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Offlinecrazyman
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Registered: 11/07/98
Posts: 932
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Last seen: 8 years, 8 months
GABA ? As a benzo substitute?
    #3617536 - 01/12/05 01:11 PM (11 years, 10 months ago)

Anyone here have any knowlege of GABA, (gamma amino butiric acid) (sp?)?
I've researched that it "can" raise the amounts of GABA in your blood/brain barrier. Benzos work by increasing availability/absorbsion of GABA, (naturally found in the brain). But I've also read that taking GABA, (available at most health food stores), is pointless because your digestive tract destroys or metabolizes it before it can reach the blood/brain barrier.
Perhaps taking an MAOI along with GABA will allow the body to utilize the oral dose of GABA, or perhaps that could be a bad combo.
I dunno....Any feedback?


--------------------
I want to live in Northern Exposure. Ed Chigliak would be my pal.



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Invisibledblaney
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Registered: 10/03/04
Posts: 7,894
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Re: GABA ? As a benzo substitute? [Re: crazyman]
    #3618359 - 01/12/05 03:56 PM (11 years, 10 months ago)

There's an Rx...Neurontin aka Gabapentin, which adds a peptide chain to the GABA molecule, allowing it to survive in the stomach and enter your brain.


--------------------
"What is in us that turns a deaf ear to the cries of human suffering?"

"Belief is a beautiful armor
But makes for the heaviest sword"
- John Mayer

Making the noise "penicillin" is no substitute for actually taking penicillin.

"This country, with its institutions, belongs to the people who inhabit it. Whenever they shall grow weary of the existing government, they can exercise their constitutional right of amending it, or their revolutionary right to dismember or overthrow it." -Abraham Lincoln


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Offlinecrazyman
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Registered: 11/07/98
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Re: GABA ? As a benzo substitute? [Re: dblaney]
    #3622485 - 01/13/05 09:02 AM (11 years, 10 months ago)

I used to take Neurontin for panic attacks, but never along with GABA in capsule form. I wonder if this may not be a safe combo..... Neurontin and OTC GABA.


--------------------
I want to live in Northern Exposure. Ed Chigliak would be my pal.



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Invisibledblaney
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Re: GABA ? As a benzo substitute? [Re: crazyman]
    #3624313 - 01/13/05 06:50 PM (11 years, 10 months ago)

Oh, no, I think you misunderstood me. Neurontin is the GABA molecule with a peptide chain. Neurontin=GABA that works, you do not need to take Neurontin and OTC GABA.


--------------------
"What is in us that turns a deaf ear to the cries of human suffering?"

"Belief is a beautiful armor
But makes for the heaviest sword"
- John Mayer

Making the noise "penicillin" is no substitute for actually taking penicillin.

"This country, with its institutions, belongs to the people who inhabit it. Whenever they shall grow weary of the existing government, they can exercise their constitutional right of amending it, or their revolutionary right to dismember or overthrow it." -Abraham Lincoln


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InvisibleJim
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Re: GABA ? As a benzo substitute? [Re: dblaney]
    #3624556 - 01/13/05 07:42 PM (11 years, 10 months ago)

I took neurontin for a long time till it started to become uneffective as a mood stabilizer. Now I take the worse alternative, depakote ER.


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Use the Fucking Reply To Feature You Lazy Pieces of Shit!

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Jim, if you were in my city, I would let you fuck my wife.


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OfflineMomaFUNKDance
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Re: GABA ? As a benzo substitute? [Re: Jim]
    #3633089 - 01/15/05 11:18 PM (11 years, 10 months ago)

you guys be careful. Don't just taken neurontin for the hell of it, its an anti-psychotic, and thus it has TERRIBLE side effects, and numerous ones at that. They are NASTY drugs.


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InvisibleJim
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Re: GABA ? As a benzo substitute? [Re: MomaFUNKDance]
    #3633641 - 01/16/05 01:28 AM (11 years, 10 months ago)

neurontin is a anticonvulsant, not antipsychotic.


--------------------
Use the Fucking Reply To Feature You Lazy Pieces of Shit!

afoaf said:
Jim, if you were in my city, I would let you fuck my wife.


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Invisibledblaney
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Registered: 10/03/04
Posts: 7,894
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Re: GABA ? As a benzo substitute? [Re: Jim]
    #3635384 - 01/16/05 05:20 PM (11 years, 10 months ago)

Yeah, it's more of a mood stablizer, anti-anxiety, anti-insomnia type thing.


--------------------
"What is in us that turns a deaf ear to the cries of human suffering?"

"Belief is a beautiful armor
But makes for the heaviest sword"
- John Mayer

Making the noise "penicillin" is no substitute for actually taking penicillin.

"This country, with its institutions, belongs to the people who inhabit it. Whenever they shall grow weary of the existing government, they can exercise their constitutional right of amending it, or their revolutionary right to dismember or overthrow it." -Abraham Lincoln


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Offlineneuro
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Re: GABA ? As a benzo substitute? [Re: crazyman]
    #3635699 - 01/16/05 06:52 PM (11 years, 10 months ago)

GABA doesn't pass the blood brain barrier all that easily, I'm unaware of digestive enzymes taking it apart before it even reaches the blood stream. But supposing that's true then there's a double whammy. Attaching peptides to it as done in gabapentin allow it to cross the BBB more easily. Taking GABA from the health food store is essentially useless in theory, but people still report having less anxiety when having had taken GABA in the morning. But i suspect that's largely placebo. Perhaps if one can take sufficient amounts of GABA (which i do not suggest as i'm sure it has peripheral actions besides just action in the brain), enough of it can eek pass the BBB (some does pass obviously but it's very minimal) one can get a real and perhaps measurable effect, but I would advise against loading up on GABA.

However if you think taking GABA works and feel noticable difference, placebo or not, who is anyone to say otherwise. So long as it works (and you can afford to keep spending the money on it).


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Offlinecrazyman
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Registered: 11/07/98
Posts: 932
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Last seen: 8 years, 8 months
Re: GABA ? As a benzo substitute? [Re: neuro]
    #3636707 - 01/16/05 11:13 PM (11 years, 10 months ago)

But what about taking it with an MAOI?..... Only one way to find out, I guess... I don't think I want to be the guinea pig. Any proven medical litterature on this subject?


--------------------
I want to live in Northern Exposure. Ed Chigliak would be my pal.



Edited by crazyman (01/16/05 11:30 PM)


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Invisibledblaney
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Registered: 10/03/04
Posts: 7,894
Loc: Here & Now
Re: GABA ? As a benzo substitute? [Re: crazyman]
    #3638486 - 01/17/05 12:59 PM (11 years, 10 months ago)

I haven't looked it up, so don't quote me on this, but I am unaware of MAO enzymes destroying GABA. AFAIK, it works more on serotonin and DMT and such.


--------------------
"What is in us that turns a deaf ear to the cries of human suffering?"

"Belief is a beautiful armor
But makes for the heaviest sword"
- John Mayer

Making the noise "penicillin" is no substitute for actually taking penicillin.

"This country, with its institutions, belongs to the people who inhabit it. Whenever they shall grow weary of the existing government, they can exercise their constitutional right of amending it, or their revolutionary right to dismember or overthrow it." -Abraham Lincoln


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Offlineneuro
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Registered: 08/11/99
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Re: GABA ? As a benzo substitute? [Re: dblaney]
    #3638842 - 01/17/05 02:26 PM (11 years, 10 months ago)

I'm not too aware of the specificity of MAO enzymes. As far as I know they'll take off the NH2 group of any molecule that contains one and only one Amino group (NH2, or NRH, or NR2).

The only thing an MAOI would do specifically would decrease the break down of the GABA in the gut and increase it's blood plasma levels since it didn't get broken down, but still we have the problem of passing the blood brain barrier. Again I don't think we could raise the levels of GABA in the body to allow the miniscule amount that would pass the BBB to have any effect in the brain. Perhaps we should go for some intracerebral infusions of ventricular injections, anyone got some micropipets they'd be willing to jam through their skulls?

To me i think it's futile. GABApentin is where it's at.


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