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Mushrooms, Mycology and Psychedelics > The Psychedelic Experience
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question: LSD vs Shrooms tolerance
    #8556599 -

Both LSD and shrooms have a big immediate tolerance: If one does LSD two nights in a row, the second time will be much less intense. we all know this. So heres the question... If one consumed mushrooms one night, then LSD the night after, would that immediate tolerance from the mushrooms affect the effectiveness of the LSD?

Thanks Peace

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Re: question: LSD vs Shrooms tolerance [Re: unsanity]
    #8556610 -

Yes, they have cross tolerance.


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Re: question: LSD vs Shrooms tolerance [Re: LSDreamer]
    #8556617 -

thanks

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Re: question: LSD vs Shrooms tolerance [Re: unsanity]
    #8556731 -

i think u gotta double your dose the second day if you wanna do them two days in a row.

But eating 3.5g of shrooms the first day does not mean taking 7g of LSD the day after. :wink:


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"As a man who has devoted his whole life to the most clear headed science, to the study of matter, I can tell you as a result of my research about atoms this much: There is no matter as such. All matter originates and exists only by virtue of a force which brings the particle of an atom to vibration and holds this most minute solar system of the atom together. We must assume behind this force the existence of a conscious and intelligent mind. This mind is the matrix of all matter."  --Max Planck

Edited by tyler_0_durden (06/23/08 11:59 PM)

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Re: question: LSD vs Shrooms tolerance [Re: tyler_0_durden]
    #8556785 -

i've been wondering lately whether LSD has a longer tolerance than shrooms. Because I've been eating LSD for the past three weekends. 7 days apart. Each time I eat slightly more, but it doesn't really seem like I'm tripping any harder.


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"This day is a lover..."

~Rumi

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Re: question: LSD vs Shrooms tolerance [Re: Nunbuh_Chrubble]
    #8557426 -

LSD has a slightly shorter tolerance than shrooms. I ate acid twice a week for awhile and tripped each time.


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Re: question: LSD vs Shrooms tolerance [Re: LSDreamer]
    #8558005 -

alright i have a question about that too, i tripped on friday night ( acid, 3 hits) and i wanted to trip again today, right now.  Would that be enough time for the tolerance to go down?  Seems like enough because its been a few days.

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Re: question: LSD vs Shrooms tolerance [Re: thizzles29]
    #8558037 -

anyone know?

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Re: question: LSD vs Shrooms tolerance [Re: thizzles29]
    #8558133 -

Yeah, you're good to go.


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Re: question: LSD vs Shrooms tolerance [Re: LSDreamer]
    #8558407 -

I find the "magic" gets lost when you decide to take acid within a week of your last trip


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Re: question: LSD vs Shrooms tolerance [Re: Razor3lade]
    #8558424 -

I find the magic is all in you.

I've tripped three days in a row plenty of times and gotten where I wanted to be each time.  It's all about your set setting and dose, you just gotta know your body and your mind and you gotta know what you're taking.

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Re: question: LSD vs Shrooms tolerance [Re: Razor3lade]
    #8558426 -

I took acid twice a week for about a month and a half to two months. tbh, each trip was better than the last.


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. [Re: Razor3lade]
    #8558427 -

.


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Edited by AnonymousRabbit (05/18/22 11:19 PM)

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Re: question: LSD vs Shrooms tolerance [Re: AnonymousRabbit]
    #8558433 -

Great for you. LSD and mushrooms have cross tolerance, though. Simple biology, I'm afraid. Set and setting can matter as much as dose, which is likely why you still had a good trip. That and its entirely possible they were very strong mushrooms.


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Re: question: LSD vs Shrooms tolerance [Re: LSDreamer]
    #8558446 -

alright, so i took 5 hits at like 10:45 ( and they're good ones because i've taken more from this batch and they have been fine) and now its 12:30 and im not really "tripping" yet.  I feel like im on acid mentally because i act the same and music sounds the same but im not getting real visuals yet, only very slight ones... Mabye it hasn't come on as hard because i ate right after i took the tabs?

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Re: question: LSD vs Shrooms tolerance [Re: thizzles29]
    #8558449 -

Eating didn't impact it. I always eat right after I take acid. Visuals are extremely variable and don't define a trip.


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. [Re: thizzles29]
    #8558450 -

.


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Edited by AnonymousRabbit (05/18/22 11:19 PM)

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Re: question: LSD vs Shrooms tolerance [Re: LSDreamer]
    #8558459 -

LSDreamer said:
Eating didn't impact it. I always eat right after I take acid. Visuals are extremely variable and don't define a trip.


i know that, but it just seems strange that im not getting much when ive taken less of the same batch and had a pretty insane trip.

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Re: question: LSD vs Shrooms tolerance [Re: AnonymousRabbit]
    #8558481 -

supernovasky said:
LSDreamer, I consider myself pretty informed in biology. Show me the peer reviewed study that show shrooms and LSD have cross tollerence, and you'll convert me. I'm unaware of any such study, so any evidence collected here or gathered from friends is annecdotal at best.

Edit: I did a little bit of my own research, so I suppose clinically, cross tollerence HAS been established, but it works in a way that would seem to confirm my own annecdotal experience:

Quote:
Definite direct tolerance also developed after chronic administration of psilocybin in both experiments, but statistically significant reductions occurred in fewer parameters of response (four in Experiment I and three in Experiment II) than was the case with LSD. Patients chronically treated with psilocybin were also cross tolerant to LSD on four (Experiment I) or three (Experiment II) measurements. The degree of direct tolerance to psilocybin was less than the degree of direct tolerance to LSD.



Tolerance seems to apply to LSD more than it applies to psilocybin.

http://www.springerlink.com/content/x3l734447m271017/



Given the nature of the topic, I seriously doubt anybody has ever done a study on the subject. There is abundant anecdotal evidence to support cross tolerance and on top of that, it just makes sense. I can think of no reason why there would NOT be cross tolerance. There is cross tolerance between amphetamines, benzos, opioids, and so on, so why would there NOT be cross tolerance between tryptamine psychedelics, esp. ones as similar as LSD and psilocin?


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. [Re: LSDreamer]
    #8558488 -

.


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Edited by AnonymousRabbit (05/18/22 11:19 PM)

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Mushrooms, Mycology and Psychedelics > The Psychedelic Experience
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