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The Skene's glands are homologous with the prostate gland in males.[7] The fluid that emerges during sex, female ejaculation, has a composition somewhat similar to the fluid generated in males by the prostate gland,[8][9] containing biochemical markers of sexual function like human urinary protein 1[10] and the enzyme PDE5 where women without the gland had lower concentrations.[11] When examined with electron microscopy, both glands show similar secretory structures,[12] and both act similarly in terms of prostate-specific antigen and prostate-specific acid phosphatase studies.[13][14][15][16] Because they are increasingly perceived as merely different versions of the same gland, some researchers are moving away from the name Skene's gland and are referring to it instead as the female prostate.[17]

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A 2007 study on two women involved ultrasound, endoscopy, and biochemical analysis of fluid. The ejaculate was compared to pre-orgasmic urine from the same woman, and also to published data on male ejaculate. In both women, higher levels of PSA, PAP, and glucose but lower levels of creatinine were found in the ejaculate than the urine. PSA levels were comparable to those in males.[5]

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