vaudvilleviktor said:

Hey people, about to try microdosing for the first time, have a few questions. Wanted to start a new thread but I'm sure there are 100s of threads on noobie micro dosing and I know people around here prefer you don't start a new one and "use the search feature".. Couldn't really find a micro dosing "mega thread" this seems to be the closest to that.

Basically I suffer from bad anxiety and depression. I had been on antidepressant and they actually did help me. But it made it nearly impossible to bust a nut during intercourse as well as worried me about long term effects, being dependant on an inorganic chemical drug for life and just increasing cynicism and distrust for the pharmaceutical industry in general these last few years. I have a decent amount of homegrown mush so figured might as well give this a shot. Did a little research but there is so much varying information it's hard to wade through it all.

Bought some empty pill capsules and filled about 30 with .05 grams of ground to powder PEs.

Just have a few questions before I start.

1.) .05 grams of PE is probably a decent starting point right? I know it seems a little low but I guess that's close to the equivalent of .1 of regular cubes?

2.) How does alcohol consumption interact with microdosing? I am admittedly a bit of an alcoholic but have cut back significantly from where I was a year ago. I still have a drink or two (a beer or glass of wine) daily and occasionally drink that plus a couple shots of hard liquor if I'm feeling really anxious. Will alcohol counteract the microdose?

3.) And what is the general consensus around her for best schedule for dosing? From what I researched elsewhere I got a varying answer from every 3 days, every other day, every day and sometimes saw people saying twice a day.

Thanks.

edit : just saw this thread https://www.shroomery.org/forums/showflat.php/Number/27805016 which answers questions 1 and 3. But raises another question- WHat is the general consensus around here for which method/schedule for a first timer, Fadiman or Stammets? And if the Stammets method, what if I don't have lions mane or niacin, is still worth following that method without those?

"Leave a bad taste, killin' my high like niacin
Stop kiddin' middlemen need Ritalin
Hit me with the full tin of gin and I'm a kid again
Keep the bong lightin' straight through the song writin'" 

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Bythesea123 said:

I recently started micro-dosing for treatment resistant depression and anxiety. You can find a wealth of information on how to microdose, treatment protocols etc on https://microdosinginstitute.com/ hope this helps x

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Quote:

Sustained overstimulation of 5-HT2BR can cause cardiac fibroblasts to proliferate and become deposited in abnormal quantities, causing cardiac valves to thicken and function abnormally, which can ultimately manifest as valve fibrosis and VHD...

...  Thus, it appears that a microdose of LSD may indeed be large enough to raise the risk of VHD. Similarly, a small dose of 3 mg psilocybin raises plasma concentrations of psilocin to 2.3 ng/mL, comparable to the levels seen after the pro-fibrotic drug pergolide, which has a somewhat weaker affinity (Table 1). This suggests that the typical doses used in microdosing could potentially be enough to trigger fibrosis or VHD in a similar manner to other drugs.

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Hooke said:

I found the Spravato (esketamine) treatment to be effective for treatment resistant depression.  I was required to be on a standard antidepressant before getting the Spravato treatments.

Although the reasoning was that Spravato worked much quicker giving the antidepressant time to start working, I personally find when taking antidepressants and using a micro or macro dose of psilocybin mushrooms, the results are better than without the SSRI, or SNRI in this case. 

Has anyone else noticed anything similar?

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ReverendMyc said:

So pleased to see this new forum. I have no disrespect for my friends who enjoy psychedelics recreationally. I have done so many, many times and sometimes still do. But in the past several years I have become far more interested in the medicinal and potential psychological benefits.

I look forward to watching this forum and the entire field of research grow.

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tree frog said:

There are risks of cardiac fibrosis and valvulopathy associated with microdosing daily.  Four on and three off is likely safer.  But if you're taking another medication that targets this receptor, or have a heart condition already, the risks would be higher.

And LSD, with its longer half-life and greater binding efficacy, would pose an even larger risk than psilocybin/psilocin.

Quote:

Sustained overstimulation of 5-HT2BR can cause cardiac fibroblasts to proliferate and become deposited in abnormal quantities, causing cardiac valves to thicken and function abnormally, which can ultimately manifest as valve fibrosis and VHD...

...  Thus, it appears that a microdose of LSD may indeed be large enough to raise the risk of VHD. Similarly, a small dose of 3 mg psilocybin raises plasma concentrations of psilocin to 2.3 ng/mL, comparable to the levels seen after the pro-fibrotic drug pergolide, which has a somewhat weaker affinity (Table 1). This suggests that the typical doses used in microdosing could potentially be enough to trigger fibrosis or VHD in a similar manner to other drugs.

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https://journals.sagepub.com/doi/full/10.1177/02698811231225609

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