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Dual studies highlight Ketamine’s potential to treat anxiety and addiction
    #25903185 -

Two new studies suggest the psychiatric benefits of ketamine treatment may extend beyond just the targeting of depression. The research demonstrates ketamine may be helpful in targeting both anxiety- and substance abuse-related depression.

Although ketamine is a relatively old drug, originally developed in the 1960s as an anesthetic, over the last decade a growing body of research has affirmed its unique, and rapid, antidepressant effects. Both the science and anecdotal evidence has become overwhelming, it is now clear that ketamine acts powerfully and rapidly as an antidepressant and is able to treat even the most difficult cases of depression.  Northwest Ketamine Clinics, with locations in Seattle and Bellevue, is the leading clinic in the region.  We’ve successfully treated hundreds of patients and remain the most respected and lowest priced ketamine provider in the area. 
Much is still unknown about the use ketamine actually is for depression.  Through research and clinical experience, we are quickly becoming able to pinpoint the proper dose for each patient and work with the patient to increase the success rate and lengthen the times between “booster” infusions. Two newly published studies are adding to our knowledge about ketamine’s psychiatric uses, adding weight to the drug’s burgeoning new potential.
The first study, led by a team from Massachusetts General Hospital and Harvard Medical School, set out to study how effective ketamine is at treating patients with anxiety-based treatment-resistant depression. This is an important question to resolve, as many traditional antidepressants do not consistently improve anxiety-based symptoms in cases of major depression.
The study took 99 subjects with treatment-resistant depression, half of whom suffered from high anxiety and half of whom displayed no anxious symptoms. The study randomly administered subjects either one of four different intravenous ketamine doses or midazolam, a general sedative that could serve as a control.
As well as demonstrating ketamine’s novel antidepressant qualities, the study revealed the drug worked equally well in both anxious and non-anxious subjects. This suggests that ketamine’s antidepressant effects are uniquely effective across different types of treatment-resistant depression, something that cannot be said for many major antidepressant drugs.
“In contrast to reports from monoaminergic antidepressants, our data suggest that patients with anxious depression respond equally as well to ketamine compared to those with non-anxious depression,” write the researchers in the published study.
The second new study comes from a team at Yale University School of Medicine. This research investigated whether ketamine could be effective in treating addiction-related depression when administered in tandem with naltrexone.
A study in 2018 offered a small but significant finding, revealing that ketamine was ineffective in treating depression when administered alongside naltrexone. These results were important because they suggested that part of ketamine’s antidepressant effects may be related to the activation of opioid receptors, which would mean long-term ketamine use may potentially result in problems with addiction, something that many researchers have long argued against.
Naltrexone, an opioid receptor blocker, is often administered effectively to combat serious substance abuse problems, so if it rendered ketamine ineffective then that would cast doubt on much research into how ketamine actually works to reduce symptoms of depression. The new Yale research was small, with a sample of only five patients, but its results strongly suggest ketamine and naltrexone do not cancel each other out.
All five subjects suffering from alcohol use disorder and depression displayed significant depressive relief from ketamine dosages despite long-term naltrexone consumption. Senior author on the study, John Krystal, says although larger studies still need to be completed the research does suggest ketamine and naltrexone may be a complementary combination that helps treat substance abuse and its related depression.
“[The results] raise the possibility that for people who have depression complicated by substance abuse disorders, the combination of ketamine and naltrexone may be a strategy to explore in the effort to optimally treat both conditions,” says Krystal.
We are still in the early stages of research regarding depression and substance abuse and large studies are still needed. This new study only consisted of five subjects, and the prior research linking ketamine to the opioid system was generated from just 12 subjects. We are still in somewhat uncharted territory regarding ketamine’s mechanistic effects of the brain and larger studies are needed. But the Yale research should assuage some fears that ketamine may be, “merely another opioid in a novel form.”
The ketamine anxiety study was published in the journal Depress Anxiety.
The ketamine naltrexone study was published in the journal JAMA Psychiatry.


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:grin::mushroom2::stoned::mushroom2::grin:

~ Love All For Being ~

https://www.youtube.com/watch?v=3DGnWzr5hXc


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Re: Dual studies highlight Ketamine’s potential to treat anxiety and addiction [Re: shroomguy087]
    #25903327 -

Ketamine is great stuff :grin:

Deffo up there with 1 of the best drugs.


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Learn to love all the things that you think are bad and then your life will start to be good.

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Re: Dual studies highlight Ketamine’s potential to treat anxiety and addiction [Re: HappySloth]
    #25903798 -

What's the point of the naltrexone besides to block opiod effect? I really hate how they force that combination ignoring that opiods are still used for pain management.

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Re: Dual studies highlight Ketamine’s potential to treat anxiety and addiction [Re: tacodude]
    #25904723 -

Quote:
What's the point of the naltrexone besides to block opiod effect? I really hate how they force that combination ignoring that opiods are still used for pain management.


the new wave of fascists say its good for the crazies and ocd I hear on the streets


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when I did that I was good at it, when did something else I was good at it
it was doing it all that I could never get straight fucking nazis in the way
not having parents had nothing to do with it

donate:dafunk

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Re: Dual studies highlight Ketamine’s potential to treat anxiety and addiction [Re: dickydonk]
    #25904730 -

some times I talk like yoda


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when I did that I was good at it, when did something else I was good at it
it was doing it all that I could never get straight fucking nazis in the way
not having parents had nothing to do with it

donate:dafunk

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Re: Dual studies highlight Ketamine’s potential to treat anxiety and addiction [Re: dickydonk]
    #25904970 -

Ketamine addiction is a nightmare. No drug is perfect.


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Never give up, never surrender.

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Re: Dual studies highlight Ketamine’s potential to treat anxiety and addiction [Re: Failboat]
    #25907939 -

I have no experience with ketamine but I have been really curious about how this will all pan out.  I have met some people who had bad ketamine habits and it has scared me away from the drug.  One of my best friends was like a big retarded baby for months when he kicked ketamine (daily IV habit).  He could hardly form sentences and would have random seizures.  I thought he wasn't gonna bounce back.  Scary shit.


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When we constantly pull things apart trying to see how it works, we may end up with only an understanding of how to destroy something
- nick sand


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Re: Dual studies highlight Ketamine’s potential to treat anxiety and addiction [Re: Psicomb]
    #25908004 -

I have experience with ketamine over the last 5 years. It worked well for me and I hope it will do the same for others. I had timed injections, followed by nasal inhalation. The stuff has a vile bitter taste when leaking out of your sinuses in to your mouth and is a little like sniffing fire, not enjoyable. A quicker method for treating depression than anything available now.

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Re: Dual studies highlight Ketamine’s potential to treat anxiety and addiction [Re: bankshot]
    #25910907 -

Ketamine has never helped me with anxiety personally (i have a panic disorder too)

Depression/ptsd sure.

Maybe my doses were too high.

Ketamine can cause anxiety provoking NDE type stuff


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Dreaming of That face again.
It's bright and blue and shimmering.
Grinning wide
And comforting me with it's three warm and wild eyes.

Prying open MY third eye


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Re: Dual studies highlight Ketamine’s potential to treat anxiety and addiction [Re: Fractal420]
    #25911287 -

I enjoyed a good gram line here and there, but usually start with .25g. Fuck needles.


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Never give up, never surrender.

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Re: Dual studies highlight Ketamine’s potential to treat anxiety and addiction [Re: Failboat]
    #25912515 -

If one uses fresh equipment and high quality K then there's not much difference between a doctor using K and using it at home as far as long term damage from needle use.

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Re: Dual studies highlight Ketamine’s potential to treat anxiety and addiction [Re: Failboat]
    #25912970 -

Quirkmeister92 said:
I enjoyed a good gram line here and there, but usually start with .25g. Fuck needles.


Gram line? Damn!

At least compared to what im used to. Railing 150mg of pure K is more than enough. In fact, i prefer low doses so even like 50mg is nice and floaty

But thats more of a party dose, not a disocciative dose. Like how at 120mg dxm is alot like adderall and not very disorienting. Or low dose mxe


--------------------
Dreaming of That face again.
It's bright and blue and shimmering.
Grinning wide
And comforting me with it's three warm and wild eyes.

Prying open MY third eye


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