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Taking SNRI antidepressants can help you learn faster, but it isn't worth it
    #22197915 -

It's true. SNRI antidepressants like Cymbalta increase adrenaline and serotonin levels in response to ordinary situations. Levels of adrenaline, and to a lesser extent, serotonin, are tightly correlated with the release of Brain-Derived Neurotropin Factor (BDNF), a chemical which is involved in Long-Term Potentiation (LTP) of synapses. LTP is the basis of memory and learning. The evolutionary purpose of the adrenaline/BDNF connection was to enable humans to learn from adrenaline-inducing situations, such as hunting for prey or running from predators. This can still be simulated via exercise. But taking SNRIs also has this effect. You will learn faster and retain your memories more strongly.

Not only that, but the serotonin reuptake inhibition in the hippocampus causes neural stem cells to migrate there, resulting in the growth of new brain cells which can be used to form new memories.

But it's not worth it. The side of effects of SNRIs include irritability, mood swings, sexual impotence, and worst of all, dependency. If you stop taking them, you will experience extreme withdrawal for an extended period of time.

Who here takes SNRIs or SSRIs? I have been physically dependent on them for 10 years. I am now trying to taper off of them, but it is extremely uncomfortable- and I have quit drugs like alcohol, oxycontin, and cigarettes, with much less difficulty.

Kinetics of Norepinephrine- and Serotonin-Induced BDNF Release in Cultured Embryonic Hippocampal Neurons

Chronic antidepressants potentiate via sigma-1 receptors the brain-derived neurotrophic factor-induced signaling for glutamate release.

Antidepressants are neuroprotective against nutrient deprivation stress in rat hippocampal neurons.

Neurotransmitter-mediated control of neurogenesis in the adult vertebrate brain

p75 neurotrophin receptor regulates basal and fluoxetine-stimulated hippocampal neurogenesis.

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Re: Taking SNRI antidepressants can help you learn faster, but it isn't worth it [Re: morrowasted] * 1
    #22198043 -

It took me like 6 months to ween off effexor and I wasn't even on a high dose. I remember being down to only like 12.5mg a day and tried to stop one weekend and I couldn't walk straight by Sunday so I started it again and had to go lower (you can only split  100mg  pill so many times like). My doc gave me a even smaller dose to split.  I was on like 2.5mg a day before I could just stop taking it.

Never got on another one since.

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Re: Taking SNRI antidepressants can help you learn faster, but it isn't worth it [Re: Sekutma]
    #22198082 -

I have noticed that whenever I take one of the 500mg Tumeric extract supplements I bought I feel a lot of energy, almost over-amped, and also sort of overheated and I attribute it too the Cymalta. I end up not taking the Cymbalta, or only taking half as much the following day, and I always feel just fine. I may try supplementing Turmeric in place of Cymbalta.

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Re: Taking SNRI antidepressants can help you learn faster, but it isn't worth it [Re: morrowasted]
    #22198106 -

If your interested in mental enhancements have you tried noontropics? I know that these won't help any depression problems but I take two noontropic supplements.

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Re: Taking SNRI antidepressants can help you learn faster, but it isn't worth it [Re: Sekutma]
    #22198123 -

I have definitely looked into the nootropic market but at this point I am trying to eliminate stuff rather than add it. I take a supplement called SAM-e that has really helped me a lot. I don't think I will buy any of the nootropic supplements for now.

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Re: Taking SNRI antidepressants can help you learn faster, but it isn't worth it [Re: morrowasted]
    #22198165 -

Noontropics are ridiculously safe and absolutely no withdrawal or dependence issues. I took them every day then one day I left them at home. I kept forgetting them at home and a few weeks later I started again. Never craved it or needed. I noticed a slight decline in my mental speed which is why I made sure to bring them to work again.  It's not like something you even feel...it's very difficult to explain.

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Re: Taking SNRI antidepressants can help you learn faster, but it isn't worth it [Re: Sekutma]
    #22198173 -

That movie limitless is actually based on noontropics. Granted... You won't get that kind of mental boost...

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Re: Taking SNRI antidepressants can help you learn faster, but it isn't worth it [Re: Sekutma]
    #22198202 -

Let me put it this way, the only way you know the noontropic is doing anything is your own observations on mental quickness.  Like do your multiplication tables in your head and time it (1x1,1x2,1x3,...10x10).  Take the noontropics and do it again (after like a week of them). I bet you do the tables way faster.  No physical feeling really exists like if you take a stimulate.

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Re: Taking SNRI antidepressants can help you learn faster, but it isn't worth it [Re: Sekutma]
    #22198452 -

Antidepressants did nothing for me. There were a few false alarms, like I thought with Prozac I had struck gold but the 'high' just disappeared the next day. Continued it for months with no effect. Who knows what that was about.

Take mushrooms for brain ailments like depression. Mushrooms really are magic.


--------------------
My solitude...
My shield...
My armour...

TESTED
WITH
FULL
FORCE

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Re: Taking SNRI antidepressants can help you learn faster, but it isn't worth it [Re: Sekutma]
    #22198577 -

Sekutma said:
Noontropics are ridiculously safe and absolutely no withdrawal or dependence issues. I took them every day then one day I left them at home. I kept forgetting them at home and a few weeks later I started again. Never craved it or needed. I noticed a slight decline in my mental speed which is why I made sure to bring them to work again.  It's not like something you even feel...it's very difficult to explain.


It depends on which ones you are talking about. Different people consider different chemicals to be nootropics.

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Re: Taking SNRI antidepressants can help you learn faster, but it isn't worth it [Re: morrowasted]
    #22198617 -

The dogs at work that take Prozac act really, really weird. They have a creepy, glossed over look in their eyes, and they constantly wag their tails for no good reason, and pant too much, and react aggressively towards other dogs in situations without seeming angry or afraid. Like they will be happy looking, then just snap at another dog because you gave it attention then go back to looking at you and wagging their tail with that glossed over look in their eyes. the prozac comes in the form of little bone-shaped treats.

the dogs that take xanax are funny. we have that takes 4mg of xanax a day. this is a 40 pound dog. If I took 4mg of xanax, I would be asleep for 48 hours. that dog is super goofy all the time. the xanax is just the same xanax bars people take, but we put it in peanut butter.

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Re: Taking SNRI antidepressants can help you learn faster, but it isn't worth it [Re: morrowasted]
    #22198626 -

That is true...Im making a new stack soon. I have only tried two but supposedly some are like thousands of times stronger then what I take. I'll definatly make a post if I notice anything. It will be a while before I start a new stack, I have like 25 days left of what I have now.

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Re: Taking SNRI antidepressants can help you learn faster, but it isn't worth it [Re: Sekutma]
    #22198647 -

Some people consider chemicals like modafinil to be a nootropic but I would say that modafinil definitely has addictive properties.

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Re: Taking SNRI antidepressants can help you learn faster, but it isn't worth it [Re: morrowasted]
    #22198738 -

Yes, actually one of the things I was going to try was something that is almost identical to modafinil. I think it's a chemical that breaks into modafinil or something like that.

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Re: Taking SNRI antidepressants can help you learn faster, but it isn't worth it [Re: Sekutma]
    #22198741 -

You are right, I shouldn't blanket it as all safe...

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Re: Taking SNRI antidepressants can help you learn faster, but it isn't worth it [Re: Sekutma]
    #22198799 -

I am trying to get off adderall... So after I graduated college I stopped adderall. Figured I would be fine. 6 months later and im feeling frustrated that I can't do my job. So I got a new doc in my new area and im back on it. Since then I've been trying to find an alternative but my current stack isn't enough.

I hate the adderall. It's going to kill me if I take it for the rest of my career.  I don't want you to get the wrong idea, I take my regular 20mg twice a day, I don't buy extra or go on binges but I KNOW it's still doing harm.  I skip weekends as often as possible.  Noontropics was the first solution that I wanted to move too. Just can't get the right  combo. I'll figure it out and get off the adderall withen the next six months I hope.

I'm open to other suggestions if you have any!!!

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Re: Taking SNRI antidepressants can help you learn faster, but it isn't worth it [Re: Sekutma]
    #22198896 -

I used to take stimulants as well but never daily. The only way, in my experience, to get off them is just to stop and let your brain heal as best as you possibly can.

You were probably thinking of adrafinil, which breaks down into modafinil in the liver.

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Re: Taking SNRI antidepressants can help you learn faster, but it isn't worth it [Re: morrowasted]
    #22198959 -

So just a bit of history when I was in like 2nd or 3rd grade my teacher told my parents that she observed attention problems. THANK GOD they didn't put me on medication then. I would be completely dependant if they had. Instead I didn't start till I went back to college (dropped out then finished like five years later). I was only on it for like two years, withdrawal wasn't even that bad. I had the same daily dosage the whole time.

My problem was keeping things straight and reading documents about topics I never encountered in school. I'm R&D for an antenna company... I really needed to keep things straight lol. Thats why I went back on it. I hate it though... I really do. Every day I try and wait as long as I can to take it. Sometimes I actually go the whole day but most days by lunch.

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Re: Taking SNRI antidepressants can help you learn faster, but it isn't worth it [Re: Sekutma]
    #22199092 -

Well, you can stop. I know people who have quit meth after 20 years of daily use. So anything is possible.

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