yeah I had never had it that bad either, I can completely relate to the feeling though. oddly jwh-018 had a 1-2 day aftereffect of making my anxiety much less and aniracetam also helped a lot. Then I was able to learn how to get over it from having experience with a lot less anxiety.

From my own experience it seems like a lot of things can be solved just by making sure your brain is at it's optimal health(eating well, nutritional supplements, exercise, sleep habits). certain nutritional supplements really helped. fish oil I'd recommend a lot, citicoline feels like it would have definitely helped at the time, and aniracetam would almost definitely help. you can get all of these for cheap off the internet.


scientific reasoning for aniracetam(since it seems perfect for anxiety)(please forgive me for the large amount of text ):

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After a confirmed test of the anxiolytic efficacy in a mouse model, haloperidol, mecamylamine, and ketanserin were applied to determine the pathways aniracetam depends on to exert its anti-anxiety effects. Haloperidol completely reversed the anxiolytic effects, and mecamylamine and ketanserin nearly completely reversed the effects. This shows that aniracetam's anxiolytic mechanism is facilitated by D2/D3, nACh, and 5-HT2A receptors

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Muscarinic cholinergic activation may play a role in the improvement of circadian temporal regulation of behavior seen with aniracetam treatment, while the anxiolytic and antidepressant effects appear to be mediated by nicotinic receptor activation, as they can be blocked by the nicotinic ACh receptor antagonist mecamylamine [27, 37].

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Administration of aniracetam to SHRSP, which normally have dopaminergic hypofunction, increases dopamine (DA) and serotonin (5-HT) release in the prefrontal cortex, basolateral amygdala, and dorsal hippocampus, areas which play important roles in regulation of emotion and mood, motivation, sleep-wakefulness, and cognition [29] [37]. Aniracetam also prevents the age-related decrease in monoamine levels in rats [38]. The monoaminergic effects have been primarily attributed to the metabolites N-anisoyl-GABA and p-anisic acid [2].

Both cholinergic and glutamatergic stimulation are involved in aniracetam-induced monoamine release [2]. Both stimulation of nicotinic cholinergic receptors and consequently NMDA receptors and a direct effect on NMDA receptors in the ventral tegmental area and dorsal raphe nucleus may respectively lead to an increase in dopamine and both dopamine and serotonin [27]. In short, there are many experimentally supported mechanisms by which aniracetam increases monoamine levels, including cholinergic-monoaminergic, glutamatergic-monoaminergic, and cholinergic-glutamatergic-monoaminergic interactions [2]. Behaviorally, the increases in DA and 5-HT are implicated in the anxiolytic and antidepressant effects of aniracetam, and partially implicated in other effects, such as improved temporal regulation of behavior [2, 27].

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There have also been a number of studies on healthy adult or young animals, with either positive or equivocal results. Gouliaev and Senning reference studies showing aniracetam to improve learning in healthy monkeys, as well as studies showing it to improve passive avoidance, learning, and maze performance in healthy rats at dosages ranging from 30-50 mg/kg i.p. and 12.5-800 mg/kg orally [1]. Other literature has commented on aniracetam's ability to improve cognitive function in healthy animals [18].

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Like other nootropics, aniracetam is very safe, although it may be slightly more toxic than piracetam. The LD50 is 4.5 g/kg orally in rats and 5.0 g/kg orally in mice [1]; for an 80 kg human, this would equate to over 500 times the standard dose of 1.5 g. Animal studies have not found evidence of toxic effects in normal animals, no teratogenic effects have been found, and aniracetam does not influence food intake in rodents [1, 3, 24]. Monkeys do not self-administer aniracetam, and after 31 days of daily dosing, no physical or behavioral withdrawal symptoms are observed upon discontinuation [34].

No drug interactions are known and there are no reported cases of overdose. It is recommended that those with renal insufficiency lower their dose however [24]. In human trials, side effects are rare, but some have been reported, such as insomnia and anxiety. These side effects disappear if the doses are restricted to earlier in the day [24], indicating that they are due to aniracetam’s stimulating effect.

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