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OfflineIce House Shaman
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Registered: 02/25/03
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Orally active DMT
    #6794982 - 04/16/07 01:34 PM (16 years, 11 months ago)

Anyone out there know weather or not an MAO-B inhibitor can be used with DMT in order to make it orally active. I have come across a supply of "Deprenyl", Deprenyl is advertised or described as an MAO-B inhibitor it does not require a prescription. I prefer to do my DMT orally so I am looking for a new MAOI I can ingest with my DMT. I have been using Syrian Rue in the past as an MAOI but it never fails to cause an uncomfortable ammount of nausea. Bottom line is I'm looking for an alternative solution to Rue and I am not interested in drinking any concoctions. I am sure that its not the DMT causing the nausea. I have had an opportunity to take DMT with a prescription MAOI called MARPLAN a couple of years back. DMT taken with Marplan was perfect. Anyone?

Respect,

IHS


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Invisibletruffleupagus
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Re: Orally active DMT [Re: Ice House Shaman]
    #6795101 - 04/16/07 02:04 PM (16 years, 11 months ago)

I'm not sure exactly what the "B" is in MAO-B but it seems like it should work. DMT combined with prescription or OTC MAOIs is called pharmahuasca I believe.

Have you tried just using Caapi though or have you only used Rue? Caapi is, after all, THE ayahuasca vine. I'm pretty sure Rue is known to cause more nausea.

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Invisibletruffleupagus
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Re: Orally active DMT [Re: truffleupagus]
    #6795145 - 04/16/07 02:19 PM (16 years, 11 months ago)

As far as I can see there are MAOIs, MAO-A inhibitors and MAO-B inhibitors. Both MAO-A and MAO-B are types of MAOIs. Because of this, I see no reason why you couldn't take your deprenyl with DMT.

Let someone with a better background in chemistry confirm that first though.

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InvisibleEllisDSox
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Registered: 01/22/07
Posts: 25,730
Re: Orally active DMT [Re: truffleupagus]
    #6795169 - 04/16/07 02:27 PM (16 years, 11 months ago)

Do NOT use prescription MAOIs in combination with psychedelics. They usually have an extremely (sometimes several days) long duration. Stick to the natural ones.


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OfflineF1234K
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Re: Orally active DMT [Re: EllisDSox]
    #6795441 - 04/16/07 03:40 PM (16 years, 11 months ago)

Syrian rue eaten or smoked i believe.


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OfflineHippie Chemist
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Registered: 04/05/07
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Re: Orally active DMT [Re: F1234K]
    #6795556 - 04/16/07 04:34 PM (16 years, 11 months ago)

What you're looking for is info on "pharmahuasca". Off the top of my head, I don't know enough about using Deprenyl to give good advice.

(a few minutes later)

According to wikipedia, both MAO-A and MAO-B metabolize dopamine, but A breaks down serotonin (tryptamines like DMT), while B breaks down phenethylamines. "MAO-A is particularly important in the catabolism of monoamines ingested in food." Guess where that takes place? The gastrointestinal tract. The gastrointestinal tract is one place where MAO-A is located, while MAO-B is mostly in blood platelets. My guess would be that MAO-B probably wouldn't make DMT active orally. As for Marplan, that was an MAO-A inhibitor; according to the pharmacokinetic data it is metabolized in the liver. Marplan should work just fine with DMT, but I'd prefer to stick with my usual Syrian rue. Just remember to be safe with oral doses of DMT, and always take the MAOI about half an hour before the DMT. It can get pretty intense. Have fun, and be safe!

http://en.wikipedia.org/wiki/MAO-A

http://en.wikipedia.org/wiki/Deprenyl

http://en.wikipedia.org/wiki/Marplan


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Long you live and high you fly
And smiles you'll give and tears you'll cry
And all you touch and all you see
Is all your life will ever be.
-Pink Floyd-

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OfflineHippie Chemist
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Re: Orally active DMT [Re: Hippie Chemist]
    #6795567 - 04/16/07 04:37 PM (16 years, 11 months ago)

If you already have the Syrian rue, you can just do a simple extraction. Then you just have to swallow a little ball of semi-solid goop that glows under a blacklight, and it shouldn't make you have the nausea.


--------------------
Long you live and high you fly
And smiles you'll give and tears you'll cry
And all you touch and all you see
Is all your life will ever be.
-Pink Floyd-

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OfflineIce House Shaman
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Re: Orally active DMT [Re: Hippie Chemist]
    #6795648 - 04/16/07 04:59 PM (16 years, 11 months ago)

Thanks a bunch Hippie!

Respect,


IHS


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you are not who i thought i was...

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OfflineHippie Chemist
Freeing Minds


Registered: 04/05/07
Posts: 430
Loc: Far Out There
Last seen: 15 years, 11 months
Re: Orally active DMT [Re: Ice House Shaman]
    #6795653 - 04/16/07 05:01 PM (16 years, 11 months ago)

Anytime, man! Happy trippin'!


--------------------
Long you live and high you fly
And smiles you'll give and tears you'll cry
And all you touch and all you see
Is all your life will ever be.
-Pink Floyd-

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