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Invisiblep4kSouL
Animals Are Cool
Registered: 01/13/05
Posts: 3,666
FUCKING YOUR BRAIN UP?
    #3951233 - 03/21/05 11:42 PM (12 years, 3 months ago)

My friend told me that if you do shrooms alot it causes your brain to get fucked up. Like the psilocybin fucks up your brain neurons permanently. I hope that's not true. :confused:


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InvisibleAhab McBathsalts
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Re: FUCKING YOUR BRAIN UP? [Re: p4kSouL]
    #3951247 - 03/21/05 11:43 PM (12 years, 3 months ago)

your friend doesn't know what he's talking about. Read some of the valuable info on this site.


--------------------
"Nobody exists on purpose. Nobody belongs anywhere. Everybody's going to die."


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Invisiblep4kSouL
Animals Are Cool
Registered: 01/13/05
Posts: 3,666
Re: FUCKING YOUR BRAIN UP? [Re: p4kSouL]
    #3951393 - 03/21/05 11:56 PM (12 years, 3 months ago)

My friend said he hurd that from this older smart guy that knows everything about shrooms :rolleyes:


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InvisibleDark_Star
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Registered: 08/21/04
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Re: FUCKING YOUR BRAIN UP? [Re: p4kSouL]
    #3951654 - 03/22/05 12:49 AM (12 years, 3 months ago)

Tell your friend that this older smart guy is in fact, a moron and completely full of shit. While you're at it, tell your friend he is full of shit and introduce him to the shroomery & erowid.


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Edited by Dark_Star (03/22/05 01:14 AM)


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Offlineerags
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Registered: 02/15/05
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Re: FUCKING YOUR BRAIN UP? [Re: Dark_Star]
    #3951737 - 03/22/05 01:05 AM (12 years, 3 months ago)

Psychedelics in general have little long term physical side effects. That is if you do them infrequently. Because Psilocybin acts as a Seratonin agonist it can "fool" your brain into thinking there is more seratonin about than it needs. The brain is pretty good at recovering from an isolated shock from most drugs (maybe not so with Dopamine agonists) but if you make use a pattern (more than once in a two week period is alot; don't suggest more than a few times a year) your brain will downregulate its seratonin receptors making you less sensitive to normal levels of seratonin. As with all things ... Moderation.


--------------------
http://www.bumwine.com/


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Invisiblep4kSouL
Animals Are Cool
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Posts: 3,666
Re: FUCKING YOUR BRAIN UP? [Re: erags]
    #3952064 - 03/22/05 02:36 AM (12 years, 3 months ago)

what happens when the serotonin is downregulated? do your emotions become sad in life permanently?


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InvisiblePsychoactive1984
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Re: FUCKING YOUR BRAIN UP? [Re: p4kSouL]
    #3952172 - 03/22/05 03:14 AM (12 years, 3 months ago)

:whatever:

Mind over matter :tongue:


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"Their is one overriding question that concerns us all: How can we get out of the fatal groove we are in, the one that is leading towards the brink?" Albert Szent-Gyorgyi
"We may not be capable of eradicating the corruption of reason, but we must nevertheless counter it at every instance and with every means." Dan Agin
"Politics is the best religion and politicians are the worst followers."
-It's ok to trip as long as you don't fall.
-Substance over Style.
-Common sense is uncommon.


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InvisibleWhiskeyClone
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Re: FUCKING YOUR BRAIN UP? [Re: p4kSouL]
    #3952586 - 03/22/05 09:45 AM (12 years, 3 months ago)

Number one Shroomery rule of thumb when it comes to drug info:

DON'T LISTEN TO YOUR FRIENDS!

THEY'RE ALWAYS FULL OF SHIT!

www.lycaeum.org
www.erowid.org


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Welcome evermore to gods and men is the self-helping man.  For him all doors are flung wide: him all tongues greet, all honors crown, all eyes follow with desire.  Our love goes out to him and embraces him, because he did not need it.

~ R.W. Emerson, "Self-Reliance"

:heartpump:


Edited by CyberChump (03/22/05 09:47 AM)


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InvisibleHeavyToilet
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Re: FUCKING YOUR BRAIN UP? [Re: p4kSouL]
    #3952857 - 03/22/05 11:39 AM (12 years, 3 months ago)

Serotonin isn't really 'downregulated'.

I believe what happens is instead of your serotonin receptors receiving all serotonin, some of the serotonin receptors receive psilocin (psilocybin is converted to psilocin after it enters the body).

A comparison of serotonin and psilocin.

As you can see, psilocin is basically the same as serotonin, only it has two more carbons and 4 more more hydrogens.

After the experience is over, your brain gets slightly confused, and releases varying amounts of serotonin until it gets the amount back to normal.

I THINK this is how it works. Go look at the sticky on how hallucinogens work


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InvisibleHeavyToilet
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Re: FUCKING YOUR BRAIN UP? [Re: erags]
    #3952879 - 03/22/05 11:44 AM (12 years, 3 months ago)

Quote:

erags said:
... it can "fool" your brain into thinking there is more serotonin about than it needs.


Quote:

your brain will downregulate its serotonin receptors making you less sensitive to normal levels of seratonin.




Do you have any sources?


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OfflineGomp
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Re: FUCKING YOUR BRAIN UP? [Re: p4kSouL]
    #3954523 - 03/22/05 06:08 PM (12 years, 3 months ago)

placebo,.. if you think it does, it do..
if you think it doesn't is doesn't...
if you do, whatever happens happen..
etc etc..

:heart:


"the heart need not believe the other organs, to work in perfect Harmonie"
-Unknown ;P


--------------------


--------------------
Disclaimer!?


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Offlineerags
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Re: FUCKING YOUR BRAIN UP? [Re: HeavyToilet]
    #3957452 - 03/23/05 02:14 AM (12 years, 3 months ago)

Quote:

HeavyToilet said:
Serotonin isn't really 'downregulated'.



-Which is why I said serotonin receptors may down-regulate.

Quote:

HeavyToilet said:I believe what happens is instead of your serotonin receptors receiving all serotonin, some of the serotonin receptors receive psilocin (psilocybin is converted to psilocin after it enters the body).



-Which is why I said your brain is "fooled" into thinking more serotonin is around? Hence the term agonist.

Quote:

Psilocybin is a potent serotonin agonist
-(http://www.heffter.org/Graphics/pics/sero+psilocin.html)




More bound receptors leads to more activation, leading to down-regulation over time. Downregulation (decreased sensitivity) of serotonin receptors is the basis (it is believed) for SSRI disconinuation and the symptomatic depression that accompanies it.
(http://www.theberries.ns.ca/Archives/2001Fall/SSRI_discontinuation.html)
(http://pharmacology.uthscsa.edu/faculty/Frazer.html)
(http://dancesafe.org/slideshow/slide18.html)

Although SSRI work to increase serotonin activity through a different mechanism than indoles there may be some parallel in downregulation with habitual use. Studies using actual psychomimectic drugs are very limited during this time of prohibition.


--------------------
http://www.bumwine.com/


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InvisibleJellric
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Re: FUCKING YOUR BRAIN UP? [Re: p4kSouL]
    #3957655 - 03/23/05 03:17 AM (12 years, 3 months ago)

It doesn't "fuck your brain up", but if one does not use them properly before they have formed their basic personality it can cause problems. [BTW this is true of any substance that temporarily alters your mindset but lets keep this conversation limited to shrooms for simplicity's sake]. If a person has any type of mental problems I would not recommend them trying shrooms.

It's important to understand that it's not the psychedelics themselves that cause the problem. Set and setting are crucial and if you take care of that the shrooms will take care of you. Educate yourself, read over some of the trip reports at this site, both good and bad, and arm yourself with knowledge.

Your're right about one thing- magic mushrooms are not to be taken lightly!


--------------------
I AM what Willis was talkin' bout.


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OfflinePhluck
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Re: FUCKING YOUR BRAIN UP? [Re: p4kSouL]
    #3958281 - 03/23/05 10:17 AM (12 years, 3 months ago)

I recommend you reference:

Psilocybin and its effects on neuron fuck-ups.
Pettigrew et al. 1994, University of Skippity


--------------------
"I have no valid complaint against hustlers. No rational bitch. But the act of selling is repulsive to me. I harbor a secret urge to whack a salesman in the face, crack his teeth and put red bumps around his eyes." -Hunter S Thompson
http://phluck.is-after.us


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Invisiblep4kSouL
Animals Are Cool
Registered: 01/13/05
Posts: 3,666
Re: FUCKING YOUR BRAIN UP? [Re: Phluck]
    #3962870 - 03/24/05 01:59 AM (12 years, 3 months ago)

So you don't want to abuse mushroom use because that could be over use of your serotonin receptors. In a way like burning out your car engine is that right?


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OfflinePhluck
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Re: FUCKING YOUR BRAIN UP? [Re: p4kSouL]
    #3963728 - 03/24/05 07:29 AM (12 years, 3 months ago)

Nothing like burning out your car engine, and I don't know if there are any studies that show overuse of psychedelics can actually cause any effects, I believe this is all theory.


--------------------
"I have no valid complaint against hustlers. No rational bitch. But the act of selling is repulsive to me. I harbor a secret urge to whack a salesman in the face, crack his teeth and put red bumps around his eyes." -Hunter S Thompson
http://phluck.is-after.us


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OfflineBloodNOil
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Re: FUCKING YOUR BRAIN UP? [Re: Phluck]
    #3963945 - 03/24/05 10:16 AM (12 years, 3 months ago)

not theory. hypothesis.


--------------------
It's like a koala bear crapped a rainbow in my brain!


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Invisiblep4kSouL
Animals Are Cool
Registered: 01/13/05
Posts: 3,666
Re: FUCKING YOUR BRAIN UP? [Re: BloodNOil]
    #3963963 - 03/24/05 10:25 AM (12 years, 3 months ago)

opinions but it is obvious that its not good to over abuse psychedelics


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InvisibleDark_Star
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Registered: 08/21/04
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Re: FUCKING YOUR BRAIN UP? [Re: BloodNOil]
    #3966168 - 03/24/05 08:48 PM (12 years, 3 months ago)

Yeah, Chinacats brain works fine.


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InvisibleRavus
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Re: FUCKING YOUR BRAIN UP? [Re: p4kSouL]
    #3968712 - 03/25/05 02:42 PM (12 years, 3 months ago)

It's obvious eh? What scientific evidence shows that overuse of psychedelics is harmful?

Mushrooms are some of the most benign things known to man.


--------------------
So long as you are praised think only that you are not yet on your own path but on that of another.


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