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Mushrooms, Mycology and Psychedelics > The Psychedelic Experience
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Mushroom-Hut Shop: Mono Tub Substrate

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All PEA's Damaging like MDMA?
    #8312107 -

I want to try PEA's, namely mescaline, but I'm very against MDMA because of its hangover and brain damage. What I want to know is, would other PEA's harm my brain like MDMA would? I don't need any of that, "it's not damaging, I didn't get a hangover." It's pretty obvious, people. Read first hand accounts. Thanks in advance!


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I have never commited an illegal act. All illegal activities mentioned here are clearly hypothetical and fictional and are solely mentioned for the purpose of observing the reactions of other patrons of the forum.

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Re: All PEA's Damaging like MDMA? [Re: coleus]
    #8312133 -

The thing with MDMA is that when it is metabolized in the synapse it releases a free-radical (super-charged oxygen atom) that damages seratonin receptor sites. Taking anti-oxydants like vitamin E or C in high doses before during and after the MDMA experience can help significantly reduce this damage.

of course that is MDMA...

As for other phenethylamines I've never heard of anything similar. *Maybe* it happens with some of the 2C- analogues, but I don't think they've done enough research to know for sure.

As for mescaline, I've never heard of any physical damage occurring. As far as I understand it mescaline is just as safe if not safer than psilocybin.


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"This day is a lover..."

~Rumi

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Re: All PEA's Damaging like MDMA? [Re: Nunbuh_Chrubble]
    #8312147 -

Hmm yeah thanks. Anyone who's read some of my other posts knows I'm a sticler for brain damage.


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I have never commited an illegal act. All illegal activities mentioned here are clearly hypothetical and fictional and are solely mentioned for the purpose of observing the reactions of other patrons of the forum.

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Re: All PEA's Damaging like MDMA? [Re: coleus]
    #8312236 -

http://www.wired.com/medtech/health/news/2005/11/69477

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Re: All PEA's Damaging like MDMA? [Re: coleus]
    #8312292 -

coleus said:
Anyone who's read some of my other posts knows I'm a sticler for brain damage.


I've read many first hand MDMA reports and I didn't get the impression that people feel like they've damaged their brains.

I'm open to this possibility, but I haven't run into any real evidence of MDMA causing brain damage. I think MDMA along with the rest of the psychedelic phenethylamines are, for the most part, very safe if taken at the appropriate dosage level.


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Let the State Disintegrate
-Leary

Edited by Mark_W (04/21/08 09:27 PM)

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Re: All PEA's Damaging like MDMA? [Re: Mark_W]
    #8312327 -

If it makes any difference, i feel that my brain has been damaged by MDMA use.

Also, it's important to add that i was an educated and responsible user and haven't taken many pills in my life time, and none for over a year now.


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for all y’all niggaz out there that be puffin shit
when the music go on, y’all listen to this alright

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Re: All PEA's Damaging like MDMA? [Re: Mark_W]
    #8312351 -

The trick with MDMA is that it causes ridiculous amounts of neuroadaptation in the serotonin system. Not to be confused with neurotoxicity.

Any modern research on MDMA that I've read suggests users regain full mental facilities after a year or so, even after very heavy usage. Just like SSRI antidepressants, the brain adapts to the abnormal chemical levels and shuts down the serotonin cycle somewhat to compensate. This only occurs with prolonged, regular use (just like an antidepressant). And again, there's the suggestion there are few truly long term side effects, though we're really too early in the game to determine that for sure.

While there have certainly been anecdotal reports of what would appear to be long term damage, no study has actually found this to be the case. All they've found is, again, neuroadaptation.

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Re: All PEA's Damaging like MDMA? [Re: Nunbuh_Chrubble]
    #8312391 -

Nunbuh_Chrubble said:
Taking anti-oxydants like vitamin E or C in high doses before during and after the MDMA experience can help significantly reduce this damage.


shit i never heard of that before, thanks nunbuh

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Re: All PEA's Damaging like MDMA? [Re: TheHauntingSoul]
    #8313381 -

Quote:
In the first study of its kind, researchers have found that peyote -- for now, the only legal hallucinogenic drug in the United States

By contrast, both alcohol and marijuana are considered bad for the brain if overused.


That makes me doubt this article, but it wasn't the direct report, so :thumbup:. See, I told you people like toastdth would jump in with their extrapolations of the issue because they don't want to accept the fact that they're kissing their serotonin receptors goodbye.I wish it wasn't damaging though, I'd be all over that shit! :crazy2:
And by the way there are people that feel like they can't get as happy as they used to, and someone osted a great story about a long time E freak that they knew that was depressed beyond description and tried to commit suicide multiple times.


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I have never commited an illegal act. All illegal activities mentioned here are clearly hypothetical and fictional and are solely mentioned for the purpose of observing the reactions of other patrons of the forum.

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Re: All PEA's Damaging like MDMA? [Re: toastdth]
    #8313432 -

toastdth said:
The trick with MDMA is that it causes ridiculous amounts of neuroadaptation in the serotonin system.  Not to be confused with neurotoxicity.





:werd:


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Feed Your Head.

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Re: All PEA's Damaging like MDMA? [Re: why_not_me]
    #8313994 -

Quote:
In the first study of its kind, researchers have found that peyote -- for now, the only legal hallucinogenic drug in the United States


Sorry, but I've been thinking about this, and it's especially funny because:
a) Peyotes illegal.
and b) There are hundreds of legal hallucinogens, both common and rare.

100th post btw :thumbup:


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I have never commited an illegal act. All illegal activities mentioned here are clearly hypothetical and fictional and are solely mentioned for the purpose of observing the reactions of other patrons of the forum.

Edited by coleus (04/22/08 11:09 AM)

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Re: All PEA's Damaging like MDMA? [Re: coleus]
    #8333804 -

Quote:
Taking anti-oxydants like vitamin E or C in high doses before during and after the MDMA experience can help significantly reduce this damage.


Sorry, I just needed to add something for everybody's safety. Vitamin E is fat soluble, so taking it in large doses is likely more harmful then helpful since it could make your fat toxic because your body can't use the fat without getting shitloads of Vitamin E. Remember, don't OD on A, E, D, or K.


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I have never commited an illegal act. All illegal activities mentioned here are clearly hypothetical and fictional and are solely mentioned for the purpose of observing the reactions of other patrons of the forum.

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Re: All PEA's Damaging like MDMA? [Re: coleus]
    #8333834 -

I found a synonymous thread:

http://www.shroomery.org/forums/showflat.php/Number/5236281#5236281


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I have never commited an illegal act. All illegal activities mentioned here are clearly hypothetical and fictional and are solely mentioned for the purpose of observing the reactions of other patrons of the forum.

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Mushroom-Hut Shop: Mono Tub Substrate

Mushrooms, Mycology and Psychedelics > The Psychedelic Experience
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