Home | Community | Message Board
You are not signed in.
Sign In New Account
Forum Index Search Posts Trusted Vendors Highlights Galleries FAQ User List Chat Store Random Growery


This site includes paid links. Please support our sponsors.

Community > The Pub
Threaded Mode Threaded  Previous topic Previous  View all topics Index  Next topic Next 

Welcome to the Shroomery Message Board! You are experiencing a small sample of what the site has to offer. Please login or register to post messages and view our exclusive members-only content. You'll gain access to additional forums, file attachments, board customizations, encrypted private messages, and much more!

Shop: Unfolding Nature Unfolding Nature: Being in the Implicate Order   Myyco.com Golden Teacher Liquid Culture For Sale   Original Sensible Seeds Autoflowering Cannabis Seeds, Bulk Cannabis Seeds

Jump to first unread post Pages: | 1 | 2  [ show all ]
Re: Synthetic cannabinoid 100-800x more potent than THC [Re: DNKYD]
    #6889442 -

DNKYD said:
Fuck the synthetics.



--------------------
Live for the moment you are in now
Don't be bogged down by your past
Don't be afraid of what lies in your future

Extras: Filter Print Post Top
Re: Synthetic cannabinoid 100-800x more potent than THC [Re: niteowl]
    #6889545 -

i want some.


--------------------


These walls, such they be, are crawling with geometric hallucinations.

Extras: Filter Print Post Top
Re: Synthetic cannabinoid 100-800x more potent than THC [Re: Asante]
    #6889700 -

why do alkanes potentiate things?

In this example the THC group has a 'dimethylheptyl' group attached to the benzene on the THC.

what about methyl-fentanyl?

why also, does the position of the group affect the potency?


--------------------
"I only ever hope to reach equilibrium, in Nature's matrix, in line with the meridian" ~ Jehst

:sun: "...and I know that I have to keep breathing, as tomorrow the sun will rise, who knows what the tide will bring?" :sun:

Free Spore Ring Europe
Send any spare spore prints you might have and help the distribution :grin:

Open Source. Freedom.  GNU/Linux

Addicting is not a word.

Extras: Filter Print Post Top
Re: Synthetic cannabinoid 100-800x more potent than THC [Re: Cepheus]
    #6889871 -

Quote:
why do alkanes potentiate things?

In this example the THC group has a 'dimethylheptyl' group attached to the benzene on the THC.

what about methyl-fentanyl?

why also, does the position of the group affect the potency?



Pharmacologically active drugs basically are chemical keys which fit onto receptors of your cells, and when such a key is in place an activation or de-activation of a process in your body takes place.

But, there is variability in receptors (locks) which allows for a group of molecules to be able to act as keys. Then there ofcourse arises the issue that some molecules will fit better than others.

If a molecule fits a receptor better, then less of the substance is needed to produce the desired effect, and the drug typically is more potent. Also, if an alteration of a molecule results in higher availability to those receptors, potency goes up too.

Lets take opiates as an example.

Morphine, the natural alkaloid, is active in a 5-25mg dose. A synthetic opioid, pethidine, is about 1/5 as strong. Heroin, which is made by heating morphine with acetic anhydride, is 2-3x as potent.

On the quest for better opioids, one of the more promising families of compounds were the derivatives of fentanyl. Fentanyl itself is a staggering 80x as potent as morphine. Here are some variations on the molecule:


<img src=http://www.shroomery.org/forums/files/06-45/307362457-fentanyls.gif>


This is only the tip of the iceberg, thousands of variations are possible.

Fentanyl is mostly broken down by cleaving the phenethyl-group off the piperidine. One can hinder that by adding a methyl group, because this gets in the way of the enzymes. Then you get alpha-methylfentanyl, which indeed is more potent, at 200x morphine. This is making an increase on availability.

If you however stick that methyl in the 3-position of the piperidine ring it will fit the "lock" far better than fentanyl itself. It fits so well in fact that it is 3.000x more potent than morphine, and three grams of this 3-methylfentanyl in fact are a million doses. (or in other words, one gram 3-MF is equivalent to a kilo of pure heroin or 3 kilos of high quality street heroin.



Quote:
In this example the THC group has a 'dimethylheptyl' group attached to the benzene on the THC.


They want this dimethylheptyl-tail on the cannabinoid molecules, because it is an optimized form, it fits the receptor very well, thats why you see it recur in many different THC analogs. And this tail fits that three-ring "body" really well, and the hydroxylated "head" (which is kinda pre-metabolized) is the finishing touch. Thats why this molecule is so potent: it fits the receptor (CB1 in this case) far better than THC does.


There are a thousand things more to it, but this basically is the main theme. Given the potency of HU-210 I wouldn't be surprised if one day molecules are found that are several thousand times more potent than THC, but they probably will have a novel structure. If they are relatively easy to synthesize and have good oral bioavailability and effects, you might be looking at one of the world's most popular recreational drugs of the future.

But HU-210 already might be a lot like this one:

Quote:
CP 55,940, is a cannabinoid which mimics the effects of naturally occurring THC (the psychoactive compound found in marijuana). CP 55,940 was created by Pfizer in 1974 and was never marketed because of its highly psychoactive nature. It is currently used by scientists to study cannabinoid effects in biology. Some effects that have been noted are a greatly decreased rates of lever pressing in exposed mice, and a greater reaction to opiates in exposed mice. CP-55940 is 40 times more potent than Δ9-THC, and fully antagonized by rimonabant (SR141716A) (Life Sci 1996;58:1239-47; last update 010106). CP 55940 produces cannabis-like effects in humans at a dose of 0.25 - 1 milligram and could potentially be used as a legal alternative to medicinal marijuana but is unlikely to be marketed for this purpose due to its abuse potential.
structure



Imagine an ultrapotent cannabinoid of increased desirability over THC. HU-210 might be it.


--------------------
Omnicyclion.org
personal empowerment for the world

:nyan: LGBT - Love God Before Tradition :nyan:

Extras: Filter Print Post Top
Re: Synthetic cannabinoid 100-800x more potent than THC [Re: Asante]
    #6890244 -

That's awesome and all.... but half the fun of getting stoned is smoking that joint, or taking a nice rip from that bong.

I guess it'd be good in places where the smell would be a big no-no.  :shrug:


--------------------
~Happy sailing~

Extras: Filter Print Post Top
Re: Synthetic cannabinoid 100-800x more potent than THC [Re: RuNE]
    #6890260 -

Like planes, and schools. Places where you really need to get high.


--------------------
The story goes, or the way that I was told
There was a king that always felt too high and then he fell too low
And so he called all the wise men to the hall
And begged them for a gift to end the rises and the falls
But here’s the thing, they came back with a ring
It was simple and was plainly unbefitting of a king
Engraved in black, it had no front or back
But there were words around the band that said
Just know: This Too Shall Pass


Extras: Filter Print Post Top
Re: Synthetic cannabinoid 100-800x more potent than THC [Re: NobodyCares]
    #6890318 -

NobodyCares said:
Like planes, and schools. Places where you really need to get high.


:clap: :thumbup:


--------------------

Extras: Filter Print Post Top
Jump to top Pages: | 1 | 2  [ show all ]

Shop: Unfolding Nature Unfolding Nature: Being in the Implicate Order   Myyco.com Golden Teacher Liquid Culture For Sale   Original Sensible Seeds Autoflowering Cannabis Seeds, Bulk Cannabis Seeds

Community > The Pub
Threaded Mode Threaded  Previous topic Previous  View all topics Index  Next topic Next 

Similar ThreadsPosterViewsRepliesLast post
* Cannabinoids Induce Brain Cell Growth? korins 1,726 8 10/19/05 11:31 AM
by Skunk420
* THC Detection Times Shorter Than First Thought HighGuy 12,214 14 02/24/06 04:14 PM
by beavis190
* Question about THC leaving yer system.
( 1 2 all )		 OneMoreRobot3021 2,554 29 12/04/05 06:13 PM
by KaptKid
* thc content of resin? Moonshoe 19,471 19 12/18/09 08:10 PM
by Rocker232
* $100,000 challenge spacedragon 1,275 3 09/01/03 07:24 PM
by Crass
* Recommendations to pass a Piss test for THC? Boosted98gsx 2,657 16 09/13/04 02:15 PM
by Psychoslut
* Organic Vs. Synthetic Anubis 2,111 15 04/10/05 11:57 AM
by baraka
* Waterpipe/Bong Question (THC & boiling point) goodoldrascal 1,096 6 01/31/06 02:47 PM
by goodoldrascal

Extra information
You cannot start new topics / You cannot reply to topics
HTML is disabled / BBCode is enabled
Moderator: Entire Staff
8,734 topic views. 2 members, 181 guests and 97 web crawlers are browsing this forum.
[ Show Images Only | Sort by Score | Print Topic ]
Search this thread:

Copyright 1997-2026 Mind Media. Some rights reserved.

Generated in 0.03 seconds spending 0.007 seconds on 15 queries.