koods said:

Yet another study shows hydroxychloroquine is associated with a higher rate of death. It’s absolutely ridiculous this has become a political issue.

Trump should double his dose for better results

This was a huge study that examined 96,000 cases. Nobody should be taking hydroxychloroquine for covid. Hydroxychloroquine patients had double the rate of death. Democrat study out the U.K..

It’s unethical to continue hydroxychloroquine trials with this kind of data.

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)31180-6/fulltext

Quote:

96 032 patients (mean age 53·8 years, 46·3% women) with COVID-19 were hospitalised during the study period and met the inclusion criteria. Of these, 14 888 patients were in the treatment groups (1868 received chloroquine, 3783 received chloroquine with a macrolide, 3016 received hydroxychloroquine, and 6221 received hydroxychloroquine with a macrolide) and 81 144 patients were in the control group. 10 698 (11·1%) patients died in hospital. After controlling for multiple confounding factors (age, sex, race or ethnicity, body-mass index, underlying cardiovascular disease and its risk factors, diabetes, underlying lung disease, smoking, immunosuppressed condition, and baseline disease severity), when compared with mortality in the control group (9·3%), hydroxychloroquine (18·0%; hazard ratio 1·335, 95% CI 1·223–1·457), hydroxychloroquine with a macrolide (23·8%; 1·447, 1·368–1·531), chloroquine (16·4%; 1·365, 1·218–1·531), and chloroquine with a macrolide (22·2%; 1·368, 1·273–1·469) were each independently associated with an increased risk of in-hospital mortality.

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Enlil said:

That goes without saying.  Whether he's morbidly obese or just obese is something we'd need more data for, though.

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natedawgnow said:

6'3" at 243 lbs would put him at obese but not morbidly obese

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Brian Jones said:

Yes he should definitely double down on his beliefs and his dosage.

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Brian Jones said:

I noticed that the mutual fund Trump invested in that makes this drug, Dodge and Cox International, is down over 25% YTD.

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Quote:

Each of three family funds list a holding in the Dodge & Cox International Stocks Fund, valued between $1,000 and $15,000.

The funds are managed by JP Morgan without any input from Trump.

According to a prospectus dated December 2019, the Dodge & Cox fund in question has Sanofi as its largest holding at 2.9%.

If all three Dodge & Cox holdings are worth the full $15,000 — $45,000 in total — then a 2.9% share of that is $1,305.

Assuming, each holding is the minimum $1,000 — a total of $3,000 — then the 2.9% stake would equate to $87.

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So he's got between $87 and $1,305 invested in Sanofi. 

Falcon91Wolvrn03 said:

Brian Jones said:

Yes he should definitely double down on his beliefs and his dosage.

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That might kill him.  It seems he's smarter than that thus far.

Brian Jones said:

I noticed that the mutual fund Trump invested in that makes this drug, Dodge and Cox International, is down over 25% YTD.

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I'm guessing you know mutual funds don't make drugs?  Regardless, Trump has very small financial tie to hydroxychloroquine producer.

Quote:

Each of three family funds list a holding in the Dodge & Cox International Stocks Fund, valued between $1,000 and $15,000.

The funds are managed by JP Morgan without any input from Trump.

According to a prospectus dated December 2019, the Dodge & Cox fund in question has Sanofi as its largest holding at 2.9%.

If all three Dodge & Cox holdings are worth the full $15,000 — $45,000 in total — then a 2.9% share of that is $1,305.

Assuming, each holding is the minimum $1,000 — a total of $3,000 — then the 2.9% stake would equate to $87.

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So he's got between $87 and $1,305 invested in Sanofi. 

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koods said:

It’s a fucking immunosuppressant. It’s just bizarre anyone thought it was a good idea in the first place.

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Quote:

koods said:It’s an off patent drug that if someone could prove it was successful at treating a new condition would stand to make billions when they get a new patent for the drug. People are pushing this so hard because it would be a financial windfall unlike anything in the history of the world. Getting a patent for a drug that nobody owns to prevent a disease that everyone is in danger of getting. Unbelievable riches.

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Quote:

koods said:Now explain how an immunosuppressant is supposed to prevent infection in the first place

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Quote:

Yeah I am pretty sure that is not how it works with an expired patent, it will remain a generic drug.

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mandrin13 said:

Quote:

koods said:It’s an off patent drug that if someone could prove it was successful at treating a new condition would stand to make billions when they get a new patent for the drug. People are pushing this so hard because it would be a financial windfall unlike anything in the history of the world. Getting a patent for a drug that nobody owns to prevent a disease that everyone is in danger of getting. Unbelievable riches.

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Yeah I am pretty sure that is not how it works with an expired patent, it will remain a generic drug.

Quote:

koods said:Now explain how an immunosuppressant is supposed to prevent infection in the first place

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Sigh, a drug does not have to prevent infection to be beneficial.

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mandrin13 said:

Quote:

koods said:It’s an off patent drug that if someone could prove it was successful at treating a new condition would stand to make billions when they get a new patent for the drug. People are pushing this so hard because it would be a financial windfall unlike anything in the history of the world. Getting a patent for a drug that nobody owns to prevent a disease that everyone is in danger of getting. Unbelievable riches.

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Yeah I am pretty sure that is not how it works with an expired patent, it will remain a generic drug.

Quote:

koods said:Now explain how an immunosuppressant is supposed to prevent infection in the first place

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Sigh, a drug does not have to prevent infection to be beneficial.

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bodhisatta said:

No one knows how paracetamol works.

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Quote:

AM404, also known as N-arachidonoylaminophenol,[1] is an active metabolite of paracetamol (acetaminophen), responsible for all or part of its analgesic action[2] and anticonvulsant effects.[3] Chemically, it is the amide formed from 4-aminophenol and arachidonic acid.

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