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Re: An Introduction to our Psychedelic Medicine, Research & Microdosing Forum [Re: sp0rz]
    #29529990 -

Maybe pause to understand context and intent before going on the attack?

Quote:
There are risks of cardiac fibrosis and valvulopathy associated with microdosing daily. 



I was suggesting that people don't microdose daily without understanding that there could be a potential risk to this receptor.

Which mirrors what you gestured towards in your argument.

Quote:
A typical microdosing regimen involves sub-threshold doses two to four times per week



Anyway, there was a study done that was posted elsewhere on this forum many months after my post (which is 16 months old now btw), that shows that even a once daily dose is likely safe.  Which doesn't mean more often is, and I wouldn't suggest more without further studies.

https://pubs.acs.org/doi/full/10.1021/acsptsci.5c00202?utm_source=tricycleday&utm_medium=newsletter&utm_campaign=this-week-in-psychedelics

But like I said it's been 16 months.  My own position has changed since then thanks to new evidence.  And you certainly came out swinging with your first post.

Nice to meet you, I guess?

Welcome to the shroomery, anyway.  Hopefully we can get off on a better foot.

:dancingshroom::jumpingfrog::dancingshroom:


--------------------
And if I only could
I'd make a deal with God
And I'd get him to swap our places
I'd be running up that road
Be running up that hill
With no problems

Edited by tree frog (03/29/26 09:36 AM)

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Re: An Introduction to our Psychedelic Medicine & Microdosing Forum [Re: Asante] * 1
    #29530047 -

Asante said:
If I could give one thing some love in the Shroomery community perception it's that Less is More.

So many people insist on doses for newbies that would blow my socks square off and i'm over 300 lbs with 33 years of psychedelics experience.

Aha! you say, But you are 4x as sensitive to psychedelics as the average person! Give you half a blotter and the Ankh symbols rotate across your field of vision, you lose your ability to understand words spoken to you, you end up on the kitchen floor for a while incapacitated, have fullblown Ego Death experiences.

You don't know whether that n00b is like that too

Less is more. An ounce of prevention beats a pound of cure.

Take half of the shrooms you intend, wait 1:30 and decide whether you want the other half to go higher, or wait 3 hours instead and add the other half to extend.

Microdoses. Mini trips. Try it.

If you trip too hard, too often, trips lose their Magic or you yourself end up beside the point.

Less. Is. More.

This forum, dealing with microdoses and mini trips, is very important, even though many won't even go here.

If you are sensitive, a veteran, therapeutically, meditatively, spiritually or brainhacking oriented, this forum and it's low dose high utility focus is crucial.

Low doses can't replace high doses - but high doses can't replace low doses, also!

Sometimes the real breakthrough isnt a flood dose, but taking too little to fulfill and fill the rest in with what you do with the trip.



This is well said. In my experience the simple natural variation in potency across many species is also unpredictable and while a threshold dose may be disappointing, a heroic dose when not prepared for it can be too much for many folks. You can always take more but you can never take less. These are powerful substances and from the aspect of harm reduction I always advise caution.

Sometimes I wonder if a lot of people simply forget how high tolerance can creep when using a lot. When I was growing a lot I was also consuming a lot. My tolerance was through the roof. If you take em 2-4 times a month, every month you will slowly develop a monster tolerance. Take year off tho and you are right back at the start.

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Re: An Introduction to our Psychedelic Medicine, Research & Microdosing Forum [Re: tree frog]
    #29560838 -

Wasn't my intent to come after you but the idea that the study you linked suggested anything useful besides a speculation.  No offense was meant.


--------------------
Would that it were possible for you to grow wings and soar into the air! Poised between earth and heaven, you might see the solid earth, the fluid sea and the streaming rivers, the wandering air, the penetrating fire, the courses of the stars and the swiftness of the movement with which heaven encompasses all. What happiness were that, my son, to see all these borne along with one impulse, and to behold Him who is unmoved moving in all that moves, and Him who is hidden made manifest through His works.

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Re: An Introduction to our Psychedelic Medicine, Research & Microdosing Forum [Re: sp0rz]
    #29562627 -

I hear you, but I was encouraging folks not to microdose every day without better studies on how psilocybin interacts with that receptor.

I wasn't telling people not to microdose at all.  But rather to stick to the suggested regimens.

But again that was quite a while ago, and we have better studies on the safety now.


--------------------
And if I only could
I'd make a deal with God
And I'd get him to swap our places
I'd be running up that road
Be running up that hill
With no problems

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Re: An Introduction to our Psychedelic Medicine & Microdosing Forum [Re: Pastywhyte]
    #29562718 -

Pastywhyte said:
If you take em 2-4 times a month, every month you will slowly develop a monster tolerance. Take year off tho and you are right back at the start.



i wish it was like that for me. i have been dosing 5-6 times a month for years now and my tolerance will drop off after a weekend.

none of it is super heroic tho just a good dose to feel all shroomery and get the furniture talking. my experiences with shroom tolerance seem to be NOT the norm:lol:

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