Quote:

People often fail to achieve the effects the first time they try the plant, possibly due to problems in the administration of the drug. With repeated use, anecdotal evidence suggests that decreased dosage may be possible for the same level experience. Due to the lack of scientific studies on Salvia, if true it is unknown whether this is due to learning proper techniques of administration or a sensitization factor, sometimes colloquially referred to as "reverse-tolerance". It should be noted that as with other hallucinogens (such as Psilocybin), some users will have a high natural tolerance to the main active constituent, Salvinorin A.

Some people who try Salvia find it difficult or impossible to achieve the desired effects. This may be due to an insufficient flame. However, sometimes the results are unpredictable. For example, a user may smoke a large amount and feel no effect, but the next day may smoke a small amount and experience a strong trip.

---

Quote:

Some people believe that it takes a few tries before one gets to ?know? the plant. Eventually, after several attempts, some people report being able to 'break through'. It almost seems as though in some cases one has to learn to ?understand? the effects. When using the quid method, people report that trying a larger amount and chewing for a longer time can help. If a person is smoking the leaves in a pipe, switching to a bong might be beneficial. Some people have said that they become more sensitive to the effects of Salvia divinorum after having smoked Cannabis, and others have suggested that drinking a beer or two beforehand might help one to relax and increase one?s ability to notice the plant?s effects. (Nevertheless, it seems wise to have experienced and become familiar with the effects of S. divinorum on its own, prior to mixing it with an other drug, and it is probably a BAD idea to get drunk and then start smoking S. divinorum.) If an individual has tried both chewing and smoking the leaves several times, and has not achieved effects, he or she might want to try a sublingual extract or one of the smokable fortified ?X? extracts (see descriptions below).

It also appears clear that some people, as with all psychoactive substances, are just more resistant to the effects and require higher doses to achieve marked alteration in thinking and perception than others. As always, experienced users recommend starting low and slowly and methodically increasing the dose over time.

---