KnyggaPlease said:

Tryptamines are serotonin antagonists

That being said both histamine and serotonin are both directly related with inflammation.

More serotonin and histamine causes an increase in inflammatory response

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Quote:

According to a recent article on Medical News Today, a study performed by Charles Nichols, pharmacologist at LSU Health Sciences Center, has concluded in the use of LSD as a very potent anti-inflammatory. The research was directed toward TNF-alpha, a potent pro-inflammatory adipokine. The researchers found that when serotonin 5-HT2A receptor proteins were activated, the receptor proteins impressively blocked TNF-alpha induced inflammatory responses. But how did these researches activate serotonin 5-HT2A? With the use of a drug belonging to the LSD family, of course! The researchers found that when TNF-alpha was injected into mice after serotonin 5-HT2A receptors were activated, there was a near complete inhibition of inflammation in comparison to mice whose receptors were not activated and had a full inflammatory response. Interestingly and most relevant to the topic of the past two weeks, the tissue that this procedure had the most powerful effect on was intestinal tissue, and doses of less than 300 times lower than what is required to illicit any behavioral effects of the drug were found to induce this powerful anti-inflammatory effect!

Although extremely interesting, LSD is a serious hallucinogenic drug with severe side effects, and although this study makes it a point to establish that only very minute doses are needed to illicit an anti-inflammatory response, they fail to mention whether or not the mice developed any side-effects from the drug. I think that a good follow up study would be to study any side effects that occur after administering the small doses of this drug over a long period of time to mice. Even in low doses, I am convinced that over a long treatment period, mice would eventually develop some sort of side effect because of the LSD families very potent abilities to cause severe mental abnormalities. Also, the drugs belonging to this family are severely addictive, it would be nice to see a follow up study done on how these mice react once the drug isn't going through their bodies. What are your thoughts and opinions?

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morrowasted said:

I dosed at about noon yesterday, and the anti-inflammatory effect lasted until I went to sleep at midnight, and when I woke up this morning the inflammation had returned to normal levels. I wish I knew what was causing the inflammation. I take several medications at night. One of them is Remeron, and there are reports that a very small percentage of people experience inflammation from taking it.

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JacksonMetaller said:

morrowasted said:

I dosed at about noon yesterday, and the anti-inflammatory effect lasted until I went to sleep at midnight, and when I woke up this morning the inflammation had returned to normal levels. I wish I knew what was causing the inflammation. I take several medications at night. One of them is Remeron, and there are reports that a very small percentage of people experience inflammation from taking it.

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Are you positive its inflammation? I mean I think it's likely I just wouldn't want to recommend an extreme change otherwise. But most chronic inflammation is caused by microbial endotoxins translocating into the blood stream from mucosal layers such as the intestinal tract and oral cavity. This happens largely because we've reduced substrate diversity in our diets leading to loss of microbial diversity and the resulting suppression of some strains while others overgrow. Add antibiotics or proton pump inhibitors or foods rich in digestive enzymes and you're disturbing the ecology further. Then add foods that compromise the integrity of the intestinal barrier (or gluten/zein/etc) and you increase the rate at which these endotoxins can pass through. This has been colloquially known as "leaky gut syndrome". There's an entire community promoting a Paleo based diet called AIP that aims to address this. I've been eating it about sixth months and went from barely being able to walk because everything felt like hot coals  to a little achiness here and there

Honestly though most of the world is probably dealing with this. Hence the increasing CVD, cancer, autoimmune, diabetes etc rates.

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JacksonMetaller said:

Add antibiotics or proton pump inhibitors or foods rich in digestive enzymes and you're disturbing the ecology further.

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Capt. Stern said:

JacksonMetaller said:

Add antibiotics or proton pump inhibitors or foods rich in digestive enzymes and you're disturbing the ecology further.

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Sorry for thread derail, but what's wrong with enzyme rich food? I know that too much of anything ruins homeostasis, but I never heard anything bad about them. Don't get me wrong I know I gotta do my homework and I will, but I'm really curious as to why you said that.

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badchad said:

It could also be generalized vasoconstriction that (visibly) appears anti-inflammatory.

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morrowasted said:

So I have been doing some research and this is what I dug up. Inflammation and its inhibition are linked with "cytokines". Different cytokines may have inflammatory or anti-inflammatory properties. Cytokine levels are modulated by serotonin activity. Different types of cytokines are modulated by different receptor subtypes. 5HT-2a, the primary receptor activated by psilocybin, inhibits the production of the cytokine TNF‐α, which is an inflammatory cytokine. Therefore, an increase in activity at 5HT-2a corresponds to an anti-inflammatory effect.

http://intimm.oxfordjournals.org/content/15/2/233.full

http://onlinelibrary.wiley.com/doi/10.1111/j.1749-6632.1998.tb10188.x/abstract;jsessionid=FAE6C258FD07236F2C921C4ECE6BBE25.f03t01

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