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 tito123   Registered: 01/23/10 Posts: 3,006 |
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Have they helped you out at all? Could you elaborate?
Did they hurt you? Were the problems they caused permanent? I'm beginning to consider them. Meditating for a few years, tons of healthy food, + just recently been doing pushups and situps. Not a very active sex life. I push myself out of my comfort zone and try socializing. I just quit smoking. I don't dwell on negative feelings. It's simply hard for me to experience pleasure, happiness, fear, or excitement. Besides drugs, very very few things will cause those feelings. Anhedonia is probably the diagnosis. Nothing debilitating. Just no enjoyment or satisfaction.
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 RideAllBears rawr  Registered: 08/09/12 Posts: 166 Last seen: 10 years, 8 months |
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I had depression for a while when I was 17. Shit sucked.
I randomly found info for a depression trial. They were testing Cymbalta on teens (to see if it gave suicidal thoughts). I did feel better on them, but I was definitely not the same. Cymbalta was chemically similar to cocaine, and my attitude reflected that daily bump. It was like I was an attention whore coke fiend for my last bit in High School. When the trial was ending, I felt much better, so I was getting off them. My doctor gave me extras to taper off. I quit cold turkey. First day it was like I was stoned, and I could feel electricity going down the middle of my brain. That night I cried, and felt helpless. The next morning I woke up and felt absolutely fine. Moral of the story: don't be prejudiced or ashamed, go to a doctor and maybe it will improve your life. Better than doing nothing and continuing feeling the same eternal indifference. Worse case scenario you don't like it, and you try to find another option. -------------------- 
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Ped Interested In Your Brain    Registered: 08/30/99 Posts: 5,494 Loc: Canada Last seen: 9 years, 9 months |
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It's not really precise to say that duloxetine (Cymbalta) is chemically similar to cocaine. On a chemical level, they are not remotely similar. On a pharmacological level, they have some overlap in terms of their mechanism, but the comparison remains apples to oranges. One trait duloxetine has in common with cocaine and uncommon with other prescription antidepressants is its sodium channel blockade. Be that as it may, this blockade is quite a bit more selective than that of cocaine.
SSRI/SNRI antidepressants are not the only antidepressants available, and in fact they aren't even the best antidepressants available. In terms of therapeutic index, SSRI/SNRI medications are an inferior category of antidepressant, as they tend to cause more in the way of unpleasant or intolerable side effects than they do therapeutic gain. Some people find tremendous relief and recovery in SSRI/SNRI medications, but this percentage is low. Tricyclic antidepressants, many of which behave as SSRI/SNRI medications in their own right (with some supplemental activity), tend to cause fewer, more tolerable side effects. Somnolence, for example, is a more tolerable side effect than emotional flattening or sexual incapacitation. Tricyclic antidepressants are much more likely to cause somnolence than they are emotional flattening or sexual incapacitation. I personally take a tetracyclic antidepressant, mirtazapine. It is, for me, orders of magnitude superior to any other antidepressant I've attempted, including the tricyclics, and including the SSRI/SNRI medications, which were by far the least effective and least tolerable of the lot. Its primary side effects have been somnolence, increased appetite, and dry mouth. Within a few weeks, I will be attempting a 45 day course of tianeptine, at 12mg twice daily. Tianeptine is an atypical tricyclic antidepressant which operates according to a completely different mechanism than conventional medications. Unlike conventional medications, tianeptine may actually help to normalize or even reverse some of the persistent neurological aberrations involved in depressive pathologies. This places it in a class unto itself, and I am greatly looking forward to the experiment. I'll report on this when appropriate. -------------------- 
 Dark Triangles - New Psychedelic Techno Single - Listen on Soundcloud
Gyroscope full album available SoundCloud or MySpace
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tito123 Registered: 01/23/10 Posts: 3,006 |
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Worst case scenario, I'll end up like David Foster Wallace who found an anti-depressant that worked for him but eventually tried weening himself off due to the negative side effects, but then he became depressed and nothing worked. And then he started taking his medicine again, but it didn't work and he killed himself. Or I'll end up with some permanent "off-feeling" or something. I'm a bit scared of these drugs.
I'll talk to my therapist about referring me to a psychiatrist, and then share this info with him.
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s240779   Registered: 12/07/10 Posts: 14,644 Last seen: 14 minutes, 2 seconds |
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Ped, what do you think of beta-carbolines (e.g. harmine) as antidepressants (going off the fact that MAOIs are used as antidepressants — and quite successfully*)?
I suggested on Bluelight that harmine's similarity to serotonin suggested it was remarkably compatible with the brain, but they told me it wasn't that similar to serotonin, despite the fact that it looks more similar than all other MAOIs.** harmine and its similarity to serotonin  Harmine is the primary chemical found in Banisteropsis caapi. It can also be found in P. harmala seeds, which are highly economical. Here's a report from someone who is currently using using beta-carbolines as an antidepressant: The mental effect for me, are better mood, calmness and energy. Also what adds to the healing, is that I can watch negativity, particularly anxiety, with less judgment, and able to release it more. It helps because then I can do things which I need to do, but anxious about. Also I feel I more the flow of things such as music, and less get stuck. For me it is actually the first time I manage to actually meditate in a way that feels relaxed enjoyable and beneficial. But this might be actually personal and not apply to everyone. [I asked this individual if his doses were getting him stoned because beta-carbolines are psychedelic in higher doses. He responded by saying his doses are not psychedelic.] 03/10/15 jivangilad http://www.shroomery.org/forums/ The use of beta-carbolines as anti-depressants has even been tested scientifically. The below studies can be downloaded here. The therapeutic potential of harmine and ayahuasca in depression: Evidence from exploratory animal and human studies. Osório et al. Located in 'The Ethnopharmacology of Ayahuasca.' Rafael Guimarães dos Santos (editor). 2011: 75-85 ISBN: 978-81-7895-526-1 Pharmacological and therapeutic effects of Peganum harmala and its main alkaloids. Moloudizargari et al. 2013. Pharmacognosy Review. 2013 Jul-Dec. 7(14): 199–212. http://www.ncbi.nlm.nih.gov/pmc/ Cf. Mono amine oxidase inhibition and anti-depressant effect Acute harmine administration induces antidepressive-like effects and increases BDNF levels in the rat hippocampus. Fortunato et al. Prog Neuropsychopharmacol Biol Psychiatry. 2009 Nov 13. 33(8):1425-30. doi: 10.1016/j.pnpbp.2009.07.021 Chronic administration of harmine elicits antidepressant-like effects and increases BDNF levels in rat hippocampus. Fortunato et al. J Neural Transm. 2010 Oct. 117(10):1131-7. Antidepressant-like effect of harmane and other beta-carbolines in the mouse forced swim test. Farzin & Mansouri. Eur Neuropsychopharmacol. 2006 Jul. 16(5):324-8. Harmane induces anxiolysis and antidepressant-like effects in rats. Aricioglu & Altunbas. 2004. 1009:196-201. DOI: 10.1196/annals.1304.024 And here's a plus: Diabetes Treatment May Soon Involve Psychedelic Ayahuasca; Chemical Harmine Triples Beta Cell Count *it is one of the oldest known antidepressants. It is sometimes regarded as the best monotherapy for extinguishing social anxiety. It's an MAOI, or more specifically a non-selective irreversible inhibitor of monoamine oxidase with a complex mode of action. It was invented in the 1950s after a similar compound used to treat tuberculosis was accidentally discovered to make people happy. Since then, science has not been able to find a compound capable of producing a statistically significantly better antidepressant effect. http://www.socialanxietysupport. They love Nardil on SocialAnxietySupport.com!  More support for MAOIs: Most Antidepressants Miss Key Target of Clinical Depression. Harryman, William. Dec 9, 2009. integral-options.blogspot.com ** Chemical Name: phenelzine Molecular Formula: C8H12N2 Formula Weight: 136.19 CAS No.: 51-71-8  Chemical Name: brofaremine Molecular Formula: C14H16BrNO2 C AS No.: 63638-91-5  Chemical Name: caroxazone Molecular Formula: C10H10N2O3 CAS No.: 18464-39-6  Chemical Name: eprobemide Molecular Formula: C14H19ClN2O2 Formula Weight: 282.769 CAS No.: 87940-60-1  Chermical Name: amiflamina Formula Weight: C12H20N2 CAS No.: 77697-37-1  Chemical Name: metralindole Molecular Formula: C15H17N3O CAS No.: 54188-38-4  Chemical Name: minaprine Molecular Formula: C17H24Cl2N4O Formula Weight: 371.3 CAS No.: 25905-77-5  Chemical Name: pirlindole Molecular Formula: C16H22N2O3S Formula Weight: 322.42 CAS No.: 60762-57-4  Chemical Name: toloxatone Molecular Formula: C11H13NO3 Formula Weight: 207.23 CAS No.: 29218-27-7  Chemical Name: moclobemide Molecular Formula: C13H17ClN2O2 Formula Weight: 268.74 CAS No.: 71320-77-9  Chemical Name: befloxatone Molecular Formula: C15H18F3NO5 Formula Weight: 349.303 CAS No.: 134564-82-2  Chemical Name: cimoxatone Molecular Formula: C19H18N2O4 CAS No.: 73815-11-9  Chemical Name: esuprone Molecular Formula: C13H14O5S Formula Weight: 282.315 CAS No.: 91406-11-0  Chemical Name: methylene blue Molecular Formula: C16H18ClN3S Formula Weight: 319.85 CAS No.: 61-73-4  Chemical Name: sercloremine Molecular Formula: C14H16ClNO Formula Weight: 249.739 CAS No.: 54403-19-9  Chemical Name: tetrindole Molecular Formula: C21H30N2O3S Formula Weight: 390.54 CAS No.: 135991-95-6  Chemical Name: tranylcypromine Molecular Formula: C9H11N Formula Weight: 133.19 CAS No.: 95-62-5 
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zzripz Stranger  Registered: 12/23/08 Posts: 8,292 Loc: Manchester, UK Last seen: 7 years, 3 months |
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I personally would not go anywhere near them! Please see this video:
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Ped Interested In Your Brain Registered: 08/30/99 Posts: 5,494 Loc: Canada Last seen: 9 years, 9 months |
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Peter Breggin is a quack. Rational people categorically ignore his rhetoric. This video is a parade of vague half-truths, exaggerations, and outright lies.
He says "All psychiatric drugs take the edge off your frontal lobe function, off of your caring, thinking, feeling." This is complete and utter nonsense. It just isn't true. He says "All psychoactive substances suppress the spirit or the soul," a vague and basically meaningless statement. He says "Most anaesthetics are related to the benzodiazepines", which is a complete fiction: very few anaesthetics have any relationship to the benzodiazepines, whether chemically or pharmacologically. He says "Anti-psychotics block dopamine, which is the pathway to the frontal lobe," and this is complete and utter nonsense: dopamine is not the "pathway to the frontal lobe", and antipsychotics do not exclusively target nor blockade dopamine function. Some antipsychotics increase dopaminergic neurotransmission in the forebrain, and the network of serotonergic neurons connecting the frontal cortices to the rest of the brain is not only far more extensive than that of dopamine, but also assisted--not blocked or suppressed--by many antipsychotic medications. He goes on to say that antipsychotics do not suppress the positive symptoms of schizophrenia (such as auditory hallucinations), but rather that they cause the patient to "stop caring" about them. This is plainly false. Except in severe patients (such as those who go untreated for too long because they listened to quacks like Peter Breggin), antipsychotic medications do eliminate these symptoms, while simultaneously restoring their affect. He says "If you are getting an effect from a psychiatric drug, it's a disabling effect," and this is by far the worst of his lies. Psychiatric drugs have enabled millions of lives. They are not ideal instruments, but they are--contrary to his bullshit--correcting a biochemical imbalance. Don't listen to this quack. He's not even a real psychiatrist. He is not certified. He's just a ageing blowhard.
--------------------
Dark Triangles - New Psychedelic Techno Single - Listen on Soundcloud
Gyroscope full album available SoundCloud or MySpace
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Ped Interested In Your Brain Registered: 08/30/99 Posts: 5,494 Loc: Canada Last seen: 9 years, 9 months |
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>> Ped, what do you think of beta-carbolines (e.g. harmine) as antidepressants (going off the fact that MAOIs are used as antidepressants — and quite successfully*)?
The usefulness of MAOI antidepressants is at best unclear. These medications target the serotonin hypothesis of depression, which believes that depression is largely or wholly mediated by serotonin. We now know that serotonin is just one piece of a much larger puzzle. MAO inhibition may have a role in the treatment of some depressive phenotypes, but its role in treating depression on the whole probably isn't very broad. Depression is now known to unfold with contributions from the catecholamine and glutamate systems. There are morphological changes in brain structure also in play. MAO inhibition does not address these dimensions in any meaningful way. While MAOIs to might be useful to some, they are not a solution to depression unto themselves. >> I suggested on Bluelight that harmine's similarity to serotonin suggested it was remarkably compatible with the brain, but they told me it wasn't that similar to serotonin They really aren't very similar. The similarities essentially begin and end with indole. All the substitutions and functional groups are different, not the least of which is the additional ring structure. Harmine won't behave similarly to serotonin in the synapse. It will, however, bind to and inactivate the monoamine oxidase enzyme, and it accomplishes this by being similar enough to serotonin to make this bind, but a stable, foreign structure not easily broken down. It therefore "ties up" monoamine oxidase, diminishing its involvement with serotonin and leading to an indirect accumulation of serotonin in the synapse. Generally speaking, I'm not a big fan of MAOIs, because the risk-benefit ratio usually isn't high enough. MAO inhibition comes with a host of drug interactions and ancillary effects on metabolism, both of which present some significant dangers. While MAO inhibition might be useful to many people, and while this shouldn't be discounted, I tend to feel that other treatment strategies are surely preferable, provided of course they are viable in their own right. --------------------
Dark Triangles - New Psychedelic Techno Single - Listen on Soundcloud
Gyroscope full album available SoundCloud or MySpace
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zzripz Stranger Registered: 12/23/08 Posts: 8,292 Loc: Manchester, UK Last seen: 7 years, 3 months |
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Definition of 'quack':
If any people are quacks it is the people you relentlessly represent and promote on these boards here (are you getting paid for it? You Should get on the bandwagon, your missing out on all the BILLIONS these drug companies are making)---the shrinks, and all those shouting to 'hawk their salve' (salve (n.) Look up salve at Dictionary.com Old English sealf "healing ointment," from West Germanic *salbo- "oily substance" (cognates: Old Saxon salba, Middle Dutch salve, Dutch zalf, Old High German salba, German salbe "ointment"), from PIE *solpa-, from root *selp- "fat, butter" (cognates: Greek elpos "fat, oil," Sanskrit sarpis "melted butter"). ) EVEn though they have no actual medical tests to scientifically prove their diganoses they come up with round a table derived from lists of behaviours they deel 'disorders'/'mental illness'. That is quackery! Dr Peter Breggin is not an untrained person pretending to be a physician which also undermines the term 'quack' you use to try and slander him: source
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Ped Interested In Your Brain Registered: 08/30/99 Posts: 5,494 Loc: Canada Last seen: 9 years, 9 months |
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I'm not going to help you to derail this thread with anti-evidence nonsense and ideological posturing, and so I'm not going to directly address your remarks. You don't need any further encouragement from me or anyone.
Credible scientists and clinicians are aware that Peter Breggin is an ageing psychiatrist whose views are out of date at best, and downright harmful at worst. He routinely denies scientific evidence, resists emerging scientific finding, and marries himself to his antiquated, demonstrably false views. The content of his books and videos is full of misrepresentation, exaggeration, distortion, and outright falsehood. I trust the OP sees this as clearly as the rest of the scientific community does. You have a different opinion, and it's best left at that. --------------------
Dark Triangles - New Psychedelic Techno Single - Listen on Soundcloud
Gyroscope full album available SoundCloud or MySpace
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s240779 Registered: 12/07/10 Posts: 14,644 Last seen: 14 minutes, 2 seconds |
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-- Despite their potential side effects, the older MAOIs (phenelzine, tranylcypromine, isocarboxazid, and selegiline) have all been proven effective in depression; some studies have found them more effective than tricyclic antidepressants (TCAs) or selective serotonin reuptake inhibitors (SSRIs).1,2 1. Thase ME, Mallinger AG, McKnight D, et al. Treatment of imipramine-resistant recurrent depression; IV; a double-blind crossover study of tranylcypromine for anergic bipolar depression. Am J Psychiatry 1992;149:195-8. 2. Thase ME, Trivedi MH, Rush AJ. MAOIs in the contemporary treatment of depression. Neuropsychopharmacol 1995;12(3):185-219. -- Source: Cole J, Bodkin A. MAO inhibitors: An option worth trying in treatment-resistant cases. Current Psychiatry, Vol. 1, No. 6, June 2002 That's significant, as you praised TCAs, above.
The MAOI warnings I always hear about sound incredibly uninsightful to me. Even my old psychiatrist shook his head and said 'I've never seen it' when sspeaking of 'the cheese effect.' And before I even continue I'd like to point out that if one of those foods is consumed when on a beta-carboline, the beta-carboline will simply be kicked out of your system, allowing you to metabolize the offending stuff as normal. It is only with the so-called irreversible MAOIs where the effect of the MAOI cannot be reversed. Anyway, the restricted food are classified as follows: Hypertensive crises with MAOIs have occurred in some patients following ingestion of foods containing large amounts of tyramine or tryptophan. In general, patients taking MAOIs should avoid protein foods that have undergone protein breakdown by aging, fermentation, pickling, smoking, or bacterial contamination. Foye's Principles of Medicinal Chemistry, Seventh Edition. Thomas L. Lemke, Ph.D., David A. Williams, Ph.D., Victoria F. Roche, Ph.D., S. William Zito, Ph.D. 2013. That's pretty narrow and many of those foods are expensive. The type of cheese used on pizza simply doesn't contain enough tyramine to present a problem. It is only aged cheese. -Can I still get drunk on it and eat pepperoni pizza? -Yes. 05-02-2014 - http://www.socialanxietysupport. I drink beer on Nardil all the time. 4 is the most I've ever had and I've never once had a sneaking suspicion that I was putting myself in danger. 08-09-2008 - http://www.socialanxietysupport. Most store bought beer is pasteurized, where the tyramine has decomposed. 'Raw' beer is an issue, however but once again that's an exotic thing. Some MAOI guides warn that beer on tap can be unpasteurized. MAOI "diet" by psychiatrists - a joke? A person in the above thread says that even when he did eat something he truly wasn't supposed to eat, all he got was a splitting headache. It's very rare to have a hypertensive crisis while on MAOIs, but the danger is there and you can get one when you least expect it. Took me two years to find out how it felt like. I ate spoiled meat and it gave me a splitting headache, felt like my head was about to explode. Before that incident i had been eating everything and paid the diet no concern at all. I still don't care about the diet, but gourmet cheese and spoiled food should be avoided at all costs. This is a good read: MAO Inhibtors: Risks, benefits, and lore. Wimbiscus, Molly MD; Olga Kostenk, MD; Donald Malone, MD. Cleveland Clinic Journal of Medicine. vol. 77, no. 12, Dec 2010 From the above article:  The first reference in this post (Cole) states that combining MAOIs with tricyclics has been determined to be safe. We have found all antidepressants that do not involve significant serotonin reuptake inhibition (e.g., bupropion, trazodone, and tricyclics other than clomipramine) can be safely administered with MAOIs. Combination therapy is worth considering because it may be effective when other approaches have failed. There are two people on SocialAnxietySupport.com who are combining MAOIS with amphetamines: -- Im not taking Nardil but I'm taking 80mg Parnate. Recent studies show that if you're MAOI resistant stimulants can help. I'm taking 70 mg of Vyvanse and Ritalin (not Adderal). My blood pressure is normal and the MAOI started working. Some people go as high as 120mg with stimulants. Just watch your blood pressure. Of course the higher you go the dietary restrictions become more pertinent. 7/2/2014 MRDIGBY http://www.socialanxietysupport. NOTE: 120 mg is two times the APA maximum recommended dose and such a dose has received acknowledgement by professionals: Jay Amsterdam at the University of Pennsylvania goes up as high as 120 mg of Parnate(tranylcypramine) and claims fewer side effects at higher doses. This Month’s Expert: Jonathan Cole, M.D. Reflections on the Use of MAOIs | Psych Central Professional Stimulant + MAOI journal -- As for Melatonin and Nardil being contraindicated, a lot of this stuff is just theoretical, I take 3mg evey night without problem. I have also taken LSD in large doses on Nardil without problem. They just make anything that effects the seritonin system contraindicated as a matter of course. zendog78 04-13-2010 http://www.socialanxietysupport. Here's a report of soemone who took MDMA, MDA, and MDE in combination with oral DMT: Jezebel. Fun, Plus 'Ghost People': An Experience with Ayahuasca, Mushrooms, MDMA, MDE, MDA, LSD, LSA, Blue Lotus, Cannabis, Alcohol, & Opium (ID 24742). Erowid.org. Jun 24, 2003. erowid.org/exp/24742 So, MAOIs don't sound that 'contraindicated' afterall. You also seem to be neglecting the fact that people aren't exactly so stupid that they wouldn't abide by relevant restrictions. Seems to me like a few restrictions on things you probably weren't going to ingest anyway is worth it if it's an effective medication...that seems to be the consensus on SocialAnxietySupport.com
Perhaps in spite of the number of changes, those changes are not very "deep." Someone on Bluelight argued that minaprine was closer to serotonin... Edited by s240779 (03/16/15 01:54 PM)
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s240779 Registered: 12/07/10 Posts: 14,644 Last seen: 14 minutes, 2 seconds |
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So there's a lot of indications that the MAOI restictions have been stupidly hyped and I look forward to gaining a more intimate understanding of the issue. This is something I've been planning on reading:
MAOI Diet Abbreviated 2.3.2 This review summarizes more research about tyramine than any previous or existing publication
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Ped Interested In Your Brain Registered: 08/30/99 Posts: 5,494 Loc: Canada Last seen: 9 years, 9 months |
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>> Someone on Bluelight argued that minaprine was closer to serotonin...
One of the reasons I don't post on Bluelight is because it would rapidly develop into a non-stop, 24-hour resistance against the unstoppable tide of silly conjecture and falsehood posted there. Bluelight is loaded to the hilt with false and misleading information. >> So, MAOIs don't sound that 'contraindicated' afterall. You also seem to be neglecting the fact that people aren't exactly so stupid that they wouldn't abide by relevant restrictions. Seems to me like a few restrictions on things you probably weren't going to ingest anyway is worth it if it's an effective medication...that seems to be the consensus on SocialAnxietySupport.com Social anxiety disorder is a completely different bird than depression, itself the central topic of this thread. MAO inhibition might be very useful for social anxiety disorder, because that condition probably does occur with serotonin as its primary substrate. The same can't be said of depression, or in the OP's case, the inability to experience enjoyment, itself a central feature of depression and one of the core motivators driving patients to seek antidepressant medications.
Don't get me wrong; I'm not saying that MAOIs are useless to the OP, just that the risk-benefit ratio probably isn't very favourable (it usually isn't), and that the mechanism of action probably isn't adequate to address OP's stated symptoms. --------------------
Dark Triangles - New Psychedelic Techno Single - Listen on Soundcloud
Gyroscope full album available SoundCloud or MySpace
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s240779 Registered: 12/07/10 Posts: 14,644 Last seen: 14 minutes, 2 seconds |
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lol the only relevance that social anxiety disorder had in my post was that of the website, SocialAnxietySupport.com that contained the posts about the food an medication restrictions. Nardil is very popular talk on that website (seven Nardil threads on the first page one day! (screenshot)) so it's a good substrate wherein to find 'experience reports' about it. On the contrary, one of the references in my last post (the first one) spoke of MAOIs being a particularly good option for depression. And a reference in my first post in this thread also stated this (Harryman — right before the big list of MAOIs). I even showed you some evidence that MAOIs are better than your praised tricyclics.
lol Have you seen the Neuroscience and Pharmacology Discussion? That's your territory, man. Edited by s240779 (03/16/15 01:19 PM)
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Ped Interested In Your Brain Registered: 08/30/99 Posts: 5,494 Loc: Canada Last seen: 9 years, 9 months |
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I tend to believe that MAOIs have a higher therapeutic index with respect to social anxiety disorder than with depression. I say this because depression is a much more complicated illness, the spectre of which far exceeds serotonin, and because MAOIs do not exceed this scope. Once again, the OP may find usefulness in MAOIs, but his symptomology does not, in my view, suggest that he would.
For that matter, I don't tend to believe that SSRI/SNRI medications would help him either. These drugs tend to flatten affect more than bolster it. They certainly don't target anhedonia, nor do MAOIs target this primary symptom. A DNRI such as bupropion is better suited if anhedonia is the primary symptom. Tianeptine also has specific relevance to anhedonia. To be clear, I did not and do not "praise" tricyclics, whether in OPs case or otherwise. I maintain that they are superior to the more recent SSRI/SNRI medications owing to their superior tolerability, but this hardly constitutes praise. Their efficacy is at least on par with SSRI/SNRI medications (this isn't saying much), but their tolerability tends to be higher. The tricyclics therefore have a higher therapeutic index. MAOIs may swim in this territory in some depressive phenotypes, but depression is too broad an illness to say that the specificity of the MAOI mechanism has special relevance to it. I don't tend to think MAOIs would help the OP, but I could of course be wrong. Ultimately this is up to him. I would certainly agree with a treatment strategy which prioritized MAOIs ahead of SSRI/SNRI medications, provided the OP is educated about and capable of navigating the inherent risks. >> Have you seen the Neuroscience and Pharmacology Discussion? That's your territory, man. Yeah, ODD and P&MWB are more than enough to keep me occupied. 
--------------------
Dark Triangles - New Psychedelic Techno Single - Listen on Soundcloud
Gyroscope full album available SoundCloud or MySpace
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zzripz Stranger Registered: 12/23/08 Posts: 8,292 Loc: Manchester, UK Last seen: 7 years, 3 months |
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OMFG THEY are here. To OP, all I say is beware. They blind you with fancy lingo. it means precisely fk all
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akira_akuma Φύσις κρύπτεσθαι ὕψιστος φιλεῖ  Registered: 08/28/09 Posts: 82,455 Loc: Onypeirophóros Last seen: 6 years, 8 months |
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 sucks. he was great.
you mean the people who know facts as opposed to slang fiction?
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zzripz Stranger Registered: 12/23/08 Posts: 8,292 Loc: Manchester, UK Last seen: 7 years, 3 months |
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Please compare 'peds' qualifcations with Dr Thomas Szasz's, and Dr Peter Breggin's, etc
Edited by zzripz (03/16/15 05:58 PM)
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akira_akuma Φύσις κρύπτεσθαι ὕψιστος φιλεῖ Registered: 08/28/09 Posts: 82,455 Loc: Onypeirophóros Last seen: 6 years, 8 months |
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um, that's stupid. Ped can be fucking Doctor Szasz, himself. you don't know, because he is just "Ped" here. LOL, how the hell did you not think of this fact before you posted?
maybe Ped is like a genius or something, not that you'd be able to tell, nor would you be seeing his qualifications.  PS: look at this guys awesome website http://www.breggin.com/ must be a real keeper for a doctor with a website like that. "what YOUR doctor might not know" (but i do and will tell you for free, but others keep you from knowing because they are not me Doctor Breggin.) and Dr Thomas Szasz is a kook. he's been entirely panned by every notable psychologist and doctor for simply extrapolating what he thinks are faults as fact. they are not FACT, but his OPINION, and should remain thus.
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zzripz Stranger Registered: 12/23/08 Posts: 8,292 Loc: Manchester, UK Last seen: 7 years, 3 months |
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you mean the ones making a packet by pushing big pharma drugs? Them?
Edited by zzripz (03/16/15 06:15 PM)
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