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Mushrooms, Mycology and Psychedelics > The Psychedelic Experience
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Important: How SAFE are shrooms in this situation?
    #794721 -

Will either of the following have any negative interactions with mushrooms? ---
*Amphetamine (Adderall)
*Prescription Antihistamines like Claritin, etc.

I'm talking about prescription doses of each...Probably a 10 or 20mg dose of Adderall is in question.

Any problems with those drugs and mushroom interaction?

THANKS!


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Disclaimer: Everything I've typed is of a fictional nature.

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Re: Important: How SAFE are shrooms in this situation? [Re: greenlight]
    #794891 -

I have a book that has drug interactions but it doesnt list shrooms...it will have like viagra+marijuanna+alcohol+cocaine+heroine=death < < just an example of my own not an actual one from the book...
I found this might give u some ideas
Background: Hallucinogenic fungi have been used in divinatory or religious contexts for at least 3000 years. However, not until the 1950s were the involved species of fungi identified and the chemical nature of active substances determined.

In general, 2 groups of mushrooms with significant psychoactive effects exist.


Mushrooms containing ibotenic acid and muscimol (isoxazoles), including Amanita gemmata, Amanita muscaria (fly agaric), and Amanita pantherina (the panther), comprise the first group. These are not to be confused with deadly Amanita phalloides, Amanita verna, and Amanita virosa. For centuries, A muscaria has been consumed in central Asia as a hallucinogen. Some Siberian tribes report that 3 fresh A muscaria mushrooms can be lethal, while others claim that eating as many as 21 of these mushrooms is safe.

Psilocybin-containing mushrooms, including Psilocybe caerulipes, Psilocybe cubensis, Gymnopilus spectabilis, Panaeolus species (eg, Panaeolus foenisecii), and Psathyrella foenisecii, comprise the second group of mushrooms with psychoactive effects.
Mushrooms containing ibotenic acid and muscimol and those containing psilocybin are New World fungal hallucinogens. Reports of toxicity associated with this group of mushrooms have increased because of their growing popularity as hallucinogens.


Pathophysiology: Ibotenic acid is an agonist at central glutamic acid receptors; its decarboxylated derivative is an agonist at gamma-amino butyric acid receptors. Central effects of these hallucinogenic mushrooms are thought to be caused by these actions. Although muscarinic acid originally was isolated from A muscaria, the clinical syndrome does not suggest marked significance; in fact, anticholinergic findings may be observed.

The psilocybin group contains the indoles psilocybin and psilocin. Psilocin and its phosphate ester, psilocybin, are similar in structure to lysergic acid diethylamide (LSD). They are structural analogues of serotonin (5-hydroxytryptamine); thus, hallucinogenic effects probably are mediated through effects on serotonergic receptors.


Frequency:


In the US: Estimating frequency of hallucinogenic mushroom use is difficult. Psilocybin-containing mushrooms are popular recreational drugs of abuse.
Mortality/Morbidity:

Mortality from hallucinogenic mushrooms is very rare.
CLINICAL Section 3 of 9

History: Hallucinogenic mushrooms usually are ingested for their psychoactive properties.

Mushrooms containing ibotenic acid and muscimol
Symptoms begin 30 minutes to 1 hour postingestion; however, symptom onset rarely may be delayed as long as 3 hours.
Hallucinations may be accompanied by dysarthria, dystaxia, and muscle cramps and may persist for as long as 8 hours.
Central nervous system (CNS) effects range from agitation to coma.
Heavy intoxication may cause vomiting, diarrhea, and seizures.
Fatal A pantherina poisonings have been reported in the Pacific Northwest.
Psilocybin-containing mushrooms
Alterations in perception begin within 30 minutes and subside after 6 hours.
Widely varying CNS manifestations, including euphoria and visual hallucinations, have been reported.
Patients presenting in the ED may experience more unpleasant effects such as fear, agitation, confusion and delirium, psychosis, and schizophrenialike syndromes.
Symptoms may include nausea and sympathomimetic activity such as mydriasis and tachycardia.
Frequent use may cause transient elevation of hepatic enzymes.
Symptoms in children include hyperpyrexia and seizures.
Physical: Predominant findings in these intoxications are neurologic.

Fever, tachycardia, and hypotension may occur because of agitation.

Neurologic findings
Ataxia
Incoordination
Confusion
Delirium
Psychosis

I did a search@www.dogpile.com for drug interactions

interesting none the less lol


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Edited by ShroomlessInOkla (08/03/02 11:11 PM)

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Re: Important: How SAFE are shrooms in this situation? [Re: greenlight]
    #795025 -

Antihistamines generally have a dulling effect & might snuff out the clarity of the Trip.

Timothy Leary wrote in his "The Psychedelic Experience" that amphetamines boost LSD, Psilocybine and Mesc.

Stanislav Grof (LSD therapist & my Psychedelic Idol) states that Ritalin may be used to intensify stuff. Allthough Ritalin inhibits Dopamine re-uptake just like Cocaine does Amphetamines are similar in that they cause a massive release of Dopamine.

Expect a highly electric trip with hightened euphoria & an increased likeliness it'll be too much and other unpleasantness.

I have a somewhat related experience regarding Stimulants + Psychedelics: I've vowed to never again use Stimulants since my first Amphetamine gave me a manageable "Drug Psychosis" (was not quite out of it but not myself either) that lasted for weeks until my friendly Doc dropped the Haldol Bomb.

I abstained from drinking coffee and tea for a week and then dropped a 500mg Caffe?ne capsule (raises Dopamine, Noradrenaline etc.) along with 20mgs of the Psychedelic called 2CB (4-Bromo-2,5-Dimethoxyphenethylamine, one of my favorites) that has some stimulant properties by itself.
I was completely blown away. It was highly electric, stronger then the speed I told about, rainbow colors flew all over the place and I had a monster of a good time, whiteknuckledly clinging onto my sanity in the Highest of spirits.
Man: in some ways it was WAY STRONGER than the 1/8 of really strong Shrooms I took back then (Level 5) It was fun but years have passed & i've never repeated the experiment.

Psychedelics + Stimulants? Be VERY,VERY CAREFUL. You might not like it, so try the Caffe?ne trick first after abstinence. I strongly dislike & discourage use of Amphetamines, btw. Seen a man go trough a living hell & not return. Shooting up 1 gram of Amphetamine a day, he's become a physical and mental wreck.




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Re: Important: How SAFE are shrooms in this situation? [Re: Asante]
    #795098 -

Wiccan_Seeker: I'd be using no more than a 10mg Adderall...


I was considering 2g or 2.5g of mushrooms with the 10mg Adderall...

That doesn't sound "dangerous" does it?


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Disclaimer: Everything I've typed is of a fictional nature.

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Re: Important: How SAFE are shrooms in this situation? *DELETED* [Re: Asante]
    #795180 -

Post deleted by 905

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Re: Important: How SAFE are shrooms in this situation? [Re: greenlight]
    #795182 -

Hi Greenlite!

Right off the bat I'm highly conservative in regard to Amphetamines & such. Adderal... Correct me if I'm wrong but I believe to have read somewhere that that's Methamphetamine, aka Crystal Meth in pill form.

Methamphetamine is 2x as potent as straight Amphetamine so a 10mg dose would be equal to 20mg of Amphetamine, the Dutch max. medical dose. I'm not talking about strenght o/t FX, but that's alot of Amphetamine, if you haven't built a tolerance to it. Amphetamines are hard on the liver and may cause the rupture of small bloodvessels, particularly in the lungs & brain.

Needless to say: I'm completely against Amphetamine use, but that doesn't help you so I'm moving in the realm of speculation here.

Combinations of drugs are usually dangerous because they meet eachother in for instance the brain and produce synergism (mutual potentiation of [side]effects).
30mg of Amphetamine (15mg of Meth/Adderal) may induce drug psychosis as it did in me some years ago. Meth is hard on the liver but Psilocybin is readily destroyed by different mechanisms and the mutual MAO pathway. I would guess that if 10mg to you is quite subtle & without adverse effects your liver won't get in much more trouble, probably less than with 20mg of Adderal alone. (This can be handled, but you really should drink alot of Water/Fruit Juice/7-UP Light since both tend to dehydrate you)
All in all I'd GUESS your liver won't be hurt provided you can stand the Adderal.

Then there's the brain. Meth opens the Dopamine sluice wide. Psilocybin and LSD inhibit Serotonin and enhance the Dopamine output. The combined Dopaminergic enhancements probably will lead to synergism as is claimed in the literature. Your Meth will be more Meth and your Shroom will be more Shroom, probably. Sounds to me like one f#ck of a ride, not necessarily a pleasant one due to sheer intensity. Suppose the mutual synergism would be 200%. Do you think you can handle 20mg of Adderal on top of 4-5gr of Shrooms? I sure can't!

High Dopamine can be highly pleasureable. But it can also lead to (Drug) Psychosis, temporary or something that needs to be stopped. After all: you're combining a psychological enhancer (Shrooms) with a strong Dopamine enhancer notorious for it's psychotic reactions.

I'm a low dose & cautious guy. I wouldn't go for it. But if you must I insist you start with amounts like 1-1.5gr of Shrooms and a mere 5mg of Adderal just to be safe. (can't guarantee that's safe, though, no solid refs, no experience with the combi) It's much better to underhit than to overshoot the mark and get a crisis instead of a high. Subtle doses of stuff may give wild effects under the magnifying glass of Psilocybin. The main danger here is psychological, not in your body. Shrooms are virtually non-toxic in the amounts we're talking about here and low-tox stuff generally doesn't give physical dangers in a mix.
But losing your mind at 100.000volts is no picnick either. It's best to be safe & try again a few weeks later than to overshoot the mark and go out of your skull in a BAD way. In my 2CB + Caffe?ne adventure i could barely hold on. Now that's a WEAK Psychedelic + a WEAK Stimulant. Take care of your head.
Too cautious? Better safe in Heaven than sorry in Hell!

PLEASE POST YOUR RESULTS HERE: we're very curious people at the Shroomery! I'd really like your info on how it went...









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Re: Important: How SAFE are shrooms in this situation? [Re: ]
    #795188 -

Cocaine? Probably because of the reasons mentioned above plus you might take too big a snort of Cocaine on top of your Trip. Shrooms and LSD magnify other drugs. If you should take a combi, take less than you would without additions.

Cocaine + LSD... Not my party, but what does it feel like??? Very curious & eager to learn!


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Edited by Asante (08/04/02 07:45 AM)

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Re: Important: How SAFE are shrooms in this situation? [Re: Asante]
    #795235 -

The first time i tried cocaine was on 3 hits...was alot of fun ...I found it to be a vary smooth ride


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Re: Important: How SAFE are shrooms in this situation? [Re: Asante]
    #796373 -

Thanks for the reply Wiccan Seeker!

"Correct me if I'm wrong but I believe to have read somewhere that that's Methamphetamine, aka Crystal Meth in pill form."

No, they do not contain methamphetamine...

A 10mg Adderall pill contains 2.5 mg each of the following:
Dextroamphetamine Saccharate
Amphetamine Aspartate
Dextroamphetamine Sulfate USP
Amphetamine Sulfate USP...

Also, (according to rxlist.com) the "total amphetamine base equivalence" in a 10mg Adderall pill is only 6.3mg ... Which, I believe, means that a 10mg Adderall is equal to only 6.3mg "pure" Amphetamine.

You can see the data reported above at this URL: http://www.rxlist.com/cgi/generic/amphet.htm

I've taken 10mg Adderalls a few times before, with no ill side effects. I found it to be a more enjoyable, more productive stimulant than caffeine ever was. I don't plan on ever using it "recreationally"...

The plan to take a 10mg Adderall during a trip was to hopefully keep me a bit more "awake" and "up" -- more willing to get up and go experiment with something rather than *lay there* ... The plan was never to get "really fucking high" on Adderall, or anything like that

Anyway, what do you think about prescription antihistamines?

A friend of mine takes them. Are there any known negative interactions?

Thanks again for all replies.



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Re: Important: How SAFE are shrooms in this situation? [Re: greenlight]
    #796780 -

Just have read that here on the Shroomery. There's no Adderall in my country, nor am I interested in them. But: they're of lower dose than I thought, allthough Dextroamphetamine is twice as potent as racemic (normal) Amphetamine, just like Meth is. Great you don't want to dive too deeply into Amphetamines

Antihistamines? Well, there's the old ones and the newer ones. Of the old ones I've personally tried Promethazine. Heavy stuff: massive sedation for me at a 25mg dose, a very dull effect, not particularly pleasant. But interactions? Since they're two different things alltogether I think you're in the clear as long as you don't take above-medical doses of the histamine antagonist. It likely diminishes both clarity and intenseness of the Trip on account of it being sedative in action. Which antihistamine are we talking about. Don't know them all, though, I have most knowledge about the older ones & they just about all boil down to the same things.

Some sources claim the newer ones are sedative in action too.
Hope to have helped, but be very cautious about combinations!


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Re: Important: How SAFE are shrooms in this situation? [Re: Asante]
    #797115 -

I wonder if not taking the prescription antihistamine the day of the trip would make a difference...


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Mushrooms, Mycology and Psychedelics > The Psychedelic Experience
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