PM (11 years, 3 months ago)

people who value MDMA and disagree with the War on Drugs.


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OfflineFospher
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Male

Registered: 02/09/05
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Loc: The Netherlands
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Re: Got E???? [Re: Vvellum]
    #4551522 - 08/18/05 02:22 PM (11 years, 3 months ago)

Molly can suck my nuts, rollers give off the most dirty vibes.


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InvisibleVvellum
Stranger

Registered: 05/24/04
Posts: 10,920
Re: Got E???? [Re: Fospher]
    #4551528 - 08/18/05 02:24 PM (11 years, 3 months ago)

:rolleyes:


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OfflineSouthPArk
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Re: Got E???? [Re: Fospher]
    #4551529 - 08/18/05 02:24 PM (11 years, 3 months ago)

Quote:

Fospher said:
who gives a fuck





I Think Most People do....

213,000 pillz are off the street...

All it Takes is 1 bad pill to take a life..

i know of 2 people who did nothing wrong to deserve to die....

Why cant everyone just Keep to the Basics??

Reefer/shroomz....

LEave out the Chems.... :whack:


--------------------

Live as if you were to die tomorrow. Learn as if you were to live forever.


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OfflineWorf
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Registered: 07/04/04
Posts: 15,663
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Re: Got E???? [Re: SouthPArk]
    #4551536 - 08/18/05 02:27 PM (11 years, 3 months ago)

southpark how are shrooms and reefer not chemicals?


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Kira: What do Klingons dream about?

Worf: Things that would send cold chills down your spine, and wake you up in the middle of the night. No, it is better you do not know


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OfflineFospher
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Male

Registered: 02/09/05
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Re: Got E???? [Re: SouthPArk]
    #4551554 - 08/18/05 02:33 PM (11 years, 3 months ago)

Quote:

SouthPArk said:
Quote:

Fospher said:
who gives a fuck





I Think Most People do....

213,000 pillz are off the street...

All it Takes is 1 bad pill to take a life..

i know of 2 people who did nothing wrong to deserve to die....

Why cant everyone just Keep to the Basics??

Reefer/shroomz....

LEave out the Chems.... :whack:




Well, chems dont have to be bad, and not all natural things are good. I agree with you nontheless bro, I've had E fuck over my best friends life...

:sad:

Stupid ass drug to do, extremely neurotoxic, extremely high-profile by the cops at all times. You hear about ecstasy busts left and right.


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InvisibleHELLA_TIGHT
Madge the Smoking Vag
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Posts: 84,350
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Re: Got E???? [Re: SouthPArk]
    #4551571 - 08/18/05 02:37 PM (11 years, 3 months ago)

I have 47 of those bags.


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InvisibleVvellum
Stranger

Registered: 05/24/04
Posts: 10,920
Re: Got E???? [Re: Fospher]
    #4552811 - 08/18/05 08:32 PM (11 years, 3 months ago)

Quote:

Well, chems dont have to be bad, and not all natural things are good. I agree with you nontheless bro, I've had E fuck over my best friends life...




How exactly did MDMA hurt your friend?


Quote:


Stupid ass drug to do, extremely neurotoxic, extremely high-profile by the cops at all times. You hear about ecstasy busts left and right.




Extremely neurotoxic? Please provide your sources.


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OfflineSerioOria
?!one#!>?

Registered: 07/23/05
Posts: 566
Loc: upstate, SC
Last seen: 11 years, 3 months
Re: Got E???? [Re: Vvellum]
    #4552823 - 08/18/05 08:36 PM (11 years, 3 months ago)

it is neurotoxic, but its not that big o deal, any other psychedelic is

e is just a little more dangerous if its abused than most


--------------------
Live every day like it is your first
or
Live every day like it is your last
My ArT!!


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InvisibleVvellum
Stranger

Registered: 05/24/04
Posts: 10,920
Re: Got E???? [Re: SerioOria]
    #4552847 - 08/18/05 08:44 PM (11 years, 3 months ago)

source?


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InvisibleSilversoul
Rhizome
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Registered: 01/01/05
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Re: Got E???? [Re: SerioOria]
    #4552945 - 08/18/05 09:03 PM (11 years, 3 months ago)



--------------------


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InvisibleMushmanTheManic
Stranger

Registered: 04/21/05
Posts: 4,587
Re: Got E???? [Re: Vvellum]
    #4552977 - 08/18/05 09:13 PM (11 years, 3 months ago)

Do you doubt that methamphetamine is neurotoxic?


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PsyPost - Psychedelic Research


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Offlined33p
Welcome to Violence

Registered: 07/12/03
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Re: Got E???? [Re: SouthPArk]
    #4553198 - 08/18/05 09:56 PM (11 years, 3 months ago)

Hell ya i got dem beans dawg



tripple stacked white(w/ brown specs) smileys with 180mg of good clean MDMA fun


--------------------
I'm a nihilist. Lets be friends.

bang bang


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Offlinecoda
Banjo Goiter
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Registered: 03/20/01
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Re: Got E???? [Re: d33p]
    #4554021 - 08/19/05 01:38 AM (11 years, 3 months ago)

Quote:

d33p said:
Hell ya i got dem beans dawg



tripple stacked white(w/ brown specs) smileys with 180mg of good clean MDMA fun





and what lab did you test that in :smile:


--------------------
To get really high is to forget yourself. And to forget yourself is to see everything else. And to see everything else is to become an understanding molecule in evolution, a conscious tool of the universe. And I think every human being should be a conscious tool of the universe. . . .

-JG



Don't fuck with the laughing jesus.


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OfflineFospher
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Registered: 02/09/05
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Re: Got E???? [Re: Vvellum]
    #4554083 - 08/19/05 01:55 AM (11 years, 3 months ago)

Quote:

bi0 said:
Quote:

Well, chems dont have to be bad, and not all natural things are good. I agree with you nontheless bro, I've had E fuck over my best friends life...




How exactly did MDMA hurt your friend?


Quote:


Stupid ass drug to do, extremely neurotoxic, extremely high-profile by the cops at all times. You hear about ecstasy busts left and right.




Extremely neurotoxic? Please provide your sources.





Might not put holes in your brain, but nontheless neurotoxic, causing neuron axon and fiber damage, long-term decrease in not only serotonin but also 5-HIAA, it's metabolite that synthesizes it to begin with. There are also decreases in the density of the serotonin reuptake transporter (SERT), the protein on the membrane of serotonergic neurons that recycles released serotonin by pulling it back into the cell. So in short, not only decreases serotonin, but prevents resynthesization of the it by depleting the brain of it's metabolites.
And in animal and primate studies, there have been permanent degration in axonal neuron structure in parts of the brain.

Quote:

Commins and
colleagues [n32] have proposed that MDMA and related compounds destroy
serotonergic neurons by releasing large amounts of serotonin and inducing
endogenous formation of 5, 6-dihydroxytryptamine, a well-known serotonergic
neurotoxin.




On experiments on primate study:

Quote:

It is not yet known whether the effects of MDMA on serotonergic neurons in
the primate are permanent or reversible. Under some circumstances,
regeneration of serotonergic nerve fibers in the central nervous system can
take place. [n26] However, for axon regrowth to occur, the cell body must be
preserved. It remains to be determined if serotonin-containing cell bodies
in the dorsal raphe nucleus of the MDMA -treated primate survive beyond two
weeks. If they do, and if regeneration of nerve fibers takes place, it is
still not certain that the new fibers would establish normal connections.




Quote:

Multiple doses of MDMA also produced large depletions
of serotonin
in the caudate nucleus, putamen, hippocampus, hypothalamus, and
thalamus of the monkey (Table 2). One of the most severely affected areas was
the cerebral cortex (Table 2), where the lowest dose (2.5 mg/kg) of MDMA
produced a 44% depletion of serotonin (Table 1).





On depletion of serotonin and it's synthesis:

Quote:



MDMA does produce long-lasting changes to the serotonergic system at some doses. These long-term changes include decreases in brain concentrations of the neurotransmitter serotonin (5-HT) and its metabolite 5-hydroxyindoleacetic acid (5-HIAA). Levels of tryptophan hydroxylase (TPH), the enzyme that begins the synthesis of 5-HT within the serotonergic nerve cell are decreased. There are also decreases in the density of the serotonin reuptake transporter (SERT), the protein on the membrane of serotonergic neurons that recycles released 5-HT by pulling it back into the cell. Most studies suggest that MDMA primarily causes long-term changes in serotonergic axons that have their cell bodies in an area of the brainstem called the dorsal raphe nucleus.




On the time lapse of the (side) effect:
Quote:



Long-lasting decreases in these serotonergic markers suggest that either (a) some type of "down regulation" has occurred, meaning the nerve cell is making and maintaining less of the markers, or (b) that serotonergic axons are permanently lost.




Quote:

The sustained acute pharmacological effects of MDMA may exhaust neuronal energy sources and antioxidant defenses, leading to damage. Metabolites of MDMA are another possible source of oxidative stress. Very few behavioral correlates of MDMA exposure have been found in drug-free laboratory animals, despite dramatic serotonergic changes, alterations in neurofunctioning, and changes in response to drugs. A growing number of studies describe differences between ecstasy users and nonusers. These studies have serious limitations, but suggest that some ecstasy users experience serotonergic changes and cognitive alterations.




http://www.erowid.org/chemicals/mdma/mdma_neurotoxicity1.shtml
http://www.erowid.org/chemicals/mdma/ref...ma_1_text.shtml

This thread (http://www.shroomery.org/forums/showflat.php/Cat/0/Number/3960989/page//fpart/3/vc/1) is good too, Im gonna quote a few posts from a user:

on taking SSRIs:
Quote:

>> I also heard if you take SSRIs it could prevent any brain damage occuring on the same sites cause the ssris will bind and prevent damage?

MDMA's neurotoxicity occurs when dopamine, in the absence of sertonin, binds to the 5-HTR transporter and is deposited into the synaptic vesicle. Once deposited, an enzyme called monoamine oxidase attemps to break dopamine down, producing H2O2, or hydrogen peroxide, which oxidizes brain cells and causes their disintegration. This is called oxidative stress.

SSRI's have greater affinity for the 5-HTR receptor site than both serotonin and dopamine. Theoretically, taking an SSRI just as the acute effects of MDMA are beginning to disappear will both prolong the experience as well as block dopamine from binding to the 5-HTR transporter, eliminating the potential for oxidative stress. Studies proving this have thus far only been carried out on mice, and there is no way of knowing how well this method of prophylaxis translates to humans.

Beacuse of it's schedule one status, there has not been sufficient study to determine the risks surrounding MDMA-induced oxidative stress, or precise data detailing the doses of MDMA necessary to make an individual particularly vulnerable to the effects of oxidative stress. Regardless, oxidative stress does occur, and is a well-documented side effect of MDMA use. The risk is quite real and should not be ignored.




I may add more to this post.


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InvisibleHELLA_TIGHT
Madge the Smoking Vag
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Re: Got E???? [Re: Fospher]
    #4554090 - 08/19/05 01:58 AM (11 years, 3 months ago)

"Multiple doses"
"some doses"

They're probably testing with a lot more than a recreational dose.


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