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Mushrooms, Mycology and Psychedelics > The Psychedelic Experience
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Re: 250 mg dmt snorted, humbled into respecting others now. [Re: Nature Boy]
    #25916759 -

Semisynthesis is a thing. Heroin is semisynthetic. So is oxycodone.

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Re: 250 mg dmt snorted, humbled into respecting others now. [Re: cjb85]
    #25916761 -

Dont forget LSD! :lsd:

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Re: 250 mg dmt snorted, humbled into respecting others now. [Re: LogicaL Chaos] * 1
    #25916773 -

and Naproxen and Asprin and... a shit ton lol really


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Re: 250 mg dmt snorted, humbled into respecting others now. [Re: RebeccaBlack]
    #25916826 -

Sure.  Of course it's a "thing" (proper terminology) for certain drugs and as the results of some preparations; but semi-synthetic is NOT a term that could ever be applicable to DMT...so stop trying to compare apples to oranges.

Either it comes from a wholly natural source (acacia, mimosa) or is fully synthesized (think Shulgin).  There's no middle ground.  Hence, referring to the DMT you snorted as semi-synthetic (like LSD) and trying to explain away the degree of nasal mucosal burn (as did the OP) because your DMT was "semi-synthetic" is idiotic.  It burns because DMT freebase is (as the name implies) a very strong base - and the LAST thing you would want to snort.

It is dirt cheap and stupid easy to turn the freebase into a fumarate salt for insufflation.  You know how I know that?  I posted the technique to this board eight YEARS 10 months ago.

https://www.shroomery.org/forums/showflat.php/Number/12506186#12506186


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All submitted posts under this user name are works of pure fiction or outright lies.  Any information, statement, or assertion contained therein should be considered pure unadulterated bullshit.  Note well:  Sorry, but I do not answer PM's unless you are a long-time trusted friend.  If you have a question, ask it in the appropriate thread.

                                                                               

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Re: 250 mg dmt snorted, humbled into respecting others now. [Re: Nature Boy]
    #25916836 -

Nature Boy said:
Sure.  Of course it's a "thing" (proper terminology) for certain drugs and as the results of some preparations; but semi-synthetic is NOT a term that could ever be applicable to DMT...so stop trying to compare apples to oranges.

Either it comes from a wholly natural source (acacia, mimosa) or is fully synthesized (think Shulgin).  There's no middle ground.  Hence, referring to the DMT you snorted as semi-synthetic (like LSD) and trying to explain away the degree of nasal mucosal burn (as did the OP) because your DMT was "semi-synthetic" is idiotic.  It burns because DMT freebase is (as the name implies) a very strong base - and the LAST thing you would want to snort.

It is dirt cheap and stupid easy to turn the freebase into a fumarate salt for insufflation.  You know how I know that?  I posted the technique to this board eight YEARS 10 months ago.

https://www.shroomery.org/forums/showflat.php/Number/12506186#12506186


Man, let the chemist do those talks, it's just cringy to read this.

Tryptamine to N,N-dimethyltryptamine is a semi-synthesis. Tryptamine is exctracted from other plants.

Freebase doesn't mean strong base, it means it's under it's basic form and not a salt form. pKa of the conjugated acid is 9, bro. You could eat stuff at pH 9.

People eat fermented shark at a pH of 9.3 and century egg (I've tried those) at pH 9,5.

Quote:
There's no middle ground.


:loldongs: What about extraction N-methyltryptamine and do one methylation? That's no middle ground at all!

Lol sorry for the sarcasm, but you speak like you know this stuff and I just can't not reply in this way :rolleyes:

''I read Pihkal, I know chemistry''
:canthelpbutlaugh:


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Re: 250 mg dmt snorted, humbled into respecting others now. [Re: RebeccaBlack] * 1
    #25916837 -

Oh, Oh, oh, and let me guess. You think near death experience are endogenous-DMT induced and it's a god molecule?!

:canthelpbutlaugh:


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Re: 250 mg dmt snorted, humbled into respecting others now. [Re: RebeccaBlack]
    #25916863 -

I pulled a tony, now, Didn't I?

Fucking emotions, I should get back on weed 24/7


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Re: 250 mg dmt snorted, humbled into respecting others now. [Re: RebeccaBlack]
    #25917968 -

You know perfectly well the OP's source was not derived from a semi-synthetic process.  I've been an active participant on this board for more than a decade and no one has ever offered up any DMT related experience from any source other than a plant based extraction.

It is preposterous and bald-faced exaggeration for the OP to suggest otherwise.  And to attribute the "burn" to that very "semi-synthetic" characteristic is just ludicrous. No matter HOW you arrive at the substance, once you insufflate freebase DMT - experientially it is precisely the same and independent of the method used to derive it.


Edited by Nature Boy (04/05/19 05:02 PM)

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Re: 250 mg dmt snorted, humbled into respecting others now. [Re: Nature Boy]
    #25917980 -

I don't know really. I've never taken DMT that wasn't made from bis-methylation of plant extracted tryptamine.

I've shared photos of my product and shared my experiences.

The color can be brown if not well purified.

Take it down a notch, bae. There's nothing that fancy about semi-synthesis.


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Re: 250 mg dmt snorted, humbled into respecting others now. [Re: RebeccaBlack]
    #25917985 -

Sure, no problem.  My argument isn't with you.


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All submitted posts under this user name are works of pure fiction or outright lies.  Any information, statement, or assertion contained therein should be considered pure unadulterated bullshit.  Note well:  Sorry, but I do not answer PM's unless you are a long-time trusted friend.  If you have a question, ask it in the appropriate thread.

                                                                               

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Re: 250 mg dmt snorted, humbled into respecting others now. [Re: Nature Boy]
    #25917996 -

Nature Boy said:
You know perfectly well the OP's source was not derived from a semi-synthetic process.  I've been an active participant on this board for more than a decade and no one has ever offered up any DMT related experience from any source other than a plant based extraction.


Well, you missed some action then.

Nature Boy said:
It is preposterous and bald-faced exaggeration for the OP to suggest otherwise.  And to attribute the "burn" to that very "semi-synthetic" characteristic is just ludicrous. No matter HOW you arrive at the substance, once you insufflate freebase DMT - experientially it is precisely the same and independent of the method used to derive it.



I agree, but you talk about freebase DMT and the guy talks about a bag of brown powder containing a mix of whatever DMT.

If impure, the method to get it is highly important. A brown semi-synthetic DMT powder isn't full spectrum, it contains other molecules that may cause this irritation that you only get from bis-reductive amination from tryptamine.

I am not saying OP is right. I'm saying you are wrong.


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Re: 250 mg dmt snorted, humbled into respecting others now. [Re: RebeccaBlack] * 2
    #25918076 -

Daijo said:
I don't know really. I've never taken DMT that wasn't made from bis-methylation of plant extracted tryptamine.

I've shared photos of my product and shared my experiences.

The color can be brown if not well purified.

Take it down a notch, bae. There's nothing that fancy about semi-synthesis.


questions...

Does nn-dmt exist as nn-dmt in plants? then we protonate it to make it highly soluble in solvent and then reduce the temp of that solvent to make it fall out... Right?

I haven't heard of tryptamine being bis-methylated in this process. Where would the methyl come from? If it's so easy to do with plant based tryptamines how come we can just get a jar or tryptamine and do the same?

How come every source of literature claims that plants contain nn-dmt? How come we can just cook the leaves in water to extract the nn-dmt and then just drink it?

How come all the chemists I've spoken to over the years I've been interested in this subject have never mentioned this semi-synthesis, only protonating and deprotonating the molecule? Or is that what you mean? Is it just an exercise in semantics?

There's something that doesn't add up here.


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We are the music makers, the dreamers of dreams.

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Re: 250 mg dmt snorted, humbled into respecting others now. [Re: Northerner]
    #25918240 -

:popcorn:


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54. The true nature of things is to be known personally , through the eyes of clear illumination and not through a sage : what the moon exactly is , is to be known with one's own eyes ; can another make him know it?

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Re: 250 mg dmt snorted, humbled into respecting others now. [Re: Northerner]
    #25918276 -

My understanding is DMT can be natural (bark/plants), semi-synthetic OR pure synthetic (huge white crystals).

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Re: 250 mg dmt snorted, humbled into respecting others now. [Re: Nature Boy] * 1
    #25918392 -

Nature Boy said:
Eatmore_lessoften said:
But sigh... to clarify this was a semi synthetic blend of freebase, plus the yellow kind mixed into it.


"Semi-synthetic."  :facepalm:
:lolsy:



I guess be snorted LSD :lol:


--------------------
Something there is mysteriously formed,
Existing before Heaven and Earth,
Silent, still, standing alone, unchanging,
All-pervading, unfailing,
I do not know its name; I call it tao.
If forced to give it a name, I call it
Great (ta). Being great, it flows out;
Flowing out means far-reaching;
Being far-reaching, it is said to return.

It's just a shot away..

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Re: 250 mg dmt snorted, humbled into respecting others now. [Re: connectedcosmos]
    #25918556 -

connectedcosmos said:
:popcorn:


At this point, it's all I can do. There so much shit being said hahaha I'm going back to League of Legends.

but seriously, fuck off with your protonations, that's not synthesis hahahahahhaa


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Re: 250 mg dmt snorted, humbled into respecting others now. [Re: RebeccaBlack]
    #25918701 -

Daijo said:
connectedcosmos said:
:popcorn:


At this point, it's all I can do. There so much shit being said hahaha I'm going back to League of Legends.

but seriously, fuck off with your protonations, that's not synthesis hahahahahhaa


Exactly. I'm glad you see the irony.

Seems that you're a lot of talk. Didn't actually want to explain how you got to "I've never taken DMT that wasn't made from bis-methylation of plant extracted tryptamine."

Called your bullshit mate.


--------------------
We are the music makers, the dreamers of dreams.

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Re: 250 mg dmt snorted, humbled into respecting others now. [Re: Northerner]
    #25918888 -

It's simply a matter of terminology.  The term semi-synthetic is inappropriate and inaccurate when applied to DMT extracted from a plant source. Protonating and deprotonating to extract and precipitate does not make the end product semi-synthetic  The term semi-synthetic  implies the use of wholly different reagents (one or more of which may have been derived from a natural source) were chemically combined to a final end-product...often in multiple intermediate steps.  That is why "semi-synthetic" is a completely accurate term for the production of LSD, for example.

Oh, and if the burn was particularly bad and the color off, it might very well be that there was some lye in the OP's admixture - a common technical error not particulary problematic when vaporizing, but a whole new kind of hell if insufflating.


--------------------
All submitted posts under this user name are works of pure fiction or outright lies.  Any information, statement, or assertion contained therein should be considered pure unadulterated bullshit.  Note well:  Sorry, but I do not answer PM's unless you are a long-time trusted friend.  If you have a question, ask it in the appropriate thread.

                                                                               

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Re: 250 mg dmt snorted, humbled into respecting others now. [Re: Nature Boy]
    #25918944 -

I cannot even imagine snorting lye laden freebase.  :omgz:


--------------------
We are the music makers, the dreamers of dreams.

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Re: 250 mg dmt snorted, humbled into respecting others now. [Re: Northerner] * 1
    #25919046 -

Northerner said:
Exactly. I'm glad you see the irony.

Seems that you're a lot of talk. Didn't actually want to explain how you got to "I've never taken DMT that wasn't made from bis-methylation of plant extracted tryptamine."

Called your bullshit mate.


:popcorn:

I simply took the tryptamine bottle from Aldrich, which they get from plant extraction. I dissolve in 1,4-dioxane, cool to 0°C in an ice bath, add some catalytic acetic acid and a hydride source (it was NaBH3CN or triacetoxyborohydride, I can't remember and would both work) and add dropwise a solution of formaldehyde over two hours at 0°C. Followed by stirring at room temperature for a couple hours until LCMS indicated complete conversion of tryptamine.

A little shit get synth'd too in there because of competing mechanisms, making the purification quite a bitch :

Here, over the decade that dude said earlier, he never witness anybody tell about semi-synthetic DMT.

Daijo said:
shadowman-x said:
repeated crystallizations mah boi . Physical separation and it's not too hard. Check out this thread .
https://www.dmt-nexus.me/forum/default.aspx?g=posts&t=6683


But check this out :

Flash chromatography followed by recryst



edit : it's the freebase, so it doesn't do nice crystals.

from Post your candy. Just go take a look at the posts
Here is the LCMS (one peak)

You can see the desired mass from the mass spec.

189 m/z corresponds to the mass of charged DMT (protonated). N,N-DMT weighs Molar mass: 188.269 g/mol. Add one proton to charge the molecule so it can move in a magnetic field in the MS, 188+1=189

I've also never had plant extracted mescaline. Got it from 3,4,5-Trimethoxybenzyl cyanide reduction with LAH.





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Edited by RebeccaBlack (04/06/19 08:18 AM)

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