orbo said:

entheogencia, it comes across a bit like you're trying to steer people away from acid, but perhaps people are misunderstanding your intentions. I do think it's an interesting question whether it will have a role within the medical establishment in the future. It seems like the new wave of research is focused on psilocybin for whatever reason. I do kinda doubt that LSD will have much of a role in western medicine in the future with all its social baggage, it seems like the window of opportunity has passed.

I don't think it'll ever really go away though

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entheogencia said:

Ketamine seems to be much safer than traditional psychedelics.

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tree frog said:

entheogencia said:

Ketamine seems to be much safer than traditional psychedelics.

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This was you.

And my age isn't any of your business.

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Bardy said:

Yeah, in a lab setting/psychiatrist office/professional setting maybe. If you’re using ketamine at home it definitely has the potential to be more destabilising than psychedelics. For starters it’s more addictive, and the short duration makes it easy to keep redosing. It’s also more likely to contain adulterants such as opioids.

Ketamine feels good and is easier to deal with most of the time, but that also makes it sneaky. It can creep up on you and you can become undone by it. I think you’ll find that people struggle with ketamine a lot more than they do with psychedelics.

If it is a one off dose of clean ketamine then yeah, it’s less world bending I’d say.

Psychedelics are definitely safer than ketamine on the whole though.

Ketamine use damages you bladder for instance. It can also give you lesions on your brain with long term use. Psychedelics in the common dosage range are physically not dangerous (maybe if you have a heart condition it could be).

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PlasmaBear said:

What if you are just a brain in a vat

Hypno slave

Forced to obey a sadistic Master

With no escape from your bondage

LSD-25 - like the geometry of the gravitoelectromagnetic monopole - hacking you and making you surrender and submit

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entheogencia said:

Does anybody know what the difference is between Lysergic Acid Diethylamide and Lysergide D-Tartrate?

There is a company currently recruiting for “LSD” clinical trials, but I’m not sure if their drug is the same as regular LSD or if it is an analog. They are calling it LSD, but there must be some reason why the chemical name is different.

https://mindmed.co/clinical-digital-trials/

Anybody can sign up for these trials. The same company is also trialing R-MDMA for autism.

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B Traven said:

I just wonder about all of this from a practical/technical/legal point of view.

When I was a teenager, acid primarily got distributed by Dead tour. It was a crazy-ass parking lot scene and there were always a fuck-ton of busts by local police and people who got busted often faced serious consequences. But you could buy a sheet for 40 bucks and flip it for as much as 5 bucks a hit. Shit, you could have zero interest in the Dead, buy tickets in advance locally, and then just trade them for sheets in the parking lot.

And at that time and place, mushrooms were kind of almost legendary. They were just so much more rare. Might still snag them in the dead lot, but it was a pleasant surprise. And A LOT more expensive.

Indoor weed cultivation hadn't fully exploded yet, and "mushroom grows" were still very very rare. And again, all of that could get you into seriously deep shit, even on a small scale.

So acid made a ton of sense. Compact, essy to hide and transport, and a relatively small cash investment could set you up as the neighborhood/school plug for a month.

Today, discussing "which has more utility and which will last: mushrooms or acid?" is kinda surreal. The question back in the day was basically "what can I get ahold of?" And, due to economies of scale and the mushroom cultivation scene still being in its infancy, the answer was usually kinda obvious.

Ketamine is SO much more harmful and dangerous than acid or mushrooms. But it's got all sorts of legitimate uses, and is available over the counter in a lot of countries. Sure, people have gotten into it lately, but it seems to me that this is fueled, in part, by the fact that it gets produced on an industrial scale in countries where it's at least nominally legal (even if 100% of a factory's outputs is getting diverted to the gray/black markets).

So I guess what I wonder about with acid is, who's producing it legally? Is there more or less acid in the world now than 30 years ago? I know that for me personally, I  have gravitated more towards mushrooms. But acid still holds a near and dear place in my heart. BUT it seems a lot less available than it was before. And I'm more sketched out by the possibility of ending up with RC's. But perhaps most importantly, the laws and enforcement patterns for weed and mushrooms are constantly evolving. I can be chill about those things, and transparent discussions of the entire supply chain and production process are not really a big deal. All the risk of jail and cloak-and-dagger shit that comes with procuring acid is just too coke and meth-y for my tastes anymore. Not having to worry about getting busted for weed, and knowing that mushrooms are absolute dead-last on law enforcement's list of priorities in my area, really puts everything else in stark relief. So, yeah, with that as my random personal perspective, I wonder what things looks like for a pharmaceutical company trying to secure permits and roll out LSD trials. Or even an underground lab in Eastern Europe somewhere.

I know one thing, though, ergot's not going anywhere. Don't forget that it's all still fungus. Maybe our future will really be bioengineered fungi that spit out whatever drugs we want.

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tree frog said:

entheogencia said:

Does anybody know what the difference is between Lysergic Acid Diethylamide and Lysergide D-Tartrate?

There is a company currently recruiting for “LSD” clinical trials, but I’m not sure if their drug is the same as regular LSD or if it is an analog. They are calling it LSD, but there must be some reason why the chemical name is different.

https://mindmed.co/clinical-digital-trials/

Anybody can sign up for these trials. The same company is also trialing R-MDMA for autism.

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LSD - d is the active isomer, the other three forms are not.  Tartrate refers to it being in a salt form.

https://www.reddit.com/r/AskChemistry/comments/12t6zl6/is_lsd_alkaline_or_acidic/

Essentially, to get LSD - d into a solid/crystalline form, it is made into a tartrate salt first.

MindMed isn't doing anything novel.  Likely rebranding it hoping for a patent (unlikely to happen, as this form isn't anything new) or rebranding it so folks are less weary (more likely)

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entheogencia said:

Considering nobody else has a patent for any LSD analog, I like their chances.

Whatever company is able to bring LSD back to market will certainly be doing something pretty novel.

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