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Re: Is it okay to roll Molly 3 times within 3 weeks? [Re: Scarab74]
    #18536934 -

I rolled like 9 weeks in a row during grad school.  I survived.  There were insane djs coming through and the dealers were giving fire as fuck molly almost literally away for free.  Just couldn't resist.


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"plus they atually think jambands are good or sumthing, so they clearly know absolutely nothing about music, clearly lol" -Bassfreak

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Re: Is it okay to roll Molly 3 times within 3 weeks? [Re: Scarab74]
    #18536984 -

i didnt bother to read past the OP but, is it okay to roll again? FUCK NO

if you roll again, will you suffer some irreversable damage? fuck if i know.

all i can tell you is that ive rolled 3 times in 3 days, plus again the following weekend.

am i fucked up? have i suffered a brain damage?

only an indepth scientific analysis can tell me that. all i can say is that i rolled over 100 times in a two and a half year period. i feel the same, however, my memory is not quite as sharp. some may call this brain damage. yet i was also doing alot of other drugs during this period. so its anyones guess as to what caused the slight memory loss. for all i know it could have been from consuming massive ammounts of cannabis.

this is my personal experience.

your roll will not be as strong if you choose to do it again, but you only live once. you will not have access to mdma for your entire life

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Re: Is it okay to roll Molly 3 times within 3 weeks? [Re: MilkdudTitties]
    #18538101 -

I rolled too much when I was younger, and I lost the magic. Even a good long break didn't bring it back. I'll eat MDMA maybe once a year now, and while it's still fun & worthwhile, it's not what it used to be......and honestly never will be again.


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Re: Is it okay to roll Molly 3 times within 3 weeks? [Re: Meesh]
    #18543487 -

Not worth it. You can make that gram last a long, long time. Just roll every once in a while and that way, you'll get the most out of your rolls. Shulgin suggested using it no more than 4 times a year, but I can understand how you may get impatient with that.  :shrug:

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Re: Is it okay to roll Molly 3 times within 3 weeks? [Re: RockyRaccoon]
    #18543659 -

i don't think you'll do any permanent damage op, but i think your second and third times will be lackluster experiences.


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I'm up to my ears in unwritten words. - J.D. Salinger

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Re: Is it okay to roll Molly 3 times within 3 weeks? [Re: Meesh] * 3
    #18543748 -

For anyone interested, here's what MDMA does to your brain and why it's bad to do it too often (we just studied this in my neuroscience class this morning and it wsa incredibly interesting for me at least):



MDMA mimicks serotonin. Actually, your body's receptors recognize MDMA more readily than serotonin. When you take MDMA, the molecule is taken up by your serotonin transport proteins. These usually reuptake serotonin to ensure you don't have a chemical imbalance. MDMA reverses these transporters, so instead of removing excess serotonin from your synapse, it shoots out more and more with no reuptake mechanism at all. MDMA also binds to VMAT2, a protein responsible for transporting recycled serotonin back into vesicles. So, even more serotonin is dumped out into your synapse. This is why it's referred to as a serotonin "dump". Then, the excess serotonin binds to the autoreceptors of the presynaptic neuron, which is responsible for regulating the neuronal biosynthesis of serotonin, and slows the production of serotonin.

In summary:

(though "block" isn't really the right term, because the molecule actually alters the function, as explained above)

:themoreyouknow::havesomescience:


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Sapere aude

"We cannot live for ourselves alone. Our lives are connected by a thousand invisible threads, and along these sympathetic fibers, our actions run as causes and return to us as results."


UBUNTU- I am because we are.


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Re: Is it okay to roll Molly 3 times within 3 weeks? [Re: JoieDeVivre]
    #18543789 -

Somebody please pronounce reuptake for me...
Re  up  take?

Also, bioassay  bi  ossey?

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Re: Is it okay to roll Molly 3 times within 3 weeks? [Re: JoieDeVivre]
    #18543856 -

JoieDeVivre said:

Thanks Joie!


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14:31

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Re: Is it okay to roll Molly 3 times within 3 weeks? [Re: shLong] * 1
    #18543868 -

Sure, no problem! I found it super interesting and figured others here would as well. :smile::thumbup:

shLong said:
Somebody please pronounce reuptake for me...
Re  up  take?

Also, bioassay  bi  ossey?


Re-up-take

bio-assay

I could be wrong, on the second one though I'm pretty sure I'm not.


--------------------
Sapere aude

"We cannot live for ourselves alone. Our lives are connected by a thousand invisible threads, and along these sympathetic fibers, our actions run as causes and return to us as results."


UBUNTU- I am because we are.


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Re: Is it okay to roll Molly 3 times within 3 weeks? [Re: JoieDeVivre]
    #18544067 -

Buy Oh Us Ay = bioassay
At least that's how I always pronounce it.

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Re: Is it okay to roll Molly 3 times within 3 weeks? [Re: abltsandwich]
    #18544076 -

did you go over why it has to make you take a dump right when it comes on?


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I'm up to my ears in unwritten words. - J.D. Salinger

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Re: Is it okay to roll Molly 3 times within 3 weeks? [Re: millzy]
    #18544087 -

:rofl: Not at all, I've never experienced that at all.


--------------------
Sapere aude

"We cannot live for ourselves alone. Our lives are connected by a thousand invisible threads, and along these sympathetic fibers, our actions run as causes and return to us as results."


UBUNTU- I am because we are.


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Re: Is it okay to roll Molly 3 times within 3 weeks? [Re: JoieDeVivre]
    #18544106 -

JoieDeVivre said:
:rofl: Not at all, I've never experienced that at all.


lucky. i've had to leave the club before to blow mud. :goodluckwiththat2:


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I'm up to my ears in unwritten words. - J.D. Salinger

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Re: Is it okay to roll Molly 3 times within 3 weeks? [Re: millzy]
    #18544122 -

Thanks, all.
Joie, could you please take a moment and, in layman's terms, describe what reuptake means..
(just a couple sentences if possible)

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Re: Is it okay to roll Molly 3 times within 3 weeks? [Re: millzy]
    #18544129 -

millzy said:
did you go over why it has to make you take a dump right when it comes on?


I'd think it's due to how nearly all stims seem to do that... Not sure why, though.

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Re: Is it okay to roll Molly 3 times within 3 weeks? [Re: shLong] * 1
    #18544215 -

shLong said:
Thanks, all.
Joie, could you please take a moment and, in layman's terms, describe what reuptake means..
(just a couple sentences if possible)


Okay, referring back to my first diagram will help explain this.



Do you see the channel labeled "SERT"? It's a transporter protein that is responsible for bringing unused serotonin (5-HT) back into the cell to recycle it so that the body has to use less energy making new neurotransmitters. That's reuptake. Most, if not all, neurotransmitters are reuptaken. (Then they're put back into vesicles by VMAT2 to await re-release into the synapse, which is non-essential information.)

Acetylcholine (Ach) is a much better example, as choline (the precursor to make Ach) is an essential amino acid meaning our bodies can't make it on their own. So, it's essential to proper function that unused Ach is recycled and its components are reuptaken into the neuron.


--------------------
Sapere aude

"We cannot live for ourselves alone. Our lives are connected by a thousand invisible threads, and along these sympathetic fibers, our actions run as causes and return to us as results."


UBUNTU- I am because we are.


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Re: Is it okay to roll Molly 3 times within 3 weeks? [Re: JoieDeVivre]
    #18544243 -

So, one side blasts serotonin matter against the "receiver", it bounces(?) back and is reuptaken to blast out again?
What from is serotonin in? Little gobs? Energy? Etc....?
Is this all contained? Can it bounce away and not get grabbed by either and just sit there and 'rot'?

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Re: Is it okay to roll Molly 3 times within 3 weeks? [Re: shLong] * 1
    #18544307 -

shLong said:
So, one side blasts serotonin matter against the "receiver", it bounces(?) back and is reuptaken to blast out again?


Yeah, serotonin is released from the presynaptic neuron via vesicles which are little membrane encoated pockets of chemicals that can fuse with the outer membrane of the neuron. That fusion leads to the dumping of serotonin into the gap between the two synaptic terminals (this gap is the synapse itself).

The serotonin floats around and firstly binds to the postsynaptic neurons. It doesn't really bounce, the serotonin is attracted to it's receptors and transporters because the binding sites have strong affinity for the molecule. So, if all the post synaptic receptors are filled with serotonin molecules, that's when the floating serotonin will be attracted to either it's transporter, it's autoreceptor or a degredation enzyme.

Quote:
What from is serotonin in? Little gobs? Energy? Etc....?


It's a molecular structure:
http://wpcontent.answcdn.com/wikipedia/commons/thumb/f/f1/Serotonin_27feb.gif/200px-Serotonin_27feb.gif

It's specific shape and the chemicals involved make it so that it can bind to the receptors on the postsynaptic neuron.

Quote:
Is this all contained? Can it bounce away and not get grabbed by either and just sit there and 'rot'?


It's a very small space and from what I know, it all stays within the synapse area. There are a few possibilities with any neurotransmitter (NT):

    [1] it binds to its respective receptor on the postsynaptic terminal
    [2] it is reuptaken into the cell (recycled for later use)
    [3] it binds to it's autoreceptors (when there is too much NT floating around) which in turn slows the biosynthesis of said NT within the cell
    [4] it is degraded by enzymes that sit on the outer edges of the synapse


--------------------
Sapere aude

"We cannot live for ourselves alone. Our lives are connected by a thousand invisible threads, and along these sympathetic fibers, our actions run as causes and return to us as results."


UBUNTU- I am because we are.


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Re: Is it okay to roll Molly 3 times within 3 weeks? [Re: JoieDeVivre]
    #18544319 -

Very nice/helpful

Thanks a lot for taking the time.

:themoreyouknow:

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Re: Is it okay to roll Molly 3 times within 3 weeks? [Re: shLong]
    #18544326 -

Sure, thanks for helping me study. :awethumb:

I hope it was all somewhat understandable and not inaccessibly worded. :lol:


--------------------
Sapere aude

"We cannot live for ourselves alone. Our lives are connected by a thousand invisible threads, and along these sympathetic fibers, our actions run as causes and return to us as results."


UBUNTU- I am because we are.


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