Is this a crock of shit or not?
Does it work any better than Immodium AD?
http://members.shaw.ca/duncancrow/salvia_kappa_opioid.html
Researchers, herbalists, mental health specialists, and especially addicts are showing interest in a sub-tropical herb that contains an anti-addictive pain killer that can even get people off other addicting substances. Yes, Virginia, even the big four: morphine, cocaine, alcohol, and nicotine, and that's not all.
Everyone knows that morphine makes one slow and apathetic, simply because morphine is an opioid substance. Opioids mimic the effects of ?morphine-like? substances called endorphins, which are normally produced by the body as a natural defence against pain. They and the narcotic pain killers (analgesics) attach themselves to specific sites on the outside of nerve cells which we have come to refer to as opioid receptors. Without the receptors, endorphins and narcotic analgesics don?t work.
There are five major groups of opioid receptors: mu, kappa, sigma, delta and epsilon. Narcotic analgesic activity occurs at the mu, kappa and sigma receptors. Opioid agonists (stimulators) such as morphine and other drugs exert their activity mainly at the mu receptor; you might call it the main addiction receptor. These peptides are physically addictive, causing dependence, asthma, obesity, apathy, ignorance and numbness. Wheat and dairy products and also beta-carbolines from prepared food also contain opioid peptides.
Pharmacologists are particularly interested today in kappa-opioid receptor agonists because they provide effective pain medications without the dependence and respiratory depression that is associated with mu receptor activation by morphine. In addition to analgesia, potential applications of kappa selective agonists include the areas of diuresis, eating disorders, motion sickness, and neuroprotection.
Areas of application for the kappa agonists include analgesia, convulsions, ischemic brain damage, hypertension, AIDS, arrhythmia and other physiological activities that may be mediated through kappa opioid receptors. Areas of application for the delta antagonists (subduers) include rheumatoid arthritis, systemic lupus erythematosis, Sjogren's Syndrome, multiple sclerosis, chronic lymphocytic leukemia, Type 1 diabetes, Epstein-Barr virus, AIDS, coronavirus infection, cytomegalovirus infection, cocaine use or addiction, antitussive agent, tolerance or physical dependence on a mu-opioid agonist and other physiological activities that may be mediated also through kappa opioid receptors.
And treatment with kappa-opioid agonists actually averts the frequent use of other drugs, not only morphine relatives, but even for cocaine and other non-opioid addictions. "The data indicate that the ability of U69593 to decrease drug seeking is not restricted to subjects experienced with cocaine self-administration. Self-administration history does, however, determine the effect of U69593 on amphetamine-produced drug seeking", concludes one study. Another states, "These findings demonstrate that U69593 attenuates cocaine self-administration and the reinstatement of drug-taking behavior which occurs in response to experimenter-administered cocaine. It is suggested that U69593 may decrease low dose cocaine self-administration by decreasing the priming effects of cocaine." From another study, it is also known that "motivational effects of cannabinoids (marihuana) are mediated by mu-opioid and kappa-opioid receptors."
It may thus be possible to use Salvinorin A to treat heroin, cocaine, alcohol and amphetamine dependency, depression, and even excessive marijuana use. Salvinorin A represents the only known non-nitrogenous kappa opioid receptor selective agonist, and it is the only diterpenoid compound known to have activity at this important receptor. This has recently opened up vast new areas for research in diterpenoid pharmacology and it represents a potential molecular target for the development of drugs to treat disorders characterized by alterations in perception, including schizophrenia, Alzheimer's disease and bipolar disorder.
Salvia Divinorum is the herbal source, and the only source, of Salvinorin A. Most powerful analgesics that are prescribed today are habit-forming; Salvia Divinorum has the potential to offer non-habit forming alternatives - an incredible breakthrough! It can reduce physical dependency and it it also can also reduce emotional dependency by its antidepressive action. Not only that but it enables people to refocus their spirituality and connectedness to nature by reframing the nature of consciousness and reality. For the addict, the herb's blatantly non-addictive and safe, albeit somewhat hallucinogenic, action at the lower doses may even appeal to people who are experienced with drugs anyway and who wish to at least reduce their monthly drug cost and thereby save money, if not pitch their drug dependency outright.
. . . Duncan Crow
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