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 s240779     Registered: 12/07/10 Posts: 14,636 Last seen: 4 hours, 12 minutes |
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IP6 + Inositol: Nature's Medicine For The Millennium! - Prof AbulKalam M Shamsuddin MD PhD - pp. 326-329:
Clinically, inositol level is decreased in the cerebrospinal fluid of patients with depression. "Demonstration that inositol enters the brain after peripheral administration provides a basis for pharmacological intervention in psychiatric disorders" conclude the authors (Agam et al 1994). Two clinical trials have shown that large amounts of inositol can improve mental depression. A double-blind controlled clinical trial was performed at the Ben Gurion University of the Negev by the Israeli Ministry of Health on clinically depressed patients. When 28 depressed patients were given 12 grams of inositol a day, a statistically significant overall benefit was found for inositol treatment when compared to the placebo group. This improvement was detected as early as week 4 on the Hamilton Depression scale, the standard measure to assess the effectiveness of an antidepressant substance (Levine, 1977). The conventional treatments for patients with anxiety disorders in the United States include antidepressants which are not without their own side-effects such as sleep disturbances, sexual dysfunction, gastrointestinal problems, weight gain etc. In that regard natural remedies may be more appealing and inositol offers itself to that service! Panic disorder The following two studies also from Israel should be convincing enough: Benjamin et al (1995) examined the effectiveness of inositol versus placebo in panic disorder in a double-blind crossover trial involving 21 patients. The patients were assigned to either 12g/day of inositol or placebo for 4 weeks each. All of the patients then crossed over to the alternate treatment arm for additional 4 weeks. The baseline number of panic attacks per week for all subjects was 9.7±l5, which decreased to 3.7±4 in subjects taking inositol (significant at P=.04) as opposed to 6.319 in the placebo arm. The mean scores of severity of panic attacks also decreased significantly from 72±140 at baseline for all subjects to 31±50 during the placebo arm and to 11±11 during inositol treatment; the difference being quite significant at P=0.007. In another study by the same group, 20 patients with panic disorder with or without agoraphobia (extreme fear of open space) were given either inositol (up to 18/day) or fluvoxamine (up to 150 mg/day) for 4 weeks in a double-blind, controlled, random-order crossover study (Palatnik et al 2001). Compared to the conventional drug fluvoxamine that decreased weekly panic attacks from 5.8±4 at baseline to 3.4±4 at endpoint, the frequency of panic attacks in the patients in inositol group decreased from 7.2±4 to 3.1±3. Statistical analysis showed that the inositol was marginally more effective than fluvoxamine from baseline to endpoint for treating the number of panic attacks (P=.049). The two treatments were considered equally effective at reducing Hamilton Anxiety scores, agoraphobia scores, and Clinical Global Impression of Severity (CGI-S) scores. Not unexpectedly, side effects were minimal with inositol treatment, as opposed to frequent nausea and tiredness associated fluvoxamine. 'All things considered', inositol was more effective than fluvoxamine in reducing the number of panic attacks with less adverse effects (Palatnik et al 2001). Obsessive-Compulsive Disorder (OCD) The effectiveness of inositol in OCD was studied in 13 patients in a double-blind controlled crossover trial of 18g/day of inositol or placebo for 6 weeks each. The patients had significantly lower scores on the Y-BOCS2 when taking inositol than when taking placebo (P=.009) (Fux et al 1996) Carey et al (2004) in Cape Town, South Africa studied the effect of inositol treatment on brain function in OCD through single-photon emission computed tomography. Fourteen subjects underwent single-photon emission computed tomography before and after receiving inositol for 12 weeks. Following treatment with inositol there was deactivation in OCD responders relative to non-responders in several areas of the brain with significant reductions in Y-BOCS and CGI-S3 scores. These results not only show the efficacy of inositol in OCD, but also suggest that inositol may exert its clinical effects through alternate neuronal circuitry to the selective serotonin reuptake inhibitors (SSRIs) – the anti-depressants. 2 Yale-Brown obsessive compulsive scale tests the severity of OCD 3 Clinical global impression scale commonly used measures of symptom severity, treatment-response and the efficacy of treatments in studies of patients with mental disorders. Benjamin, J., Agam, G., Levine, J., Bersudsky, Y., Kofman, O., Belmaker, R.H.: Inositol treatment in psychiatry. Psychopharmacol Bull. 31:167-75. 1995 Benjamin, J., Levine, J., Fux, M., Aviv, A., Levy, D., Belmaker, R.H. Double-blind, placebo-controlled, crossover trial of inositol treatment for panic disorder. Am J Psychiatry 152:1084-1086, 1995. Fux, M., Levine, J., Aviv, A., Belmaker, R.H. Inositol treatment of obsessive-compulsive disorder. Am J Psychiatry 153:1219-1221, 1996. Palatnik, A., Frolov, K., Fux, M., Benjamin, J.: Double-blind, controlled, crossover trial of inositol versus fluvoxamine for the treatment of panic disorder. J Clin Psychopharm 21:335–339,2001. Depression-free, Naturally - Joan Mathews-Larson: Inositol: This B vitamin is required for the proper action of brain neurotransmitters such as serotonin and acetylcholine. Thus, low inositol levels induce depression. Furthermore, inositol has been shown to be efective in stopping panic disorders. Unlike drugs, this water-soluble vitamin has no significant side effects. (p. 49) Another B vitamin, inositol, has kept a low profile for a long time. Researchers were not able to demonstrate deficiency symptoms until just recently. In the eighties, studies at the Princeton Brain Bio Center showed that inositol has quantitative brain effects similar to those of the tranquilizer Librium. At that time, Carl Pfeiffer knew inositol was interacting with powerful brain neurotransmitters, but he did not understand how loading inositol by supplementation might affect receptor function. In 1996, Israeli researchers discovered that inositol converts into a substance that regulates the action of serotonin within nerve cells. This knowledge allowed them to treat obsessive-compulsive disorder (persistent intrusive thoughts and senseless repetive behavior) successfully by giving 18 grams of powdered inositol three times a day. It worked as well and as quickly as the selective serotonin reuptake inhibitors (SSRIs) Prozac and Luvox, which are the accepted treatments for obsessive-compulsive disorder—and it acccomplised this without drug side effects. Inositol's ability to regulate serotonin, a calming neurotransmitter, has also been applied to treating panic disorder, and it has proven itself a powerful brain chemical in reducing anxiety. (pp. 157-158) It is good to take tryptophan with the B vitamin inositol, which changes into a substance that regulates serotonin's effectiveness within nerve cells. A double-blind study reported in 1995 confirms inositol's effectiveness with depression. Inositol powder is sweet and good-tasting. One and a half teaspoonsful three times daily is the researched dosage according to the American Journal of Psychiatry. (p. 182) An Israeli study recently appearing in the American Journal of Psychiatry reports that the B vitamin inositol effectively eliminates symptoms of obsessive-compulsive disorder over a six-week period, and unlike current drug treatments, it has absolutely no side effects! Inositol works by regulating the action of serotonin within the nerve cells; it has a soothing effect on spinal cord nerves, the brain, and cerebrospinal fluid, and produces antianxiety effects similar to the drug Librium. (pp. 228-229) J. Levine, et al., "Double Blind, Controlled Trial of Inositol Treatment of Depression," American Journal of Psychiatry 152 (1995): 792–94. p. 336 R. E. Banks, et al., "Incorporation of Inositol into the Phosphornositides of Lympho Blastoid Cell Lines Established from Bipolar Manic-Depressive Patients," Journal of Affective Disorders, no. 1 (May 19, 1990): 1–8. p. 338 R. Vadnel, et al., "Role of Inositol in Treatment of Psychiatric Disorders: Basic and Chemical Aspects," CNS DRUGS 7, no. 1 (January 1997): 6–16. p. 340 I am the Inositol expert. Yes many studies have confirmed it's effectiveness. Do a search cos it will bore the regulars here............. If you cannot find my stuff, PM me and I'll sort you some bookmarks. One final thing. Nothing works for everyone! But it has proven to be as effective as AD's and anxiety meds (usually AD and anxiety meds are the same)... Go to health shop. Buy a couple of bottles and some b-vit complex. Take a few grams of inositol per day... one day thousands will rave about inositol.......... 26-Jul-2001, GaryWary, http://www.elitefitness.com/foru If you're using it for depression/anxiety, I like 3 divided doses over the course of the day, for you that would be before school, after school, before bed. 6 grams is a good starting dose, you may need to adjust upwards, you will know relatively quick as it acts fast in those it helps. It has been studied up to 50 gr/day with no adverse sides, so don't worry about splurging. Find a powder vs. cap, it is a lot more cost effective. BTW, you can spoon it directly into your mouth, it is a vitamin B sugar, so it is pretty palatable and just melts in your mouth. If you are using it for sleep, a couple grams before bed should be sufficient. 07-May-2003, themachine, http://www.elitefitness.com/foru Take note of the following: Why combine Inositol with IP6? The scientific premise has been that the addition of inositol to IP6 in a 1:1 molar ratio would yield more of the lower inositol phosphate, IP3 (Ins 1,4,5 P3 is the most active isomer) a key regulator in cell, thereby increasing the efficiency of IP6. Indeed experiments have proven that the combination has resulted in synergistic, most consistent and safe anti-cancer, and immune enhancing effect.  From the safety + efficacy point of view, while both inositol and IP6 independently show anti-cancer action, their effects are however variable in different models and species. In some models, IP6-alone though reduced the overall tumor incidence, alarmingly it had increased the size of the tumors in the animals that did not respond to it. The anti-cancer effect of Inositol in vivo is relatively week (in vitro it does not have anti-cancer action as it is an essential compound for culturing cells in the lab). However, when all the various tumor parameters (tumor number, tumor burden, incidence etc) were taken into account, the combination of IP6+Inositol was the safest and the most effective (please consult Table 1 in page 1056 of the original paper in the Journal "Carcinogenesis" 1995 volume 16 and other related papers).* Thus, based on the available lab data, for safety and efficacy, human clinical trials must include the combination of IP6 + Inositol and NOT IP6 alone.*Vucenik, I., Yang, G-Y., and Shamsuddin, A.M.: Inositol hexaphosphate and inositol inhibits DMBA-induced rat mammary cancer, Carcinogenesis 16:1055-1058, 1995. | http://carcin.oxfordjournals.org http://ip-6.net/FAQ.html Also, the above site belongs to the first author quoted in this post. It contains detailed information along with colorful diagrams on how inositol functions. Edited by s240779 (02/07/13 08:33 AM)
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wikiInositol or its phosphates and associated lipids are found in many foods, in particular fruit, especially cantaloupe and oranges- Some preliminary results of studies on high-dose inositol supplements show promising results for people suffering from problems such as bulimia, panic disorder, obsessive-compulsive disorder, agoraphobia, and unipolar and bipolar depression.
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s240779 Registered: 12/07/10 Posts: 14,636 Last seen: 4 hours, 12 minutes |
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So what does inositol do in the human body? Well, tons of things, actually. It is a key part of the second messenger system. Que? Well, in the pony express line that is a cell, surface proteins and receptor complexes (the mailer) hand off signals to the second messengers (the riders on the ponies) who pass the signal along eventually to other cell systems (the message recipients), such as the nucleus. All the major neurotransmitter systems use inositol as part of their messaging line - I'm talking dopamine, norepinephrine, serotonin, acetylcholine… "The potential importance of inositol in psychiatric disorders is thereby evident when one considers the number of receptor types/subtypes that interact with this signal transduction pathway."
Biochem nerds will already know this next bit, but biochem nerd wanna-be's listen up (the rest of you can skip to after the picture, because this bit is a little dry) => Inositol is used to make inositol triphosphate (IP3) and diacylglycerol (DAG). IP3 binds IP3 receptors, particularly calcium channels in the endoplasmic reticulum, which will cause calcium levels in the cytoplasm to increase, causing a cascade of intracellular activity. Calcium and DAG can activate protein kinase C, which (as all kinases do) goes around sticking phosphates on things, leading to altered activity. Anyone learning molecular biology and biochemistry will see this pathway mentioned so many times your eyeballs will glaze over. So, in short, inositol is vital. Picture! (from wikipedia):  http://evolutionarypsychiatry.bl mrsD: My husband and son are both using inositol for anxiety. It works! 2grams /day is the typical dose. They do skip every now and then, feeling confident, but always return to it. Chemar: Faith just adding that Inositol has really helped my son with his OCD/anxiety too 07-14-2007, http://neurotalk.psychcentral.co Hi and welcome my son had a similar problem tho he was taking 5HTP (5 hydroxy tryptophan) rather than L tryptophan he had used the 5HTP for a number of years to help with his OCD related to Tourette Syndrome and it really helped him! however, he found it eventually started making him feel edgy, restless and "wired" so stopped he now uses Inositol instead and finds it much better with no side effects. he needs quite a high dose (12 gm) but is very pleased with the results. It is usually recommended to take vitB6 with it (as also recommended with tryptophan and 5HTP) 03-19-2009, Chemar, http://neurotalk.psychcentral.co Inositol has greatly helped my depression, it really works. It has completely and totally reduced my mood problems. ... It feels as if I had a car which badly needed a wheel alignment, and inositol has given me smooth steady control over the car ;D ... All in all I feel more functional and sane now that I am not laughing hysterically tripping on my mind one day drawing frenetically and feeling like I understand everything, but then 2 days later I am crying in my car feeling like it is hard to move my body and thinking. Yea, that's a good thing I don't have that problem anymore, I was way lower functioning then. 05-15-2011, ItsTheWooo2, http://evolutionarypsychiatry.bl Edited by s240779 (01/28/13 08:12 PM)
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