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OfflinePsilosopherr
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Exact differences between heroin and morphine
    #18758417 - 08/26/13 03:33 AM (10 years, 5 months ago)

So I'm pretty confused about this. Heroin, once it enters the body, turns back into morphine right? Because it was originally "synthesized" from the morphine in poppy latex. Therefore, the high should be the same?

So what is the point of making morphine into heroin? To make more of it, and basically cut it? To make it easier to use?

And what exactly do they do when they 'synthesize' morphine into heroin? not really looking for a big tek, just the gist.

And, are the other alkaloids from poppy latex just discarded when they change it to heroin you think? why would they do that?

Any other info on differences would be much appreciated :yesnod:


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InvisibleDawks
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Re: Exact differences between heroin and morphine [Re: Psilosopherr]
    #18758425 - 08/26/13 03:43 AM (10 years, 5 months ago)

Heroin is much, much more potent than morphine. It also crossed the blood brain barrier faster and causes a more intense "rush."


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OfflineAce1928
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Re: Exact differences between heroin and morphine [Re: Dawks]
    #18758431 - 08/26/13 03:49 AM (10 years, 5 months ago)

http://en.wikipedia.org/wiki/Heroin

Explains it pretty well.
Unfortunately you never get it on the street in its pure form


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InvisibleDawks
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Re: Exact differences between heroin and morphine [Re: Psilosopherr]
    #18758432 - 08/26/13 03:50 AM (10 years, 5 months ago)

>And what exactly do they do when they 'synthesize' morphine into heroin? not really looking for a big tek, just the gist.

Basically they first separate the morphine from the plant material/fats from the opium latex. Then they react this together with acetic anhydride and sodium bicarbonate. There's more to it but that's the gist.


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OfflinePsilosopherr
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Re: Exact differences between heroin and morphine [Re: Dawks]
    #18758433 - 08/26/13 03:55 AM (10 years, 5 months ago)

Quote:

Dawks said:
>And what exactly do they do when they 'synthesize' morphine into heroin? not really looking for a big tek, just the gist.

Basically they first separate the morphine from the plant material/fats from the opium latex. Then they react this together with acetic anhydride and sodium bicarbonate. There's more to but that's the gist.



Do the other chemicals take up space and make the texture, or is something actually happening?

And how can it be more potent if it's derived from morphine? You extract it, mix it with other stuff, and it gets more potent? is this due to the opium latex containing a lot of junk(plant matter, fats)?


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Invisiblerulesq
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Re: Exact differences between heroin and morphine [Re: Psilosopherr]
    #18758440 - 08/26/13 04:00 AM (10 years, 5 months ago)

From erowid:

Quote:

In the acetylation of morphine to yield heroin (diacetylmorphine) the phenolic OH group on the 3-carbon is the first to react to give, as an intermediate, 3-O-monoacetylmorphine, which is further acetylated to heroin. Similarly, when heroin is deacetylated, either by hydrolysis or enzymatically, the more reactive 3-acetyl group tends to be removed first to yield 6-O-monoacetylmorphine as the predominant intermediate, although low levels of 3-O-monoacetylmorphine may also be formed under these conditions (Fig. 3




idk about the potency thingy, could be just a body/brain chemistry thing :shrug:

oh, from BL:

Quote:

The difference simply lies in heroin's advantageous lipid solubility. It is 3 times as effective in this area. The advantage allows it to cross the BBB 3 times as fast, thus saqting the relevant, in this case Mu, receptors that much faster.




Quote:

Think of heroin not so much as a different drug than morphine but as 2 acetyl groups which act as a vehicle for the faster and more efficient transmission of morphine across the blood-brain barrier. Non-parenteral administration of morphine and diamorphine produces identical effects, IV heroin produces a bigger rush because it crosses the BBB faster.




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Edited by rulesq (08/26/13 04:03 AM)


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InvisibleDawks
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Re: Exact differences between heroin and morphine [Re: Psilosopherr]
    #18758448 - 08/26/13 04:11 AM (10 years, 5 months ago)

>And how can it be more potent if it's derived from morphine?

In chemistry this is just how it goes. Some ligands are more potent than others, probably because of how the specific structure of the ligand interact with its receptor.

For instance this is 2cb which has a dose of 25mg and lasts 4 hours:



and this is DOB which has a dose of 2mg and lasts over 20 hours (that's over 10 times as potent and lasts 5 times as long).




Notice that 2cb and DOB are exactly the same except DOB has a methyl group at the alpha carbon?

In fact, just to blow your mind a little, if that broken wedge representing the methyl group was a solid wedge the drug would be inactive as the S isomer of DOB is inactive.


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Offlineakira_akuma
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Re: Exact differences between heroin and morphine [Re: Dawks]
    #18758465 - 08/26/13 04:25 AM (10 years, 5 months ago)

:havesomescience: chemistry is kewl.


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Invisiblerulesq
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Re: Exact differences between heroin and morphine [Re: akira_akuma]
    #18758485 - 08/26/13 04:33 AM (10 years, 5 months ago)

Quote:

akira_akuma said:
:havesomescience: chemistry is kewl.



Indeed. Wish I had paid more attention to chemistry in school :shrug:


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Offlineakira_akuma
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Re: Exact differences between heroin and morphine [Re: rulesq]
    #18758489 - 08/26/13 04:34 AM (10 years, 5 months ago)

i wish school would actually let you TRY chemicals.  :elmo:


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Invisiblerulesq
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Re: Exact differences between heroin and morphine [Re: akira_akuma]
    #18758496 - 08/26/13 04:38 AM (10 years, 5 months ago)

:lol:

We actually got to do it, but it was ammonium chloride aka Salmiakki(Salt Liquorice). so it wasn't that special

:cookiemonster:


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Offlineakira_akuma
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Re: Exact differences between heroin and morphine [Re: rulesq]
    #18758497 - 08/26/13 04:38 AM (10 years, 5 months ago)

that shit's for squares! :mad: pure Oxymorphone for the entire class!


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Invisiblerulesq
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Re: Exact differences between heroin and morphine [Re: akira_akuma]
    #18758505 - 08/26/13 04:41 AM (10 years, 5 months ago)

2nd that

:rail2:


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