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Ice House Shaman
Rider on the Storm
Registered: 02/25/03
Posts: 1,244
Loc: PNW
Last seen: 1 year, 4 months
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Orally active DMT
#6794982 - 04/16/07 01:34 PM (16 years, 11 months ago) |
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Anyone out there know weather or not an MAO-B inhibitor can be used with DMT in order to make it orally active. I have come across a supply of "Deprenyl", Deprenyl is advertised or described as an MAO-B inhibitor it does not require a prescription. I prefer to do my DMT orally so I am looking for a new MAOI I can ingest with my DMT. I have been using Syrian Rue in the past as an MAOI but it never fails to cause an uncomfortable ammount of nausea. Bottom line is I'm looking for an alternative solution to Rue and I am not interested in drinking any concoctions. I am sure that its not the DMT causing the nausea. I have had an opportunity to take DMT with a prescription MAOI called MARPLAN a couple of years back. DMT taken with Marplan was perfect. Anyone?
Respect,
IHS
-------------------- you are not who i thought i was...
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truffleupagus
Registered: 02/19/06
Posts: 3,103
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I'm not sure exactly what the "B" is in MAO-B but it seems like it should work. DMT combined with prescription or OTC MAOIs is called pharmahuasca I believe.
Have you tried just using Caapi though or have you only used Rue? Caapi is, after all, THE ayahuasca vine. I'm pretty sure Rue is known to cause more nausea.
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truffleupagus
Registered: 02/19/06
Posts: 3,103
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As far as I can see there are MAOIs, MAO-A inhibitors and MAO-B inhibitors. Both MAO-A and MAO-B are types of MAOIs. Because of this, I see no reason why you couldn't take your deprenyl with DMT.
Let someone with a better background in chemistry confirm that first though.
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EllisDSox
King Hella!
Registered: 01/22/07
Posts: 25,730
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Do NOT use prescription MAOIs in combination with psychedelics. They usually have an extremely (sometimes several days) long duration. Stick to the natural ones.
-------------------- Disclaimer: If you have any kind of heart condition, my posts are not for you. You could literally die from reading the first couple of words in any one of them. Scroll down the page, live your life and prosper, but don't read my posts because your heart will probably explode. I am not joking.
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F1234K
Wizard Of Tryptamines
Registered: 10/14/06
Posts: 1,241
Last seen: 12 years, 1 month
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Re: Orally active DMT [Re: EllisDSox]
#6795441 - 04/16/07 03:40 PM (16 years, 11 months ago) |
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Syrian rue eaten or smoked i believe.
-------------------- Im Not Living, Im Just Killing Time
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Hippie Chemist
Freeing Minds
Registered: 04/05/07
Posts: 430
Loc: Far Out There
Last seen: 15 years, 11 months
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Re: Orally active DMT [Re: F1234K]
#6795556 - 04/16/07 04:34 PM (16 years, 11 months ago) |
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What you're looking for is info on "pharmahuasca". Off the top of my head, I don't know enough about using Deprenyl to give good advice.
(a few minutes later)
According to wikipedia, both MAO-A and MAO-B metabolize dopamine, but A breaks down serotonin (tryptamines like DMT), while B breaks down phenethylamines. "MAO-A is particularly important in the catabolism of monoamines ingested in food." Guess where that takes place? The gastrointestinal tract. The gastrointestinal tract is one place where MAO-A is located, while MAO-B is mostly in blood platelets. My guess would be that MAO-B probably wouldn't make DMT active orally. As for Marplan, that was an MAO-A inhibitor; according to the pharmacokinetic data it is metabolized in the liver. Marplan should work just fine with DMT, but I'd prefer to stick with my usual Syrian rue. Just remember to be safe with oral doses of DMT, and always take the MAOI about half an hour before the DMT. It can get pretty intense. Have fun, and be safe!
http://en.wikipedia.org/wiki/MAO-A
http://en.wikipedia.org/wiki/Deprenyl
http://en.wikipedia.org/wiki/Marplan
-------------------- Long you live and high you fly And smiles you'll give and tears you'll cry And all you touch and all you see Is all your life will ever be. -Pink Floyd-
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Hippie Chemist
Freeing Minds
Registered: 04/05/07
Posts: 430
Loc: Far Out There
Last seen: 15 years, 11 months
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If you already have the Syrian rue, you can just do a simple extraction. Then you just have to swallow a little ball of semi-solid goop that glows under a blacklight, and it shouldn't make you have the nausea.
-------------------- Long you live and high you fly And smiles you'll give and tears you'll cry And all you touch and all you see Is all your life will ever be. -Pink Floyd-
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Ice House Shaman
Rider on the Storm
Registered: 02/25/03
Posts: 1,244
Loc: PNW
Last seen: 1 year, 4 months
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Thanks a bunch Hippie!
Respect,
IHS
-------------------- you are not who i thought i was...
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Hippie Chemist
Freeing Minds
Registered: 04/05/07
Posts: 430
Loc: Far Out There
Last seen: 15 years, 11 months
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Anytime, man! Happy trippin'!
-------------------- Long you live and high you fly And smiles you'll give and tears you'll cry And all you touch and all you see Is all your life will ever be. -Pink Floyd-
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